Aminoacids and derivatives

<p>Applications α-Methyldopa Methyl Ester is an impurity in the synthesis of L-α-Methyl DOPA Methyl Ester Hydrochloride which is a Methyldopa angiotensin II analog.<br>References Karle, I., et al.: Biochemistry, 29, 6747 (1990), Biron, E., et al.: Bioorg. Med. Chem., 12, 1279 (2004),<br></p>

<p>Applications N-Octanoylglycine is a derivative of Glycine (G615990) and is an amphiphilic lipoamino acid commonly used in cosmetics for its antibacterial properties. N-Octanoylglycine is the active ingredient in products designed to treat seborrheic dermatitis on the scalp and acne prone skin.<br>References Georgalas, A.: Cosmet. Toiletries, 127, 96 (2012); Nakamura, S.: Frag. J., 39, 36 (2011);<br></p>

<p>Impurity L-5-Hydroxytryptophan(Tryptophan EP Impurity D)<br>Applications 5-Hydroxy-L-Tryptophan (L-5-Hydroxytryptophan(Tryptophan EP Impurity D)) is a hydroxylated metabolite of L-Tryptophan (T947210).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gartside, S., et al.: Eur. J. Pharmacol., 179, 103 (1990); Gijsman, H., et al.: J. Clin. Psychopharmacol., 22, 183 (2002),; Schruers, K., et al.: Psychiatry Res., 113, 237 (2002);<br></p>

<p>Applications Glycyl-glycyl-glycine is used as a model peptide for studies of physicochemical parameters and molecular associations of small peptides. It is also used as a copper chelator.<br></p>

<p>Applications A labelled metabolite of 5-Hydroxytryptamine, also known as Serotonin (S274990).<br>References Uutela, P. et al.: Anal. Chem., 81, 8417 (2009); Koehle, C. et al.: Biochem. Pharmacol., 69, 1397 (2005); Krishnaswamy, S. et al.: Xenobiotica, 33, 169 (2003);<br></p>

<p>Applications L-Kynurenine-d4 Trifluoroacetic Acid Salt is the isotope labelled analog of L-Kynurenine. L-Kynurenine is a tryptophan metabolite which is a precursor of kynurenic acid, an antagonist of N-methyl-aspartate receptor.<br>References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990);, Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003); Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003); Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007)<br></p>

<p>Applications N-Acetyl-L-Tryptophan, is a derivative of L-Tryptophan (T947210), that can be used as competitive inhibitor to identify and characterize tryptophanases. It can also be used as an NK1 tachykinin receptor antagonist, that may help to develop a novel therapeutic intervention for the treatment of reperfusion injury in acute ischemic stroke.<br>References Turner, R. J., et al.: Neuroscience, 220, 1 (2012);<br></p>

<p>Applications Benzyl Acetate, is found naturally in many flowers, It has pleasant sweet aroma reminiscent of jasmine, and thus is used widely in perfumery industry, and also as a flavouring agent. It is also used as a solvent.<br>References Schiestl, F. P., et al.: J. Chem. Ecology, 29 (2004); Qian-qian, M., et al.: Jingxi Huagong, 30, 442 (2013);<br></p>

<p>Applications Glycine-15N,d2, is the labeled analogue of Glycine (G615990), a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.<br>References Scott, D. et al.: J. Neurosci., 21, 3063 (2001); Laube, B. et al.: Neuropharmacology, 47, 994 (2004); Papadakis, M. et al.: J. Biol. Chem., 279, 14703 (2004); Chen, P. et al.: Mol. Pharmacol., 67, 1470 (2005); Wolosker, H. et al.: Mol. Neurobiol., 36, 152 (2007);<br></p>

<p>Applications Tyramine Hydrochloride is a naturally occurring monoamine derived from tyrosine. Neurotransmitter.<br>References Roy, K., et al.: J. Mol. Liq., 230, 104-112 (2017); Roy, M. N., et al.: Chem. Phys. Lett., 655-656, 43-50 (2016)<br></p>

<p>Applications A labelled, essential amino acid.<br>References Liu, F., et al.: Bioorg. Med. Chem., 18, 4167 (2010), Kumar, R., et al.: Eur. J. Med. Chem., 45, 2265 (2010), Cai, W., et al.: Bioorg. Med. Chem., 18, 1899 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications L-Carnitine-d3 Chloride is the isotope labelled analog of L-Carnitine (C184110); a vitamin (enzyme cofactor). It is an essential cofactor of fatty acid metabolism and is required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney with the highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)<br></p>

<p>Applications Labelled 2-Methylbutyrylglycine (M294340). 2-Methylbutyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).<br>References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),<br></p>

<p>Applications Specific GABA-B receptor agonist. Muscle relaxant (skeletal).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahuja, S., et al.: Anal. Profiles Drug Subs., 14, 527 (1985), Brogden, R.N., et al.: Drugs, 8,1 (1974)<br></p>

<p>Applications 4-amino-3-phenylbutanoic acid (cas# 1078-21-3) is a GABAA receptor agonist, used for treatment of disorders influenced by dysfunction of pancreatic β cells and also used in combination with other agents.<br>References Birnir, B., et al.: PCT Int. Appl. 56pp. (2019)<br></p>

<p>Applications L-Serine is used in the synthesis of purines and pyrimidines as antibacterial/antifungal agents, as well as acting as a proteinogenic compound.<br>References Olivella, M. et al.: Bioorg. Med. Chem., 20, 6109 (2012);<br></p>

<p>Applications A metabolite of Carbidopa (C175915).<br>References Vickers, S., et al.: Drug Metab. Dispos., 2, 6 (1974), Vickers, S., et al.: J. Med. Chem., 18, 134 (1975),<br></p>

<p>Stability Hygroscopic<br>Applications One of the metabolites found in the lymph fluid collected from dietary stressed rats.<br>References Ardawi, M., et al.: Biochem. J., 212, 835 (1983), Otton, R., et al.: J. Endocrinol., 174, 55 (2002), Gu, H., et al.: Anal. Chem., 79, 89 (2007),<br></p>