Others

Impurity Fulvestrant EP Impurity A
Applications Fulvestrant (F862500) impurity A. The S-isomer of Fulvestrant.
References Sharman, G.J., et al.: Mag. Resonance Chem., 39, 549 (2001),

Impurity Lorazepam USP Related Compound A
Stability hygroscopic
Applications Lorazepam is an anxiolytic compound that potentiates GABAergic synaptic transmission by binding at the benzodiazepine site on the GABAA receptor.1,2 This product is intended for forensic and research applications. Lorazepam acts as ananticonvulsant. Lorazepam USP Related Compound A.Controlled substance (depressant).
References Rutgers, G., et al.: Anal. Profiles Drug Subs., 9, 397 (1980), Korkmaz, S., et al.: Eur. Neuropsychopharmacol., 8, 175 (1998), D’Onofrio, G., et al.: N. Engl. J. Med., 340, 915 (1999),

Stability Hygroscopic
Applications A metabolite of Memantine (M218000), used for the treatment of neurological disorders.
References Eiichi, K., et al.: Chem. Pharm. Bull., 33, 4680 (1985),

Applications 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate is an intermediate of Silodosin (S465000) which is an α1a-adrenoceptor antagonist and used in the treatment of benign prostatic hypertophy.
References Francesco, C., et al.: Eur. J. Org. Chem., 27, 6011 (2015)

Applications Zaleplon Formide is an impurity of Zaleplon (Z145000), a selective non-benzodiazepine GABAA receptor agonist.
References Radl, S., et al.: J. Heterocycl. Chem, 47, 276 (2010); Allen, D., et al.: Eur. J. Clin. Pharmacol., 45, 313 (1993); Beer, B., et al.: J. Clin. Pharmacol., 34, 335 (1994); Rosen, A.S., et al.: Biopharm. Drug Dispos., 20, 171 (1999)

Stability Hygroscopic
Applications Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic.
References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),

Stability Hygroscopic
Applications 7-Methyl Memantine is an impurity of Memantine (HCl salt, M218000) which is used as an antiparkinsonian and antispasmodic.
References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)

Applications An impurity of labelled Salicylic Acid synthesis
References Kovacik, J., et al.: J. Agric. Food Chem., 57, 9848 (2009), Gao, X., et al.: Anal. Biochem., 393, 163 (2009), Rocher, F., et al.: Plant Physiol., 150, 2081 (2009),

Impurity Atenolol EP Impurity E
Applications 4,4'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis-benzeneacetamide is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker. Atenolol EP Impurity E
References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984);

Applications N-Formyl Memantine is an impurity of Memantine (M218000). Memantine impurity E per USP.
References Gerzon, K., et al.: J. Med. Chem., 6, 760 (1963),

Applications Dehydro Silodosin is an impurity of Silodosin (S465000).
References Moriyama., et al.: Eur. J. Pharmacol., 331, 39 (1997), Zhu, J., et al.: Br. J. Pharmacol., 131, 546 (2000),

Applications N-Nitrosoatenolol is an N-nitroso derivative of Atenolol (A790075), which is a cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II). N-Nitrosoatenolol can be used for its genotoxic effect in rat and human hepatocytes.
References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984); Robbiano, L., et.al., Cancer Res., 51, 2273-2279, (1991);

Applications Labelled Diazepam, an anxiolytic; muscle relaxant (skeletal); anticonvulsant.Diazepam is a Controlled substance (depressant).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 79 (1972); Mandelli, M., et al.: Clin. Pharmacokinet., 3, 72 (1978); Bertilsson, L., et al.: Pharmacol. Ther., 45, 85 (1990); Murray, J.B., et al.: J. Psychol., 124, 655 (1990); Pellock, J.M., et al.: Drug Saf., 27, 383 (2004);

Applications Silodosin is an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertrophy.
References (1) Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995) (2) Murata, S., et al.: J. Urol., 164, 578 (2000)

Applications 1,3-Propanediol is a common organic reagent used in the synthesis of polymers and used in industrial organic chemistry for the synthesis of lubricants, foods, medicines and cosmetics.
References Sun, Y. et al.: Bioproc. Renew. Res. Commod. Bioprod., 289 (2014);

Stability Unstable in Methanol
Applications Used in the synthesis of cyanogen glycoside. A component contains in antiperspirants, deodorants, body soaps, shampoos, hair rinses, and hair; it inhibits volatile steroid formation by resident bacteria.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Marouf, A., et al.: Pharm. Biol., 39, 263 (2001), Fukuda, T., et al.: Biol. Pharm. Bull., 26, 271 (2003), Butler, M., et al.: J. Nat. Prod., 67, 2141 (2004), He, J., et al.: J. Nat. Prod., 69, 121 (2006),

Applications 2,2,4,4-Tetramethyloctane is a volatile compound of vegetarian soybean kapi, a fermented Thai food condiment.
References Allagheny, N., et al.: Int. J. Food Microbiol., 29, 321 (1996); Han, B., et al.: Food Control., 15, 265 (2004); Ouoba, L., et al.: J .Appl. Microbiol., 99, 1413 (2005); Zhang, J., et al.: Inter. J. Food Sci. Technol., 42, 263 (2007);

Applications 7-Ketoabiraterone Acetate is an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.
References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)

Applications Labelled Bimatoprost (B386800). Bimatoprost is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.
References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004),

M04074 - 5-Bromo-6-chloro-3-indolyl beta-D-glucuronide cyclohexylammonium salt

Applications Useful for diagnostic determination of Melamine and related compounds in kidney tissue.
References Mast, R., et al.: Food Chem. Toxicol., 21, 807 (1983), Yokley, R., et al.: J. Agric. Food Chem., 48, 3352 (2000), Ehling, S., et al.: Food Addit. Contam., 24, 1319 (2007), Vail, T., et al.: J. Anal. Toxicol., 31, 304 (2007),

Applications It is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases; an indolinone as triple angiokinase inhibitors. An antitumor agent.
References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)

Applications A potent, selective and orally active labelled cysteinyl leukotriene type 1 receptor antagonist. Used as an antiasthmatic.
References Matassa, V.G., et al.: J. Med. Chem., 33, 1781 (1990), Findlay, S.R., et al.: J. Allergy Clin. Immunol., 89, 1040 (1992), Krell, R.D., et al.: Am. Rev. Respir. Dis., 141, 978 (1990), Dunn, C.J., Drugs, 61, 285 (2001),

Applications Tert-butyl Acetate is a common solvent used in the production of various industrial cleansers, thinners and adhesives and is also known as a VOC.Environmental contaminants; Food contaminants
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mackay, D., et al.: SAR. QSAR. Enviro. Res., 23, 205 (2012); Yang, Y.S., et al.: Toxicol. Res., 26, 293 (2010);

Impurity Atenolol USP Related Compound D; Atenolol EP Impurity F
Applications 4,4'-[[(1-methylethyl)imino]bis[(2-hydroxy-3,1-propanediyl)oxy]]bis-benzeneacetamide (Atenolol USP Related Compound D; Atenolol EP Impurity F) is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker.
References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984); Caplar, V., et al.: Acta. Pharma. Jugoslavica., 33, 71 (1983);