Amides

Applications Cyanoacetamide has been used in photometric and fluorimetric postcolumn labeling.
References Honda S., et. al.: Anal. biochem., 134, 483(1983)

Applications N-DODECYL-ACETAMIDE (cas# 3886-80-4) is a useful research chemical.

Stability Hygroscopic
Applications Used as an intermediate in the industrial preparation of non-ionic X-ray contrast agents such as Iohexol (I729500), Ioversol (I737000), Ioxilan (I737500), Iopamidol (I735600).
References Rongved, P., et al.: Carbohydrate Res., 297, 325 (1997),

M02441 - Rolipram

Applications 2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).
References Carter, J., et al.: Bioorg. Med. Chem. Lett., 9, 1167 (1999); Rheault, T., et al.: ACS Med. Chem. Lett., 4, 358 (2013);

Applications Octadecanamide (cas# 124-26-5) is a useful research chemical.

Applications 1,1-Cyclohexanediacetic acid monoamide is an impurity of Gabapentin (G117250), an amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Gabapentin is used as an anticonvulsant.
References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)

Applications N,N-Dimethylacrylamide is a useful reagent for regioselective reactions.
References Cho, S., et al.: J. Am. Chem. Soc., 130, 9254 (2008); Grimster, N., et al.: Angew. Chem. Int. Ed., 44, 3125 (2005);

Applications (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxamide is a part of the synthetic preparation of the synthesis and inhibitory effect on ADP-induced platelet aggregation of ticagrelor derivatives as antiplatelets agents.
References Zhang, H., et al.: Bioorganic Med. Chem. Lett., 22, 3598 (2012).

Applications NN'-Bis(2-hydroxyethyl)urea (cas# 15438-70-7) is a useful research chemical.

Applications CHLOROFLUOROACETAMIDE (cas# 431-09-4) is a useful research chemical.

Applications Acetamide is used as plasticizer and as industrial solvent (1). It can be used for the transamidation of carboxamides in 1,4-dioxane in the absence of a catalyst (2) . Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
References 1. Ma, X. et al.: Carb. Polym. 2004 Aug:57(2):197-2032. Vanjari, R. et al.: Tetrahedron. Lett. 2013 MayL54(20):2553-5

Applications 4-Hydroxythiobenzamide is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.
References Sierra, M. et al.: J. Med. Chem., 50, 685 (2007); Zhong, W. et al.: Bioorg. Med. Chem. Lett., 17, 5384 (2007);

Applications Isobutyramide