Acids and Synthetic Reagents

<p>Applications 2-Amino-5-methylphenyboronic acid, pinacol ester<br></p>

<p>Applications (S)-(-)-2-Methylbutanol is a reagent in the isolation of KM-01 from the two fungi Drechslera avenae and Pycnoporus coccineus<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, S., et al.: Bioorg. Med. Chem., 6, 1975 (1998);<br></p>

<p>Applications Bevirimat is a HIV-1 maturation inhibitor, targetting the Gag CA-SP1 cleavage site. HIV Inhibitor.<br>References Coric, P. et al.: Eur. J. Med. Chem., 62, 453 (2013); Waki, K. et al.: PLoS Path., 8, e1002997 (2012);<br></p>

<p>Applications 4-(Trifluoromethyl)benzonitrile is used in the synthesis of quinazolines for amidines. Also used in the synthesis of s-transferase p1-1 and cancer cell proliferation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lv, Y. et al.: Chem. Comm., 49, 6349 (2013); Yang, X. et al.: J. Med. Chem., 53, 1015 (2010);<br></p>

<p>Applications Dihydrokainic acid is an EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake.<br>References Grunewald, M., et al.: J. Biol. Chem., 275, 9684 (2000); Shimamoto, K., et al.: Mol. Pharmacol., 53, 195 (1998);<br></p>

<p>Applications α-Phenyllongifolol is an impurity in the synthesis of Longifolene (L469455) which is a constituent of black cumin seed and may exhibit anticancer and antibacterial activities.<br>References Hajhashemi, V., et al.: Phytother. Res 18, 195 (2004); Bourgou, S., et al.: S Afr J Bot 76, 210 (2010)<br></p>

<p>Applications (Ethoxycarbonylmethyl)triphenylphosphonium-13C2 bromide is an intermediate in the synthesis of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone-13C5, which is an isotope labelled Mutagen X (MX) is a chlorinated furanone that accounts for more of the mutagenic activity of drinking water than any other disinfection byproduct. DNA damages provoked by the six mutagens (furylframide, MX, 4-nitroquinoline N-oxide, sodium azide, 1-nitropyrene, and captan) used in the present study have been known to subject to the nucleotide excision repair system.<br>References Hakulinen, P., et al.: Toxicol. Lett., 151, 439 (2004), Richardson, S., et al.: Mutat. Res., 636, 178 (2007), Kim, J., et al.: Environ. Toxicol., 23, 319 (2008),<br></p>

<p>Applications (+)-Biotinyl 3,6,9-Trioxaundecanediamine is a biotin derivative and is used as a reagent in the synthesis of a potent, covalent BTK inhibitor for B-cell lymphoma.<br>References Wu, H., et al.: ACS Chem. Biol., 9, 1086 (2014)<br></p>

<p>Applications 1-Iodo-3-nitrobenzene is a reactant used int he synthesis of Vismodegib (V674700), an, antineoplastic drug that targets the Hedgehog (Hh) pathway. Inhibition of the Hh signaling may be effective in the treatment and prevention of many types of human cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cao, M., et. al.: Chem. Papers, 68, 1408 (2014); Gupta, S. et al.: Ther. Advances in Med. Oncology 2,237(2010)<br></p>

<p>Applications CEP-28122 is used as an orally efficacious inhibitor of (ALK), analplastic lymphoma kinase, in the treatment of cancer.<br>References Gingrich, D. et al.: J. Med. Chem., 55, 4580 (2012);<br></p>

<p>Applications Ethyl (2R,4S)-4-Methylpipecolate is an intermediate in the preparation of Argatroban (A769000).<br>References Hilpert, K. et al.: J. Med. Chem., 37, 3889 (1994), Kim, K. et al.: Med. Chem. Res., 6, 377 (1996),<br></p>

<p>Applications [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene] Dichloro(o-isopropoxyphenylmethylene)ruthenium is a cross-metathesis catalyst used for installation of S-allylcysteine in proteins for enabling olefin metathesis on proteins.<br>References Lin, Y.A., et al.: J. Am. Chem. Soc., 132, 16805 (2010); Chalker, J.M., et al.: Chem. Comm., no vol., 3714 (2009)<br></p>

<p>Applications [4,​4'-​Bis(tert-butyl)​-​2,​2'-​bipyridine]​bis[3,​5-​difluoro-​2-​[5-​(trifluoromethyl)​-​2-​pyridinyl]​phenyl]​iridium(III) hexafluorophosphate is commonly used as a catalyst in the synthesis of various compounds such as saturated N-​heterocycles from aldehydes, fosmidomycin analogue, and many more.<br>References Jindakun, C., et al.: Org. Lett. 20, 2071-75 (2018); Guo, T., et al.: Adv. Synth. Catal., 360, 1352-57 (2018); Abbas, S.Y., et al.: Org. Lett., 20, 868-71 (2018)<br></p>

<p>Applications (R)-(-)-α-Methoxyphenylacetic Acid is a useful synthetic intermediate. It is used as a reactant in the synthesis of dopamine receptor agonists. It can also be used to prepare hydroxytriamides as potent γ-secretase inhibitors.<br>References Biswas, S., et al.: J. Med. Chem., 51, 101 (2008); Prasad, C., et al.: Bioorg. Med. Chem. Lett., 14, 1917 (2004)<br></p>

<p>Applications A useful synthetic intermediate for carbohydrate synthesis.<br></p>

<p>Applications AC 220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).<br>References Zarrinkar, P., et al.: Blood, 114, 2984 (2009); Sato, T., et al.: Blood, 117, 3286 (2011)<br></p>

<p>Applications GI 254023X is an ADAM10 metaloproteinase inhibitor.<br>References Hoettecke, N., et. al.: Neurodegeneration Diseases, 7, 232 (2010)<br></p>

<p>Applications ML324 is a JMJD2 demethylase inhibitor. It blocks the initiation of viral lytic infection and HSV-1 reactivation in the sensory ganglia of latently infected mice.<br>References Liang, Y., et al.: Sci. Translational Med., 5, 167ra5 (2013)<br></p>

<p>Applications Disodium Tetrachloropalladate is an inorganic compound used in organometallic chemistry for the preparation of phosphine complexes of palladium.<br>References Ramirez-Rave, S., et al.: J. Orgometallic. Chem., 749, 287 (2014);<br></p>

<p>Applications tert-Butyl Methylcarbamate is an substituent in the synthetic preparation of PF-06463922, a macrocyclic inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1).<br>References Johnson, T. W., et al.: J. Med. Chem., 57, 4720 (2014);<br></p>

<p>Applications Silver Carbonate is used in organic synthesis in the Koenigs-knorr glycosylation reaction. It is also known as Fetizon's reagent acting as an oxidising agent on celite forming lactones form diols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fetizon, M., et al.: J. Chem. Soc. Chem. Comm., 19, 1118 (1969);<br></p>

<p>Applications A sulfanilamide derivative of Chitosan with antifungal properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tashiro, T., et al.: Bioorg. Med. Chem., 16, 8896 (2008), Alcalde, E., et al.: J. Med. Chem., 52, 675 (2009),<br></p>

<p>Applications Vadimezan is a drug that displayed vascular-disrupting activity and induced haemorrhagic necrosis and tumour regression in pre-clinical animal models. It is a substrate for the immune adaptor protein STING in mice.<br>References Buchanan, C.M., et al.: Clin. Sci., 122, 449 (2012); Fruh, M., et la.: Clin. Lung. Cancer., 14, 34 (2013); Chem. and Eng. News page 24 Feb. 26, 2018<br></p>

<p>Applications Tetramethylammonium Bromide (cas# 64-20-0) is a useful research chemical.<br></p>

<p>Applications NE-100 is a potent and selective σ1 receptor antagonist.<br>References Sabino, V., et al.: Psychopharmacology, 205, 327 (2009); Kunitachi, S., et al.: Brain Res., 1279, 189 (2009)<br></p>

<p>Applications A reagent used in the synthesis of glycidol, a stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.<br>References Palomo, J.M. et al.: Tetrahedron Asymm., 16, 869 (2005); Hiles, R.A., et al.: Food Cosmet. Toxicol., 19, 347 (1981); Thompson, E.D., et al.: Food Chem. Toxicol., 22, 665 (1984);<br></p>

<p>Stability Light Sensitive<br>Applications Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kajikawa, N., et al.: Arzneim.-Forsch., 39, 495 (1989), Demolis, J.-L., et al.: J. Cardiovasc. Pharmacol., 22, 711 (1993), Okuda, Y., et al.: Prostaglandins, 52, 375 (1996),<br></p>

<p>Applications A 769662 is an AMP-activated protein kinase (AMPK) activiator. A 769662 selectively activates cardiac AMPK heterotrimeric complexes contg. α2/β1-subunits.<br>References Timmermans, A.D., et. al.: Am. J. Phys., 306, H1619 (2014)<br></p>

<p>Applications N-(3-Bromopropyl)phthalimide is used in synthesis of several organic compounds including that of flavonoid derivatives which act as selective ABCC1 modulators with potential use as pharmacological tools for investigation of the role of ABCC1. It is also used in the synthesis of Hederagenin which is a triterpene template for the development of new antitumor compounds.<br>References Obreque, B., et al.: Eur. J. Med. Chem., 109, 124 (2016); Rodriguez-Hernandez, D., et al.: Eur. J. Med. Chem., 105, 57 (2015);<br></p>

<p>Applications (S)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane is often used in biosynthetic preparations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Spelberg, J.H., Tetrahedron, Asy., 10, 2863 (1999);<br></p>

<p>Applications D-(-)-Diisopropyl Tartrate is a reagent for kinetic resolution of racemic allylic alcohols and α-furfuryl amides by enantioselective epoxidation.<br>References Lee, E., et al.: J. Org. Chem., 1994, 59 1444; Jung, M., et al.: J. Am. Chem. Soc., 115, 12208 (1993); Wang, Z., et al.: Tetrahedron, 49, 2641 (1993)<br></p>

<p>Applications 7-Methoxy-2-naphthol is used as a reactant in the preparation of 9-hydroxy benzopyrene (H829410). It is also used in the preparation of (pyridyl)naphthalenes as highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.<br>References Pinto-Bazurco Mendieta, M.A.E., et al.: J. Med. Chem. 56, 6101 (2013)<br></p>

<p>Applications 1-Bromooctadecane is a reagent in the preparation of branched glycosyl phosphatidyl inositol (GPI) anchors of rat brain Thy-1.<br>References Pekari, K., et al.: J. Org. Chem., 68, 1295 (2003);<br></p>

<p>Applications 3-Chloro-2-fluorobenzyl Bromide (cas# 85070-47-9) is a compound useful in organic synthesis.<br></p>

<p>Applications MK-886 is a potent and selective inhibitor of FLAP and Cox-1.<br>References Gillard, J., et al.: Can. J. Physiol. Pharmacol., 67, 456-464 (1989);<br></p>