Carboxylic Acids

<p>Applications N-Caproic Acid Isopropyl Ester (cas# 2311-46-8) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Methyl 3-Phenyloxirane-2-carboxylate (cas# 37161-74-3) is a useful research chemical.<br></p>

<p>Applications 3-((E)-(2,4-Dimethylphenyl)diazenyl)-2,4-dihydroxy-5-((4-sulfophenyl)diazenyl)benzoic Acid is an intermediate in the synthesis of Acid Orange 24 (A189835), which is used in trickling biofilters for wastewater treatment. Acid Orange 24 is used in suncare compositions. It also serves as a raw material for cosmetics. Mutagenicity test for dye compositions in cosmetics.<br>References Garzon-Zuniga, M. A., et al.: Water Environ. Res., 83, 107 (2011); Anon.: IP.com Journal, 11, 5 (2011); Muzzall, J. M., et al.: Mutat. Res., Genet. Toxicol. Testing, 67, 1 (1979)<br></p>

<p>Applications Pentachlorophenyl Cyanoacetate is an intermediate used in the synthesis of Cefacetrile (C231500), which is a cephalosporin antibiotic. Antibacterial.<br>References Dajan, A., et al.: Vet. Microbiol., 35, 213 (1993), Becker, M., et al.: Anal. Chim. Acta, 520, 19 (2004), El-Shaboury, S., et al.: J. Pharm. Biomed. Anal., 45, 1 (2007),<br></p>

<p>Applications Triacontanoic Acid has agricultural applications and is a useful compound in the removal of residual pesticides from fruit via ozone-microbubble treatment.<br>References Li, C., et al.: Food Control, 120, 107548 (2020)<br></p>

<p>Stability Hygroscopic<br>Applications tert-Butyl (((mesityl)sulfonyl)oxy)carbamate is a useful reagent for the enantioselective aziridination of α,β-unsaturated aldehydes.<br>References Arai, H., et l.: Tetrahedron Lett., 50, 3329(2009)<br></p>

<p>Applications tert-Butyl carbamate is used to prepare N-Boc-protected anilines. It is also used in the synthesis of tetrasubstituted pyrroles, functionalized with ester or ketone groups at C-3 position.<br>References Bhagwanth, S., et al.: J. Org. Chem., 74, 4634 (2009); Cadierno, V., et al.: J. Heterocycl. Chem., 47, 233 (2010)<br></p>

<p>Applications Methyl Phenylacetate is used as a reagent in the synthesis of various organic reactions, one of which is the synthesis of Vulpinic Acid (V850000); a lichen metabolite with anti-inflammatory properties.<br>References Shachak, M., et al.: Science, 236, 1098 (1987); Froberg, L., et al.: Lichenologist, 25, 83 (1993); Hesbacher, S., et al.: J. Chem. Ecology, 21, 233 (1995)<br></p>

<p>Applications Used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers.<br>References Leeman, M. et al.: Angew. Chem. Int. Ed., 47, 1287 (2008); Eur. J. Med. Chem., 45, 3564 (2010);<br></p>

<p>Applications 3-FERROCENOYLPROPIONIC ACID (cas# 1291-72-1) is a useful research chemical.<br></p>

<p>Applications 5-(3-Benzyloxyphenyl)nicotinic acid<br></p>

<p>Applications 6-chloro-imidazo[2,1-b]thiazole-5-sulfonic acid amide (cas# 112582-89-5) is a useful research chemical.<br></p>

<p>Applications 9-Acridinecarboxylic acid is used in the synthesis of short DNA-binding peptides.<br></p>

<p>Applications 5-Pyrimidylboronic Acid, is one of the new heteroarylpyrimidine derivatives via Suzuki cross-coupling reactions.<br>References Saygili N, et al.: Org Biomol Chem. 2004 Mar 21;2(6):852-7. Epub 2004 Feb 23.<br></p>

<p>Applications 2-Ethylheptanoic Acid is used in the preparation of prostaglandin which is for for promoting bone growth<br>References Barrett, S., et al.: PCT Int. Appl., 331 (2015)<br></p>

<p>Applications 3-(N,N-Dimethylamino)phenylboronic Acid (cas# 178752-79-9) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Hydroxy-5-(phenylethynyl)benzoic Acid has antiinflammatory activity.<br>References Shen, T.-Y., et al.: U.S. (1972), US 3657430 A<br></p>

<p>Applications methyl 3-chloro-4-hydroxyphenylacetate (cas# 57017-95-5) is a useful research chemical.<br></p>

<p>Applications Racecadotril intermediate. A β-thiopropionyl-amino acid derivative used as β-lactamase inhibitor.<br>References Sanger, F., et al.: Biochem. J., 39, 507 (1945), Dawson, P., et al.: Science, 266, 776 (1994),<br></p>

<p>Applications 2,4-Dihydroxy-5-((4-sulfophenyl)diazenyl)benzoic Acid is an intermediate in the synthesis of Acid Orange 24 (A189835), which is used in trickling biofilters for wastewater treatment. Acid Orange 24 is used in suncare compositions. It also serves as a raw material for cosmetics. Mutagenicity test for dye compositions in cosmetics.<br>References Garzon-Zuniga, M. A., et al.: Water Environ. Res., 83, 107 (2011); Anon.: IP.com Journal, 11, 5 (2011); Muzzall, J. M., et al.: Mutat. Res., Genet. Toxicol. Testing, 67, 1 (1979)<br></p>

<p>Applications (Z)-Benzyl (2-Amino-2-(hydroxyimino)ethyl)carbamate is an intermediate used in the synthesis of N-((5-Hydroxy-6-oxo-4-((2,4,6-trifluorobenzyl)carbamoyl)-1,6-dihydropyrimidin-2-yl)methyl)-1,3,4-oxadiazole-2-carboxamide (H950690), which is a derivative of Raltegravir (R100305), a potent integrase (IN) inhibitor for WT and S217Q PFV IN.<br>References Hare, S., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 20057 (2010); Hicks, C., et al.: Clin. Infect. Dis., 48, 931 (2009); Moss, D., et al.: Antimicrob. Agents Chemother., 56, 3020 (2012); Hare, S., et al.: Mol. Pharmacol., 80, 565 (2011)<br></p>

<p>Applications p-Cyanobenzoic Acid Trimer is used in the synthetic preparation of Terbium Triazinetribenzoate Formate Metal Organic Framework (MOF).<br>References Han, Y., et al.: J. Mater. Chem. A Mater. Energy Sustain., 3, 24525 (2015)<br></p>

<p>Applications exo-2,3-Norbornanedicarboxylic Acid Monoamide is an impurity in the synthesis of Lurasidone (L474920) an antipsychotic used for treatment of schizophrenia.<br>References Ishiyama, T., et al.: Eur. J. Pharmacol., 572, 160 (2007), Cole, P., et al.: Drugs of the Fut., 33, 316 (2008),<br></p>

<p>Applications 3-Cyclohexylbutanoic Acid (cas# 4361-38-0) is a useful reagent for the preparation of oxoheterocyclylalkyl hydroxypiperidinylketones as USP19 inhibitors for treating diseases.<br>References Hewitt, P., et al.: PCT Int. Appl. (2018), WO 2018020242 A1<br></p>

<p>Applications 5-Hexynoic Acid<br></p>

<p>Impurity Lubiprostone Impurity VI<br>Applications 7-((1R,2R,3R)-3-(cyclohexylmethoxy)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoic Acid is a useful chemical reagent.<br></p>

<p>Applications Methyl 2-Cyclopentanonecarboxylate is used in the synthesis of functionalized ketones.<br>References Mashima, K. et al.: J. Org. Chem., 59, 3064 (1994); Hamashima, Y. et al.: J. Am. Chem. Soc., 124, 11240 (2002);<br></p>

<p>Applications 3-Cyanobenzoic Acid, is a building block used for the synthesis of a variety of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids, that can be used for the synthesis of a metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.<br>References Ramu, T., et al.: Chem. Lett., 42, 722 (2013);<br></p>

<p>Applications (2,5-Dimethylphenyl)boronic Acid is a useful synthetic intermediate. It can be used to prepare fluorenones/indenofluorenediones.<br>References Liu, T., et al.: Org. Lett., 13, 2452 (2011)<br></p>

<p>Applications 2-anilinobutanoic acid (cas# 67832-70-6) is a useful research chemical.<br></p>

<p>Applications 5-(aminomethyl)-2-furoic acid hydrochloride (cas# 934-65-6) is a useful research chemical.<br></p>

<p>Applications 4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoic acid (cas# 189365-92-2) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Tetrahydrofuran-2,5-dicarboxylic Acid (cas# 2240-81-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Bromosuccinic acid is prepared from Succinic acid (S688765), an important precursor in many chemicals used in the food, chemical and pharmaceutical fields. Bromosuccinic acid is also used as a reagent to prepare L-Hydrazinosuccinic acid.<br>References Gutowsky, H., et al.: J. Chem. Phys., 31, 1278 (2004); Song, H. &amp; Lee, S.: Enzyme Microb. Tech., 39, 352 (2006); Yamada, R., et al.: BBA-Prot. Struc. Mol. Enzym., 831, 82 (1985)<br></p>

<p>Stability Store Under Argon; Air Sensitive<br>Applications 4-Mercaptobenzoic Acid (cas# 1074-36-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References J. Org. Chem., 2835 (1962)<br></p>

<p>Applications Glycolic Anhydride Diacetate, is the product of reaction involving Lead tetraacetate as an oxidizing agent It is also an intermediate in the synthesis of Chrysogine, a metabolite of Penicillium chrysogenum and some related 2-substituted 4-(3H)-quinazolinones.<br>References Dimroth, O., et al: Berichte der Deutschen, 56B, 1375 (1923); Bergman, J., et al.: Tetrahedron, 46, 1295 (1990);<br></p>

<p>Applications Tetronic Acid (cas# 4971-56-6) is a useful research chemical.<br></p>

<p>Applications N-Phenylanthranilic acid is used in biological studies for inhibitors of aldo-keto reductase 1C3 based on N-phenyl-aminobenzoates.<br>References Adeniji, A. O., et al.: J. Med. Chem., 55, 2311 (2012);<br></p>

<p>Applications Mevinolinic Acid, Monoammonium Salt can be used as reactant/reagent in process for the preparation of the Simvastatin precursor, 2,2-dimethylbutanoic acid (1S,3R,7S,8S,8aR)-8-[(3R,5R)-7-(cyclopropylamino)-3,5-dihydroxy-7-oxoheptyl]-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-1-naphthalenyl ester, via an amidation reaction.<br>References Khanna, J., et al.: Indian, IN 184809 A1 20000930 (2000)<br></p>

<p>Applications 2-(methylamino)octanoic acid (cas# 101080-67-5) is a useful research chemical.<br></p>

<p>Applications Methyl 2-Aminothioazole-4-carboxylate (cas# 118452-04-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Isopropylphenylacetic acid (cas# 4476-28-2) is a useful research chemical.<br></p>

<p>Applications 2-Cyclohexylideneacetic acid (cas# 1552-91-6) is a useful research chemical.<br></p>

<p>Applications GAMMA-CHLOROCROTONIC ACID (cas# 26340-58-9) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Magnesium acetate tetrahydrate (cas# 16674-78-5) is a useful research chemical.<br></p>

<p>Applications 5-(Diphenylphosphinyl)pentanoic Acid, can be used for the preparation of praseodymium coordination polymers with diphenylphosphorylvalerate ligand. It is also a by product in the preparation of prostaglandin analogs.<br>References Spichal, Z., et al.: Polyhedron, 48, 99 (2012); Zhao Y. et al.: PCT Int. Appl. 43pp.Patent, 2016<br></p>

<p>Applications 3-[(2-Hydroxyethyl)Amino]Propanoic Acid (cas# 5458-99-1) is a useful research chemical.<br></p>

<p>Applications L-Menthyl 2,2-Dihydroxyacetate is used as a reagent in the synthesis of Lamivudine (L172500); a potent nucleoside reverse transcriptase inhibitor used for the treatment of chronic hepatitis B. L-Menthyl 2,2-Dihydroxyacetate is also used as a reagent in the synthesis of 4-acetoxy-3-hydroxyethylazetidin-2-one, a key intermediate for the preparation of penem and carbapenem antibiotics.<br>References Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944); Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997); Perry, C.M., et al.: Drugs, 53, 657 (1977); Goodyear, M.D., et al.: Tetrahedron Lett., 46, 8535 (2005); Kametani, T., et al.: Heterocycles, 25, 241 (1987)<br></p>

<p>Applications Phosphorodichloridic Acid is an intermediate used in the synthesis of Cefotiam Dihydrochloride-13C, 15N2 (C243007), which is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations.<br>References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)<br></p>

<p>Applications 1,3-Diethylbarbituric Acid can be used as reactant/reagent in green preparation of spiropyran derivatives via three-component cyclization of indantrione with active methylene compounds and cyclic diketones in the presence of compact fluorescent lamp.<br>References Rai, P., et al.: ChemistrySelect, 1, 4450 (2016)<br></p>

<p>Impurity Fluorouracil EP Impurity B; Fluorouracil USP Related Compound B<br>Applications A 5-hydroxy derivative of the nucleobase Uracil (U801000) and an isomer of Barbituric Acid (B118650). Studies show that it can form stable base pairs with all four bases in a DNA duplex. It has been used as oxidative DNA damage biomarker in tissue engineered skin. Fluorouracil EP Impurity B. Fluorouracil USP Related Compound B<br>References Varatharasa T. et al.: Chem. Comm., 3, 400 (2005); Jaruga, P. et al.: Nucleic Acid Res., 24, 1389 (1996); Rodriguez, H. et al.: Adv. Exp. Med. Biol., 534, 129 (2003);<br></p>

<p>Applications 2,2-Dimethyloctanoic Acid is used in biological studies as benzyl dimethyloctanoate metabolite of sewage bacteria.<br>References Millier, A., et al.: Bull. Environ. Contam. Toxicol., 28, 113 (1982);<br></p>

<p>Applications Cyclohexylacetic acid<br></p>

<p>Applications (2-Oxopropyl)Carbamic Acid Tert-Butyl Ester (cas# 170384-29-9) is a useful research chemical.<br></p>

<p>Applications 4-CYANO-4-[(ETHYLSULFANYLTHIOCARBONYL)SULFANYL]PENTANOIC ACID (cas# 1137725-46-2) is a useful research chemical.<br></p>