Carboxylic Acids

<p>Please enquire for more information about 2-(4,5-Dimethoxy-2-(thiomorpholin-4-ylsulfonyl)phenyl)acetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Methyl 5-(((4-(tert-butyl)phenyl)sulfonyl)methyl)furan-2-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-(N-((3,4-Dimethoxyphenyl)methyl)carbamoyl)prop-2-enoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>The compound trans-3-(4-methylbenzoyl)acrylic acid is a potent and selective inhibitor of serine/threonine protein kinase. It has been shown to inhibit the proliferation of eosinophils in vitro, as well as to suppress the release of leukotrienes from human mast cells. The mechanism of action is by inhibiting phosphatidylcholine-specific phospholipase C, which leads to the inhibition of protein kinase C. This inhibition prevents the phosphorylation of various proteins, including cytoskeletal proteins that are required for cell division.</p>

<p>Please enquire for more information about ethyl 2-(4-(pyrimidin-2-ylamino)-3,5-thiazolyl)acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 3-((4-ethoxyphenyl)amino)-5-methyl-2,4-thiazolecarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 4-oxo-7-(benzyloxy)hydroquinoline-3-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-((4-(2-Fluorophenyl)piperazinyl)carbonyl)cyclohexanecarboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-((4-(2-Fluorophenyl)piperazinyl)carbonyl)pyridine-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about ethyl 2-(4-((4-((ethoxycarbonyl)methyl)-2,5-thiazolyl)amino)-3,5-thiazolyl)acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 3-((2-bromophenyl)amino)-5-methyl-2,4-thiazolecarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-((3-(Trifluoromethoxy)phenyl)amino)-1,3-thiazole-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-((5,5-Dimethyl-3-oxocyclohex-1-enyl)amino)benzoic acid (DMACBA) is a channel inhibitor that blocks the voltage-gated sodium channels in neurons. It has been shown to be effective against malignant brain tumors. DMACBA inhibits the conformational changes of the channel caused by glycols and microwave irradiation. It also stabilizes the open state of the channel, preventing it from closing again after being opened by an action potential. This agent is stable in water and forms dimers with benzoic acid. DMACBA binds to pyrimidine in DNA, inhibiting bacterial replication and transcription.</p>

<p>Please enquire for more information about 2-((4-(Benzo[3,4-d]1,3-dioxolan-5-ylmethyl)piperazinyl)carbonyl)cyclohexanecarboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-((2-Fluorophenyl)amino)-1,3-thiazole-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 3-(benzylamino)-5-methyl-2,4-thiazolecarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about methyl 2-((3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl)carbonylamino)acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-((3-Fluorophenyl)amino)-4-methyl-1,3-thiazole-5-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-((2-Chloro-3-oxocyclohex-1-enyl)amino)benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(4-(tert-Butyl)phenoxy)pyridine-3-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about methyl 2-(4,5-dimethoxy-2-(((4-(trifluoromethylthio)phenyl)amino)sulfonyl)phenyl)acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(N-(3-Pyridylmethyl)carbamoyl)cyclohexanecarboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(2,4-Dichlorophenylamino-3,5-thiazolyl)acetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(2,3,6-Triazino[5,4-β]indol-3-ylthio)propanoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(2-Pyridylamino)-4-methyl-1,3-thiazole-5-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-((3-(Trifluoromethyl)phenyl)amino)-4-methyl-1,3-thiazole-5-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-(Prop-2-enylamino)-2,4-thiazole-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-Chloro-6-fluorocinnamic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-(5-(trifluoromethyl)-2-pyridyloxy)benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 3-((3-bromophenyl)amino)-5-methyl-2,4-thiazolecarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(N-(3,5-Bis(trifluoromethyl)phenyl)carbamoyl)cyclohexanecarboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-((1-oxo-2-phenylinden-3-yl)amino)benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-((4-Methoxyphenyl)amino)-4-methyl-1,3-thiazole-5-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-(4-(tert-Butyl)phenyl)-2-(1-methylindol-3-yl)-4-oxobutanoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about ethyl 4-((3-fluorophenyl)amino)-3,5-thiazolecarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about ethyl 2-amino-4-(4-butoxyphenyl)-7,7-dimethyl-5-oxo-4,6,7,8-tetrahydro2H-chromene-3-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(2-(N-Benzo[3,4-d]1,3-dioxolen-5-ylcarbamoyl)phenyl)acetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(4-(4-(Trifluoromethyl)phenylamino)-3,5-thiazolyl)acetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 2-(4-(2,5-dichlorophenylamino)-3,5-thiazolyl)acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-((1-Oxo-2-phenylinden-3-yl)amino)benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 2-(4-(3,4-dichlorophenylamino)-3,5-thiazolyl)acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(4,5-dimethoxy-2-(((4-(trifluoromethylthio)phenyl)amino)sulfonyl)phenyl)acetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-(N-(4-(Trifluoromethoxy)phenyl)carbamoyl)prop-2-enoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 2-(4-(2-(trifluoromethyl)phenylamino)-3,5-thiazolyl)acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Applications Dibromoacetic Acid is a halogenated disinfection byproduct. Dibromoacetic Acid was found to induce apoptotic changes and hydroxyl radical formation in human peripheral blood mononuclear cells (PBMCs). Dibromoacetic Acid also found to exhibit carcinogenic activity in which mice and rats were exposed to drinking water containing different concentrations of Dibromoacetic Acid that resulted in increased incidences of mononuclear cell leukemia, malignant mesothelioma, hepatocellular neoplasms, and hepatoblastoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Michalowicz, J., et al.: Toxicol. In Vitro 29, 1416 (2015); Natl Toxicol Program Tech Rep Ser. 537, 1 (2007)<br></p>

<p>Applications 6-Cyclohexylhexanoic Acid (cas# 4354-56-7) is useful for the preparation of N-​Acylethanolamine Acid Amidase (NAAA) inhibitors, which exhibit anti-inflammatory and analgesic activities.<br>References Ren, J., et al.: RSC Advances, 7, 12455 (2017)<br></p>

<p>Applications Amino(3-​chlorophenyl)​acetic Acid functions as intermediate useful in the preparation of synthetic penicillins, also used in the structure-activity relationship examination of several drugs containing the benzyl moiety, their roles in biochemical and pharmacological processes.<br>References Hansch, C., et al.: J. Med. Chem., 13, 957 (1970); Holdrege, C. T., et al.: Can. (1975), CA 966853 A2 19750429;<br></p>

<p>Applications (2R)-4-(1,1-Dimethylethyl) Ester 2,4-Morpholinedicarboxylic Acid is used in the preparation of renin inhibitors.<br>References Yuan, J. et al.: Bioorg. Med. Chem. Lett., 21, 4836 (2011); Fish, P. et al.: Tetra. Lett., 50, 389 (2009);<br></p>

<p>Applications 5-Chlorohexanoic acid CAS#: 112176-22-4 is a building block used in organic synthesis.<br>References Liang, S., et al., Green Chemistry., 20, 680 (2018)<br></p>

<p>Applications Used for production of peptide thioester.<br>References Gaeta, A., et al.: Bioorg. Med. Chem. Lett., 20, 4649 (2010),<br></p>

<p>Applications A more base-stable alternative to Ellman’s reagent for the quantification of thiol contents and enzymatic assays under basic pH conditions. . It reacts with free thiols similar to Ellman’s reagent but has dramatically improved stability under alkaline conditions, making it an excellent alternative to Ellman’s reagent.<br>References Zhang, H., et al.: Bioorg. Chem., 26, 356 (1998), Chen, Y., et al.: Biochem., 43, 11491 (2004),<br></p>

<p>Applications 2,2-Diethylhexanoic Acid is a pollutant that is found in anaerobic environment of river sediments,<br>References Chau, H., et al.: Appl. Biochem. Biotechnol., 70, 853 (1998); McInerney, M., et al.: Appl. Env. Microbiol., 41, 1029 (1981)<br></p>

<p>Applications 2-(Phenylamino)nicotinic Acid (cas# 16344-24-4) is a useful research chemical.<br></p>

<p>Applications 5-Formylfuran-2-boronic Acid Neopentyl Glycol Ester is a useful reagent in lapatinib synthesis.<br>References Radl, S., et al.: PCT Int. Appl. (2014), WO 2014059956 A1<br></p>

<p>Applications 2-Mercapto-succinic acid diethyl ester (cas# 23060-14-2) is a useful research chemical.<br></p>

<p>Applications 4-Phthalimidobutyric Acid can be used to evaluate nootropicactivity of newly synthesized gaba derivative in mice.<br>References Saleem, S., et.al.: Indo Am. J. Pharm., 5, 5527-5547, (2018);<br></p>

<p>Applications 2-hydroxy-5-[2-(4-hydroxyphenyl)propan-2-yl]benzoic acid (cas# 101949-49-9) is a useful research chemical.<br></p>

<p>Applications 3-​Hydroxypivalic Acid is a general reagent used in the synthesis of AZD8835, a potent and selective inhibitor of PI3K and PI3Kδ in the treatment of cancers.<br>References Barlaam, B. et al.: Bioorg. Med. Chem. Lett., 25, 5155 (2015);<br></p>

<p>Applications Ethyl Acetate (2-13c, 99%) (cas# 58735-82-3) is a useful research chemical. This isotopic compound is used as a tracer in various experiments, for instance, during the conversion of oxygenated and hydrocarbon molecules to particulate matter for fuel purposes, and biosynthesis of terpenes.<br>References Aaron, E., et.al., Combust Flame, 161,2966-2974,(2014); Citron,C., et.al., Chem Comm,50,5224-5226,(2014);<br></p>

<p>Applications S-Acetylthioacetic Acid (cas# 1190-93-8) is a compound useful in organic synthesis.<br>References Fox, M., et al.: J. Microbiol. Methods, 56, 221 (2004),<br></p>

<p>Applications Methyl 2-Aminothiazole-5-carboxylate (cas# 6633-61-0) is a compound useful in organic synthesis.<br></p>

<p>Impurity Xylometazoline EP Impurity F<br>Applications 2,​6-​Dimethyl-​4-​tert-​butylphenylacetic Acid is an impurity of Xylometazoline (X749950), a vasoconstrictor involved in signal transduction, also used as a nasal decongestant. May be used in treatments involving ischemic injury due to the ability to shift energy metabolism from mitochondrial to glycolysis (2).<br>References 1. Fliri, A. et al.: J. Med. Chem. 2009 Dec 24;52(24):8038-46.2. Gohil, V. et al.: Nat Biotechnol. 2010 Mar;28(3):249-55.<br></p>

<p>Applications 3-(3-THIENYL)ACRYLIC ACID (cas# 102696-71-9) is a useful research chemical.<br></p>

<p>Applications 5-(3,4-Dichlorophenyl)-2-furoic acid is a reactant in the preparation of dantrolene (D185000) which has a potential to treat vascular dysfunction.<br>References Ellis, K.O., et al.: J. Pharm. Sci., 69, 327 (1980); Harrison, G.G., et al.: Brit. J. Anaesth., 60, 279 (1988); Murasawa, S., et al.: Bioorg. Med. Chem., 20, 6384 (2012);<br></p>

<p>Applications DL-3-(Benzylthio)lactic Acid is used in the preparation of somatostatin analogs, affecting growth hormones.<br></p>

<p>Applications TERT-BUTYL N-(DIAMINOMETHYLIDENE)CARBAMATE (cas# 219511-71-4) is a useful research chemical.<br></p>

<p>Applications 2-(4-Aminophenyl)propanoic acid is a reagent in the preparation of 3-aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents (Erratum).<br>References Pevarello, P., et al.: J. Med. Chem., 48, 5058 (2005);<br></p>

<p>Stability Volatile<br>Applications METHYL AZIRIDINE-2-CARBOXYLATE (cas# 5950-34-5) is a useful research chemical.<br></p>

<p>Applications Tricosanoic Acid 1,2,3-Propanetriyl Ester, can be used for the manufacture of cosmetics, and perfumes.<br>References Oro, L., et al.: Acta Pharmacol. Toxicol., 18, 141 (1961),<br></p>

<p>Applications 6-Chloro-1-benzofuran-2-carboxylic Acid is used to prepare cis-diaminocyclohexane derivatives as factor Xa inhibitors. It is also used to synthesize tachykinin NK2 receptor antagonists.<br>References Bioorg. Med. Chem., 17, 8206 (2009); Gensini, M., et al.: ChemMedChem, 5, 65 (2010)<br></p>

<p>Applications Dibenzothiophene-2-boronic acid is a useful reagent for organic synthesis and other chemical processes.<br>References Duncton, M. A. J., et al.: Org. Lett., 10, 3259 (2008)<br></p>

<p>Applications Methyl 2-(4-Bromophenyl)-2,2-dimethylacetate (cas# 154825-97-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 3-chlorosulfonylthiophene-2-carboxylate<br></p>

<p>Applications 3-Acetamidophenyl acetate<br></p>

<p>Applications tert-Butyl N-(Benzyloxy)carbamate has been used in the synthesis of Deferoxamine Mesylate (D228980), an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients<br>References Bergeron RJ, et al. 1992. J Med Chem. Dec 11;35(25):4739-44Inati A, et al. 2010. Am J Hematol. Oct;85(10):782-6 Selim M, et al. 2010. Transl Stroke Res. Mar;1(1):35-9<br></p>

<p>Applications A reagent used in the synthesis of glycidol, a stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.<br>References Palomo, J.M. et al.: Tetrahedron Asymm., 16, 869 (2005); Hiles, R.A., et al.: Food Cosmet. Toxicol., 19, 347 (1981); Thompson, E.D., et al.: Food Chem. Toxicol., 22, 665 (1984);<br></p>

<p>Applications 4-Hydroxy-3,5-dimethylbenzoic Acid is used in the synthesis of Mexiletine (M340800) derivatives as orally bioavailable inhibitors. Also, used as a chemical reagent in the preparation of potent transthyretin (TTR) amyloidogenesis inhibitors affecting thyroid hormone.<br>References Frederickson, M. et al.: J. Med. Chem., 51, 183 (2008); Johnson, S. et al.: J. Med. Chem., 51, 260 (2008);<br></p>

<p>Applications 2-CYCLOPENTYL-2-PHENYLACETIC ACID (cas# 3900-93-4) is a useful research chemical.<br></p>

<p>Applications Androstenediol 17-Acetate is used in synthetic preparation for direct organocatalytic stereoselective transfer hydrogenation of conjugated olefins of steroids. Androstenediol 17-Acetate is also obtained from Dehydro Epiandrosterone (D229585) which is a major secretory steroidal product of the adrenal gland; secretion progresively declines with aging. May have estrogen-or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione. It is used in treatment of menopausal syndrome.<br>References Ebeling, P., et al.: Lancet, 343, 1479 (1994); Morales, A.J., et al.: J. Clin. Endocrinol. Metab., 78, 1360 (1994); Ramachary, D.B., et al.: RSC Advances, 3, 13497-13506 (2013); Yahara, M., et al.: J. Toxicol. Sci., 2, 161 (1977);<br></p>

<p>Applications Used in the preparatiom of esters of 6-aminohexanoic acid as antibacterial agents. EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo xy peptidase, plasmin, and plasminogen activator.<br>References Dolezal, P., et al.: Pharm. Res., 10, 1015 (1993), Vavrova, K., et al.: Curr. Med. Chem., 12, 2273 (2005), Holas, T., et al.: Bioorg. Med. Chem., 14, 7671 (2006),<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-(Dimethoxyphosphoryl)acetic acid<br></p>

<p>Applications Cyclopentylacetic acid is a reagent the synthesis of Cyclopentamine (C988355), which is a vasoconstrictor that acts as a releasing agent of the neurotransmitters norepinephrine, epinephrine and dopamine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schmidt, J.L. et al.: J. Pharmacol. Exp. Ther., 145, 83 (1964); Iversen, L.L.: J. Pharm. Pharmacol., 16, 435 (1964);<br></p>

<p>Applications Ethyl 2-(2,6-Dichlorophenyl)acetate (cas# 90793-64-9) is a useful research chemical.<br></p>