Ketones

<p>Please enquire for more information about 1-(2,4-difluorophenyl)-3-(4-methylphenylthio)pyrrolidine-2,5-dione including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 1-(5-Methyl-3-(3-pyridyl)-2,4-thiazolyl)ethan-1-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 6-Amino-3-(tert-butyl)-2-methylindeno[3,2-c]pyrazol-4-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 1-(4-(2-Nitro-4-(trifluoromethyl)phenoxy)phenyl)ethan-1-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-(Chloromethyl)-1,3-dioxolan-2-one is a chemical compound that is used as a reagent in organic synthesis. It can be prepared by reacting 4-chloro-2-oxopentanenitrile with formaldehyde. 4-(Chloromethyl)-1,3-dioxolan-2-one has been used in the synthesis of epoxides and other compounds. The reaction mechanism involves an initial nucleophilic attack by chlorine on the electrophilic carbon atom. This leads to the formation of a reactive intermediate which then reacts with another molecule of formaldehyde to form 4-(chloromethyl)-1,3-dioxolan-2-one and release hydrogen chloride gas. Kinetic studies have shown that the rate of this reaction increases with increasing temperature but reaches an optimum at about 60°C. 4-(Chloromethyl)-1,3-dioxolan-2-one</p>

<p>Please enquire for more information about 4-(4-((Aminothioxomethyl)amino)phenyl)-1,4-thiazaperhydroine-1,1-dione including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 5,5-Dimethyl-3-(benzylamino)cyclohex-2-en-1-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 5-Methyl-1-phenyl-1,2,4-triazolin-3-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-Chloro-5,5-dimethyl-3-(4-phenylpiperazinyl)cyclohex-2-en-1-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Applications (E)-1-(Benzo[b]​thiophen-​2-​yl)ethanone Oxime is an isomer of N-​(1-​Benzo[b]​thiophen-​2-​yl-​ethyl)​-​hydroxylamine a reagent used in the preparation of Zileuton, an anti-asthmatic drug.<br>References Guinchard, X. et al.: J. Org. Chem., 73, 2028 (2008)<br></p>

<p>Stability Volatile<br>Applications Cyclobutanone is a member of cycloketone compounds that have potential genotoxic and cytotoxic effects and are most commonly found in irradiated food.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anandon, A., et al.: EFSA Journal, 9, 1930 (2011); Delincee, H., et al.: Radiat. Phys. Chem., 63, 431 (2002); Obana, H. ,et al.: J. Health Sci., 52, 375 (2006)<br></p>

<p>Applications 1-Cyclopropyl-1,3-butanedione is a reagent in regioselective synthesis of pyrazolylpyrazolopyrimidine derivatives in aqueous medium for antimicrobial agents.<br>References Novinson, T., et al.: J. Med. Chem., 17, 645 (1974); Aggarwal, R., et al.: Eur. J. Med. Chem., 46, 3038 (2011)<br></p>

<p>Applications 4-Cyanocyclohexanone is used to prepare nicotinamides as PDE4 D isoenzymes inhibitors. It is also used as an anthranilic acid replacement in niacin receptor agonist.<br>References Marfat, A., et al.: PCT Int. Appl. (1998), WO 9845268 A1 19981015; Schmidt, D., et al.: Bioorg. Med. Chem. lett., 20, 3426 (2010)<br></p>

<p>Applications 1-(1,3-Benzodioxol-5-yl)-1-hexanone is an intermediate used in the synthesis of 1-(1,3-benzodioxol-5-yl)-2-(1-pyrrolidinyl)-1-Hexanone (B207110), which is also known as MDPHP, is a synthetic cathinone.<br>References Fowble, K. L.; et al.: Talanta, 179, 546 (2018).<br></p>

<p>Applications 1-Cyclohexylethanone is used in the synthesis of thiosemicarbazide derivatives which exhibits biological activity.<br>References Venkatesh, K., et al.: J. Chem. Pharm. Res., 7, 437-445 (2015)<br></p>

<p>Applications 1-(2-Hydroxy-4,6-dimethylphenyl)-ethanone was investigated for its properties as an antibacterial agent and urease inhibitory effects.<br>References Ngan, L.T., et al.: J. Agri. Chem., 60, 9062 (2012); Chermenskaya, T.D., et al.: Industrial. Crops. Prod., 36, 122 (2012);<br></p>

<p>Applications 2-Isobutyrylcyclohexanone (cas# 39207-65-3) is a useful research chemical.<br></p>

<p>Applications 2,5-dimethoxycyclohexa-2,5-diene-1,4-dione (cas# 3117-03-1) is a useful research chemical.<br></p>

<p>Applications 3-Hydroxy-cyclohexanone is a chemical reagent used in organic synthesis. Used in enantioselective conjugate-addition reactions as well as the cross coupling of enantioenriched secondary potassium β-trifluoroboratoamides.<br>References Molander, G. et al.: Adv. Synth. Catal., 355, 3037 (2013); Kitanosono, T. et al.: Chem. Asian J., 9, 179 (2014);<br></p>

<p>Applications 2-Hexylidenecyclopentanone is a compound that is found in fragrance.<br>References Scognamiglio, J., et al.: Food Chem. Tox., 3, S577 (2012)<br></p>

<p>Applications 7-Hydroxy-1-indanone (cas# 6968-35-0) is a useful research chemical.<br></p>

<p>Applications Cyclododecanone is a general chemical reagent used in organic synthesis.<br>References Hu, Y. et al.: Org. Biomol. Chem., 14, 3022 (2016);<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications Acetoxymethyl Vinyl Ketone (cas# 38982-28-4) is a compound useful in organic synthesis.<br>References Zingel, V., et al.: Eur. J. Med. Chem., 25, 673 (1990), Sabourin, P., et al.: Carcinogenesis, 13, 1633 (1992),<br></p>

<p>Applications 1,3-Cyclopentanedione was used in the synthesis of chemical probes for selective labeling of sulfenic acid proteins. It was also used to synthesize enaminones with possible anticonvulsant activity.<br>References Qian, J., et al.: Chem. Comm., 47, 9203 (2011); Scott, K., et al.: J. Med. Chem., 36, 1947 (1993)<br></p>

<p>Applications (Z)-1-(Benzo[b]​thiophen-​2-​yl)ethanone Oxime is an isomer of N-​(1-​Benzo[b]​thiophen-​2-​yl-​ethyl)​-​hydroxylamine a reagent used in the preparation of Zileuton, an anti-asthmatic drug.<br>References Guinchard, X. et al.: J. Org. Chem., 73, 2028 (2008)<br></p>

<p>Applications 5-[(4-Fluorobenzylidene]-2,4-thiazolidinedione (cas# 262601-87-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Cyclopentanone-2-carbonitrile (cas# 2941-29-9) is a useful research chemical. It acts as a reagent in the preparation of quinolines<br>References Larsen, R. D., et al.: Science of Synthesis, 15, 389 (2005)<br></p>

<p>Applications 1-(2,5-Dihydroxyphenyl)ethanone is an intermediate used in various synthetic preparations of pharmaceutical goods, 1-(2,5-Dihydroxyphenyl)ethanone was untilized in the synthesis of new flavonoid fatty acid esters with anti-adipogenic and glucose consumption enhancing activities.<br>References Zhao, W., et al.: Bioorg. Med. Chem., 19, 3192 (2011); Jayashree, B.S., et al.: Asian. J. Chem., 22, 1055 (2010); Benites, J., et al.: Bioorg. Med. Chem., 16, 862 (2008);<br></p>

<p>Applications (2E)-2-Hexylidenecyclopentanone, is a compound that is found in fragrance.<br>References Scognamiglio, J., et al.: Food Chem. Tox., 3, S577 (2012)<br></p>

<p>Applications 2-Hexanone is used in various organic chemical syntheses. It is used in the synthesis of (+/-)-monomorine. It is also used in the preparation of alcohols by transfer hydrogenation of ketones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Le, T. et al.: Tetrahedron Lett., 53, 5660 (2012); Ikhile, M. et al.: Tetrahedron Lett., 53, 4925 (2012);<br></p>

<p>Applications Phenoxy-2-propanone is a general chemical reagent used in the preparation of α-arylthio ketones via DL-proline.<br>References Vaquer, A. et al.: RSC Adv. 5, 96695 (2015);<br></p>

<p>Applications 1-​(3-​Hydroxyphenyl)​-​1-​propanone is a reactant used to synthesize tricyclic fused pyridines, a family of alkaloids with antimalarial activity.<br>References Zheng, L., et al.: J. Org. Chem., 81, 8911-8919 (2016)<br></p>

<p>Applications Methyl 2-Cyclopentanonecarboxylate is used in the synthesis of functionalized ketones.<br>References Mashima, K. et al.: J. Org. Chem., 59, 3064 (1994); Hamashima, Y. et al.: J. Am. Chem. Soc., 124, 11240 (2002);<br></p>

<p>Applications 5β-Estrane-3,17-dione is an intermediate in the synthesis of neuroactive steroids useful in the treatment of CNS-related diseases.<br>References PCT Int. Appl. (2015), WO 2015180679 A1 20151203;<br></p>

<p>Applications 4,4-Dimethyl-1,3-cyclohexanedione (cas# 562-46-9) is a useful research chemical.<br></p>

<p>Applications 4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-butanone is a useful synthetic intermediate. It is a reagent used to prepare moverastin derivatives, an inhibitor of tumor cell migration. It can also be used in preparation of substituted alkene derivatives capable of releasing fragrant compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sawada, M., et al.: Bioorg. Med. Chem. Lett., 21, 1385 (2011);<br></p>

<p>Applications (E)-2-Heptylidenecyclopentanone, is a common substance that is found in fragrances.<br></p>

<p>Applications 3,4-DIHYDROXY-3-CYCLOBUTENE-1,2-DIONE (cas# 2892-51-5) is a useful research chemical.<br></p>

<p>Applications 4-Phenylcyclohexanone is used in the synthesis of CCR2 antagonists for the treatment of rheumatoid arthritis, atherosclerosis and other disease states. Also used in the preparation of coumarins via dehydrogenation and Heck coupling reactions.<br>References Subasinghe, N. et al.: Bioorg. Med. Chem. Lett., 23, 1063 (2013); Kim, D. et al.: Chem. Comm., 49, 4021 (2013);<br></p>

<p>Applications 2-Acetylcyclohexanone is used in the synthesis of 1-(pyridyl)ethanol derivatives that can reduce keto-esters and ketones. Also used in the synthesis of phenothiazine derivatives that can inhibit protein farnesyltransferase molecules and some that show anti-proliferative activity.<br>References Baciu-Atudosie, L. et al.: Bioorg. Med. Chem. Lett., 22, 6896 (2012); Kawano, S. et al.: Biosci. Biotech. Biochem., 75, 1055 (2011);<br></p>

<p>Applications 9-HEPTADECANONE (cas# 540-08-9) is a useful research chemical.<br></p>

<p>Applications 2-Cyclopentylcyclopentanone (cas# 4884-24-6) is a useful research chemical.<br></p>

<p>Applications Cyclohexyl phenyl ketone is a useful research chemical in organic synthesis.<br>References Yang, Tonghao, et al.: Org. Let., 20(7), 1875-1879 (2018);Jarava-Barrera, Carlos, et al.: Chem. - A Euro. J., 23(69), 17478-17481 (2017)<br></p>

<p>Applications 2-Heptacosanone is a useful research chemical for organic synthesis and other chemical processes.<br>References Dastillung, M., et al.: J. Chem. Res. Synopses, 5, 166 (1980), Liu, Q., et al.: Advan. Mater. Res., 230, 842 (2011)<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-(2-oxopropyl)-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione (cas# 57384-79-9) is a useful research chemical.<br></p>

<p>Applications (5Z,9Z,13Z)-Geranylgeranylacetone is the structural analogue of Teprenone (T103500), an anti-ulcerative. Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects). Reports indicate that GGA protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression. Other studies have shown that GGA induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice.<br>References Murakami, M., et al.: Arzneim.-Forsch., 31, 799 (1981); Nishizawa, Y., et al.: Xenobiotica, 17, 575 (1987)<br></p>

<p>Applications 5-Acetoxy-3-chloro-2-pentanone (cas# 13051-49-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 4,5-Dimethyl-3-hydroxy-2(5H)-furanone is a fragrant compound that is a key indicator of maple syrup urine disease, a disorder affecting newborn children that is the result of its inability to properly metabolize Valine (V094205), Leucine (L330110) and Isoleucine (I820175). 4,5-Dimethyl-3-hydroxy-2(5H)-furanone is naturally found in fenugreek seeds, and is an odourant present in sherry wines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Blank, I., et al.: Prog. Flav. Prec. Stud., No vol. given, 103 (1993); Guerra, P. &amp; Yaylayan, V.: J. Agr. Food Chem., 59, 4699 (2011); Mackenzie, D. &amp; Woolf, L.: Brit. Med. J., 1, 90 (1959); Podebrad, F., et al.: J. Inh. Metab. Dis., 22, 107 (1999)<br></p>

<p>Impurity: Propafenone EP Impurity H<br>Applications: Flavanone (Propafenone EP Impurity H) is a Propafenone (P757500) impurity.<br>References Kitagawa, S., et al.: Biol. Pharm. Bull., 29, 1 (2006), Boccard, J., et al.: Eur. J. Pharm. Sci., 36, 254 (2009),<br></p>

<p>Applications 3,​3-​Dimethyl-​2,​4-​pentanedione is used in asymmetric hydrosilation of ketones.<br>References Kuwano, R., et al.: Bull. Chem. Soc. Jpn., 73, 485 (2000).<br></p>

<p>Applications 1-[3,4-Bis(phenylmethoxy)phenyl]ethanone is an intermediate in synthesizing Arbutamine (A766300). It is a cardiac stimulant. Arbutamine stimulates adrenergic receptors.<br>References Sinusas, A., et al.: J. Nucl. Med., 35, 664 (1994); Sansoy, V., et al.: Circulation, 92, 994 (1995); Elhendy, A., et al.: Eur. J. Nucl. Med., 23, 1354 (1996);<br></p>

<p>Applications 1,3-Indandione is one of the starting materials in the one-pot multi-component synthesis of indenone-fused heterocyclic derivatives. Also it acts as electron-withdrawing end group used for organic photovoltaic cell application.<br>References Bayayt, M., et al.: Tetrahedron, 73, 1196-1204 (2017); Lim, E.: Mol. Cryst. Liq. Cryst., 635, 94-101 (2016);<br></p>

<p>Applications 4-Hydroxyphenylacetone (cas# 770-39-8) is a useful research chemical.<br></p>

<p>Applications iso-Butyl Vinyl Ketone is a major component in the secretion of Iporangaia pustulosa and Neosadocus maximus.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rocha, D.F., et. al. J. Nat. Prod., 74, 658 (2011)<br></p>

<p>Applications 1,8-Dioxacyclotetradecane-2,9-dione, can be used in synthetic preparation of lipase-catalyzed ring-opening polymerization of molecularly pure cyclic oligomers for use in synthesis and chemical recycling of aliphatic polyesters.<br>References Kondo, A., et al.: Macromolecular Bioscience, Vol. 8, Iss. 6, P: 533-539 (2008):<br></p>

<p>Applications 4,4-Dimethoxy-2-butanone is a reactant in the synthesis of naphthalimide-naphthyridine derivatives as a fluorescent probe for the detection of hydroxyl radicals in living cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Meng, L., et. al.: Chem. Commun., 50, 4843 (2014)<br></p>

<p>Applications 1-[2-Hydroxy-4,6-bis(ethoxymethoxy)phenyl]ethanone (cas# 128837-25-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 4'-Hydroxyflavanone (cas# 6515-37-3) could be a useful antitumor agent, specifically studied as a strong aromatase inhibitor against estrogen-dependent breast cancer.<br>References Kizilcan, D. S., et al.: Struct. Chem., 31, 1339 (2020)<br></p>

<p>Applications 4-(Morpholin-4-yl)cyclohexanone is a useful synthetic intermediate. It was used to synthesize diastereomeric 3,6-diaminobicyclo[3.1.0]hexane derivatives.<br>References Vilsmaier, E., et al.: Synthesis, 12, 1142 (1991)<br></p>

<p>Applications Dimethyl-1,3-acetonedicarboxylate is used in the preparation of optically active lycorane. It has also been substituted into bispidone derivatives for their use as ligands in PET imaging.<br>References Yoshizaki, H. et al.: J. Org. Chem., 60, 2016 (1995); Legdali, T. et al.: J. Org. Chem., 77, 11167 (2012);<br></p>

<p>Applications 2-ETHYL-1-INDANONE (cas# 22351-56-0) is a useful research chemical.<br></p>

<p>Applications 2-NONADECANONE (cas# 629-66-3) is a useful research chemical.<br></p>

<p>Applications 3-(prop-2-yn-1-yl)thiazolidine-2,4-dione (cas# 39137-29-6) is a useful research chemical.<br></p>

<p>Applications 2-Hydroxyimino-3-pentanone is an intermediate in the preparation of indole derivatives.<br>References Goya, P., et al.: J. Med. Chem., 35, 3977 (1992), Masaguer, C., et al.: Chem. Pharm. Bull., 47, 621 (1999), Wu, S., et al.: Bioorg. Med. Chem. Lett., 16, 5859 (2006),<br></p>

<p>Stability Moisture Sensitive<br>Applications (3R,4R)-Dihydro-3,4-bis(phenylmethoxy)-2,5-furandione is an intermediate in the synthesis of N-alkenylsuccinimide derivatives.<br>References Ohwada, J., et al.: Bull. Chem. Soc. Jap., 63, 287 (1990);<br></p>

<p>Applications Used in the preparation of benzopyran derivatives for their antiinflammatory properties.<br></p>

<p>Applications Benzyl p-Toluylketone (cas# 2001-28-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wu, Z., et al.: Bioorg. Med. Chem. Lett., 18, 2211 (2008), Gadad, A., et al.: Bioorg. Med. Chem., 16, 276 (2008),<br></p>

<p>Applications 1-(2-AMINO-5-HYDROXYPHENYL)ETHANONE (cas# 30954-71-3) is a useful research chemical.<br></p>

<p>Applications 3-Isochromanone can be used to prepare an organic catalyst.<br>References Wu, G., et.al.: Faming Zhuanli Shenqing, 31, (2021);<br></p>

<p>Applications (2R,​3S,​4S,​5S)-5-Hydroxy-2,3,4-tris(phenylmethoxy)-5-[(phenylmethoxy)methyl]-cyclohexanone was used in the synthetic preparation of N-substituted valiolamine derivatives.<br>References Fukase, H., et al.: J. Org. Chem., 57, 3642 (1992);<br></p>

<p>Applications 5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione is an impurity of the DPP-IV inhibitor Sitagliptin (S491000).<br>References Ye, F. et al.: Hech. Huax., 18, 767 (2010); Ahn, J.H, et al.: Bioorg. Med. Chem. Lett., 17, 2622 (2007);<br></p>

<p>Applications Cyclohexyl Vinyl Ketone is a reagent used in the synthesis of α,β-unsaturated carbonyl compounds which are aminotrifluoromethylathiolated.<br>References Xiao, Q. et al.: Org. LEtt., 17, 6090 (2015) ;<br></p>