Carboxylic Acids

<p>Please enquire for more information about 2-((3-(Trifluoromethyl)phenyl)amino)-1,3-thiazole-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Phenyl-1,3-thiazolidine-4-carboxylic acid is a thiourea that can be synthesized by the ring opening of an oxazolidinone. It has been shown to have potent cytotoxicity against prostate cancer cells and is used in the synthesis of chalcone and cellulose derivatives. 2-Phenyl-1,3-thiazolidine-4-carboxylic acid has also been shown to react with olefins to form enantiopure products. The reaction products are known for their anti-cancer properties.</p>

<p>Please enquire for more information about 2-(4-Tolylamino-3,5-thiazolyl)acetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-((3,5-Dichlorophenyl)amino)-1,3-thiazole-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 2-(4-(3,4-dichlorophenylamino)-3,5-thiazolyl)acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about methyl 3-(((4,4-dimethyl-2,6-dioxocyclohexylidene)methyl)amino)thiophene-2-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(2-(N-(2,4-Difluorophenyl)carbamoyl)phenyl)acetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(2-(N-(4-(Trifluoromethoxy)phenyl)carbamoyl)phenyl)acetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Methyl 2-(2-(chlorosulfonyl)-4,5-dimethoxyphenyl)acetate is a potent anticancer drug that is active against cancer cells. It has been shown to inhibit the ATP binding site on the enzyme topoisomerase II. This inhibition may be due to its ability to form covalent bonds with primary amines in the enzyme's active site. Methyl 2-(2-(chlorosulfonyl)-4,5-dimethoxyphenyl)acetate inhibits topoisomerase II and prevents DNA unwinding, thereby inhibiting DNA replication and transcription. Methyl 2-(2-(chlorosulfonyl)-4,5-dimethoxyphenyl)acetate also inhibits cancer cell growth by blocking DNA replication and transcription. This drug also has a pharmacological effect on the central nervous system; it is an antagonist of the serotonin receptor type 3 (5HT3).</p>

<p>Please enquire for more information about Ethyl 4-((2,5-dichlorophenyl)amino)-3,5-thiazolecarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(2,6-Dichlorophenylamino-3,5-thiazolyl)acetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about ethyl 3-((2,5-dichlorophenyl)amino)-5-methyl-2,4-thiazolecarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about ethyl 2-(4-(3-chlorophenylamino)-3,5-thiazolyl)acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-((5,5-Dimethyl-3-oxocyclohex-1-enyl)amino)benzoic acid (DMACBA) is a channel inhibitor that blocks the voltage-gated sodium channels in neurons. It has been shown to be effective against malignant brain tumors. DMACBA inhibits the conformational changes of the channel caused by glycols and microwave irradiation. It also stabilizes the open state of the channel, preventing it from closing again after being opened by an action potential. This agent is stable in water and forms dimers with benzoic acid. DMACBA binds to pyrimidine in DNA, inhibiting bacterial replication and transcription.</p>

<p>Please enquire for more information about ethyl 2-amino-4-(4-butoxyphenyl)-7,7-dimethyl-5-oxo-4,6,7,8-tetrahydro2H-chromene-3-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1,1-Cyclopropanedicarboxylic acid is a polycarboxylic acid that is an acyclic nucleoside phosphonate. It can be used to treat malonic acidosis, which is a metabolic disorder caused by the accumulation of malonic acid. This substance has been shown to inhibit the enzyme activities of malonyl-CoA decarboxylase and acetyl-CoA carboxylase and decrease the levels of malonyl-CoA in cells. 1,1-Cyclopropanedicarboxylic acid may also be a growth factor for some organisms and can be used as a quinoline derivative.</p>

<p>Please enquire for more information about 2-((3-Bromophenyl)amino)-4-methyl-1,3-thiazole-5-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-((4-Phenoxyphenyl)amino)-4-methyl-1,3-thiazole-5-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-((1-Oxo-2-phenylinden-3-yl)amino)benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-((3,5-bis(Trifluoromethyl)phenyl)amino)-1,3-thiazole-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about ethyl 3-((2-chlorophenyl)amino)-5-methyl-2,4-thiazolecarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 2-(4-(3-fluorophenylamino)-3,5-thiazolyl)acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(4-(4-Fluorophenylamino)-3,5-thiazolyl)acetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 4-((3-bromophenyl)amino)-3,5-thiazolecarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(4-(3-(Trifluoromethyl)phenylamino)-3,5-thiazolyl)acetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-[(4-Nitrophenyl)thio]benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about ethyl 2-(4-(4-fluorophenylamino)-3,5-thiazolyl)acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 2-(4-(2,5-dichlorophenylamino)-3,5-thiazolyl)acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Methyl 3-(((4,4-dimethyl-2,6-dioxo-3,5-dioxanylidene)methyl)amino)thiophene-2-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-(4-(tert-Butyl)phenyl)-2-(1-methylindol-3-yl)-4-oxobutanoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-((2-Nitrilo-4,4-dimethyl-3-oxopent-1-enyl)amino)propanoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-((4-Ethyl-5-oxo-3-thioxo-2,4-thiazolidinylidene)methyl)benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-((4-Fluorophenyl)amino)-1,3-thiazole-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 3-((3,4-dimethoxyphenyl)amino)-5-methyl-2,4-thiazolecarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 4-((2-fluorophenyl)amino)-3,5-thiazolecarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 4-((3,4-dimethoxyphenyl)amino)-3,5-thiazolecarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-(N-(2-(3,4-dimethoxyphenyl)ethyl)carbamoyl)pyridine-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about ethyl 2-(2-amino-1,3-thiazol-4-yl)benzenecarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(N-(3,5-Bis(trifluoromethyl)phenyl)carbamoyl)cyclohexanecarboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-(5-(trifluoromethyl)-2-pyridyloxy)benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(2,4-Dichlorophenylamino-3,5-thiazolyl)acetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-(4-Bromophenyl)-2-(7-ethylindol-3-yl)-4-oxobutanoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about methyl 3-(2-indol-3-yl-2-oxoacetylamino)thiophene-2-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-(N-((3,4-Dimethoxyphenyl)methyl)carbamoyl)prop-2-enoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Applications 3-Cyclohexylbutanoic Acid (cas# 4361-38-0) is a useful reagent for the preparation of oxoheterocyclylalkyl hydroxypiperidinylketones as USP19 inhibitors for treating diseases.<br>References Hewitt, P., et al.: PCT Int. Appl. (2018), WO 2018020242 A1<br></p>

<p>Applications Ethyl 4-bromoacetoacetate<br></p>

<p>Applications Carbonochloridic Acid 1,2,2,2-Tetrachloroethyl Ester is used in the synthesis of Doxorubicin (D558000), is used as an antineoplastic. Also used in the synthesis of metabolites of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antine oplastic.<br>References Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969), Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984); Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>

<p>Applications Ethyl 4-Oxo-5-hexanoic Acid Ester is used in the synthesis of analogs of 5-aminolevulinic acid (ALA), which are potential inhibitors of ALA dehydratase (porphobilinogen synthase), an early enzyme of tetrapyrrole biosynthesis;Also, it is an intermediate of 4-Oxo-6-(2-oxo-5-vinylpyrrolidin-1-yl)hexanoic Acid (O858780), which is derived from Ethyl Succinoyl Chloride (E818230), which is used in the synthesis of bivalent ligands for D2/D3 dopamine receptors. Also used in the preparation of antimicrobial pyrrolo-isoquinolinones. Vigabatrin Impurity 2<br>References Appleton, D., et al.: J. Chem. Soc., Perkin Trans., 89-101 (1998); Gogoi, S. et al.: ACS Med. Chem. Lett., 3, 991 (2012)<br></p>

<p>Applications DITHIOCARBONIC ACID S,S'-DIETHYL ESTER (cas# 623-80-3) is a useful research chemical.<br></p>

<p>Applications 4-Acetylphenylboronic acid4-Acetylphenylboronic Acid is used in several metal catalyzed cross-coupling reaction studies.<br>References Saito, S., et al.: J. Org. Chem., 2, 8024 (1997); Sakai, M., et al.: Organomet., 16, 4229 (1997); Molander, G., et al.: J. Org. Chem., 68, 4302 (2003);<br></p>

<p>Applications 3,4-Epoxycyclohexanecarboxylate Methyl Ester is a useful reagent for organic synthesis.<br></p>

<p>Impurity Mesna EP Impurity C<br>Applications 2-Acetylthioethanesulfonic Acid (Mesna EP Impurity C) is an impurity in the synthesis of Mesna (M225750), used to protect the bladder wall from the harmful effects of some cancer-fighting drugs.<br>References Tekeres, M., et al.: Clin. Ther., 4, 56 (1981), Brock, N., et al.: Eur. J. Cancer Clin Oncol., 18, 1377 (1982), James, C.A., et al.: Br. J. Clin. Pharmacol., 23, 561 (1987);<br></p>

<p>Applications 9-Acridinecarboxylic acid is used in the synthesis of short DNA-binding peptides.<br></p>

<p>Applications Dibromoisocyanuric acid is a bromine compound with a superior bactericidal activity.<br>References Gottardi, W., et al.: J. Appl. Microbiol., 116, 1427 (2014)<br></p>

<p>Applications tert-Butyl 2-(3-Aminophenyl)acetate can be used as anti-heparanase to treat diseases and disorders associated with heparanase activity.<br>References Giannini, G., et.al.: PCT Int. Appl., 103, (2018);<br></p>

<p>Applications (S)-tert-butyl 4-aminoazepane-1-carboxylate (cas# 878630-84-3) is a useful research chemical.<br></p>

<p>Applications A more base-stable alternative to Ellman’s reagent for the quantification of thiol contents and enzymatic assays under basic pH conditions. . It reacts with free thiols similar to Ellman’s reagent but has dramatically improved stability under alkaline conditions, making it an excellent alternative to Ellman’s reagent.<br>References Zhang, H., et al.: Bioorg. Chem., 26, 356 (1998), Chen, Y., et al.: Biochem., 43, 11491 (2004),<br></p>

<p>Applications 3-(2,3-Dihydroxyphenyl)propionic acid is a degradation product of the aromatic compound Phenylpropionate (PP).<br>References Provencher, S., et al.: Biochemistry, 20, 33 (1981), Ferrandez, A., et al.: J. Bacteriol., 179, 2573 (1997), Torres, B., et al.: J. Biol. Chem., 278, 27575 (2003),<br></p>

<p>Applications 2,4-Diaminobenzenesulfonic acid (cas# 88-63-1) is a useful reagent for improving the chlorine resistance and water permeability of polyamide (PA) membrane in water treatment.<br>References Meng, Q. W., et al.: ACS Applied Mat., 12, 35393 (2020)<br></p>

<p>Applications 4-(Methylamino)-3-nitrobenzoic Acid (cas# 41263-74-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Amino-4-hydroxybenzoic acid (cas# 38160-63-3) is a useful research chemical.<br></p>

<p>Applications Ethyl 2-Ethylacetoacetate was a useful reagent in systematic investigation of saccharomyces cerevisiae enzymes catalyzing carbonyl reductions.<br>References Kaluzna, I., et al.: J. Am. Chem. Soc., 126, 12827 (2004);<br></p>

<p>Applications 5-carbamoylpentanoic acid (cas# 334-25-8) is a useful research chemical.<br></p>

<p>Applications (2S)-2-acetamido-5-(diaminomethylideneamino)pentanoic Acid (cas# 155-84-0) is a useful research chemical.<br></p>

<p>Applications Phenyl[2-phenylthio)phenyl]carbamate is an intermediate utilized for the synthesis of Quetiapine Hemifumarate (Q510000), an atypical antipsychotic agent used for the treatment of patients with schizophrenia, biopolar disorder and to treat major depressive disorder.<br>References Niphade, N.C., et al.: Org. Proc. Rsch. Dev., 13, 792 (2009); Stolarczyk, E.U., et al.: Pharm. Dev. Tech., 14, 27 (2009);<br></p>

<p>Applications Methyl 2-Bromo-1-cyclopentenecarboxylate is a versatile reactant that can be derived from Cyclopentanone (C988395), which is a compound used in the synthesis of various simple and complex organic compounds. Cyclopentanone is also used in the synthesis of peptidase IV inhibitors for the treatment of type 2 diabetes.<br>References Imamoto, T. et al.: J. Am. Chem. Soc., 112, 5244 (1990); Augeri, D. et al.: J. Med. Chem., 48, 5025 (2005);<br></p>

<p>Applications 1-(1-phenylcyclobutanecarbonyl)piperidine-4-carboxylic acid (cas# 1099048-69-7) is a useful research chemical.<br></p>

<p>Applications N-​Methylaniline Trifluoroacetate is regent used in organic synthesis, functioning as an α-methylating agent for ketones and activates internucleodecoupling upon removal.<br>References Nikolaev, V. et al.: E-Eros. Encyc. Reag. Org. Synth, 1, (2001); Wallace, D. et al.: Tetrahedron Lett., 54, 4425 (2013);<br></p>

<p>Applications 4-(3,4-dipropoxyphenyl)-4-oxobutanoic acid (cas# 568553-00-4) is a useful research chemical.<br></p>

<p>Applications 3-​Hydroxypivalic Acid is a general reagent used in the synthesis of AZD8835, a potent and selective inhibitor of PI3K and PI3Kδ in the treatment of cancers.<br>References Barlaam, B. et al.: Bioorg. Med. Chem. Lett., 25, 5155 (2015);<br></p>

<p>Applications 2-Acetylphenylboronic Acid is a reactant used in the synthesis of potent, selective phenylimidazole-based tissue factor/factor VIIa (FVIIa) inhibitors.<br>References Glunz, P.W., et. al.: Bioorg. Med. Chem. Lett., 25, 21699 (2015)<br></p>

<p>Applications S-Acetylthioacetic Acid (cas# 1190-93-8) is a compound useful in organic synthesis.<br>References Fox, M., et al.: J. Microbiol. Methods, 56, 221 (2004),<br></p>

<p>Applications Methyl 2-(benzhydrylthio)acetate is a useful reagent for organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications Magnesium acetate tetrahydrate (cas# 16674-78-5) is a useful research chemical.<br></p>

<p>Applications 3-[5-(2-thienyl)-2-furyl]propanoic Acid (cas# 24090-38-8) is a useful research chemical.<br></p>

<p>Applications Ethyl trans-2-(4-aminocyclohexyl)acetate, HCl<br></p>

<p>Applications 2-Cyclohexylideneacetic acid (cas# 1552-91-6) is a useful research chemical.<br></p>

<p>Applications 5-(Ethoxycarbonyl)thiophene-3-boronic Acid is a useful reagent for preparing hydroxyimino(phenyl)propanones as GPBAR1 agonists.<br>References Bissantz, C., et al.: U.S. Pat. Appl. Publ. (2012), US 20120010190 A1<br></p>

<p>Applications 3,4-Bis(isobutoxycarbonyl)benzoic Acid is a useful reagent in organic synthesis.<br></p>

<p>Applications 5-Hydroxy-3-phenylbenzoic Acid can be used in biological study of preparation and identification of hydroxybenzoic acids as lactate receptor agonists and antilipolytics. It can also be used in discovery of new series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.<br>References Duffy, B. C., et al.: Bioorg Med Chem Lett, 25, 2818 (2015), Dvorak, C. A., et al.: ACS Med Chem Lett, 3, 637 (2012)<br></p>

<p>Applications 2-Dibenzyloxyphosphanylacetic acid (cas# 53243-58-6) is a useful research chemical.<br></p>

<p>Applications 4-(3-aminopropyl)-1,2,5-oxadiazole-3-carboxylic acid 5-oxide (cas# 352647-66-6) is a useful research chemical.<br></p>

<p>Applications 3-(3-Furyl)acrylic Acid is a reactant in the preparation of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.<br>References Hornberger, K.R., et. al.: Bioorg. Med. Chem. Lett., 23, 4517 (2013)<br></p>

<p>Applications Ethyl (7Z)-4-Oxo-7-decanoic Acid Ester is an intermediate used in the synthesis of (Z)-γ-Jasmolactone (J210470), which is a compound that has a fruity, flowery and sweet taste and is commonly used as a fruit flavouring agent to enhance the peach flavour in a variety of food items.<br>References Clososki, G., et al.: Synth. Comm., 34, 817 (2004); Coelho, G., et al.: Hand. Fruit Veg. Flav., No vol. given, 211 (2010); Missio, L. &amp; Comasseto, J.: Tetrahedron: Asymm., 11, 4609 (2000); Wamhoffa, H. &amp; Gribbleb, G.: Adv. Hetero. Chem., 106, 185 (2012)<br></p>

<p>Applications 1-Hydroxycyclopentanecarboxylic Acid is a reagent used in the preparation of pyridone-conjugated monobactam antibiotics showing gram-negative activity.<br>References Brown, M. et al.: J. Med. Chem., 56, 5541 (2013); Rozhko, E. et al.: ChemCatChem., 5, 1998 (2013);<br></p>