Carboxylic Acids

<p>Applications 3-(2-Hydroxypropan-2-yl)phenylboronic acid<br></p>

<p>Applications Tricosanoic Acid 1,2,3-Propanetriyl Ester, can be used for the manufacture of cosmetics, and perfumes.<br>References Oro, L., et al.: Acta Pharmacol. Toxicol., 18, 141 (1961),<br></p>

<p>Applications A useful wittig reagent.<br></p>

<p>Applications 2-[(Dipropylamino)sulfonyl]benzoic Acid, is a building block used in various chemical synthesis.<br></p>

<p>Applications Agomelatine Acetic Acid is a research reagent used in studies of nucleophilic ring opening.<br>References Chatterjee, A., et al. : Tetrahedron, 33, 85 (1977)<br></p>

<p>Applications N-(4-bromo-2-thienyl)-carbamic Acid 1,1-Dimethylethyl Ester, is an intermediate for the synthesis of bicyclic inhibitors of ROCK protein kinsae.<br>References Hahmann, C. et al.: Cell. Mol. Life Sci., 67, 171 (2010);<br></p>

<p>Applications 2-(prop-2-ynyloxy)propanoic acid (cas# 134126-59-3) is a useful research chemical.<br></p>

<p>Applications Methyl 1-formylcyclopropane-1-carboxylate, is a building block used in the synthesis of chemical compounds.<br></p>

<p>Applications (±)-Paraconic Acid is used as a reagent in the synthesis of methylenecarboxybutyrolactones which have antibacterial activity.<br>References Tonari, K., et al.: J. Oleo Sci., 51, 259 (2002)<br></p>

<p>Applications 5-Bromopentylboronic Acid<br></p>

<p>Applications 4-fluorobutanoic acid (cas# 462-23-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-(2-(Methoxycarbonyl)phenoxy)benzoic Acid is an intermediate in the synthesis of Balsalazide (B116300) related compounds.<br></p>

<p>Applications (2-Oxopropyl)Carbamic Acid Tert-Butyl Ester (cas# 170384-29-9) is a useful research chemical.<br></p>

<p>Applications (2,3,4-Trimethoxyphenyl)boronic Acid is a reagent used in the synthesis of heteroaryl, mono and bicyclic compounds which may be used as inhibitors for EGF and PDGF receptor tyrosine kinases. Also used in the synthesis of non-steroidal CYP 17 inhibitors in the treatment of prostate cancer<br>References Hutschenreuter, T. et al.: J. Enz. Inhib. Med. Chem., 19, 17 (2004);<br></p>

<p>Applications 5-Oxo-1,3-dioxolane-4,4-diacetic Acid is used as a reagent to synthesize vibrioferrin, a siderophore. It can also be used as a building block of lipophilic isosteres of nucleoside triphosphates which are potential inhibitors of HIV reverse transcriptase.<br>References Takeuchi, Y., et al.: Chem. Pharm. Bull., 47, 459 (1999); Weaver, R., et al.: Bioorg. Med. Chem. Lett., 6, 2405 (1996)<br></p>

<p>Applications 2-amino-3-hydroxy-3-phenylpropanoic acid (cas# 7695-56-9) is a useful research chemical.<br></p>

<p>Applications (6,7-dimethoxy-4-oxoquinazolin-3(4H)-yl)acetic acid (cas# 877140-09-5) is a useful research chemical.<br></p>

<p>Applications 2-hydroxy-2,3-dihydro-1H-indene-2-carboxylic acid (cas# 13193-24-3) is a useful research chemical.<br></p>

<p>Applications Dibenzothiophene-2-boronic acid is a useful reagent for organic synthesis and other chemical processes.<br>References Duncton, M. A. J., et al.: Org. Lett., 10, 3259 (2008)<br></p>

<p>Applications 3,4-Epoxycyclohexanecarboxylate Methyl Ester is a useful reagent for organic synthesis.<br></p>

<p>Applications 5-(aminomethyl)-2-furoic acid hydrochloride (cas# 934-65-6) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 3-Hydroxy-5-nitrobenzoic acid<br></p>

<p>Applications Ethyl 4-bromoacetoacetate<br></p>

<p>Applications Hexahydro-4-oxo-1(2H)-azocinecarboxylic Acid 1,1-Dimethylethyl Ester is a chemical reagent used in organic synthesis.<br></p>

<p>Applications 1,2-Diaminopropane-N,N,N',N'-tetraacetic Acid is an aminopolycarboxylic acids found at ultra-trace levels in water; Also, it is used in the construction of Eu3+ ion-selective membrane electrode as suitable ionophore.<br>References Nette, D., et al.: Anal. Chim. Acta, 884, 124-132 (2015); Abedi, M. R., et al.: E-J. Chem., 8, S467-S473 (2011)<br></p>

<p>Applications Used in the preparatiom of esters of 6-aminohexanoic acid as antibacterial agents. EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo xy peptidase, plasmin, and plasminogen activator.<br>References Dolezal, P., et al.: Pharm. Res., 10, 1015 (1993), Vavrova, K., et al.: Curr. Med. Chem., 12, 2273 (2005), Holas, T., et al.: Bioorg. Med. Chem., 14, 7671 (2006),<br></p>

<p>Applications Androstenediol 17-Acetate is used in synthetic preparation for direct organocatalytic stereoselective transfer hydrogenation of conjugated olefins of steroids. Androstenediol 17-Acetate is also obtained from Dehydro Epiandrosterone (D229585) which is a major secretory steroidal product of the adrenal gland; secretion progresively declines with aging. May have estrogen-or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione. It is used in treatment of menopausal syndrome.<br>References Ebeling, P., et al.: Lancet, 343, 1479 (1994); Morales, A.J., et al.: J. Clin. Endocrinol. Metab., 78, 1360 (1994); Ramachary, D.B., et al.: RSC Advances, 3, 13497-13506 (2013); Yahara, M., et al.: J. Toxicol. Sci., 2, 161 (1977);<br></p>

<p>Applications Formamidine Acetate is a versatile reactant used in the tetrazine-based cycloadditions applied to pretargeted live cell imaging with norbornene modified monoclonal antibody.<br>References Devaraj, N., et al.: Bioconjugate Chem., 19, 2297 (2008);<br></p>

<p>Applications 4,4'-Dithiobisbenzoic Acid Dimethyl Ester (cas# 35190-68-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Aminomethylphenylacetic Acid is an intermediate of Ceforanide (C242930), a cephalosporin based antibiotic used in the sterilization in various medical procedures.<br>References Zhao, Y., et. al.: Res. Chem. Int. 40, 1637 (2014); Sifakis, S. et al.: Arch. Gyne. Obst., 272, 201 (2005); DiPiro, J. et al.: Antimicrob. Agents Chemother., 27, 287 (1985)<br></p>

<p>Applications 2,2-Dimethylbutyrate (DMB) is a potential treatment for thalassemia and hemoglobinopathies.<br>References Yeh, K., et al.: J. Pharmacokinet. Biopharm., 6, 79 (1978), Cunningham, M., et al.: Blood, 104, 34 (2004), Rund, D., et al.: N. Engl. J. Med., 353, 1135 (2005),<br></p>

<p>Applications 6-Bromohexanoic Acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rosen, D. B., et al.: PCT Int. Appl. (2020), WO 2020254617 A1<br></p>

<p>Applications Carbonochloridic Acid 1,2,2,2-Tetrachloroethyl Ester is used in the synthesis of Doxorubicin (D558000), is used as an antineoplastic. Also used in the synthesis of metabolites of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antine oplastic.<br>References Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969), Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984); Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>

<p>Applications 4-(Aminomethyl)-Cyclohexanecarboxylic Acid (cas# 701-54-2) is a useful research chemical.<br></p>

<p>Applications 3,5-Dinitro-o-toluic Acid is used to gather data for partition coefficients of solutes and vapors into anhydrous THF and 1,4-dioxane using Abraham model.<br>References Saifullah, M., et al.: J. Solution Chem., 40, 2082 (2011);<br></p>

<p>Applications 6-Chloronicotinic Acid, is an organic building block used for the synthesis of various biologically active compounds, including inhibitors. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors.<br>References Xie, Y., et al.: Bioorg. Med. Chem. Lett., 23, 2306 (2013); Shiroya, U., et al.: Med. Chem. Res., 22, 5227 (2013);<br></p>

<p>Applications 2-Phenoxypropionic Acid is used in organic chemistry reduction reactions. Used in the synthesis of PPAR (peroxisome proliferator-activated receptor (PPAR) ligands.<br>References Brown, P. et al.: Synthesis., 7, 778 (1997);<br></p>

<p>Applications Methyl 5-bromofuran-2-carboxylate<br></p>

<p>Applications 2,5-Furandicarboxylic Acid Diethyl Ester (cas# 53662-83-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Trifluoromethanesulfonic Acid Magnesium Salt is a strong acid that is used as a catalyst for esterification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howells, R. D., et al.: Chemical Rev., 77, 69 (1977);<br></p>

<p>Applications 2-Hydroxy-4-oxopentanoic acid is a derivative of 4-Oxopentanoic Acid, which is produced from marine algal biomass Gelidium amansii. Thermophilic bacteria growth inhibitor.<br>References Thomasser, C. et al. Appl. Biochem. Biotech. 98, 765 (2002); Jeong G. et al.: Appl. Biochem. Biotech. 161, 41 (2010)<br></p>

<p>Applications 2-(bis(2-(tert-butoxy)-2-oxoethyl)amino)acetic acid (cas# 171557-31-6) is a useful research chemical.<br></p>

<p>Applications γ-Isodurylic Acid is an intermediate in the synthesis of Ketoprofen (K200800) related compounds.<br>References Colomina, M., et al.: J. Chem. Thermodynamics., 19, 1139 (1987);<br></p>

<p>Applications Eicosanedioic Acid is an intermediate used to prepare haloperidol-based bivalent ligands targeting dopamine D2-like receptors.<br>References Salama, I., et al.; Bioorg. Med. Chem. Lett., 24, 3753 (2014)<br></p>

<p>Applications 2-Phenylthio-5-propionylphenylacetic Acid is a useful synthetic intermediate in the synthesis of Zaltoprofen (Z146000); an inhibitor of Cox-1 and Cox-2. Zaltoprofen preferentially inhibits Cox-2.<br>References Chen, W., et al.: Faming Zhuanli Shenqing. CN 1986528 A 20070627. Jun 27, 2007; Yamamoto, M., et al.: Chirality, 2, 280 (1990); Inoue, M., et al.: J Pharmacol. Exp. Ther., 293, 662 (2000)<br></p>

<p>Applications methyl 3-chloro-4-hydroxyphenylacetate (cas# 57017-95-5) is a useful research chemical.<br></p>

<p>Applications 4'-Hydroxyazobenzene-4-carboxylic acid hydrate<br></p>

<p>Applications 4-Phthalimidobutyric Acid can be used to evaluate nootropicactivity of newly synthesized gaba derivative in mice.<br>References Saleem, S., et.al.: Indo Am. J. Pharm., 5, 5527-5547, (2018);<br></p>

<p>Applications tert-butyl 2-(4-(bromomethyl)phenyl)acetate (cas# 77292-91-2) is a useful research chemical.<br></p>

<p>Applications 3-Amino-4-hydroxybenzoic acid (cas# 1571-72-8) is a useful research chemical.<br></p>

<p>Applications 17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic Acid is used for preparation of glutamic acid-containing acylating reagents for selective acylation of amino group(s) in peptides or proteins.<br>References Christensen, C., et al.: PCT Int. Appl. (2010), WO 2010084169 A2 20100729.<br></p>

<p>Applications 2-((tert-bButoxycarbonyl)amino)-2-(hydroxymethyl)-4-(4-octylphenyl)butyl Acetate is the intermediate in the synthesis of Mono-O-acetyl Fingolimod TFA (F524600), which is an impurity of Fingolimod (F805000, HCl salt) which is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001). Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002). Mtaloubian, M., et al.: Nature, 427, 355 (2004)<br></p>

<p>Stability Moisture Sensitive<br>Applications Propylphosphonic Anhydride is used to prepare aryloxybenzylmorpholines as dual serotonin and noradrenaline reuptake inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fish, P., et al.: Bioorg. Med. Chem. Lett., 18, 2562 (2008)<br></p>

<p>Applications Methyl (1R,4S)-4-Amino-2-cyclopentene-1-carboxylate (2S,3S)-2,3-Dihydroxybutanedioic Acid is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br></p>

<p>Applications Cyclopentylacetic acid is a reagent the synthesis of Cyclopentamine (C988355), which is a vasoconstrictor that acts as a releasing agent of the neurotransmitters norepinephrine, epinephrine and dopamine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schmidt, J.L. et al.: J. Pharmacol. Exp. Ther., 145, 83 (1964); Iversen, L.L.: J. Pharm. Pharmacol., 16, 435 (1964);<br></p>

<p>Applications Oxirane-​2-​carboxylic Acid is used as reactant in the synthesis of glutathione peptidomimetics as components of antiparkinson prodrugs.<br>References More, S., Vince, R.: J. Med. Chem., 51, 4581 (2008);<br></p>

<p>Stability Volatile<br>Applications METHYL AZIRIDINE-2-CARBOXYLATE (cas# 5950-34-5) is a useful research chemical.<br></p>

<p>Applications 4-tert-Butoxyphenylboronic Acid is a compound used in the preparation of nitrophenylphenol via cross-coupling reaction of nitrohalobenzenes with phenylboronic acids and deprotection.<br>References Kumamoto, N., et al.: Preparation of nitrophenylphenol, JP 2001055360 (2001);<br></p>

<p>Applications Hexacosanoic Acid (cas# 506-46-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-(Diethylphosphono)propanoic acid<br></p>

<p>Applications 3-Trimethylstannyl Benzoic Acid (cas# 161767-56-2) is a compound useful in organic synthesis.<br></p>

<p>Applications A reagent used in the synthesis of glycidol, a stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.<br>References Palomo, J.M. et al.: Tetrahedron Asymm., 16, 869 (2005); Hiles, R.A., et al.: Food Cosmet. Toxicol., 19, 347 (1981); Thompson, E.D., et al.: Food Chem. Toxicol., 22, 665 (1984);<br></p>