Backbone Sugars and Nucleobases

Impurity Fluorouracil EP Impurity E
Applications Used for the experimental and clinical treatment of neoplastic and viral diseases. Fluorouracil EP Impurity E.
References Yu, H., et al.: J. Biol. Chem., 268, 15935 (1993), Staleva, L., et al.: Mutat. Res., 370, 81(1996), Harris, V., et al.: J. Mol. Biol., 326, 1389 (2003)

Applications Adenine Hydrochloride can be utilized in uses for enhanced detection of hydrogen peroxide with platinized microelectrode arrays for analyses of mitochondria activities. It can also be used for biological use in method for producing Cordyceps sinesis by fermentation.
References Ben-Amor, S., et al.: Electrochim. Acta., 126, 171-178 (2014); Jia, J., et al.: Faming Zhuanli Shenqing, CN 101407767 A 20081117 (2008);

Applications 5-Carboxy-2-thiouracil is a possible anti-tumor agent when part of a metal complex.

Applications (E)-5-(2-Carboxvinyl)uracil (cas# 57412-59-6) is a compound useful in organic synthesis.

Applications Pyrimidine with the ability to form complexes with heavy metal ions.
References Iltzsch, M., et al.: Biochem. Pharmacol., 48, 781 (1994),

Applications 4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylthiopyrimidine (cas# 895129-11-0) is a compound useful in organic synthesis.

Applications 5-Azauridine (cas# 1476-82-0) is a useful research chemical.

Applications Used in the preparation of pyrrolotriazines.

Applications N2-Acetyl-O6-diphenylcarbamoylguanine is a reactant in the synthesis of 1',2'-oxetane-nucleosides bearing 2'-C-Me substituents with anti-HCV activity.
References Komsta, Z., et. al.: Tetrahedron Lett., 55, 6216 (2014)

Applications 6-Chloro-7-deazaguanine (cas# 84955-31-7) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications 2,4-Dithiouridine (cas# 13239-96-8) is a compound useful in organic synthesis.

Applications 4-Amino-1,3-dimethyl-5-nitrosouracil is a useful building block for organic synthesis.

Applications 6-Amino-5-nitrouracil (cas# 3346-22-3) is a compound useful in organic synthesis.
References Graves, A., et al.: J. Mol. Biol., 377, 914 (2008),

Applications 5-O-Trityl-2,3’-anhydrothymidine (cas# 25442-42-6) is a compound useful in organic synthesis.

Applications 6-Amino-1,3-dimethyl-5-nitrosouracil (cas# 3346-61-0) is a compound useful in organic synthesis.
References Varma, R., et al.: J. Ocular Pharmacol. Ther., 16, 571 (2000),

Applications Tris(trimethylsilyl)guanine is an intermediate used in the synthesis of 9-(2-Hydroxyethyl)guanine (H942035), which is an impurity of the antiviral agent Acyclovir (A192400). 9-(2-Hydroxyethyl)guanine is a nucleoside phosphotransferase acceptor.
References Kamimura, A. et al.: Agric. Biol. Chem., 37, 2037 (1973);

Stability Hygroscopic
Applications 6-Azauridine is can be applied in antiviral studies.

Applications A DNA adduct ethylene oxide hydroxyethylnitrosourea. It is also used in the preparation of acyclic nucleosides and nucleotides as antiviral agents.
References Snoeck, R., et al.: Antimicrob. Agents Chemother., 32, 1839 (1988), Bronson, J., et al.: J .Med. Chem., 32, 1457 (1989), Balzarini, J., et al.: J. Biol. Chem., 266, 8686 (1991),

Applications 5,6-Diaminouracil sulfate is an intermediate in the synthesis of Paraxanthine (P192500) and Paraxanthine analogs.
References Mueller, C.E., et al.: J. Med. Chem., 36, 3341 (1993),

Applications Adenosine analog
References Barbieri, D., et al.: Bioorg. Med. Chem. Lett., 8, 2533 (1998),

Applications 7-Deazaguanine (cas# 7355-55-7) is a compound useful in organic synthesis.

Applications N4-Aminocytidine (cas# 57294-74-3) is a useful research chemical.

N6-Methyladenine is a modification of adenine in DNA. It is formed by the methylation of the N6 position of adenine, which is a group P2 purine base. The structural analysis of this compound has been studied using x-ray diffraction data, and it has been found that it may inhibit cancer cells by modifying their DNA. This compound can also be used as an antimicrobial agent to treat infections caused by eukaryotes such as bacteria and fungi. N6-Methyladenine may be useful in transcriptional regulation and cellular transformation.

8-Cyclopentyl-1,3-dimethylxanthine (CPT) is a xanthine derivative that binds to the adenosine receptor and inhibits the phosphodiesterase enzyme. CPT is used in vivo as a model for measuring locomotor activity, dopamine receptors, adenosine receptors, and glutamate receptors. The binding of CPT to these receptors can lead to bronchoconstriction by stimulating the release of vasoactive substances from airway cells and increasing the sensitivity of airway cells to bronchoconstrictor stimuli. This drug also has been shown to inhibit calcium ion influx into cytosol and increase intracellular levels of cAMP.

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8-Aminoguanine is an anti-cancer agent that is used to treat leukemia. It is a hydrophobic molecule with a redox potential of −0.20 V and has been shown to inhibit the enzyme ribonucleotide reductase in vitro and in vivo. 8-Aminoguanine inhibits the production of guanine nucleotides, which are necessary for DNA synthesis and cell division. This drug also has angiogenic properties, which may be due to its ability to stimulate the formation of new blood vessels by increasing nitric oxide synthase activity. 8-Aminoguanine has also been shown to improve congestive heart failure by reducing myocardial fibrosis and ventricular hypertrophy through activation of the glycosidic bond cleavage system.

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6-Amino-1-methyl-5-nitrosouracil is a neutral form of the molecule that has both protonated and unprotonated forms. It is a bidentate ligand that can bind to a metal ion. The nitrogen atom in the molecule is an important part of its structure, as it contains two nitro groups and one amino group. 6-Amino-1-methyl-5-nitrosouracil has been used in techniques such as spectroscopies and dinitroso analysis. The neutral form of the molecule can be converted into its ionic form by adding either chlorine or nitrate ions to it, which causes the nitrogen atoms to be more electronegative. This conversion changes the nature of the compound, making it more acidic. Dehydration also occurs when water molecules are removed from 6-amino 1 methyl 5 nitrosourea, which causes a change in shape and shifts its properties to

9-(β-D-xylofuranosyl)guanine (9XG) is a trifluoride. It is an antiviral agent that inhibits the growth of herpes virus, in particular by methylating guanosine to 9-methylguanosine in the viral DNA. 9XG binds to the viral DNA and prevents its replication through the inhibition of RNA synthesis. The drug is active against many different types of viruses and has been shown to be effective against tissue cultures infected with herpes virus. 9XG is synthesized from guanosine and boron trifluoride etherate, which are reacted at -78 degrees Celsius for three days. This yields a mixture of compounds with various peracylation groups, which are then separated by chromatography.

1) Non-toxicity: belong to flower-stem dye, easy to biodegrade, no carcinogenic toxicity.

Intermediate in the synthesis of Decitabine

5-Methylcytosine is a nucleic acid that is found in the DNA and RNA of the cell. It is an important component of methylation, which is the process by which a methyl group is added to a molecule. This process can lead to cellular transformation, a process that can cause cancer. 5-Methylcytosine has also been shown as a molecular pathogenesis factor in infectious diseases such as HIV and herpes simplex virus type 1. The presence of 5-methylcytosine in nuclear DNA has been detected by analytical techniques such as gas chromatography/mass spectrometry (GC/MS). There are many analytical methods, including GC/MS, that can be used to detect 5-methylcytosine in cellular nuclei.

6-Azauracil is a heterocycle with the chemical formula C8H10N2O3. It is approved by the FDA to treat HIV infections and has been shown to have pharmacokinetic properties in humans. 6-Azauracil is structurally similar to uracil, which is found in RNA, but lacks the hydroxyl group on the para position of the heterocyclic ring. The synthesis of this drug was accomplished through acid complex formation with nucleotides and nitrous acid. The compound inhibits replication of retroviruses by competitive inhibition of primer binding. 6-Azauracil has also been shown to be toxic in rats, leading to congestive heart failure and death when administered at high doses. This drug may also act as an anti-inflammatory agent by inhibiting prostaglandin synthesis or platelet aggregation.

Pyrimidine nucleobase; allosteric regulator and coenzyme for reactions

2’-Amino-2’-deoxy-β-D-arabinouridine is a modified nucleoside based on uridine, in which the 2'-hydroxyl group of the sugar has been replaced with an amino group, and the sugar itself is arabinose (a stereoisomer of ribose). This compound is of possible interest in nucleic acid chemistry and antisense or RNA-interference research.

1,3,9-Trimethylxanthine is a naturally occurring purine alkaloid that has been shown to have cytosolic calcium ion-antagonistic properties. It can also act as an antioxidant by donating electrons to free radicals and inhibiting lipid peroxidation. This compound is found in coffee beans and other sources of caffeine. It binds to the receptor for adenosine, which causes the antagonistic effects on intracellular calcium concentration. Trimethylxanthine can also be used to treat ventricular arrhythmias and increase locomotor activity in mammals. Trimethylxanthine has been shown to be effective in wastewater treatment as it removes organic pollutants from water by oxidizing them with hydrogen peroxide or chlorine gas.

Building block in the synthesis of nucleoside antiviral agents

N4-Acetylcytosine is an inhibitor of serine proteases, glycosidases and nucleosidases. It has been shown to inhibit the replication of a wide range of viruses including HIV, herpes simplex virus type 1, and adenovirus. N4-Acetylcytosine also inhibits the proliferation of cervical cancer cells.

6-Aminouracil is a hydroxylated form of uracil. It has inhibitory properties against protein synthesis in bacteria, acting as an inhibitor of the enzyme dihydroorotase. 6-Aminouracil has been shown to be effective against PC3 cells and has high resistance to hydrolysis by acid or alkali. The reaction mechanism for the conversion of uracil to 6-aminouracil is unclear; however, it may involve a nucleophilic attack on the hydroxyl group.

Intermediate in the synthesis of alogliptin

5,6-Diaminouracil sulfate is an amine that is used as a precursor in the production of the anti-cancer drug 5-fluorouracil. It can be synthesized from diaminopyrimidine and uracil. This compound has two amino groups, which are both substituted with hydrogens. The aminouracile group is substituted with a hydrogen and an amino group. 5,6-Diaminouracil sulfate has pyrimidone rings that are fused together to form a six-membered ring.

Purine nucleobase; component of nucleic acids and coenzymes

5-Methylcytosine hydrochloride salt is a metabolite of cytosine that occurs naturally in the body. It is used as an inhibitor of DNA methylation to study the effect of this process on gene expression. 5-Methylcytosine hydrochloride salt has been shown to inhibit the production of growth factors, such as insulin-like growth factor 1, and radiation energy. It also causes oxidative damage to DNA and inhibits the oxidation of urea nitrogen in lettuce. The matrix effect may interfere with the analysis of 5-methylcytosine hydrochloride salt by spectrometry.

6-Phenyl-2-thiouracil (6PTU) is an alkylthio group that inhibits the growth of microorganisms by binding to DNA. 6PTU binds to the oxygen nucleophiles in DNA and prevents transcription and replication. It also has a positive effect on the synthesis of proteins, which may be due to its ability to regulate gene transcription. 6PTU has been shown to inhibit cell growth in culture by blocking protein synthesis. This drug is used as an analytical method for determining urinary glucose levels in animals because it reacts with glucose in urine samples. The reaction produces a chromatographic peak that can be quantified using an electrochemical detector.

5-Iodouracil is an irreversible inhibitor of 5-hydroxytryptamine 2B receptor (5-HT2B) that is a group p2 molecule. It has been found to be effective in the treatment of various types of cancer, including colorectal cancer. 5-Iodouracil inhibits cell proliferation by blocking the binding of the growth factor to its receptor on the surface of cells. The drug also inhibits the enzyme activities of human serum albumin and tyrosine phosphatase.