Aminoacids and derivatives

<p>Applications Labelled Lacosamide (L098500). Lacosamide is a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006), Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007)<br></p>

<p>Applications N-Methyl-N-nitroso-1-octadecylamine was found to present in various hair-care products when investigated through thermal energy analyzer.<br>References Morrison, J.B., et al.: Food. Chem. Toxicol., 21, 69 (1983); Rainey, W.T., et al.: Biomed. Mass. Spec., 5, 395 (1978);<br></p>

<p>Stability Hygroscopic<br>Applications Carbocisteine Lactam is an impurity of the mucolytic agent Carbocisteine (C178760).<br>References Anonymous., et al.: Biochem. J., 219, 345 (1984); Sanger, F., et al.: Biochem. J., 59, 509 (1955); Hekman, C., et al.: J. Pharm. Biomed. Anal., 20, 763 (1999);<br></p>

<p>Applications 6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in electrophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system.<br>References Ohta ,S. et al.: Chem. Pharm. Bull., 28, 1917 (1980); Shagger, H. et al.: Anal. Biochem., 199, 223 (1991); Soter, N.A. et al.: J. Immunol., 114, 928 (1975);<br></p>

<p>Applications 3-O-Methylcarbidopa is an impurity of Carbidopa (C175915) with potential use as therapeutic agents to treat hypertension and Parkinson's disease.<br>References Gelber, L. et al.: J. Chrom., 257, 317 (1983); Kallwass, H. et al.: Bioorg. Med. Chem., 2, 557 (1994);<br></p>

<p>Stability Hygroscopic<br>Applications Indole-3-carboxaldehyde- 13C8 is the labelled Indole-3-carboxaldehyde (I615020) which is a tryptophan (T947200) metabolite from Streptomyces staurosporeus and it is chemical constituent from Inula wissmanniana. Indole-3-carboxaldehyde and other tryptophan metabolites play an important role in mammalian gut immune homeostasis.<br>References Yang, S., et al.: J. Nat. Prod., 60, 44 (1997); Cheng, X. et al.: Chem. Nat. Compd., 49, 815 (2013); Zelante, T., et al,: Immunity, 39, 372 (2013)<br></p>

<p>Applications 4-amino-3-phenylbutanoic acid (cas# 1078-21-3) is a GABAA receptor agonist, used for treatment of disorders influenced by dysfunction of pancreatic β cells and also used in combination with other agents.<br>References Birnir, B., et al.: PCT Int. Appl. 56pp. (2019)<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Serotonin (5-hydroxytryptamine, 5-HT).<br>References Breithaupt, T., et al.: J. Exp. Biol., 202, 837 (1999), Endo, T., et al.: Toxicology, 153, 189 (2000), Sneddon, L., et al.: J. Exp. Biol., 203, 537 (2000), Stuart, J., et al.: J. Neurochem., 84, 1358 (2003),<br></p>

<p>Applications L-Serine is used in the synthesis of purines and pyrimidines as antibacterial/antifungal agents, as well as acting as a proteinogenic compound.<br>References Olivella, M. et al.: Bioorg. Med. Chem., 20, 6109 (2012);<br></p>

<p>Applications 4-(4-Chlorophenyl)-2,6-piperidinedione (cas# 84803-46-3) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Descarboxymethyl-N-carboxyethyl Lacosamide is an impurity of Lacosamide (L098500), an anticonvulsant drug that enhances sodium channel slow inactivation, and is used to treat patients with epilepsy.<br>References Doty, P., et al.: Neurotherapeutics, 4, 145 (2007); Perucca, E., et al.: Nat. Rev. Drug Discov., 7, 973 (2008); Sake, J., et al.: CNS Drugs, 24, 1055 (2010)<br></p>

<p>Stability Hygroscopic<br>Applications Biogenic polyamine formed from spermidine and occurring in almost all tissues. Essential for both normal and neoplastic tissue growth. Involved in the modulation of calcium-dependent immune processes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Israel, et al.: J. Med. Chem., 7, 710 (1964), Janne, J., et al.: Biochim. Biophys. Acta, 473, 241 (1978). Theoharides, T.C., et al.: Life Sci., 27, 703 (1980), Horn, Y., et al.: Cancer Res., 42, 3248 (1982),<br></p>

<p>Applications Indole-3-pyruvic Acid is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmental changes.<br>References Kong, W., et al.: Plant Cell Physiol, 56, 715-726 (2015)<br></p>

<p>Applications D-Lysine is the unnatural isomer of L-Lysine (L468895) that has the ability to reduce non-enzymatic glycation in vitro. D-Lysine also exists as polypeptide chains of poly-D-lysine, a nonspecific adhesion-promoting molecule that has the potential to be a polymeric drug carrier.<br>References Chen, Q., et al.: J. Biol. Chem., 269, 26602 (1994); Sensi, M., et al.: Diabetologia, 36, 797 (1993); Vermeersch, H., &amp; Remon, J.: J. Control. Rel., 32, 225 (1994)<br></p>

<p>Applications Isotope labelled Glycine is a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.<br>References Scott, D., et al.: J. Neurosci., 21, 3063 (2001), Laube, B., et al.: Neuropharmacology, 47, 994 (2004), Papadakis, M., et al.: J. Biol. Chem., 279, 14703 (2004), Chen, P., et al.: Mol. Pharmacol., 67, 1470 (2005), Wolosker, H., et al.: Mol. Neurobiol., 36, 152 (2007),<br></p>

<p>Applications α-Methyldopa Methyl Ester is an impurity in the synthesis of L-α-Methyl DOPA Methyl Ester Hydrochloride which is a Methyldopa angiotensin II analog.<br>References Karle, I., et al.: Biochemistry, 29, 6747 (1990), Biron, E., et al.: Bioorg. Med. Chem., 12, 1279 (2004),<br></p>

<p>Applications Glycine 6-Ethylchenodeoxycholate-d5 is the labelled version of Glycine 6-Ethylchenodeoxycholate (G625250) which can be used as reactant/reagent in synthetic preparation of bile acid analogs as FXR/TGR5 agonists.<br>References Or, Y., et al.: PCT Int. Appl., WO 2016073767 A1 20160512 (2016)<br></p>

<p>Applications Cadaverine is a polyamine produced by the decarboxylation of L-lysine, and is also produced by Escherichia coli (E.coli) cells when grown in acidic pH. Cadaverine is known to inhibit porin-mediated outer membrane permeability in E.coli.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mimitsuka, T., et al.: Biosci., Biotech., Bioch., 71, 2130 (2007); Sanartzidou, H., et al.: J. Bacteriol., 185, 13 (2003)<br></p>

<p>Applications A labelled, essential amino acid.<br>References Liu, F., et al.: Bioorg. Med. Chem., 18, 4167 (2010), Kumar, R., et al.: Eur. J. Med. Chem., 45, 2265 (2010), Cai, W., et al.: Bioorg. Med. Chem., 18, 1899 (2010),<br></p>