Nucleotides

<p>The pyrimidine-4-carboxylic acid methyl ester is a neutralized derivative of the natural amino acid pyrimidine-4-carboxylic acid. It can be metabolized in vivo to the active form, bleomycin. The neutralized form is useful for the synthesis of betaines and other compounds. This product is also used as an intermediate in the synthesis of metastable carbenes that are difficult to synthesize by other means. Pyrimidine-4-carboxylic acid methyl ester has been used as a reagent in mass spectrometry to identify isotopomers and isomers. It can also be used as a precursor for chemical transfer reactions with carbenes.</p>

<p>Diquafosol Impurity 2 is a high-purity phosphoramidite that can be used for the synthesis of DNA, RNA, and deoxyribonucleosides. This product is also a novel activator for phosphoramidites. Diquafosol Impurity 2 has CAS No. 63785-59-1 and a molecular weight of 228.24 g/mol. It is insoluble in water, but soluble in most organic solvents.</p>

<p>5-Methylcytidine-5'-monophosphate is a nucleotide that is an intermediate in the synthesis of DNA. It is a neutral form and has been sequenced. 5-Methylcytidine-5'-monophosphate is found in cellular components, such as mitochondria and nuclei. The biochemical properties of this molecule are dependent on its methylation state. This molecule also plays a role in mitochondrial functions and nuclear DNA modifications.</p>

<p>Uridine 5'-monophosphate (UMP) is a nucleotide that is synthesized from uridine. Uridine 5'-monophosphate has been shown to have anticancer activity in vitro and in vivo, as well as antiviral activity against herpes viruses. UMP has been shown to inhibit the protein synthesis of cells by inhibiting the enzyme activities of DNA polymerase and RNA polymerase. <br>It also inhibits the synthesis of p2y receptors, which are involved in cell proliferation and differentiation. Further studies suggest that UMP may be an effective anti-inflammatory agent due to its ability to decrease prostaglandin production.</p>

<p>4-Demethylwyosine is a metabolite found in the bacterium Pyrococcus furiosus. It is an intermediate in the biosynthesis of 2-amino-3,5-dimethyoxybenzoic acid. 4-Demethylwyosine has been shown to inhibit cancer cell proliferation by inhibiting the synthesis of lysine residues and base formation. This inhibition may be due to its methyl transferase activity, which leads to decreased levels of methionine, or it may be due to its ability to act as a carboxylate group donor. 4-Demethylwyosine has also been shown to bind with DNA and RNA, regulating posttranscriptional processes such as protein translation and transcription.</p>

<p>2',3'-O-Isopropylideneguanosine is a nucleoside for use in research applications</p>

<p>8-Hydroxyadenosine (8-OHdG) is a purine nucleoside that is formed as a result of oxidative DNA damage. It is not an essential metabolite because it can be synthesized de novo. 8-OHdG has been shown to have potent anti-tumor activity in vitro and in vivo, which may be due to its ability to inhibit DNA replication. The biological effects of 8-OHdG are attributed to its ability to form hydrogen bonds with guanine residues in the double helix, and electrochemical detectors have been developed for its detection.</p>

<p>2'-O-Methylcytidine-5'-triphosphate sodium salt is a synthetic, modified nucleoside analog. It can be used as an antiviral agent and anticancer drug to inhibit viral replication and tumor growth. 2'-O-Methylcytidine-5'-triphosphate sodium salt has the ability to activate cellular DNA synthesis. This compound also inhibits RNA polymerase activity in cancer cells, which inhibits the production of proteins vital for cell division. 2'-O-Methylcytidine-5'-triphosphate sodium salt can be used as a phosphoramidite building block for the synthesis of oligonucleotides with novel structures.</p>

<p>Please enquire for more information about Poly(2'-O-Methyladenosine 5'-monophosphate) sodium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Protein kinase B inhibitor;</p>

<p>2',3'-Anhydroadenosine is a nucleoside for a range of applications</p>

<p>1'-13CUridine is a nucleoside analog attached to an isotope</p>

<p>The N1-methyladenosine is a reversible modification in tRNA, mRNA and long non-coding RNA</p>

<p>Kinetin is a plant hormone that regulates cell proliferation and differentiation. Kinetin riboside is a derivative of kinetin in which the ribose moiety has been converted to ribosyl-ribitol. Kinetin riboside has shown the ability to inhibit cancer cells by inducing apoptosis, which may be related to its ability to inhibit cyclin D2 and mitochondrial membrane potential. In addition, kinetin riboside has been shown to protect against oxidative stress and decrease mitochondrial function in cells. This compound may have therapeutic potential for cancer treatment and other diseases caused by oxidative stress or mitochondrial dysfunction.</p>

<p>Pro-drug of 5-FU; anti-cancer agent</p>

<p>N-Cbz gemcitabine is a novel nucleoside analog that is chemically modified to be activated by enzymes in the cell. It has been shown to have high purity and high quality. In addition, N-Cbz gemcitabine is an anticancer drug that is most effective against cells with a low number of nucleotides per cell. This drug has shown antiviral properties and is used for the treatment of HIV/AIDS patients.</p>

<p>2-Thiocytidine is a nucleoside that is an intermediate in the synthesis of thiamine. It has been shown to be effective in the treatment of prostate cancer cells, which may be due to its ability to inhibit protein synthesis. 2-Thiocytidine binds to the catalytic site of ribonucleotide reductase (RR) and inhibits the enzyme's activity, thereby inhibiting DNA synthesis. This drug also has been shown to inhibit crosslinking caused by UV light or other agents that generate reactive oxygen species. 2-Thiocytidine binds to the active site of RR and prevents the formation of the enzyme-substrate complex. This binding prevents reduction of ribose into ribonucleotides and inhibits DNA synthesis.</p>

<p>N6-Etheno 2'-deoxyadenosine is a nucleoside analogue that inhibits DNA synthesis by binding to the enzyme thymidylate synthase, which catalyzes the conversion of deoxyuridine monophosphate to thymidine monophosphate. This drug has been shown to be genotoxic in vitro and in vivo, as evidenced by its ability to induce chromosomal aberrations in cultured human lymphocytes and disrupt DNA replication in mammalian cells. It also reacts with mismatched base pairs and dna duplexes, leading to their degradation. N6-Etheno 2'-deoxyadenosine binds reversibly to antibodies and can be detected using an analytical method that employs monoclonal antibodies.</p>

<p>3',5'-Di-O-acetyl-2'-deoxy-5-iodouridine is an inorganic, deoxyribonucleoside. It is the acetyl derivative of 2'-deoxy-5-iodouridine, which is an analog of uracil. 3',5'-Di-O-acetyl-2'-deoxy-5-iodouridine has been shown to have antiviral properties against herpes simplex virus type 1 (HSV1) and herpes simplex virus type 2 (HSV2) in animals. This drug also has antiangiogenic properties, inhibiting the growth of new blood vessels and tissues at the site of a tumour. Studies have shown that 3',5'-di-O acetyl 2'-deoxyuridine can be incorporated into exudates from human cancer patients and can inhibit tumor cell proliferation in vivo.</p>

<p>2′-O-(2-Methoxy-2-oxoethyl)-5-methyl-uridine is a nucleoside that can be used as an anticancer drug and antiviral agent. It has shown potent in vitro cytotoxic activity against human leukemia cells and other cancer cell lines, including breast, prostate, ovarian, and colon cancers. 2′-O-(2-Methoxy-2-oxoethyl)-5-methyl-uridine also has good antiherpetic potential. This compound is a novel and synthetic nucleoside with high purity, high quality, and excellent stability. It is soluble in water, methanol, ethanol, acetone, acetonitrile; slightly soluble in chloroform; insoluble in ether or hexane. CAS No. 149301-23-5</p>

<p>5-Chloro-2',3'-dideoxy-3'-fluorouridine is a nucleoside analog that inhibits the replication of HIV by competing with other nucleosides for incorporation into viral DNA, thereby inhibiting the production of new viruses. This drug has been shown to have an inhibitory effect on the replication of HIV and has been approved as an antiretroviral agent. 5-Chloro-2',3'-dideoxy-3'-fluorouridine is active against most HIV strains and is able to suppress viral load in patients with chronic hepatitis B or C. It also inhibits the hepatic metabolism of drugs metabolized by cytochrome P450 enzymes, such as CYP3A4 inducers. The effective dose for this drug ranges from 100 mg to 200 mg per day.</p>

<p>2-Amino-6-chloro-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine is a protected nucleoside analog.In this compound the sugar’s hydroxyl groups are acetylated to make it chemically stable and reactive in nucleoside chemistry.</p>

<p>2′-O-[2-(Methylamino)-2-oxoethyl]adenosine is a nucleoside that can be used as an anticancer, antiviral, and anticoagulant. It is synthesized from the natural nucleosides adenosine and cytidine. 2′-O-[2-(Methylamino)-2-oxoethyl]adenosine has been shown to inhibit the growth of tumor cells in vitro. This compound also inhibits viral replication by inhibiting DNA synthesis through inhibition of ribonucleotide reductase and deoxyribonucleotide reductase. 2′-O-[2-(Methylamino)-2-oxoethyl]adenosine is phosphorylated by ATP to produce 2′-O-[2-(methylamino)-2-oxoethyl]adenosinophosphate (AMP). AMP then binds to the purinergic receptor P1, which leads to</p>

<p>1-(3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-b-D-arabinofuranosyl)-5-iodouracil is a modified nucleoside analog for research applications. It contains a uracil base with an iodine atom, a fluorinated sugar that produces increased metabolic stability and benzoyl-protecting groups at the 3'- and 5'-hydroxyl positions, commonly used in nucleoside synthesis.</p>

<p>N6-Benzoyl-2'-O-methyladenosine is a nucleoside that is chemically synthesized. It has been shown to be an inhibitor of the polyhedrosis virus, which causes an infectious disease in silkworms. N6-Benzoyl-2'-O-methyladenosine also inhibits viral replication by interfering with the synthesis of messenger RNA. This compound can be used as a silver nitrate or silver salt prodrug for treating diseases caused by viruses and bacteria. This drug is not active against DNA viruses because it does not possess phosphate groups on its structure.</p>

<p>2'-Deoxy-2'-fluoroadenosine-5'-triphosphate tetralithium salt (FdATP) is a competitive inhibitor of ATP. It inhibits the synthesis of RNA, DNA, and protein in cell culture at high concentrations. FdATP is also an analog of adenosine triphosphate (ATP), which is needed for cellular energy production. The competitive inhibition of ATP by FdATP prevents the formation of a phosphorylated enzyme that is required for the initiation of DNA synthesis. This can lead to cell death, as the cells cannot produce proteins required for growth and replication.</p>

<p>2'-Deoxyadenosine monohydrate (2'-dA) is an adenosine nucleotide that is synthesized by the enzyme adenosine kinase. It is a competitive inhibitor of phosphodiesterase and inhibits the activity of this enzyme, which breaks down cyclic nucleotides to their corresponding monophosphate form. This leads to elevated levels of cAMP, which can cause neuronal death by apoptosis. 2'-dA has been shown to have sublethal effects on neurons at concentrations that are below those required for neuronal death and apoptosis. This may be due to its ability to inhibit the synthesis of ATP, thereby limiting the production of phosphoryl groups from ATP. The inhibition of ATP synthesis also reduces the amount of energy available for other processes within cells.</p>

<p>5'-O-tert-Butyldiphenylsilyl-thymidine (TBS-T) is a class of nucleoside that is synthesized by condensation of two molecules of 5'-O-tert-butyldiphenylsilyl-2',3'-dideoxyuridine (TBDPS) and N6-benzoyladenine. TBS-Ts are used in the synthesis of phosphorothioate oligodeoxynucleotides. They have been shown to be useful as activators for the formation of phosphite linkages at the 3' terminus of DNA oligonucleotides. TBS-T is also used in other applications, such as the preparation of diastereomerically pure nucleosides for use in chemical reactions.</p>

<p>Thymidine 3′-monophosphate disodium is a chemotherapeutic agent that has been shown to have antiviral and anticancer properties. It is a nucleoside analogue, which mimics the structure of thymidine and inhibits DNA synthesis by interfering with the DNA replication process. Thymidine 3′-monophosphate disodium is also used as an activator in the synthesis of deoxyribonucleosides and ribonucleosides. This product is synthetic, high quality, and not chemically modified. It has CAS number 68698-19-1 and molecular weight of 242.06 g/mol.</p>

<p>5'-O-DMT-thymidine 3'-O-succinate triethylammonium salt is a novel antiviral agent that inhibits viral replication by competing with natural nucleosides for incorporation into the viral DNA or RNA. The 5'-O-DMT group prevents the elimination of thymidine from the monophosphate form. This product has a high purity and quality, as well as potent antiviral activity against HIV and other viruses.</p>

<p>2-Methylthioadenosine is a purine nucleoside which induces necrotic cell death. It is the first of its kind to be shown to have activity against squamous carcinoma cells, and is activated by nucleoside phosphorylase in order to produce its cytotoxic form. 2-Methylthioadenosine also inhibits the transcription-polymerase chain reaction and increases oxidative injury. This drug has been shown to have receptor activity in brain cells, as well as chemotactic activity for gland cells. 2-Methylthioadenosine has been used as a model organism for polymerase chain reactions, and has been shown to inhibit p2y receptors in the human colon cancer cell line HT29.</p>

<p>5'-O-(4,4'-Dimethoxytrityl)adenosine is a phosphoramidite that can be used as an activator for the synthesis of DNA. It is also used in the preparation of modified nucleosides and has anticancer activity. 5'-O-(4,4'-Dimethoxytrityl)adenosine is a modified ribonucleoside with high quality and high purity. This product has been shown to have antiviral activity against HIV-1.</p>

<p>5'-Deoxy-5-fluorocytidine is a cytosolic nucleoside analogue that is phosphorylated by cellular enzymes to the active form 5'-deoxy-5-fluorouridine monophosphate. It is a prodrug, which is activated in the body to release 5-FU and inhibits the growth of cancer cells. 5'-Deoxy-5-fluorocytidine has been shown to be effective against metastatic colorectal cancer in humans and resistant breast cancer in mice. The drug can also be used as an oral prodrug for 5-FU, which has a wide therapeutic index and low toxicity. Studies have shown that it selectively inhibits proliferation of solid tumours through inhibition of protein synthesis and cell division. The drug also has antiangiogenic effects, which are thought to contribute to its antitumor activity.</p>

<p>2'-Deoxy-3,5-dimethylcytidine is a nucleoside analog that is an activator of the ribonucleotide reductase enzyme. It has been shown to have anticancer properties in vitro and in vivo. 2'-Deoxy-3,5-dimethylcytidine has also been shown to be effective against HIV and herpes virus infections. 2'-Deoxy-3,5-dimethylcytidine is synthesized from deoxyribonucleosides or nucleosides by phosphitylation with phosphoramidites or diphosphates. The CAS number for this product is 198198-29-7.</p>

<p>5'-O-DMT-2'-O-hexylphthalimidouridine is a novel nucleoside analog with anticancer activity. It is a modified nucleoside that has been synthesized and purified in high purity. 5'-O-DMT-2'-O-hexylphthalimidouridine is an activator of DNA and RNA synthesis and has antiviral properties. It also inhibits the production of tumor necrosis factor alpha (TNFα) by human synovial cells. This compound binds to the RNA polymerase II enzyme, which prevents transcription of genetic material from DNA templates into messenger RNA. This leads to inhibition of protein synthesis and cell death by apoptosis.</p>

<p>2'-O-Methylcytidine is a nucleoside with a hydroxyl group on the 2' carbon. The hydroxyl group makes it an effective inhibitor of viral replication, and it has been shown to be active against HIV-1 in cell culture. 2'-O-Methylcytidine is also metabolized by nucleotide salvage pathways, and the metabolic response can be studied using proton nuclear magnetic resonance (NMR) spectroscopy and x-ray diffraction data. It has been found that 2'-O-Methylcytidine inhibits protein synthesis in cancer cells, and this may be due to its ability to bind to the response element on DNA.</p>

<p>Coenzyme and regenerating electron donor in catabolic processes</p>

<p>4-Hydroxy-6-methylpyrimidine (4-OHMP) is a metabolite of trimethyltin. It is formed in the liver by methylation of 4,6-dimethylpyrimidine (4,6-DMPU). The levels of 4-OHMP in urine samples are used to monitor exposure to this agent. The median values for urinary concentrations of 4-OHMP are typically 10 times higher than those found in blood samples. The metabolite can be detected in urine up to 2 weeks after an individual’s last contact with trimethyltin. This compound has been shown to inhibit the synthesis of glycol dimethyl ethers and carbamates.</p>

<p>Trimethylguanosine is a hydrogen-bonded base that is found in the DNA of all living organisms. It has a diagnostic role in cancer and metabolic disorders, as well as in the study of cell culture. Trimethylguanosine can be used to identify cancer cells by measuring its fluorescence properties, which are different from those of healthy cells. This compound also has a role in the diagnosis of metabolic disorders, such as diabetes mellitus and renal disease. Trimethylguanosine is also involved in biological function, and is necessary for the synthesis of proteins and nucleic acids.</p>

<p>L-Cytidine is a nucleoside that is found in the body, and is also used as a drug. It is a precursor to other nucleosides, such as cytidine triphosphate, which is involved in DNA synthesis and repair. L-Cytidine has been shown to be effective against HIV infection by inhibiting the activity of the enzyme ns3 protease. This inhibition prevents viral proteins from being released from cells and infecting other cells. L-Cytidine has also been shown to be an inhibitor of creatine kinase and glycosidation, two enzymes that are necessary for cell metabolism. L-Cytidine has also been shown to be reactive with halides, which may lead to unwanted side effects.</p>

<p>N6-Benzoyl-2'-O-(2-methoxyethyl)adenosine is a novel nucleoside that can be used as an antiviral agent. It is an activator of viral polymerase and inhibits the proliferation of cells infected with HIV. This compound has been synthesized from 2'-deoxyadenosine monophosphate, which is a precursor to RNA and DNA synthesis. N6-Benzoyl-2'-O-(2-methoxyethyl)adenosine has also been shown to inhibit the growth of experimental tumors in mice. The synthesis of this compound is reliable and reproducible, making it a high quality product.</p>

<p>2'-Deoxy-5'-O-DMT-cytidine is an organic compound. It is a synthetic, combinational and amine nitrogen containing heterocyclic compound that is used in organic synthesis. This chemical is also used as a building block for the synthesis of heterocyclic compounds with other functional groups such as thionyl, formulae, chlorides and hydrogen atoms.</p>

<p>1-(α-D-Ribofuranosyl)uracil is a nucleoside analog made up of a uracil attached to a ribose sugar at the 1-position, with the sugar in the α configuration. This compound is of interest in biochemistry research and nucleoside chemistry, especially when studying stereochemistry or synthesizing analogs.</p>

<p>2',3'-Dideoxyinosine is a purine analog that can suppress human immunodeficiency virus (HIV) replication after intracellular metabolic conversion</p>

<p>Uridine 5'-monophosphate disodium salt (UDP-MS) is a structural analog of uridine that is used as a dietary supplement. It has been shown to inhibit phosphodiesterases and cyclic nucleotide phosphodiesterases, which are enzymes that degrade the secondary messenger, cyclic adenosine monophosphate (cAMP). This inhibition leads to increased levels of cAMP in cells, which stimulates protein kinase A activity and promotes cellular differentiation. The analysis of UDP-MS has been performed using liquid chromatography with ultraviolet detection.</p>

<p>2'-Deoxy-5-formylcytidine is a nucleoside analog that is used as a chemotherapeutic agent. It is cytotoxic to cells by binding to DNA and preventing the synthesis of DNA, RNA, and protein. The drug has been shown to induce cellular senescence in human fibroblasts, which can be reversed by the addition of deuterium. 2'-Deoxy-5-formylcytidine also inhibits the production of reactive oxygen species (ROS) by inducing the expression of antioxidant enzymes such as superoxide dismutase 2 and glutathione peroxidase 1. The oxidation products are misincorporated into DNA strands, leading to intramolecular hydrogen bonds with cytosine bases. These modifications lead to denaturation of DNA and inhibition of transcription and replication.<br>2'-Deoxy-5-formylcytidine also interacts with oligodeoxynucleotides, which leads to misinc</p>

<p>7-Deaza-2'-deoxyxanthosine is an oligodeoxynucleotide that is a substrate for the enzyme dUTPase. The allyl group on 7-deaza-2'-deoxyxanthosine is used to attach it to the 3' end of DNA, where it acts as a competitive inhibitor of RNA synthesis. The ethyl group at the end of the molecule is used to attach it to the 5' end of DNA, where it inhibits transcription and replication by binding with RNA polymerase. 7-Deaza-2'-deoxyxanthosine has been shown to be effective in preventing stenosis following coronary bypass surgery, as well as in treating heart disease by reducing levels of xanthosine.</p>

<p>Uridine 5'-diphosphate choline ammonium salt is a chemical compound that contains two molecules of uridine and one molecule of choline. It is a hexamer with an empirical formula of C6H14N4O13P3. Uridine 5'-diphosphate choline ammonium salt can be found in plants and animals, as well as being synthesized by the human body. This compound is present in the interstitium, which are the spaces between cells, and may play a role in the nutritional status of humans.</p>

<p>2'-Deoxy-2'-fluoroinosine is a modified nucleoside analog derived from inosine, where the 2' hydroxyl group of the sugar (normally present in ribonucleosides) is replaced with a fluorine atom, and the molecule contains a deoxyribose sugar.</p>

<p>2,4,6-Trichloro-5-methylpyrimidine is a nucleoside for use in research applications</p>

<p>Thymidine-5'-diphosphate-L-rhamnose disodium is a nucleoside that belongs to the class of modified nucleosides. It is a synthetic, modified thymidine with a phosphate group at the 5'-position and L-rhamnose at the 2' position. Thymidine-5'-diphosphate-L-rhamnose disodium has antiviral and anticancer activities, as well as high purity and high quality. This compound has been shown to inhibit HIV replication in vitro and in vivo. Thymidine-5'-diphosphate-L-rhamnose disodium is also used in the synthesis of DNA and RNA.</p>

<p>2'-Azido-2'-deoxyadenosine is a synthetic nucleoside analog of adenosine in which the 2'-hydroxyl group of the ribose sugar is replaced by an azido group (–N₃), and the 3'- and 5'-hydroxyl groups remain intact. This modification confers unique chemical properties, including the ability to participate in bioorthogonal "click" chemistry reactions, particularly azide-alkyne cycloadditions, making it useful for labeling and tracking nucleic acids in biochemical studies. Additionally, the azido substitution can influence enzymatic recognition and incorporation by polymerases, allowing its use in studying nucleic acid metabolism, drug design, and therapeutic nucleoside analog development.</p>

<p>2'-C-Methyluridine is a synthetic nucleoside analog derived from uridine, modified with a methyl group at the 2'-carbon of the ribose sugar. This small chemical change has important implications for RNA biology, antiviral drug development, and biochemical research, especially in targeting RNA viruses.</p>

<p>5'-O-DMT-5-[N-(6-(trifluoroacetamido)hexyl)-3-E-acrylamido]-2'-deoxyuridine is a novel phosphoramidate nucleoside monophosphate, which is a phosphate analog of 2'-deoxyuridine. It has been shown to be an activator for DNA polymerases and is able to inhibit the replication of DNA in vitro. It also has antiviral properties, as it inhibits the synthesis of viral RNA. 5'-O-DMT-5-[N-(6-(trifluoroacetamido)hexyl)-3-E-acrylamido]-2'-deoxyuridine also has anti-inflammatory effects, as it inhibits prostaglandin synthesis.</p>

<p>3'-O-Methylcytidine is an acidic guanine nucleoside that is a component of RNA. It is a biochemical building block and a co-substrate in the synthesis of DNA and RNA. 3'-O-Methylcytidine has been shown to be hydroxylated by the enzyme cytidine 5'-monophosphate, which leads to its termination when it reaches the ribosome. This nucleoside also inhibits bacterial growth through inhibition of ribosomal function, leading to reduced protein synthesis. 3'-O-Methylcytidine can act as an environmental pollutant, especially in chloride environments such as seawater. It has been found to be globally distributed in dinucleotides and monomethylated forms, with biosynthetic pathways similar to other nucleic acids.</p>

<p>Adenosine 5'-diphosphate monosodium salt (ADP) is an adenine nucleotide which is phosphorylated into ATP by the enzyme ATPase. This phosphorylation is essential in cellular homeostasis due to its role in energy storage and nucleic acid metabolism.</p>

<p>2'-Deoxy-5'-O-DMT-2'-fluoro-N4-phenoxyacetylcytidine is a monophosphate nucleotide analog that is used as an antiviral agent. It inhibits viral replication by inhibiting the activity of DNA polymerase, which is needed to synthesize DNA. 2'-Deoxy-5'-O-DMT-2'-fluoro-N4-phenoxyacetylcytidine has been shown to be effective against HIV and HSV in vitro and in vivo. This nucleotide analog has also been shown to be potent against Hepatitis B viruses and adenovirus type 3.<br>2'-Deoxy-5'-O-DMT-2'-fluoro-N4-phenoxyacetylcytidine is phosphoramidate derivative of cytosine with a fluorine substitution at the 2' position on the sugar moiety, making it a novel compound. The pyrid</p>

<p>Deoxynucleoside with an alkyne handle on the base which can be used for conjugation via click chemistry.</p>

<p>2'-Deoxyguanosine 3'-monophosphate sodium is a novel, synthetic nucleoside that inhibits DNA replication and transcription. It has been shown to be a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type I (HTLV-I). 2'-Deoxyguanosine 3'-monophosphate sodium is in the category of nucleosides, which are phosphorylated compounds that can be incorporated into DNA by DNA polymerase. This product has a high purity and is synthesized from diphosphate.</p>

<p>N-Succinyl-5-aminoimidazole-4-carboxamide ribose disodium salt is a novel modified nucleoside with anticancer activity. The compound is a monophosphate, which activates DNA and RNA synthesis. This agent also has antiviral and antifungal effects. N-Succinyl-5-aminoimidazole-4-carboxamide ribose disodium salt is synthesized from diphosphate and deoxyribonucleosides. It was first patented in 1979 and has been approved by the US Food and Drug Administration (FDA) for use as a pharmaceutical agent. N-Succinyl-5-aminoimidazole-4-carboxamide ribose disodium salt can be used to produce phosphoramidites, which are synthetic DNA building blocks that are used in the production of DNA and RNA synthesis.</p>

<p>1-(3`,5`-Di-O-benzoyl-2`-chloro-2`-deoxy-beta-L-arabinofuranosyl)thymine is a nucleoside analog for research applications. This compound is made up of a thymine base and the sugar 2'-Chloro-2'-deoxy-β-L-arabinofuranose. The sugar has the L-arabinose configuration and a 2'-Chloro substitution which can alter its interactions with enzymes and enhance resistance to degradation. It also contains benzoyl groups that protect the hydroxyls during chemical synthesis.</p>

<p>Uridine-5-oxyacetic acid methyl ester is a modified nucleotide that is an intermediate in the biosynthesis of uridine. This molecule can be synthesized from 5-hydroxymethyluridine and malonic acid by a methyltransferase. Uridine-5-oxyacetic acid methyl ester can also be obtained from the metabolism of deoxyribose. Analysis of this molecule is possible with spectrometric, mass spectrometric, and chemical structures methods. It has been shown to have a function in translation and protein synthesis. The chemical structure of uridine-5-oxyacetic acid methyl ester has been determined to be guanosine-3',5'-bis(2'-carboxyethyl)phosphate, which is different from that found in DNA or RNA.</p>

<p>2'-O-Methyl-5-propynylcytidine is an antiviral drug that inhibits the replication of retroviruses by competitive inhibition of the viral RNA polymerase. It has been shown to be effective against HIV, HSV and CMV. This drug also has shown anticancer activity in vitro and in vivo. 2'-O-Methyl-5-propynylcytidine has a novel mechanism of action and is used as a building block for oligonucleotide synthesis because it is resistant to degradation by nucleases.</p>

<p>Riboflavin 5'-adenosine diphosphate disodium salt hydrate is a chemical compound that can be used as a substrate for nitrate reductase in the presence of molecular oxygen. It can be used to identify mollicutes and diagnose radiation-induced lesions. The reaction mechanism involves the conversion of riboflavin 5'-adenosine monophosphate to riboflavin 5'-adenosine diphosphate by an enzyme called nitrate reductase, which is present in the microorganism. This reaction is accompanied by the release of electrons, which are detected by a fluorescence detector. The rate constant for this reaction is <br>k=1.5x10^-4/s at pH 7 and 37 degrees Celsius with an electrochemical detector and k=2.0x10^-3/s at pH 7 and 37 degrees Celsius with a carbonyl oxygens detector. Riboflavin 5'-</p>

<p>2'-Deoxy-N2-DMF-5'-O-DMT-guanosine is a monophosphate nucleoside that has antiviral, anticancer, and high purity properties. It is synthesized by the phosphoramidite method from 2'-deoxy-N2-DMF and 5'-O-DMT guanosine. This compound has been shown to inhibit the growth of human cancer cells in vitro and in vivo. It also inhibits HIV replication in vitro and is not toxic to normal cells.</p>

<p>1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)uracil is a nucleoside analog and contains a uracil base, and a 2'-deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl sugar moiety. The 2'-fluoro modification is of particular interest due to its potential to alter the chemical and biological properties of the resulting oligonucleotides. Fluorinated nucleosides and their analogs have been extensively studied for their antiviral and anticancer activities. The incorporation of fluorine into nucleoside analogs can also affect their interaction with DNA and RNA, leading to changes in their therapeutic potential.</p>

<p>1-Methylpseudouridine is a substitute for uridine in modified mRNA. This substitution has shown to increase transfection by reducing immuogenicity. The 1-methylpseudouridine substituted mRNA increases protein expression due to low immune stimulation as it evades detection by the edosomal Toll-like receptor (TLR3).</p>

<p>1-(2'-Deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-iodouracil is a nucleoside analog with antiviral properties. It consists of a modified uracil base (5-iodouracil) attached to a fluorinated arabinofuranosyl sugar moiety. In cell culture, it inhibits the replication of varicella-zoster virus, herpes simplex virus type 1 and 2 and cytomegalovirus.</p>

<p>9-(b-D-Ribofuranosyl)purine (9-BRP) is a purine nucleoside that is used in the synthesis of dyes. It has been shown to be an effective inhibitor of the enzyme phosphodiesterase 3B, which breaks down cyclic adenosine monophosphate (cAMP), and therefore can prevent kidney fibrosis. 9-BRP has also been shown to inhibit the synthesis of collagen by binding to cAMP. In addition, 9-BRP binds to DNA and forms hydrogen bonds with nitrogen atoms on the phosphate groups in DNA. This interaction prevents the formation of hydrogen bonds between water molecules in water vapor and phosphate groups, thus slowing down their rate of dissociation from each other. 9-BRP also has a high affinity for Toll-like receptor 4 (TLR4), which is involved in the inflammatory response, making it an ideal therapeutic candidate for treating inflammation and renal fibrosis.</p>

<p>b-Nicotinamide mononucleotide, or NMN, is a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme found in all living cells that is essential for various metabolic processes. NAD+ is involved in critical functions such as DNA repair, gene expression, and cellular stress responses.</p>

<p>3-Methyl-2-nitropyridine is a high yield byproduct of formamide, which can be activated to form an intermediate for the synthesis of nucleosides. The kinetics and labeling of this intermediate were studied using a transfer experiment. 3-Methyl-2-nitropyridine is acidic, with a pKa value of 3.6, and is reactive towards nucleophiles. It is also catalytic, yielding methyl groups and dioxane as products when heated at temperatures between 180°C and 220°C. In addition, it undergoes nucleophilic substitutions at methoxy groups.</p>

<p>N2-Isobutyryl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxane-diyl)guanosine is a nucleoside that is activated by phosphorylation. It has been shown to be an inhibitor of cancer cell growth and proliferation in vitro. This compound was also found to inhibit the expression of two oncogenes (c-MYC and c-Ki67) and induce the expression of the tumor suppressor gene p53. This nucleoside is synthesized from 2'-deoxyadenosine monophosphate (2'-DAMP) with a modified DNA synthesis protocol.</p>

<p>2-Aminoadenosine is a synthetic nucleoside analog of adenosine in which the purine base is 2,6-diaminopurine, featuring an additional amino group at the C2 position. This modification enhances hydrogen bonding potential and alters base-pairing specificity, allowing it to form three hydrogen bonds with uracil or thymine, in contrast to adenine's two. As a result, 2-aminoadenosine has been studied for its impact on nucleic acid stability, replication fidelity, and enzymatic recognition. It has also shown potential in antiviral and anticancer research due to its ability to disrupt normal RNA and DNA metabolism.</p>

<p>5-Chloro-2-iodopyrimidine is an organic molecule that belongs to the class of trifluoromethylated molecules. It was discovered by a team of chemists in 2006 and has been used as a reagent for the efficient trifluoromethylation of organic molecules. 5-Chloro-2-iodopyrimidine can be catalyzed with copper, which is responsible for its unique reactivity. The synthesis of this molecule has been shown to be efficient in organic chemistry.<br>END&gt;</p>

<p>2,8-Dimethyladenosine is a methylated derivative of the purine nucleoside adenosine, in which methyl groups are added at the 2-position and 8-position of the adenine base.</p>

<p>3'-Deoxythymidine (3DT) is a nucleoside analog that has high resistance to HIV. It is an analogue of the human insulin-like growth factor-1 (IGF-1), which binds to the IGF-1 receptor and inhibits the binding of IGF-1 to its receptor, thereby inhibiting the growth of cells. 3DT has been shown to have a protective effect against radiation in mice, with an LD50 at a dose of 5.0 mg/kg for radiation exposure. 3DT also has antiviral activity against murine sarcoma virus, as well as other biological properties such as enzyme activities and disease activity. This drug may be used in future research on polymerase chain reactions (PCRs) and DNA sequencing, since it is chemically stable and can be easily synthesized.</p>

<p>N4-Benzoyl-2'-deoxy-a-cytidine is a novel, modified nucleoside that has shown anticancer and antiviral activity. It is synthesized by the enzymatic oxidation of 2'-deoxyadenosine with benzoyl chloride and sodium bicarbonate. N4-Benzoyl-2'-deoxy-a-cytidine has been shown to activate transcription, increase DNA synthesis, and inhibit virus replication. It also inhibits bacterial growth, but does not appear to have any effect on mammalian cells.</p>

<p>Incorporated in DNA/RNA hybrids and mismatch pairs to analyse helix stability</p>

<p>3'-Deoxycytidine is a nucleoside analog used to treat hepatitis. It is an inhibitor of the viral enzyme reverse transcriptase and prevents the synthesis of viral DNA by blocking the formation of low-energy hydrogen bonds between the 3'-hydroxyl group and the 5'-phosphate group of deoxyribonucleotide triphosphates. 3'-Deoxycytidine can be synthesized using solid-phase methods, and has been shown to inhibit human immunodeficiency virus (HIV) in control experiments. This drug also has been shown to have anti-inflammatory effects in experimental bladder inflammation models.</p>

<p>7-Deaza-2',3'-dideoxyguanosine is a nucleoside analogue that is silylated on the 2' and 3' hydroxyl groups. It is also substituted with a deoxygenated 7-deaza-2',3'-dideoxyribose moiety. The substitution of the ribose sugar with deoxygenated 7-deaza-2',3'-dideoxyribose prevents the formation of hydrogen bonds between the sugar and phosphate backbones, which inhibits the enzyme ribonucleotide reductase from catalyzing the conversion of ribonucleotides to deoxynucleotides. This in turn blocks DNA synthesis, leading to cell death.br&gt;<br>7-Deaza-2',3'-dideoxyguanosine has been shown to be effective against Mycobacterium tuberculosis and Mycobacterium avium complex.</p>