Carboxylic Acids

Applications 4-Ethylbenzoic acid

Applications (-)-α-Kainic Acid Monohydrate is the monohydrated form of (-)-α-Kainic Acid (K135010); a naturally occurring neuroexcitatory chemical that is a selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.
References Wacker, D.A., et al.: Synlett, 503 (1997); Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)

Applications 2-Carboxyfuran-5-boronic acid, pinacol ester

Applications (±)-Paraconic Acid is used as a reagent in the synthesis of methylenecarboxybutyrolactones which have antibacterial activity.
References Tonari, K., et al.: J. Oleo Sci., 51, 259 (2002)

Applications Isostearic acid is a useful synthetic intermediate. It is used in the synthesis of methyl-branched poly(hydroxyalkanoate)s, biosurfactants and silver nanoparticles.
References Smyth, T., et al.: Appl. Microbio. Biotechnol., 87, 1347 (2010); Anand, M., et al.: J. Phys. Chem. B, 110, 14693 (2006); Hsieh, H., et al.: Langmuir, 26, 10031 (2010); Ashby, R., et al.: Appl. Microbio. Biotechnol., 85, 359 (2009)

Applications tert-Butyl carbamate is used to prepare N-Boc-protected anilines. It is also used in the synthesis of tetrasubstituted pyrroles, functionalized with ester or ketone groups at C-3 position.
References Bhagwanth, S., et al.: J. Org. Chem., 74, 4634 (2009); Cadierno, V., et al.: J. Heterocycl. Chem., 47, 233 (2010)

Applications 4-N-OCTYLOXYBENZOIC ACID (cas# 2493-84-7) is a useful research chemical.

Stability Store FROZEN
Applications Material that was assayed to be approximately 80% pure was diluted to 5% in benzene.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Stability Light Sensitive
Applications Azobenzene-4,4'-dicarboxylic Acid (cas# 586-91-4) is a useful research chemical.

Applications 2,2-Dimethyloctanoic Acid is used in biological studies as benzyl dimethyloctanoate metabolite of sewage bacteria.
References Millier, A., et al.: Bull. Environ. Contam. Toxicol., 28, 113 (1982);

Applications (1S,2S)-1,2-Cyclopropanedicarboxylic acid is an reagent used in the synthesis of bleomycin (B595800), a antitumor and antibiotic agent.
References Huang, L., et al.: Heterocycles., 41, 1181 (1995); Umezawa, et al.: J. Antibiot., 19, 200 (1966); Burger, R.M., et al.: Life Sci., 28, 715 (1981); Marugesan, N., et al.: J. Biol. Chem., 257, 8600 (1982); Saito, S., et al.: J. Antibiot., 36, 92 (1983);

Applications 4-fluorobutanoic acid (cas# 462-23-7) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications (9H-Purin-6-ylamino)-acetic acid (cas# 10082-93-6) is a useful research chemical.

Applications 2,5-Dihydroxybenzoic Acid Butylamine Salt [Matrix for MALDI-TOF/MS] (cas# 666174-80-7) is a useful research chemical.

Applications 3-Aminohydantoic Acid is an intermediate in the synthesis of new derivative of 5-Nitro-2-furfural, proved to be bactericidal.
References Swirska, A., et al.: Rocz. Chem., 31, 1335 (1957);

Applications 1H,1aH,6H,6aH-cyclopropa[a]indene-1-carboxylic acid (cas# 501418-06-0) is a useful research chemical.

Applications Methyl (3α,5β,6α)-3-(Acetyloxy)-6-bromo-7-oxo-cholan-24-oic Acid Ester is an intermediate used in the synthesis of ω-Muricholic Acid (M732760), which is used in the regulation of weight gain and lipid metabolism by bacterial bile acid modification in gut for the control of obesity and hypercholesterolemia.
References Joyce, Susan A., et al.: Proc. Natl. Acad. Sci. USA, 111, 7421 (2014)

Applications 5-Chloropentyl acetate is a Friedel-Crafts haloalkyl ester with antibacterial properties.

Applications Methyl Dimethylbenzeneacetate (cas# 57625-74-8) is a compound useful in organic synthesis.

Applications 4-Acetylbutyric Acid is used in the synthesis of selective indomethacin analogues for AKR1C3 inhibition in the treatment of castrate-resistant prostate cancer. Also used to prepare PARP inhibitors for the treatment of cancer as well.
References Liedtke, A. et al.: J. Med. Chem., 56, 2429 (2013); Zhu, G. et al.: Bioorg. Med. Chem., 20, 4653 (2012);

Applications (5-Formylfuran-2-yl)boronic Acid is a reagent used in Suzuki cross-couplings with deactivated aryl bromides and activated aryl chlorides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Trinh, T. N., et al.: Org. Biomol. Chem., 12, 9562-9571 (2014);

Applications 2,2,5-Trimethyl-1,3-dioxane-5-carboxylic Acid Ethenyl Ester (cas# 865860-80-6) is a compound useful in organic synthesis.

Applications 2-(Diphenylphosphino)benzoic Acid is used in small molecule control of protein function through staudinger reduction.
References Luo, J., et al.: Nat. Chem., 8, 1027 (2016)

Applications O-Acetyl Mandelic Acid is a useful reagent for the synthesis of hindered triazolopyridinone derivatives.
References Ye, Z., et al.: Nat. Commun., 11, 3628 (2020)

Applications 4-(3,4-dipropoxyphenyl)-4-oxobutanoic acid (cas# 568553-00-4) is a useful research chemical.

Applications o-Bromophenoxyacetic acid

Applications tert-Butyl Bromoacetate is a halogenated t-butyl acetate commonly used as an alkylating agent. tert-Butyl Bromoacetate is used in the synthesis of collagenase inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Steinman, D.H. et al.: Bioorg. Med. Chem. Lett., 8, 2087 (1998); Fray, M.J. et al.: J. Med. Chem., 46, 3514 (2003): Neri, P. et al.: J. Org. Chem., 59, 3880 (1994);

Applications Ethyl 5-amino-1-benzofuran-2-carboxylate is used as an synthetic intermediate in the preparation of indolebutylpiperazines, a class of dual 5-HT1A receptor agonists and serotonin reuptake inhibitors. Ethyl 5-amino-1-benzofuran-2-carboxylate was also used as a potential radiolabelled analog for melanoma imaging and targeted radiotherapy.
References Chezal, J.M., et al.: J. Medn. Chem., 51, 3133 (2008); Heinrich, T., et al.: J. Medn. Chem., 47, 4684 (2004);

Applications 3-Furoic Acid, is metabolized by Corynebacterium fascians from soil, limonoid metabolism based on a biological studies.
References Hasegawa, S., et al.: J. Arg. Food Chem., 31, 807 (1983)

Applications 5-Chloronicotinic Acid is used as reagent/reactant luminescence and hydrothermal preparation of cobalt/cadmium/lead chloronicotinate phenanthroline MOF.
References Gao, Z.Q., et al.: J. Solid State Chem., 241, 121-130 (2016)