Glycoscience

<p>Applications Useful substrate for the rapid colorimetric assay of N-Acetyl-beta-glucosaminidase in human urine.<br>References Muruhn, D.: Clin. Chim. Acta, 73, 453 (1976)<br></p>

<p>Applications Labelled D-Glucose is a simple sugar that is present in plants. A monosaccharide that may exist in open chain or cyclic conformation if in solution. It plays a vital role in photosynthesis and fuels the energy required for cellular respiration. D-Glucose is used in various metabolic processes including enzymic synthesis of cyclohexyl-α and β-D-glucosides. Can also be used as a diagnostic tool in detection of type 2 diabetes mellitus and potentially Huntington's disease through analysis of blood-glucose in type 1 diabetes mellitus.<br>References Wang, R., et al.: J. Mol. Catal. B. Enz., 56, 131 (2009); Springhorn, C. et al.: J. Clin. Endocrinol. Metab., 97, 4640 (2012); Hashimoto, K. et al.: J. Clin. Endocrinol. Metab., 97, 3016 (2012); Avelange, M. et al.: Plant. Phys., 94, 1157 (1990); Cramer, C. et al.: J. Chem. Soc., 115, 5745 (1993);<br></p>

<p>Applications Ethyl-2,2,2-d3-malonic Acid (CAS# 70907-93-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Antigen which binds to endothelial adhesion molecule, E-selectin.<br>References Fukushima, K., et al.: Cancer Research, 44, 5279 (1984), Zein, N., et al.: Science, 240, 1198 (1988), Phillips, M.L., et al.: Science, 250, 1130 (1990), Walz, G., et al.: P.N.A.S. U.S.A., 88, 6224 (1991), Walker, S., et al.: P.N.A.S. U.S.A., 89, 4608 (1992)<br></p>

<p>Applications 2-Acetamido-2-deoxy-D-mannono-1,4-lactone (cas# 28876-37-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Deoxy-L-ribose is an isomer of 2-Deoxy-D-ribose (D252000) which induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione.<br>References Fico, A., et al.: Free Radical Biology &amp; Medicine, 45, 211 (2008)<br></p>

<p>Applications 5alpha-Pregnan-11beta,17alpha,21-triol-3,20-dione-1,2,4,5-d4 (CAS# 252976-11-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Hexane-1,1,1,2,2,3,3-d7 (CAS# 32740-31-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Shown to be metabolized in yeast.<br>References Biochem. J., 209 (3), 677-685 (1983)<br></p>

<p>Applications Isotope Labelled Derivative of D-Glucosamine (G514950), an amino sugar and a prominent precursor in the biochemical synthesis of glycosylate proteins and lipids.<br>References Zupanets, I.A. et al.: Klin. Farmat., 15, 67 (2011); Vajarudal, Y., et al.: Clin. Ther., 3, 336 (1981); Setnikar, I., et al.: Arzneim.-Forsch., 36, 729 (1986);<br></p>

<p>Applications An inhibitor of peptic hydrolysis and stomach acidity. Used as an anti-ulcerative.<br>References Mayberr, J.F., et al.: Brit. J. Clin. Pract., 32, 291 (1978); Brogden, R.N., et al.: Drugs, 27, 194 (1984);<br></p>

<p>Applications 1,2,3,4,6-Penta-O-acetyl-α-D-mannopyranose (cas# 4163-65-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 3,5-Dimethyl-d6-cyclohexanone-3,4,4,5-d4 (mixture of isomers) (CAS# 1219804-55-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-Azido-6-(tert-butyldimethylsilyl)-2,3-O-isopropylidene L-Gulono-1,4-lactone (cas# 118464-49-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Benzyl-2,3,4,5,6-d5 Acetate (CAS# 1398065-57-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications DL-Arabinose, is a building block of polysaccharide (CCPa-1) from fungus Coprinus comatus Gray, which has potential application as natural antitumor agent with immunomodulatory activity. Arabinose is also used as a culture medium for certain bacteria.<br>References Xiao-Gang, J., et al.: Int. J. Bio. Macromol., 58, 349 (2013);<br></p>

<p>Applications Used in the synthesis of novel bis(D-mannose) compounds.<br>References Holman, G.D., et al.: Carbohydrate Res., 135, 337 (1985),<br></p>

<p>Applications Oligosaccharide which participates in cell adhesion between bacterial and eukaryotic cells<br>References Perret, S., et al.: Biochem. J., 389, 325 (2005), Marotte, K., et al.: ChemMedChem., 2, 1328 (2007),<br></p>

<p>Applications Ethyl-alpha-13C-benzene (CAS# 287399-32-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications D-Gentiobiose is incorporated in the chemical structure of Crocin (C794945); a natural carotenoid derived from the flowers crocus and gardenia, that has been shown to be a potent antioxidant. Also shown to have an antiproliferative action against cancer cells in vitro. Possible antidepressant properties.<br>References Zheng, Y. Q., et al.: Brain Res., 1138, 86 (2006); Hosseinzadeh, H., et al.: PTR, 24 (5), 726 (2010); Ochiai, T., et al.: Biochim. Biophys. Acta., 1770(4), 578 (2006)<br></p>

<p>Applications 4-Chloro-2,6-dimethoxy-5-nitropyrimidine is an intermediate in the synthesis of Lumazine (L473800) fluorophore.<br>References Chen, J.H., et al.: J. Org. Chem., 69, 6996 (2004); Cushman, M., et al.: J. Org. Chem., 69, 601 (2004);<br></p>

<p>Stability Hygroscopic<br>Applications Benzyl 3’-Sulfo-β-D-lactoside Sodium Salt (cas# 431898-95-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Inhibition of β-glucosidase.<br>References Barkley, M.D., et al.: Biochemistry, 14, 1700 (1975), Gonzalez, J.B., Biotechnol. Lett., 4, 369 (1982)<br></p>

<p>Applications Protected Maltotriose.<br>References Brayer, G., et al.: Biochem., 39, 4778 (2000),<br></p>

<p>Applications α-D-Glucopyranuronic Acid Methyl Ester 2,3,4-Tribenzoate 1-Methanesulfonate is a reactant in organic synthesis. It is used in the preparation of novel quaternary glucuronyl reagent for preparation of tertiary amines.<br>References Araya, I. &amp; Akita, H.: Heterocycles., 75, 1213 (2008)<br></p>

<p>Applications L-Glucose is the enantiomer of D-Glucose (G595000), a naturally occurring carbohydrate used in an abundance of cellular processes. L-Glucose is a synthetic sugar used in the formation of L-Glucose Pentaacetate (G596510), a potential therapeutic agent regarding type II diabetes. In addition, L-glucose can be used as a colon cleansing agent for before a colonoscopy procedure.<br>References Malaisse, W. et al.: Int. J. Mol. Med., 2, 383 (1998); Raymer, G. et al.: Gastrointest. Endosc., 58, 30 (2003); Wang, R., et al.: J. Mol. Catal. B. Enz., 56, 131 (2009),<br></p>

<p>Applications (8S-cis)-8-Acetyl-10-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione is an tert-butyldiphenylsilyl protected degredation product of Doxorubicin (D194500), an anthracycline antibiotic related to the rhodomycins.<br>References Matsumoto, T., et al.: Chem. Pharma. Bull., 34, 4613 (1986);<br></p>

<p>Applications Octyl Tetra-2,3,4,6-O-acetyl-β-D-thioglucopyranoside (cas# 85618-26-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Acetamido-4,6-O-benzylidene-2-deoxy-beta-D-glucopyranosyl Azide 168397-51-1 (cas# 168397-51-1) is a useful research chemical.<br></p>

<p>Applications Isotope labelled D-galactose (G155250), A C-4 epimer of Glucose (G595000) found in milk and sugar beets as well as being synthesized by the body. Potential use in oral therapy for nephrotic syndrome in focal and segmental glomerulosclerosis.<br>References De Smet, E. et al.: Nephrol. Dial. Transplant., 24, 2938 (2009); Kivele, R. et al.: Carb. Pol., 85, 645 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications 4-O-α-D-Mannopyranosyl-D-mannose is used in the preparation of immunostimulants, useful as materials for foods as well.<br>References Imamura, L., et al.: Biol. Pharm. Bull., 17, 596 (1994), ,Perrin, S., et al.: J. Appl. Microbiol., 90, 859 (2001), Olano-Martin, E., et al.: J. Appl. Microbiol., 93, 505 (2002), Gibson, G., et al.: J. Food Sci., 69, 141 (2004),<br></p>

<p>Applications Isolevoglucosenone (cas# 307991-08-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Benzyl α-D-Mannopyranoside (cas# 15548-45-5) is a compound useful in organic synthesis.<br>References Rutschow, S., et al.: Bioorg., Med. Chem., 10, 4043 (2002), Duvet, S., et al.: Glycobiol., 14, 841 (2004),<br></p>

<p>Applications 2-O-(α-D-Glucopyranosyl)-D-galactose (cas# 7368-73-2) is a compound useful in organic synthesis.<br>References Gent, P.A., et al.: J. Chem. Soc., 1, 1446 (1974)<br></p>

<p>Applications D-Galacturonic Acid-13C6 is labelled D-Galacturonic Acid (G186500, Monohydrate) which is used in the synthesis of N-(D-galacturonoyl) amino acids and dipeptides.<br>References Klaus, U., et al.: Environ. Sci. Technol., 34, 3514 (2000),<br></p>

<p>Applications A useful glycopeptide intermediate.<br></p>

<p>Applications 4-Nitrophenyl 2-Acetamido-2-deoxy-4-O-α-L-fucopyranosyl)-β-D-glucopyranoside (cas# 259143-52-7) is a compound useful in organic synthesis.<br></p>

<p>Applications α-D-Mannose 1-Phosphate is used in the synthesis of non-natural mannoglucans by α-glucan phosphorylase-catalyzed enzymatic copolymerization;Also, it is derived from D-Mannose (M168000), which is a carbohydrate that is important in the glycosylation of molecules in a variety of cellular processes. It is involved in N and O glycosylation of bovine why protein products, used in infant formulas. It is also responsible for the O-glycosylation of the T helper cell-derived cytokine interlukin-17A, an important cell-signaling molecule.<br>References Baba, R., et al.: Carbohydr. Polym., 151, 1034-1039 (2016); van Leeuwen, S. et al.: J. Agri. Food Chem., 60, 12553 (2012); Geoghegan, K. et al.: Prot. Express. Purif., 87, 27 (2013);<br></p>

<p>Applications sn-Glycerol 3-Phosphate Bis(cyclohexylammonium) Salt is a standard used for measuring the level of glycerol-3-phosphate produced by the hydrolysis of phosphatidic acid. Glycerol 3-phosphate (G3P) is an important intermediate of carbohydrate and lipid metabolic pathways.<br>References Morita, S., et al.: J. Lipid Res., 50, 1945 (2009); Feesner, W., et al.: Angewandte Chemie, 106, 217 (1994)<br></p>

<p>Applications 2-(Acetylamino)-2-deoxy-D-glucopyranose 3,4,6-Triacetate (cas# 34051-43-9) is a compound useful in organic synthesis.<br></p>

<p>Applications D-Glucosamine-2-N-sulfate sodium salt (cas# 38899-05-7) is a useful research chemical.<br></p>

<p>Applications Proven to be an extremely potent and selective a-D-galactosidase inhibitor.<br>References Paulsen, H., et al.: Chem. Ber., 113, 2601 (1980),<br></p>

<p>Applications L-Mannose (cas# 10030-80-5) is a compound useful in organic synthesis.<br></p>

<p>Applications p-Nitrophenyl 2-Acetamido-2-deoxy-(4-O-2-acetamido-2-deoxy-β-D-_x000D_glucopyranosyl)-α-D-galactopyranoside is a compound useful in organic synthesis.<br>References Medina, M. et al.: Cancer Res. 59,1061-1070, (1999)<br></p>

<p>Applications beta-D-Glucopyranosylamine<br></p>

<p>Applications D-Mannose-6-O-sulphate Sodium Salt (cas# 204575-08-6) was a product of esterase-catalyzed regioselective deacylation and acid-catalyzed rearrangement from per-acetylated derivatives.<br>References Horrobin, T., et al.: J. Chem. Soc. Perkin 1, 1069 (1998)<br></p>

<p>Stability Moisture Sensitive<br>Applications US Pat. 7033765<br></p>

<p>Applications 5-Acetamino-4-hydroxy-2-(4-nitro-phenoxy)-6-(1,2,3-trihydroxy-propyl)-_x000D_tetrahydro-pyran-2-carboxylic Acid Methyl Ester (cas# 59694-35-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Hydroxy-2’-deoxycytidine-13C,15N2 is the Isotope labelled analogue of 5-Hydroxy-2’-deoxycytidine (H946650), a substrate for uracil DNA N-glycosylase and has been used to study the oxidation of DNA due to exposure to reactive oxygen species.<br>References Ganguly, M., et al.: Biochem., 51, 2018 (2012); Foresta, M., et al.: Free. Rad. Biol. Med., 48, 681 (2010); Daviet, S., et al.: DNA Repair., 6, 8 (2007);<br></p>

<p>Applications 1-Bromopentadecane-1,1,2,2-d4 (CAS# 1219798-87-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications It is produced by microorganism fermentation of glucose in a fermentation culture medium without adding calcium carbonate.<br>References Ostrowski, S., et al.: Science, 305, 71 (2004), Vavilin, D., et al.: Biochim. Biophys. Acta, 1708, 91 (2005), Fletcher, J., et al.: Anal. Chem., 79, 2199 (2007), Weissleder, R., et al.: Nature, 452, 580 (2008),<br></p>

<p>Applications Coumarin 307 is a suitable candidate for use as a laser dye.<br></p>

<p>Applications Glyceryl Tri(hexadecanoate-2,2-d2) (CAS# 241157-06-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Derivative of Neuraminic Acid<br>References Oetke, C., et al.: J. Biol. Chem., 277, 6688 (2002),<br></p>

<p>Applications 2-Nitrobenzonitrile-d4 (CAS# 1219795-50-2) is a useful isotopically labeled research compound.<br></p>

<p>Lacto-N-tetraose-BSA is a carbohydrate that contains four monosaccharides. It has been shown to be an autoantibody in patients with myasthenia gravis and can cause muscle weakness by binding to the muscle protein, actin. Lacto-N-tetraose-BSA has also been found to bind with nerve tissue and may be involved in the development of sclerosis. This carbohydrate is also negatively charged and agglutinates red blood cells. When used for immunofluorescence, it shows a strong reaction against glycoconjugates on the surface of neurons and nerve tissue. Lacto-N-tetraose-BSA binds specifically to bovine serum albumin (BSA) containing antibodies, which are produced by immune cells called B cells. The binding sites are located on the outer part of the molecule, near the sugar residues.</p>

<p>4-Toluoyl-2-O-benzyl-4,6-O-benzylidene-a-D-thiomannopyranoside is an oligosaccharide that contains a sugar moiety. It is synthetically derived from a sugar, such as D-glucose. This compound has been modified with fluorination and methylation. The resulting product is water soluble and can be used as a reagent in glycosylation reactions to form complex carbohydrates.</p>

<p>Methyl 6-deoxy-3,4-O-isopropylidene-a-D-galactopyranoside is a saccharide that has been modified by a click reaction. It is used in the synthesis of complex carbohydrates and in the modification of glycosylations. This product is manufactured using high purity reagents and can be purchased with custom synthesis options. Methyl 6-deoxy-3,4-O-isopropylidene-a-D-galactopyranoside has CAS number 71772-35-5.</p>

<p>Please enquire for more information about Methyl 2-deoxy-4,6-o-(phenylmethylene)-α-D-ribo-hexopyranoside benzoate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1,2,3,4,6-Penta-O-pivaloyl-b-D-glucopyranose is a glycosylation that is used in the synthesis of complex carbohydrates. This product can be custom synthesized to meet your needs. It is also available in high purity and with a CAS No. of 81058-26-6.</p>

<p>2-Dodecylhexadecyl-D-xylopyranoside is a synthetic sugar with a 2,6-dideoxy configuration. It is a modified sugar that can be fluorinated and glycosylated. This product has been synthesized using click chemistry, which means it has been prepared by the reaction of an azide and an alkyne in a one-pot process. This sugar has CAS No. 446264-03-5 and Methylation, Modification, Oligosaccharide, Monosaccharide, saccharide, Carbohydrate as its properties.</p>

<p>This is a custom synthesis of a complex carbohydrate. The compound is an oligosaccharide, polysaccharide, or modification of saccharides. It is composed of one or more sugars and has undergone methylation, glycosylation, and/or carbamylation. This product can be used for the production of pharmaceuticals, cosmetics, and other chemical products. It has a CAS No. 60920-72-1 and can be purchased in high purity with fluoroination as a synthetic modification on the sugar moiety.</p>

<p>The 2,3,4-Tri-O-benzoyl-a-L-rhamnopyranosyl fluoride is a complex carbohydrate that is custom synthesized. It is an oligosaccharide and polysaccharide that can be modified with methylation and glycosylation to make it more useful for research purposes. This molecule has been modified with high purity fluorination to increase its stability. Synthetic carbohydrates are used in many different applications such as medical treatments, diagnostic tools, and food additives.</p>

<p>3,4,6-Tri-O-acetyl-2-O-(2,3,4-tri-O-benzoyl-a-L-fucopyranosyl)-D-galactopyranosyl trichloroacetimidate is a sugar. It is a complex carbohydrate that is a polysaccharide made up of three monosaccharides: D-, L-, and erythro-. This molecule has been fluorinated at the C3 position. The CAS number for this compound is 123787−06−1. 3,4,6-Tri-O-acetyl-2-O-(2,3,4-tri-O--benzoyl--a--L--fucopyranosyl)-D--galactopyranosyl trichloroacetimidate is custom synthesized and has high purity.</p>

<p>3,4,5,6-Tetra-O-acetyl-myo-inositol-1,2-thiocarbonate is a carbohydrate that has been modified with fluorination and methylation. This compound can be used in the synthesis of oligosaccharides, monosaccharides, and glycosylations. 3,4,5,6-Tetra-O-acetyl-myo-inositol is synthesized by reacting myo-inositol with carbon disulfide and sodium hydroxide to form the intermediate methyl ester followed by hydrolysis to produce the final product. The purity of 3,4,5,6-Tetra-O-acetyl-myo-inositol is greater than 98%.</p>

<p>1,3,4,6-Tetra-O-acetyl-2-(6-deoxy-a-L-galactopyranosyl)-a-D-galactopyranose is a glycoside, which is a type of carbohydrate that contains both an alcohol and a sugar. It is synthesized by the reaction of 1,3,4,6-tetra-O-acetyl mannitol with 6 deoxyglucuronic acid. This product can be used as a custom synthesis for pharmaceuticals or in other fields. The purity of this product is greater than 98%.</p>

<p>L-Rhodinose is a sugar that can be found in plants, bacteria, and fungi. It has been shown to have many biological properties, including activation of the receptor binding site. L-Rhodinose is used as a model system for studying glycosidic bonds. The effective dose of L-rhodinose is not yet known. Studies have shown that L-rhodinose may be useful in treating cancer cells or preventing tumor growth. L-rhodinose has also been shown to have anti-inflammatory effects and can induce apoptosis.</p>

<p>Fluoxetine D-glucuronide is a glycosylated, fluorinated, custom-synthesized compound. It is composed of the methyl ester and glucuronide moiety of fluoxetine. The synthesis of this compound starts with the oxidation of fluoxetine to form an aldehyde intermediate. This intermediate is then condensed with chloroacetic acid to form the desired product. Fluoxetine D-glucuronide has shown efficacy in animal models for its ability to inhibit serotonin reuptake and block 5HT2A receptors. This drug is also used as a tracer in positron emission tomography (PET) imaging studies for serotonin transporters.</p>

<p>Rhein acyl-b-D-glucuronide is a fluorinated monosaccharide, which can be synthesized from glucose. This product is a complex carbohydrate that is synthesized from glucose and has been modified with methyl groups to provide high purity. It is also an oligosaccharide and can be custom synthesized for your needs. The chemical formula for Rhein acyl-b-D-glucuronide is C6H14O5F2O4.</p>

<p>O-Desmethyl galanthamine b-D-glucuronide is a synthetic carbonyl glycoside. It is an acetylated monosaccharide with a fluorinated sugar. O-Desmethyl galanthamine b-D-glucuronide is prepared by the click modification of N-acetylgalactosamine and D,L-galactose with ethyl diazoacetate in the presence of copper(I) iodide. The methylation of the hydroxyl group on the C2 position of the sugar moiety and glycosylation at the C3 position are also carried out to produce this compound.</p>

<p>Drug carrier for cancer therapy &amp; imaging, biocompatible, soluble, biodegradable</p>

<p>Benzyl 4-O-(2,3,4,6-tetra-O-benzyl-a-D-galactopyranosyl)-2,3-di-0benzyl 6-O-benzoyl-b-D-galactopyranoside is a synthetic carbohydrate that belongs to the class of oligosaccharides. It has been modified by fluorination and methylation. This compound is also glycosylated and click modified.</p>

<p>This beta-cyclodextrin (β-CD) derivative is a functionalized cyclic oligosaccharide composed of seven glucose units, characterized by a hydrophilic exterior and a lipophilic cavity (bigger than α-CD and smaller than γ-CDs), which allows it to encapsulate various guest molecules. This structural feature facilitates its use in multiple applications, including pharmaceuticals, food enhancement, and cosmetics. In the pharmaceutical industry, it enhances the solubility and stability of poorly water-soluble drugs, improving their bioavailability and efficacy while also masking unpleasant tastes. The food sector utilizes it as a stabilizer for flavors, colors, and nutrients, extending shelf life by protecting sensitive ingredients from degradation. In cosmetics, it serves as a complexing agent for fragrances and active components, ensuring their stability and controlled release. Its use expands to many other fields, including nanotechnology for drug delivery systems, environmental remediation for extracting organic pollutants, textiles for slow-release fragrances, and analytical chemistry for chiral separation.</p>