Antiparasitics
Antiparasitics are compounds designed to treat and prevent parasitic infections by inhibiting the growth and survival of parasites. This category includes a range of antiparasitic agents intended exclusively for laboratory use and not for human consumption. These products are essential for research purposes, allowing scientists to study parasitic life cycles, mechanisms of action, and the development of resistance. The use of antiparasitics in laboratory settings aids in the discovery and optimization of new treatments for parasitic diseases, contributing to advancements in medical and veterinary parasitology. Researchers rely on these products to enhance their understanding of parasitic infections and to develop more effective therapies.
Found 704 products of "Antiparasitics"
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Diethyl Isobutylmalonate
CAS:Controlled Product<p>Applications Diethyl Isobutylmalonate is used as a reagent in the synthesis of quinoline-based zinc metallo-aminopeptidase inhibitors which have antimalarial activity.<br>References Flipo, M., et al.: Bioorg. Med. Chem. Lett., 13, 2659 (2003)<br></p>Formula:C11H20O4Color and Shape:NeatMolecular weight:216.275-Nitro-1H-quinolin-2-one
CAS:Controlled Product<p>Applications 5-Nitro-1H-quinolin-2-one is used in the synthetic preparation of novel antileishmanial agents for Leishmania donovani promastigotes.<br>References Paloque, L., et al.: Europ. J. Med. Chem., 54, 75 (2012);<br></p>Formula:C9H6N2O3Color and Shape:NeatMolecular weight:190.163-Chloro-N-(3-methoxyphenyl)propanamide
CAS:Controlled Product<p>Applications 3-Chloro-N-(3-methoxyphenyl)propanamide acts as an inhibitor towards DOXP-reductoisomerase (DXR), a primary target for antimalarial drugs.<br>References Bodill, T. et al.: Bioorg. Med. Chem., 21, 4332 (2013);<br></p>Formula:C10H12ClNO2Color and Shape:NeatMolecular weight:213.6623-Des(methoxyimino)-23-hydroxy Moxidectin O-TBS
CAS:Controlled ProductFormula:C42H66O8SiColor and Shape:NeatMolecular weight:727.054-(Aminomethyl)-cyclohexanone Hydrochloride
CAS:Controlled Product<p>Applications 4-(Aminomethyl)-cyclohexanone Hydrochloride is used to prepare dispiro-1,2,4-trioxolanes with antimalarial activities. It is also used to synthesize aminopyrimidines as SYK inhibitors useful in the treatment of SYK-mediated diseases.<br>References Tang, Y., et al.: Bioorg. Med. Chem. Lett., 17, 1260 (2007); Altman, M., et al.: PCT Int. Appl. (2011), WO 2011075515 A1 20110623<br></p>Formula:C7H13NO·HClColor and Shape:NeatMolecular weight:127.18 + 36.463-Aminopropionitrile (Stabilized with K2CO3)
CAS:Controlled ProductFormula:C3H6N2Color and Shape:NeatMolecular weight:70.09Pseurotin A
CAS:Controlled Product<p>Applications Pseurotin A shows antiparasitic and anticancer activity. It exhibits inhibition towards IgE (immunoglobin E) production.<br>References Martinez-Luis, S. et al.: Nat. Prod. Comm., 7, 165 (2012); Bioorg. Med. Chem. Lett., 19, 1457 (2009);<br></p>Formula:C22H25NO8Color and Shape:NeatMolecular weight:431.444-Methoxy-6-(2-phenylethyl)-2H-pyran-2-one
CAS:Controlled Product<p>Applications 4-Methoxy-6-(2-phenylethyl)-2H-pyran-2-one is a Kawain (K145490) derivative that is known to exhibit antimalarial and antituberculosis activities. 4-Methoxy-6-(2-phenylethyl)-2H-pyran-2-one has been identified as a lead compound for the dual treatment of malaria and leishmaniasis.<br>References McCracken, S.T., et al.: Bioorg. Med. Chem., 20, 1482 (2012); Elzaawely, A.A.. et al.: Food. Chem., 103, 486 (2007); Xuan, T.D., et al.: J. Natural. Med., 62, 188 (2008);<br></p>Formula:C14H14O3Color and Shape:NeatMolecular weight:230.262'-O-(2-Methoxyethyl)-5-methylcytidine (~90%)
CAS:Controlled ProductFormula:C13H21N3O6Purity:~90%Color and Shape:NeatMolecular weight:315.324,4'-Dimethyldiphenylamine
CAS:Controlled Product<p>Applications 4,4'-Dimethyldiphenylamine is a reagent used in the comparative studies of the analgesic and anti-inflammatory properties of N-phenylanthranilic acids and mefenamic acid, and the anti parasitic activities of some substituted diphenylamines.<br>References Izard-Verchere, C., et al.: Chimica Therapeutica, 6, 346 (1971)<br></p>Formula:C14H15NColor and Shape:NeatMolecular weight:197.282-Hydroxy-1-methyl-9,10-anthracenedione
CAS:Controlled ProductFormula:C15H10O3Color and Shape:NeatMolecular weight:238.242,5-Diacetoxy-2,5-dihydrofuran (Mixture of Isomers) (>90%)
CAS:Controlled Product<p>Applications 2,5-Diacetoxy-2,5-dihydrofuran is used as a reagent to synthesize Mexicanin H, a biologically active sesquiterpene lactone that exhibits antiparasitic activity against Trypanosoma cruzi (a parasite that causes Chagas disease)<br>References Jimenez-Ortiz, V., et al.: Parasitology, 91, 170 (2005); Romo, J., et al.: Tetrahedron Lett., No vol. given, 1029 (1966)<br></p>Formula:C8H10O5Purity:>90%Color and Shape:NeatMolecular weight:186.16PBD-5,11-dione
CAS:Controlled Product<p>Applications PBD-5,11-dione (cas# 18877-34-4) is a useful research chemical.<br></p>Formula:C12H12N2O2Color and Shape:NeatMolecular weight:216.243-[(Dimethylamino)methyl]-2-hexanone
CAS:Controlled ProductFormula:C9H19NOColor and Shape:ColourlessMolecular weight:157.25Benzenebutanoic Acid Ethyl Ester
CAS:Controlled Product<p>Applications Benzenebutanoic Acid Ethyl Ester is used in the synthesis of thiazolium salts with potent antimalarial activity. Also used in the preparation of novel lactate dehydrogenase A inhibitors. This compound is suitable for lactate dehydrogenase (LDH) related research.<br>References Hamze, A. et al.: J. Med. Chem., 48, 3639 (2005); Ward, R. et al.: J. Med. Chem., 55, 3285 (2012);<br></p>Formula:C12H16O2Color and Shape:NeatMolecular weight:192.25Tizoxanide - 98%
CAS:<p>Anti-parasitic; pyruvate ferredoxin oxidoreductase inhibitor</p>Formula:C10H7N3O4SPurity:Min. 95%Molecular weight:265.01573Oxfendazole
CAS:<p>Oxfendazole is a benzimidazole anthelmintic with action on microtubule formation in parasitic worms and is used for treating gastrointestinal parasites in livestock.</p>Formula:C15H13N3O3SPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:315.35 g/molAmoscanate
CAS:<p>Amoscanate is an antischistosomal agent, which is a synthetic compound with a broad spectrum of activity against parasitic infections. Its mode of action involves the disruption of parasite metabolism and structure, ultimately leading to the elimination of schistosomes. Schistosomes are trematode worms responsible for schistosomiasis, a significant parasitic disease affecting millions of people worldwide.</p>Formula:C13H9N3O2SPurity:Min. 95%Molecular weight:271.3 g/molIvermectin
CAS:<p>Naturally produced by the soil bacterium Streptomyces avermitili, it is clinically used in the treatment of parasitosis in both humans and animals. Ivermectin is commercially available as a mixture of 80% 22, 23-dihydroavermectin B1a and 20% 22, 23-dihydroavermectin B1b. In 2020, Ivermectin indicated that it was a good antiviral agent in the treatment of SARS-CoV-2 and a new mechanism of action has been suggested. Ivermectin would act on importin α/β heterodimer and affect nuclear transport and the translocation of viral proteins.</p>Formula:C48H74O14Purity:85%MinMolecular weight:875.1 g/mol4′-O-De(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-O-demethylavermectin A1a
CAS:<p>4′-O-De(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-O-demethylavermectin A1a is a semi-synthetic derivative of avermectin, which is a naturally occurring compound isolated from the fermentation broth of the soil bacterium *Streptomyces avermitilis*. This compound exhibits potent antiparasitic activity by targeting the glutamate-gated chloride channels in the nervous systems of parasitic organisms. By binding and activating these channels, it increases the permeability of the cell membrane to chloride ions, resulting in paralysis and death of the parasite.</p>Formula:C41H60O11Purity:Min. 95%Molecular weight:728.91 g/molPF 1022A
CAS:<p>PF 1022A is a cyclooctadepsipeptide, which is a type of cyclic peptide composed of amino acids and hydroxy acids. It is derived from the fermentation products of the fungus *Mycelia sterilia*, a member of the *Rosellinia* genus. Its mode of action involves disrupting glutamate-gated chloride channels in parasitic nematodes, which leads to paralysis and eventual death of the parasite.</p>Formula:C52H76N4O12Purity:Min. 95%Molecular weight:949.18 g/molHalofuginone
CAS:<p>Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.</p>Formula:C16H17BrClN3O3Purity:99.53%Color and Shape:Off-White SolidMolecular weight:414.68Satranidazole
CAS:<p>Satranidazole is an antimicrobial agent that falls under the category of synthetic nitroimidazoles. It is derived from chemical synthesis and is designed to combat infections caused by specific organisms. The mode of action involves the reduction of the nitro group within the organism, creating reactive intermediates that disrupt DNA synthesis and lead to cell death. This mode of action is notably effective against protozoal infections and anaerobic bacterial infections.</p>Formula:C8H11N5O5SPurity:Min. 95%Molecular weight:289.27 g/molICA
CAS:<p>ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 µM).</p>Formula:C13H10N4SPurity:99.68%Color and Shape:SolidMolecular weight:254.31Piperaquine
CAS:<p>Piperaquine is a bisquinoline antimalarial compound and a companion compound to artemisinin.</p>Formula:C29H32Cl2N6Purity:98%Color and Shape:SolidMolecular weight:535.51BPH-715
CAS:<p>BPH-715 inhibits the liver-stage growth of P. falciparum with an IC50 of 10 μM for P. falciparum exoerythrocytic forms in HepG2 cells.</p>Formula:C17H31NO7P2Purity:98.91%Color and Shape:SolidMolecular weight:423.38Quinfamide
CAS:<p>Quinfamide is a compound with the potential to treat tropical parasitic infections such as Amoebiasis and Helminthiasis.</p>Formula:C16H13Cl2NO4Purity:99.92%Color and Shape:SolidMolecular weight:354.18Halofuginone hydrobromide
CAS:<p>Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.</p>Formula:C16H17BrClN3O3·HBrPurity:97.01% - 99.73%Color and Shape:SolidMolecular weight:495.59Antimalarial agent 26
CAS:<p>Antimalarial agent 26, a derivative of 1,4-naphthoquinones, demonstrates antimalarial properties through oral administration.</p>Formula:C20H22N4O3Purity:98%Color and Shape:SolidMolecular weight:366.41Antiparasitic agent-18
CAS:<p>Antiparasitic agent-18 (compound 3a) exhibits potent and selective antiprotozoal activity, demonstrating effective inhibition of T.</p>Formula:C25H21N7OPurity:98%Color and Shape:SolidMolecular weight:435.48Antimalarial agent 19
CAS:<p>Compound 6e, an antimalarial, targets P. falciparum K1 (EC50 0.3 µM) and P. berghei (EC50 15.3 µM); has high solubility and stability.</p>Formula:C22H33Cl2N5SPurity:98%Color and Shape:SolidMolecular weight:470.5Antimalarial agent 24
CAS:<p>Compound 24 (Compound 7), an in vitro antimalarial agent, demonstrates inhibitory activity against the Plasmodium falciparum W2 strain with an IC50 of 0.81 μM</p>Formula:C20H16N4O2Purity:98%Color and Shape:SolidMolecular weight:344.37Antimalarial agent 29
CAS:<p>Compound 29 (also known as Compound 16) is an antimalarial agent that demonstrates inhibition of the P.</p>Formula:C18H10ClF3N2Purity:98%Color and Shape:SolidMolecular weight:346.73Antileishmanial agent-14
CAS:<p>Antileishmanial agent-14, a sulfuretin analog, exhibits potential activity against Leishmania donovani promastigotes (IC 50 = 4.1 μM) and inhibits infection by</p>Formula:C23H26ClNO5Purity:98%Color and Shape:SolidMolecular weight:431.91Insecticidal agent 2
CAS:<p>Insecticidal agent 2 (example 2) is an effective pesticide that significantly inhibits pest growth [1].</p>Formula:C16H8ClF7N2O2Purity:98%Color and Shape:SolidMolecular weight:428.69Antileishmanial agent-15
CAS:<p>Antileishmanial agent-15 (compound 13c) exhibits potent activity against L.</p>Formula:C28H39N5O4Purity:98%Color and Shape:SolidMolecular weight:509.64Epsiprantel
CAS:<p>Epsiprantel is an orally active antiparasitic drug that inhibits various tapeworms, including Echinococcus granulosus (granular echinococcus), in dogs.</p>Formula:C20H26N2O2Purity:98.09%Color and Shape:SolidMolecular weight:326.43CRK12-IN-2
CAS:<p>CRK12-IN-2, a potent CRK12 inhibitor, has EC50 of 3.2 nM for T. congolense and 0.08 nM for T. vivax; treats trypanosomiasis in animals.</p>Formula:C23H33F2N5O3S2Purity:99.26% - 99.70%Color and Shape:SolidMolecular weight:529.67Symetine
CAS:<p>Symetine（L 16726） is a small molecule compound with antiparasitic activity that can be used to study amoebic liver abscesses in guinea pigs.</p>Formula:C30H48N2O2Purity:99.79%Color and Shape:SolidMolecular weight:468.71(Rac)-ACT-451840
CAS:<p>(Rac)-ACT-451840 is an isomer of ACT-451840 exhibiting antimalarial activity against Plasmodium falciparum NF54.</p>Formula:C47H54N6O3Purity:99.25%Color and Shape:SolidMolecular weight:750.97Chalcone 4 hydrate
CAS:<p>Chalcone 4 hydrate, an anti-parasite compound, inhibits the growth of Theileria and Babesia.</p>Formula:C16H15ClO4Purity:99.54%Color and Shape:SolidMolecular weight:306.74Phosphodiesterase-IN-1
CAS:<p>Phosphodiesterase-IN-1 (Compound 7), a phosphodiesterase (PDE) inhibitor, exhibits anti-Plasmodium and antiproliferative activities. It effectively inhibits P. falciparum (strain 3D7) with an IC 50 value of 0.64 μM [1].</p>Formula:C15H15FN4OColor and Shape:SolidMolecular weight:286.3MMV006833
CAS:<p>MMV006833 is an inhibitor of Plasmodium falciparum. It targets the lipid transfer protein PfSTART1, inhibiting the ring-stage development of Plasmodium falciparum.</p>Formula:C19H27ClN2O4SColor and Shape:SolidMolecular weight:414.95Topoisomerase II inhibitor 16
CAS:<p>Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the</p>Formula:C19H12F4N6OPurity:98%Color and Shape:SolidMolecular weight:416.33SQ109
CAS:<p>SQ109 (NSC-722041) is an effective inhibitor of the trypomastigote form of the parasite (IC50 = 50 nM). SQ109 is an antitubercular agent and targets MmpL3.</p>Formula:C22H38N2Purity:99.70% - 99.91%Color and Shape:SolidMolecular weight:330.55Antitrypanosomal agent 2
CAS:<p>Antitrypanosomal agent 2 shows potent and specific antiparasite activities against Trypanosoma brucei.</p>Formula:C17H13N5O3Purity:99.2%Color and Shape:SolidMolecular weight:335.32Artelinic acid
CAS:<p>Artelinic acid is an artemisinin analog with antimalarial activity and is used for the treatment of multi-drug resistant strains of Plasmodium falciparum.</p>Formula:C23H30O7Purity:97.49% - 97.69%Color and Shape:SolidMolecular weight:418.48Bithionol sulfoxide
CAS:<p>Bithionol sulfoxide (Bithionoloxide) is a compound with inhibitory effects against parasites, inhibiting Fasciola hepatica and Schistosoma mansoni.</p>Formula:C12H6Cl4O3SPurity:98.76%Color and Shape:Off White To Tinch Pink Crystalline PowderMolecular weight:372.05Rufigallol
CAS:<p>Rufigallol, an anthraquinone with six OH groups, induces DLC and fluoresces when aggregated, showing antimalarial effects with vitamin C and ketones.</p>Formula:C14H8O8Purity:98.92% - 99.27%Color and Shape:SolidMolecular weight:304.21Antimalarial agent 30
CAS:<p>Antimalarial agent 30 has anti-Plasmodium berghei liver stage parasite activity and antimalarial activity for the study of malarial infections.</p>Formula:C18H11F3N2Purity:99.83% - 99.90%Color and Shape:SolidMolecular weight:312.29Brotianide
CAS:<p>Brotianide (BAY-VA4059) has anthelmintic activity and is highly potent against liver fluke and gastric fluke infestations and can be used to treat acute,</p>Formula:C15H10Br2ClNO2SPurity:97.44% - 98.12%Color and Shape:SolidMolecular weight:463.57JCP174
CAS:<p>JCP174 is a depalmitoylase inhibitor that enhances Toxoplasma host-cell invasion by targeting TgPPT1.</p>Formula:C12H12ClNO3Purity:97.05%Color and Shape:SolidMolecular weight:253.68Allopurinol riboside
CAS:<p>Allopurinol riboside, an allopurinol metabolite, inhibits purine nucleoside phosphorylase in parasites with a Ki of 277 μM.</p>Formula:C10H12N4O5Purity:99.46% - 99.73%Color and Shape:SolidMolecular weight:268.23UCT943
CAS:<p>UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM).</p>Formula:C22H20F3N5OPurity:99.87%Color and Shape:SolidMolecular weight:427.42AP-C5
CAS:<p>AP-C5 inhibits cGKII with a Pic50 of 7.2, useful in diarrheal disease research.</p>Formula:C16H13N5Purity:99.82%Color and Shape:SolidMolecular weight:275.31DDD85646
CAS:<p>DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.</p>Formula:C21H24Cl2N6O2SPurity:97.8% - 99.76%Color and Shape:SolidMolecular weight:495.43Myrrhterpenoid O
CAS:<p>Unfortunately, you did not provide the description of the chemical compound that needs to be rewritten.</p>Formula:C16H20O3Purity:98%Color and Shape:SolidMolecular weight:260.33Propamidine
CAS:<p>Propamidine acts as a covalent inhibitor of TMPRSS2 and exhibits antibacterial properties. [1]</p>Formula:C17H20N4O2Purity:98%Color and Shape:SolidMolecular weight:312.37UCB7362
CAS:<p>UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction.</p>Formula:C25H26ClN5O3Purity:97.67%Color and Shape:SolidMolecular weight:479.96Antileishmanial agent-16
CAS:<p>Antileishmanial agent-16 (compound 14c), an anti-Leishmania agent, exhibits potent activity against Leishmania major promastigotes (IC50 = 0.59 µM) and</p>Formula:C27H37N5O4Purity:98%Color and Shape:SolidMolecular weight:495.61Antileishmanial agent-17
CAS:<p>Antileishmanial agent-17, a coumarin hybrid, exhibits potent antileishmanial activity (IC50 <0.78 μM) while proving non-toxic to normal VERO cells.</p>Formula:C27H37N5O5Purity:98%Color and Shape:SolidMolecular weight:511.61SID 26681509
CAS:<p>SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).</p>Formula:C27H33N5O5SPurity:98.16%Color and Shape:SolidMolecular weight:539.65FIKK9.1-IN-1
CAS:<p>FIKK9.1-IN-1 (Compound 1), an antimalarial agent (IC50: 2.68 μg/mL), serves as a FIKK9.1 inhibitor by interacting with the ATP-binding residues within FIKK9.1,</p>Formula:C22H22N2SePurity:98%Color and Shape:SolidMolecular weight:393.38ELQ-596
CAS:<p>ELQ-596, a quinolone derivative, exhibits antimicrobial activity against several protozoan parasites, including the intraerythrocytic parasites Plasmodium and Babesia. ELQ-596 attenuates babesiosis in immunosuppressed mice [1].</p>Formula:C24H17ClF3NO3Color and Shape:SolidMolecular weight:459.84Fervenulin
CAS:<p>Fervenulin, from Streptomyces sp. CMU-MH021, halts egg hatch (MIC: 30 μg/mL) and kills J2 larvae (MIC: 120 μg/mL) of M. incognita.</p>Formula:C7H7N5O2Purity:99.75%Color and Shape:SolidMolecular weight:193.16Z-Pro-Pro-CHO
CAS:<p>Z-Pro-Pro-CHO acts as a prolyl oligopeptidase inhibitor with half-maximal inhibitory concentrations (IC50) of 0.16 μM for human prolyl oligopeptidase and 0.01</p>Formula:C18H22N2O4Purity:98%Color and Shape:SolidMolecular weight:330.38BTG 502
CAS:<p>BTG 502 is an alkylamide insecticide that binds to voltage-gated sodium channels, antagonising the activation of sodium channels by Batrachotoxin (BTX).</p>Formula:C21H24BrNOPurity:99.30%Color and Shape:SolidMolecular weight:386.33EDI048
CAS:<p>EDI048, also known as compound 1.16, is an orally active inhibitor of Cryptosporidium PI4K, utilized in the study of cryptosporidiosis [1].</p>Formula:C25H21ClN4O4Purity:98%Color and Shape:SolidMolecular weight:476.91OfChi-h-IN-2
CAS:<p>OfChi-h-IN-2 (compound TQ19) is a potent inhibitor of OfChi-h, exhibiting a K i of 0.33 μM, and significantly impairs the growth and development of Ostrinia</p>Formula:C25H28ClN5O3Purity:98%Color and Shape:SolidMolecular weight:481.98Eugenitin
CAS:<p>Eugenitin, a polyketide from Mycoleptodiscus indicus, exhibits inhibitory activity against Leishmania major with an LD50 of 39.9 μM and demonstrates low</p>Formula:C12H12O4Purity:98%Color and Shape:SolidMolecular weight:220.22Antileishmanial agent-23
CAS:<p>Antileishmanial agent-23 (compound G1/9), a potent and selective trypanothione reductase (TR) inhibitor, exhibits an IC50 of 2.24 ± 0.52 μM.</p>Formula:C20H17N3O4S2Purity:98%Color and Shape:SolidMolecular weight:427.5Phylloflavan
CAS:<p>Phylloflavan, an antileishmanial compound, exhibits an intracellular half maximal effective concentration (EC50) of 3.2 nM in RAW 264.7 cells and inhibits the</p>Formula:C26H26O10Purity:98%Color and Shape:SolidMolecular weight:498.48MMV688533
CAS:<p>MMV688533 has antimalarial activity.</p>Formula:C24H15F6N5O2Purity:99.12%Color and Shape:SoildMolecular weight:519.4Dehydroemetine
CAS:<p>Dehydroemetine, a synthetic emetine, treats amoebic infections and leishmaniasis, and resists metronidazole amoebiosis.</p>Formula:C29H38N2O4Purity:98.68% - 99.68%Color and Shape:SolidMolecular weight:478.62ZY-19489
CAS:<p>ZY-19489: Antimalarial, potential single-dose cure, FDA orphan drug status.</p>Formula:C24H32FN9Purity:>99.99%Color and Shape:SoildMolecular weight:465.57GSK3186899
CAS:<p>GSK3186899 is an inhibitor of Cdc2-related kinase 12 with an EC50 of 1.4 μM for L. donovani.</p>Formula:C19H28F3N7O3SPurity:98.35% - 99.61%Color and Shape:SolidMolecular weight:491.53CWHM-1552
CAS:<p>CWHM-1552 is an effective Plasmodium falciparum inhibitor. For the 3D7 and Dd2 strains, the IC50s are 51 nM and 53 nM.</p>Formula:C22H27F2N3OPurity:99.56%Color and Shape:SolidMolecular weight:387.47Ac-Atovaquone
CAS:<p>Ac-Atovaquone, an ester-acetylated derivative of atovaquone, acts as a potent inhibitor of cytochrome bc1 (cytochrome bc1). This compound shows potential for use in malaria research.</p>Formula:C24H21ClO4Color and Shape:SolidMolecular weight:408.87WR-27653
CAS:<p>WR-27653 (RC-12), a derivative of Catechol, demonstrates significant activity against hypnozoites in the Plasmodium cynomolgi-Rhesus monkey (Macaca mulatta) model, which is considered the gold standard. Additionally, WR-27653 exhibits antimalarial properties.</p>Formula:C20H36BrN3O2Color and Shape:SolidMolecular weight:430.423PFK-IN-1
CAS:<p>PFK-IN-1 (compound 1) is an inhibitor of 6-phosphofructo-1-kinase (PFK), demonstrating IC50 values of 0.41 and 0.23 μM against T. brucei and T. cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T. brucei. The compound has a half-life of 9.7 minutes in rat liver microsomes and 408 minutes in mouse liver microsomes.</p>Formula:C18H15Cl2N3O4SColor and Shape:SolidMolecular weight:440.3Ipronidazole
CAS:<p>Ipronidazole (RO-71554) is an orally effective antiprotozoal agent used to prevent and ameliorate histomoniasis in turkeys, commonly referred to as blackhead disease.</p>Formula:C7H11N3O2Color and Shape:SolidMolecular weight:169.18Arohynapene B
CAS:<p>Arohynapene B is an anticoccidial compound that inhibits the growth of Eimeria parasites.</p>Formula:C18H22O3Color and Shape:SolidMolecular weight:286.366NEU-1017
CAS:<p>NEU-1017 serves as a broad-spectrum antiparasitic compound, effectively inhibiting T. brucei, L. major, and P. falciparum with EC50 values of 210 nM, 240 nM, and 3 nM, respectively.</p>Formula:C33H31ClFN5O3SColor and Shape:SolidMolecular weight:632.147SLU-10906
CAS:<p>SLU-10906 (Compound 63) is an orally active inhibitor of Cryptosporidium. It demonstrates activity against the parasite in cell-based infection models with an EC50 of 0.19 μM and exhibits no cytotoxicity. SLU-10906 is a promising candidate for research in cryptosporidiosis.</p>Formula:C22H21BFN5O2Color and Shape:SolidMolecular weight:417.244SPB07935
CAS:<p>SPB07935 inhibits plasmepsin II in the malaria-causing parasite Plasmodium falciparum and serves as an antimalarial agent. It affects the life cycle of P. falciparum, hindering the growth of the parasite's FcB1 and 3D7 strains, with IC50 values of 8 μM and 4.7 μM, respectively.</p>Formula:C22H15N5O4S2Color and Shape:SolidMolecular weight:477.516Menoctone
CAS:<p>Menoctone is an orally effective antimalarial agent that inhibits blood-induced rodent malaria. It enhances the antimalarial effects of chloroquine or quinine, making it useful for malaria research.</p>Formula:C24H32O3Color and Shape:SolidMolecular weight:368.51Insecticidal agent 16
CAS:<p>Insecticidal agent 16 (compound A21) exhibits insecticidal activity against Plutella xylostella, with LC50 values of 1.2 and 13.2 µg/mL respectively.</p>Formula:C21H13Cl2F6N5O2SColor and Shape:SolidMolecular weight:584.32Antimalarial agent 48
CAS:<p>Antimalarial agent 48 (Compound 15a) is a triazine compound with antimalarial activity, showing effectiveness against Plasmodium falciparum K1 and Plasmodium falciparum FCR3 with IC50 values of 280 and 290 nM, respectively. It holds promise for research in the field of anti-infective treatments.</p>Formula:C19H14F3N11Color and Shape:SolidMolecular weight:453.383MMV03
CAS:<p>MMV03 is an antimalarial compound effective against Plasmodium falciparum, with an EC50 of 0.6 μM.</p>Formula:C19H14N4OSColor and Shape:SolidMolecular weight:346.406Antimalarial agent 44
<p>Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.</p>Formula:C37H37N5O7Color and Shape:SolidMolecular weight:663.72MED6-189
CAS:<p>MED6-189, an analog of kalihinol, disrupts the apicoplast functions and vesicular transport in the malignant malaria parasite (P. falciparum, IC50 < 50 nM). The compound specifically targets the apicoplast, which is a non-photosynthetic plastid essential for isoprenoid synthesis, found in most apicomplexan parasites.</p>Formula:C17H26N2OColor and Shape:SolidMolecular weight:274.40Isazofos
CAS:<p>Isazofos is a broad-spectrum organophosphate insecticide and nematicide effective in controlling a variety of lawn pests, such as nematodes (Radopholus similis). It also demonstrates efficacy in managing rice gall midge.</p>Formula:C9H17ClN3O3PSColor and Shape:SolidMolecular weight:313.74PfCLK3-IN-1
<p>PfCLK3-IN-1 (Compound 4) serves as a covalent inhibitor of the malaria parasite CLK3 (Pf CLK3) under alkaline conditions, with a pEC50 of 7.1. It inhibits the maturation of gametocytes during the sexual stage of the parasite, thereby hindering transmission. Additionally, PfCLK3-IN-1 effectively suppresses the Dd2-B2 clone of the malaria parasite, exhibiting an IC50 of 239.5 nM.</p>Formula:C28H27ClN4O4Color and Shape:SolidMolecular weight:518.99PIQ-2
CAS:<p>PIQ-2 (compound 54) serves as an antiprotozoal agent, displaying potent activity against IP. falciparum 3D7 and B. divergens Rouen, with IC50 values of 9.4 nM and 1.6 nM, respectively.</p>Formula:C23H21F3N4O3Color and Shape:SolidMolecular weight:458.43Ferrocene
CAS:<p>Ferrocene, a crucial structural core in bioorganometallic chemistry, is renowned for its intrinsic stability, excellent oxygen reduction capabilities, and low toxicity. It also exhibits antimalarial and anticancer properties.</p>Formula:C10H10FeColor and Shape:SolidMolecular weight:186.03Erythromycin B
CAS:<p>Erythromycin B exhibits antimalarial activity by effectively inhibiting the asexual growth of Plasmodium falciparum.</p>Formula:C37H67NO12Color and Shape:SolidMolecular weight:717.93SAL-0010042
CAS:<p>SAL-0010042 is an inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP in gametocytes with an IC50 of 48.9 nM, thereby activating PKG and inhibiting the growth and development of Plasmodium (IC50s for 3D7 and Dd2 are 142 nM and 218 nM, respectively). It also inhibits hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, respectively.</p>Formula:C15H15FN4OColor and Shape:SolidMolecular weight:286.304DNA crosslinker 6
CAS:<p>DNA crosslinker 6 (compound 1) is an anti-mitotic agent known for its strong binding affinity to AT-DNA and inhibition of AT-hook 1 binding to DNA (IC50=0.03 µM). Additionally, it exhibits anti-protozoal activity, effectively inhibiting T. brucei with an EC50 of 0.83 µM.</p>Formula:C19H21N7OColor and Shape:SolidMolecular weight:363.42Etofamide
CAS:<p>Etofamide, an antimicrobial agent, exhibits an IC50 of 5.96 mg/L against amoebae.</p>Formula:C19H20Cl2N2O5Color and Shape:SolidMolecular weight:427.28
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