Carboxylic Acids

<p>Applications (+/-)-Nipecotic Acid (cas# 498-95-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl Isobutyrylacetate is used in the synthesis of piperazine derivatives as possible multireceptor atypical antipsychotics, affecting dopamine and serotonin receptor properties . Also used in the synthesis of pyrazinecarboxamide DGAT1 (diacylglycerol acyltransferase 1) inhibitors used in the treatment of obesity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, Y. et al.: J. Med. Chem., 56, 4671 (2013); J. Med. Chem., 55, 10610 (2012);<br></p>

<p>Applications 3-Hydroxy-2-nitrobenzoic Acid (cas# 602-00-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Agomelatine Acetic Acid is a research reagent used in studies of nucleophilic ring opening.<br>References Chatterjee, A., et al. : Tetrahedron, 33, 85 (1977)<br></p>

<p>Applications BENZYL CYANOMETHYLCARBAMATE (cas# 3589-41-1) is a useful research chemical.<br></p>

<p>Applications 2-(methylamino)octanoic acid (cas# 101080-67-5) is a useful research chemical.<br></p>

<p>Stability Epimerize in solution<br>Applications 5-Hydroxy-1,3-oxathiolane-2-carboxylic Acid is used in the synthesis of potent antiviral agent (-)-2’-Deoxy-3’-thiacytidine and its enantiomer.<br>References Jin, H.L., et al.: J. Org. Chem., 60, 2621 (1995);<br></p>

<p>Applications 2-hydroxy-2,3-dihydro-1H-indene-2-carboxylic acid (cas# 13193-24-3) is a useful research chemical.<br></p>

<p>Applications 2-Carboxyfuran-5-boronic acid, pinacol ester<br></p>

<p>Applications Eicosanedioic Acid is an intermediate used to prepare haloperidol-based bivalent ligands targeting dopamine D2-like receptors.<br>References Salama, I., et al.; Bioorg. Med. Chem. Lett., 24, 3753 (2014)<br></p>

<p>Applications GAMMA-CHLOROCROTONIC ACID (cas# 26340-58-9) is a useful research chemical.<br></p>

<p>Applications 2,3-Dimethylphenylacetic Acid (cas# 30981-98-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-[(2-Hydroxyethyl)Amino]Propanoic Acid (cas# 5458-99-1) is a useful research chemical.<br></p>

<p>Applications 4-N-OCTYLOXYBENZOIC ACID (cas# 2493-84-7) is a useful research chemical.<br></p>

<p>Stability Store FROZEN<br>Applications Material that was assayed to be approximately 80% pure was diluted to 5% in benzene.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Acetylphenylboronic Acid is a reactant used in the synthesis of potent, selective phenylimidazole-based tissue factor/factor VIIa (FVIIa) inhibitors.<br>References Glunz, P.W., et. al.: Bioorg. Med. Chem. Lett., 25, 21699 (2015)<br></p>

<p>Applications L-Menthyl 2,2-Dihydroxyacetate is used as a reagent in the synthesis of Lamivudine (L172500); a potent nucleoside reverse transcriptase inhibitor used for the treatment of chronic hepatitis B. L-Menthyl 2,2-Dihydroxyacetate is also used as a reagent in the synthesis of 4-acetoxy-3-hydroxyethylazetidin-2-one, a key intermediate for the preparation of penem and carbapenem antibiotics.<br>References Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944); Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997); Perry, C.M., et al.: Drugs, 53, 657 (1977); Goodyear, M.D., et al.: Tetrahedron Lett., 46, 8535 (2005); Kametani, T., et al.: Heterocycles, 25, 241 (1987)<br></p>

<p>Applications (9H-Purin-6-ylamino)-acetic acid (cas# 10082-93-6) is a useful research chemical.<br></p>

<p>Applications 2,5-Dihydroxybenzoic Acid Butylamine Salt [Matrix for MALDI-TOF/MS] (cas# 666174-80-7) is a useful research chemical.<br></p>

<p>Applications 3-Trimethylstannyl Benzoic Acid (cas# 161767-56-2) is a compound useful in organic synthesis.<br></p>

<p>Impurity Fluorouracil EP Impurity B; Fluorouracil USP Related Compound B<br>Applications A 5-hydroxy derivative of the nucleobase Uracil (U801000) and an isomer of Barbituric Acid (B118650). Studies show that it can form stable base pairs with all four bases in a DNA duplex. It has been used as oxidative DNA damage biomarker in tissue engineered skin. Fluorouracil EP Impurity B. Fluorouracil USP Related Compound B<br>References Varatharasa T. et al.: Chem. Comm., 3, 400 (2005); Jaruga, P. et al.: Nucleic Acid Res., 24, 1389 (1996); Rodriguez, H. et al.: Adv. Exp. Med. Biol., 534, 129 (2003);<br></p>

<p>Applications Carbamic Acid 2-​Hydroxypropyl Ester is an organic reagent used in the preparation of polyurethane foams.<br>References Mueller, E. et al.: Angew. Makri, Chem., 34, 111 (1973)<br></p>

<p>Applications Cyclohexylacetic acid<br></p>

<p>Applications 4-CYANO-4-[(ETHYLSULFANYLTHIOCARBONYL)SULFANYL]PENTANOIC ACID (cas# 1137725-46-2) is a useful research chemical.<br></p>

<p>Applications DITHIOCARBONIC ACID S,S'-DIETHYL ESTER (cas# 623-80-3) is a useful research chemical.<br></p>

<p>Applications tert-Butyl Methylcarbamate is an substituent in the synthetic preparation of PF-06463922, a macrocyclic inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1).<br>References Johnson, T. W., et al.: J. Med. Chem., 57, 4720 (2014);<br></p>

<p>Applications Methyl Dimethylbenzeneacetate (cas# 57625-74-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Cyclopentenecarboxylic Acid can be used for enantioselective 1,3-dipolar cycloadditions of diazoacetates and solid-phase synthesis of substituted indolines. It can also be used to develop antagonists for A1- and A2-adenosine receptors.<br>References Sibi, M. P., et al.: Org Lett. 9, 1553 (2007); Nicolaou, K. C., et al.: J. Am. Chem. Soc. 122, 2966 (2000); Jacobson, K. A., et al.: Biochem. Pharmacol. 37, 3653 (1988)<br></p>

<p>Applications 4-Acetylbutyric Acid is used in the synthesis of selective indomethacin analogues for AKR1C3 inhibition in the treatment of castrate-resistant prostate cancer. Also used to prepare PARP inhibitors for the treatment of cancer as well.<br>References Liedtke, A. et al.: J. Med. Chem., 56, 2429 (2013); Zhu, G. et al.: Bioorg. Med. Chem., 20, 4653 (2012);<br></p>

<p>Applications (5-Formylfuran-2-yl)boronic Acid is a reagent used in Suzuki cross-couplings with deactivated aryl bromides and activated aryl chlorides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trinh, T. N., et al.: Org. Biomol. Chem., 12, 9562-9571 (2014);<br></p>

<p>Applications 4-(Cyclopropylcarbonyl)-α,α-dimethylbenzeneacetic Acid is used for the preparation of Terfenadine ((T114500) analogs.<br>References Uchida., et al.: Chem. Pharm. Bull., 37, 958 (1989),<br></p>

<p>Applications 3-​Hydroxypivalic Acid is a general reagent used in the synthesis of AZD8835, a potent and selective inhibitor of PI3K and PI3Kδ in the treatment of cancers.<br>References Barlaam, B. et al.: Bioorg. Med. Chem. Lett., 25, 5155 (2015);<br></p>

<p>Applications 2-(Diphenylphosphino)benzoic Acid is used in small molecule control of protein function through staudinger reduction.<br>References Luo, J., et al.: Nat. Chem., 8, 1027 (2016)<br></p>

<p>Applications Methyl 2-(4-Bromophenyl)-2,2-dimethylacetate (cas# 154825-97-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Phenylmethyl ester N-[(3aS,4R,6S,6aR)-tetrahydro-6-hydroxy-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]-Carbamic acid is a useful chiral building block. It has been used in the synthesis of all-cis carbocyclic precursor of ticagrelor via oxidation/stereoselective reduction sequences.<br>References Wlodarczyk, J.; et al.: Tet. Lett., 56, 6093 (2015).<br></p>

<p>Applications o-Bromophenoxyacetic acid<br></p>

<p>Applications 2-Pyridylphosphonic Acid is used as ligand in the hydrothermal preparation of copper(II)-lanthanide(III) and zinc(II)-lanthanide(III) pyridylphosphonate coordination polymers.<br>References Ma, Y., et al.: Chem. Eur. J., 13, 4759 (2007);<br></p>

<p>Applications 4-Oxooctanoic Acid is one of mid-chain oxocarboxylic acids detected in Antarctic aerosols and possible precursors to the production of low molecular weight diacids such as succinic acid.Also, it is derived from 4-Octanolide (O239723), which is one of the fine organic aerosol emitted from meat cooking operations that was examined by high-resolution gas chromatography.<br>References Nishikiori, M., et al.: Chikyu Kagaku, 30, 27-34 (1996); Rogge, W., et al.: Environ. Sci. Technol., 25, 1112 (1992)<br></p>

<p>Applications 4,5-dimethylthiophene-3-carboxylic acid (cas# 19156-52-6) is a useful research chemical.<br></p>

<p>Applications 2-benzylcyclopropane-1-carboxylic acid (cas# 103986-55-6) is a useful research chemical.<br></p>

<p>Applications 2-(4-Aminophenyl)propanoic acid is a reagent in the preparation of 3-aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents (Erratum).<br>References Pevarello, P., et al.: J. Med. Chem., 48, 5058 (2005);<br></p>

<p>Stability Temperature Sensitive<br>Applications 2-Oxocyclopentanecarboxylic Acid is a reactant that has been used in the synthesis of Piragliatin, a glucokinase activator.<br>References Sarabu, R., et. al.: J. Med. Chem., 55, 7021 (2012)<br></p>

<p>Applications Dibromoisocyanuric acid is a bromine compound with a superior bactericidal activity.<br>References Gottardi, W., et al.: J. Appl. Microbiol., 116, 1427 (2014)<br></p>

<p>Applications 4-(Aminomethyl)-Cyclohexanecarboxylic Acid (cas# 701-54-2) is a useful research chemical.<br></p>

<p>Applications 6-Chloro-1-benzofuran-2-carboxylic Acid is used to prepare cis-diaminocyclohexane derivatives as factor Xa inhibitors. It is also used to synthesize tachykinin NK2 receptor antagonists.<br>References Bioorg. Med. Chem., 17, 8206 (2009); Gensini, M., et al.: ChemMedChem, 5, 65 (2010)<br></p>

<p>Applications Clavulanic Acid 2-Amino-2,4,4-trimethylpentane Salt is an intermediate in the synthesis of Clavulanic Acid Potassium Salt (C563750), a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977); Ball, A.P., et al.: Lancet, 1, 620 (1980); Brogden, R.N., et al. Drugs, 22, 337 (1981)<br></p>

<p>Applications Ethyl 3,4-dihydro-2H-pyran-2-carboxylate (cas# 83568-11-0) is a useful research chemical.<br></p>

<p>Applications 4-Formylbenzenesulfonic Acid is used in preparation method for 3-Phenyl-L-serine derivatives.<br>References Xu, W., et al.:PCT Int. Appl., (2020):<br></p>

<p>Applications 2-(Methoxyimino)-3-oxo-butanoic Acid 1,1-Dimethylethyl Ester is an intermediate used in the synthesis of Cefotaxime Bromoacetyl Analogue (C242940), which is an impurity of Cefotaxime (C242950), a broad spectrum third generation cephalosporin antibiotic.<br>References Wise, R., et al.: Antimicrob. Agents Chemother., 14, 807 (1978), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 11, 139 (1982),<br></p>

<p>Applications Benzothiophene-5-boronic acid<br></p>

<p>Applications (2R)-4-(1,1-Dimethylethyl) Ester 2,4-Morpholinedicarboxylic Acid is used in the preparation of renin inhibitors.<br>References Yuan, J. et al.: Bioorg. Med. Chem. Lett., 21, 4836 (2011); Fish, P. et al.: Tetra. Lett., 50, 389 (2009);<br></p>

<p>Applications 3-Amino-4-hydroxybenzoic acid (cas# 1571-72-8) is a useful research chemical.<br></p>

<p>Applications (+)-Dibenzoyl-D-Tartaric Acid Monohydrate (cas# 80822-15-7) is a useful research chemical.<br></p>

<p>Applications A useful synthetic intermediate.<br>References Li, A., et al.: J. Med. Chem., 42, 706 (1999), Low, E., et al.: Bioorg. Med. Chem. Lett., 19, 196 (2009),<br></p>

<p>Applications 4-(Cyanophenyl)boronic Acid Pinacol Ester is used to prepare arylparacyclophanes via Suzuki aryl cross-coupling of bromoparacyclophane with arylboronic acid and arylboronates. It’s also used to prepare tyrosine-modified analogs of α4β7 integrin inhibitor biotin-R8ERY.<br>References Roche, A., et al.: Org. Biomol. Chem.,, 3, 515 (2005); Papst, S., et al.: Bioorg. Med. Chem., 20, 5139 (2012)<br></p>

<p>Applications tert-Butyl 2-(diethylphosphono)acetate is a chemical reagent used in the synthesis of pharmaceuticals such as Clopidogrel (C587250), s prodrug anticoagulant.<br>References Shaw, S. et al.: J. Org. Chem., 80, 7019 (2015);<br></p>

<p>Applications Diethyl 1,1-Cyclopropanedicarboxylate (cas# 1559-02-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-​Chloro-​3-​sulfobenzoic acid is a useful chemical for the preparation of pyridinylbiphenylcarboxamide derivatives for the use as nervous system agents.<br>References Wei, Z.L., et al.: PCT Int. Appl. 199pp. Patent 2009 CODEN:PIXXD2;<br></p>

<p>Applications 3-(3-THIENYL)ACRYLIC ACID (cas# 102696-71-9) is a useful research chemical.<br></p>

<p>Applications 2,2-Dimethyloctanoic Acid is used in biological studies as benzyl dimethyloctanoate metabolite of sewage bacteria.<br>References Millier, A., et al.: Bull. Environ. Contam. Toxicol., 28, 113 (1982);<br></p>