Organoboranes

Applications Tris(trimethylsilyl)guanine is an intermediate used in the synthesis of 9-(2-Hydroxyethyl)guanine (H942035), which is an impurity of the antiviral agent Acyclovir (A192400). 9-(2-Hydroxyethyl)guanine is a nucleoside phosphotransferase acceptor.
References Kamimura, A. et al.: Agric. Biol. Chem., 37, 2037 (1973);

Applications 3,4-Dihydro-2H-1,4-benzoxazine-7-boronic acid pinacol ester is a useful intermediate for the synthesis of naphthamides which functions as VEGFR-2 kinase inhibitors for cancer treatment.
References Lv, Y., et al.: ACS Med. Chem. Lett., 5, 592 (2014)

Applications Tetramethylammonium Triacetoxyborohydride is used in the synthesis of Peloruside A. Epoxypropanoate is a neurokinin substance P receptor antagonist synthesized from this compound.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gazaille, J. et al.: Org. Lett., 14, 178 (2012); Prevost, S. et al.: Tetrahedron Asymm., 21, 16 (2010);

Applications 2-Cyclohexylvinylboronic Acid is used in the synthesis of vinylbenziodoxolones, a novel type of hypervalent iodine(III) reagents.
References Stridfeldt, E., et al.: Chem. Eur. J., 22, 16066-16070 (2016)

Stability Moisture Sensitive
Applications Chloroborane Methyl Sulfide Complex is a reagent in the synthesis of 3,4-Dimethyl-5-pentyl-2-furanundecanoic Acid (D477535); a furan fatty acid known to exhibit radical-scavenging ability and having anti-inflammatory properties.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Grahl, N., et al.: Marine. Biol., 157, 1567 (2010); Spiteller, G., et al.: Lipids., 40, 75 (2005); Wakimoto, T., et al.: PNSA., 108, 17533 (2011)

Applications 3-(N,N-Dimethylamino)phenylboronic Acid (cas# 178752-79-9) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Tetrabutylammonium tetrafluoroborate (cas# 429-42-5) is a useful research chemical.

Applications 1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-ol is used as a reagent in the synthesis of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease.
References Ding, C.Z., et al.: Bioorg. Med. Chem. Lett., 20, 7317 (2010)

Applications 3-Acetylphenylboronic acid

Applications (E)-2-(1-Butenyl)-1,3,2-benzodioxaborole (cas# 106094-36-4) is a compound useful in organic synthesis.

Applications (3-Aminopropyl)trimethoxysilane is used in the synthesis of aspirin imprinted polymer on silica gel surface and appreciation on drug sustained release. Fluorine-doped; lectin functionalized ZnO nanoarrays as 3D nano-biointerface for bacterial detection.
References Lu, P., et al.: Gaofenzi Cailiao Kexue Yu Gongcheng, 33, 130 (2017); Zheng, L., Talanta, 167, 600 (2017)

Applications 3-(2-Hydroxypropan-2-yl)phenylboronic acid

Applications 3-O-tert-Butyldimethylsilyl-cholest-5-ene-3-ol 24-(2-hydroxyisopropyl) 24-Phenyl Sulfinate is an intermediate in the preparation of Campesterol (C155360).

Applications (4-((4aR)-7-(Benzyloxy)-3,4,4a,5-tetrahydro-2H-chromen-3-yl)phenoxy)(tert-butyl)dimethylsilane is an protected intermediate in the synthesis of isoflavone Daidzein (D103500) related compounds.

Stability Volatile
Applications Allyltrimethylsilane is used in the allylation of aldehydes, imines, allylic and benzylic alcohols, and chiral α-keto-amides that are derived from (S)-proline esters.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yadav, J.S., et al.: Tetrahedron Lett., 43, 3783 (2002); Aggarwal, V.K., et al.: Tetrahedron Lett., 37, 3745 (1996); Wang, D.K., et al.: J. Org. Chem., 64, 4233 (1999); Kaur, G., et al.: Tetrahedron Lett., 38, 2521 (1997); Soai, K., et al.: J. Chem. Soc., Chem. Commun., 15, 1016 (1984)

Applications TETRAMETHYLAMMONIUM BOROHYDRIDE (cas# 16883-45-7) is a useful research chemical.

Applications (2-Ethynylphenyl)boronic acid

Applications 5-(Ethoxycarbonyl)thiophene-3-boronic Acid is a useful reagent for preparing hydroxyimino(phenyl)propanones as GPBAR1 agonists.
References Bissantz, C., et al.: U.S. Pat. Appl. Publ. (2012), US 20120010190 A1

Applications Trimethoxy(octyl)silane is a surface modifier used as additive for polymer encapsulation and for controlled drug delivery.
References Erdem, B., et al.: Langmuir, 17, 2664 (2001); Doadrio, J., et al.: J. Mater. Chem., 16, 462 (2006);

Applications tert-Butylmethoxydimethylsilane is used as a reactant in the preparation of chlorosilanes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Masaoka, S., et al.: J. Organomet. Chem., 691, 174 (2006);

Applications Triethylsilane is a trialkylsilicon hydride used in the synthesis of alkylsilanes via hydrosilation of olefins. Triethylsilane is also used as an effective reducing agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cesca, S. et al.: Chim. Indust., 51, 1093 (1969): Svoboda, P. et al.: Coll. Czech. Chem. Comm., 37, 1585 (1972); Tsuji, J. et al.: Tetrahedron, 30, 2143 (1974):

Applications methyl 4-(bromomethyl)-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas# 1626407-50-8) is a useful research chemical.

Applications 2-Hydroxyphenylboronic acid

Applications (5-Formylfuran-2-yl)boronic Acid is a reagent used in Suzuki cross-couplings with deactivated aryl bromides and activated aryl chlorides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Trinh, T. N., et al.: Org. Biomol. Chem., 12, 9562-9571 (2014);

Applications Butylboronic Acid is a boronic acid derivative that can be used as a transport carriers in membrane-based sugar separations. Butylboronic Acid is used as an analytical reagent in the determination of serum glucose.
References Smith, B.D. et al.: ACS Symp. Ser., 642, 194 (1996); Prendergast, J.L. et al.: Anal. Bional. Chem., 397, 1779 (2010);

Applications Allylboronic acid pinacol ester
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4-Ethylsulfonylphenylboronic acid is used in the discovery of small molecular RIP1 kinase inhibitors for the treatment of pathologies associated with necroptosis.
References Harris, P. A,, et al.: ACS Med. Chem. Lett., 4, 1238 (2013)

Applications 4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1-butanamine is a reactant that is used for the synthesis of various racemic and biotinylation of azamacrocycles.
References Krivickas, S.J., et al.: J. Org. Chem. 72, 8280 (2007).

Stability Moisture Sensitive
Applications 4-(N,N-Dimethylaminosulfonyl)phenylboronic acid pinacol ester

Applications 5-Bromopentylboronic Acid

Applications 2,6-Dimethylphenylboronic acid

Applications trans-Campestanyl 3-(4-(tert-Butyldimethylsilyl)oxy)-ferulate is an intermediate used in the synthesis of trans-Campestanyl Ferulate (C155308), which is used for synthesis of trans-feruloyl-β-sitostanol.
References Condo, A., et al.: J. Agric. Food Chem., 49, 4961 (2001);

Applications Stigmasteryl-O-tert-butyldimethylsilane Ferulate is an intermediate used in the synthesis of Stigmasteryl Ferulate (S686768), which is used for purification and identification of components of γ-oryzanol in rice bran oil.
References Xu, Z., et al.: J. Agric. Food Chem., 47, 2724 (1999);

Stability Moisture Sensitive
Applications n-Octadecyltrichlorosilane (cas# 112-04-9) is a useful research chemical.
E0

Applications 2-tert-Butyldimethylsilyloxyethyl Tosylate is an intermediate in the synthesis of Everolimus (E945400), which is Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.
References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001), Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001), Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002),

Applications TRIMETHYL(BROMODIFLUOROMETHYL)SILANE (cas# 115262-01-6) is a useful research chemical.

Applications 2-Carboxyfuran-5-boronic acid, pinacol ester

Applications 5-Formylfuran-2-boronic Acid Pinacol Ester could be useful for the diastereoselective synthesis of cyclic peptide macrocycles via Petasis borono-Mannich reaction
References Yamaguchi, A., et al.: Chem. Commun. (Cambridge, U. K.), 55, 10567 (2019)

Applications Di(p-anisyl)iodonium Tetrafluoborate (cas# 1426-58-0) is a compound useful in organic synthesis.

Applications 1-Butenylboronic Acid is a reagent used in the synthesis of polyene natural products.
References Lee, S. J., et al.: J. Am. Chem. Soc., 130, 466-468 (2008)

Applications 1,2,2-Trimethylcyclopropyl Boronic Acid is the boronic acid analogue of 1,2,2-Trimethylcyclopropane. Boronic acid derivatives are widely used in several applications in organic synthesis.

Applications Benzo[b]thien-3-ylboronic acid is used in the synthesis and evaluation of dual wavelength fluorescent benzo[b]thiophene boronic acid derivatives for sugar/glycoprotein sensing.
References Akay, S., et al.: Chem. Biol. Drug Des., 70, 279 (2007)

Applications Trichloro[2-(chloromethyl)-2-propen-1-yl]silane is an intermediate used in the synthesis of 2-​(Chloromethyl)​allyl-​trimethylsilane (C371430), which is one of the reagents to synthesize Leucasandrolide A Macrolide (I) via Mukaiyama aldol coupling.2-​(Chloromethyl)​allyl-​trimethylsilane was used in catalytic Sakurai reaction of α,​β-​enones.
References Kopecky, D., et al.: J. Am. Chem. Soc., 123, 8420 (2001).Lee, P., et al.: J. Org. Chem., 66, 8646 (2001).

Applications 1,1,1,5,7,7,7-Heptamethyl-3,3-bis[(trimethylsilyl)oxy]tetrasiloxane is used in the analysis of organosilicon compounds (eg hexamethyldisiloxane) using gas chromatography or mass spectrometry.
References Wurst, M., et al.: Chromatographia, 6, 359 (1973), Wurst, M.: Chemicky Prumysl, 22, 124 (1972)

Applications Ethynyltrimethylsilane is used in the production of novel histone deacetylase inhibitors for the treatment of Freidreich’s ataxia. It also aids in the preparation of conjugated polymers with sn anthracene backbone.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Xu, C. et al.: Pharmaceu. 4, 1578 (2011); Kobayashi, E. et al.: J. Polym. Sci. Part A: Polym. Chem., 28, 2641 (1990);

Applications 4-(Cyanophenyl)boronic Acid Pinacol Ester is used to prepare arylparacyclophanes via Suzuki aryl cross-coupling of bromoparacyclophane with arylboronic acid and arylboronates. It’s also used to prepare tyrosine-modified analogs of α4β7 integrin inhibitor biotin-R8ERY.
References Roche, A., et al.: Org. Biomol. Chem.,, 3, 515 (2005); Papst, S., et al.: Bioorg. Med. Chem., 20, 5139 (2012)

Applications Tetramethylammonium Tetrafluoroborate (cas# 661-36-9) is a useful research chemical.

Applications 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopent-2-en-1-one (cas# 1370008-65-3) is a useful research chemical.

Applications 5-Formylfuran-2-boronic Acid Neopentyl Glycol Ester is a useful reagent in lapatinib synthesis.
References Radl, S., et al.: PCT Int. Appl. (2014), WO 2014059956 A1

Applications (1-acetyl-2,3-dihydro-1H-indol-5-yl)boronic acid (cas# 905971-97-3) is a useful research chemical.

Applications tert-Butyldiphenylchlorosilane is used to synthesize interphenylene phenyloxazoles, compounds that have antagonistic activity against thromboxane receptors which can be used for treatment of circulatory disorders, angina and stroke.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hadjipavlou–Litina, D. & Kontogiorgis, C.: Int. Elect. J. Mol. Des., 1, 300 (2002); Misra, R., et al.: Bioorg. Med. Chem. Lett., 2, 937 (1992)

Applications 4-(Methoxycarbonyl)phenylboronic Acid is used in the synthesis and evaluation of several organic compounds including that of 4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate which is a potent inhibitor of intracellular NAAA activity. Also used in the design and synthesis of BMS-955176 which is a potent, orally active second generation HIV-1 maturation inhibitor.
References Nuzzi, A., et al.: Eur. J. Med. Chem., 111, 138 (2016); Rogueiro-Ren, A., et al.: ACS Med. Chem. Lett., 7, 568 (2016);

Applications Perphenylcyclopentasilane is an intermediate in the synthesis of Cyclopentasilane (C988380), a reagent used for depositing silicon on surfaces for electronics applications.
References Morisaki, Y., et al.: Chem. Lett., 38, 498 (2009);

Applications 3-((1-Oxo-1-(3-(trimethylsilyl)propoxy)propan-2-yl)thio)propanoic acid is useful reagent for organic reactions and synthesis.

Applications 2-(6,6-Dimethyl-1-cyclohexen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane was used in the preparation of conformationally constrained cyclic carboxylic acid derivatives useful as GPR40 modulators for treating metabolic disorders.

Applications Methoxy4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-benzenemethanol, is prepared synthetically from vanillin (V097500) with an intermediate of methoxy-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-benzaldehyde (M269710).
References Gowravarm, S. et al.: Adv. Synth. Catal., 343, 169 (2001)

Applications tert-Butyldimethyl(4-(nitrosophenyl)butoxy)silane is an intermediate used in the synthesis of (E)-S-(3-((4-((4-(4-hydroxybutyl)phenyl)diazenyl)phenyl)amino)-3-oxopropyl) methanesulfonothioate (H895230), which is a useful research chemical.

Applications 4-Carboxyphenylboronic acid is a reagent used in suzuki coupling reactions.
References Hu, Z., et al.: Wuji Huaxue Xuebao, 34, 387 (2018); Ibrahim, M., et al.: J. Organomet. Chem., 859, 44 (2018); Erami, R. S., et al.: Catalysts, 7, 76 (2017)

Applications Isopropenylboronic Acid Pinacol Ester, can be used as an intermediate in the synthesis of variety of cyclic and acyclic organic compounds. It is also shown that the α-Substituted Allyl/Croty of this compound can be used for highly Diastereo- and Enantioselective allylboration of aldehydes.
References Salaun, J. et al.: Topics in Curr. Chem. 1, 144 (1988); Chen, J. et al.: J. Amer. Chem. Soci., 135, 5316 (2013);

Applications N-Pentylboronic Acid is used in the synthesis of (-)-Δ8-THC and (-)-Δ9-THC. Also it aids in the synthesis of boronic acid inhibitors of endothelial lipase.
References O'Connell, D. et al.: Bioorg. Med. Chem. Lett., 22, 1397 (2012); Cheng, L. et al.: Org. Lett., 15, 764 (2013);

Applications (2,5-Dimethylphenyl)boronic Acid is a useful synthetic intermediate. It can be used to prepare fluorenones/indenofluorenediones.
References Liu, T., et al.: Org. Lett., 13, 2452 (2011)

Applications 5-Ethyl-2-fluorophenylboronic acid

Applications 3-(Cyclopropylaminocarbonyl)phenylboronic acid

Applications Thiazol-4-ylboronic acid (cas# 1016642-07-1) is a useful research chemical.

Applications 5-Aminoboronphthalide is used as a reactant in the preparation of 2,1-benzoxaborole peptide isoquinoline derivatives as HCV NS3 protease inhibitors. It is also used as reactant in the synthesis of nanocarrier for chemomechanically driven guest delivery fueled by intracellular ATP.
References Li, X., et al.: Bioorg. Med. Chem. Lett., 21, 2048 (2011); Biswas, S., et al.: Nat. Chem., 5, 613 (2013);

Applications tert-Butyl (5-Chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate is used as a reactant in the synthesis of BRAF-kinase inhibitors.
References Repik, Alexey E., et al.: PCT Int. Appl., WO 2017146604 A1 20170831 (2017)

Applications 4-Carboxymethylphenylboronic acid

Applications N-Propylboronic Acid is a chemical reagent used in the synthesis of pharmaceutical agents such as inhibitors of mTOR for use in anti-tumor treatments. Also used to synthesize endothelial lipase inhibitors
References Takeuchi, C. et al.: J. Med. Chem., 56, 2218 (2013); O'Connell, D. et al.: Bioorg. Med. Chem. Lett., 22, 1397 (2012);

Applications m-Carborane, 98% (cas# 16986-24-6) is a useful research chemical.