
Purines and Pyrimidine Derivatives
Purines have a bicyclic structure, consisting of a six-membered ring fused to a five-membered ring, both containing nitrogen atoms in key positions. Purine derivatives, such as adenine and guanine, are essential for the formation of DNA and RNA. These compounds have therapeutic applications in cancer and viral disease treatments by inhibiting cell replication. Pyrimidines, on the other hand, have a monocyclic six-membered structure with two nitrogen atoms. Their derivatives, such as cytosine, thymine, and uracil, are also essential components of DNA and RNA and are used in chemotherapy and antiviral treatments.
At CymitQuimica, we offer purine and pyrimidine derivatives for research in molecular biology, genomics, and the development of innovative therapies.
Found 8948 products of "Purines and Pyrimidine Derivatives"
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Methotrexate-5-monomethyl ester
CAS:<p>Methotrexate-5-monomethyl ester is an analytical standard that is synthesized synthetically. The synthetic route used to produce the compound has been optimized for high purity, making this product suitable for use as a drug product or impurity standard. The structure of methotrexate-5-monomethyl ester was confirmed by 1H and 13C NMR spectroscopy and mass spectrometry. Methotrexate-5-monomethyl ester is an impurity found in the synthesis of methotrexate and is a metabolite of methotrexate. It has been shown to inhibit DNA synthesis and protein synthesis in animal cells, which may be due to its ability to inhibit transcription factors such as NFATc1, NFkB, STAT3, STAT5A and STAT5B.</p>Formula:C21H24N8O5Purity:Min. 95%Molecular weight:468.47 g/molClopidogrel Impurity A
CAS:<p>Clopidogrel Impurity A is a medicine that is used for the prevention of heart attacks, strokes, and blood clots in people with an increased risk of these events. It is not intended to be used for immediate relief from sudden symptoms. Clopidogrel Impurity A is a substance that may be found in some preparations of clopidogrel. The presence of this substance can be detected by liquid chromatography-mass spectrometry (LC-MS/MS) methods. The structural analysis of this substance was determined using enantiomeric resolution and chromatographic methods. This impurity has been shown to have no effect on the bioavailability of the parent drug, clopidogrel, when given orally to Sprague-Dawley rats.</p>Formula:C15H15Cl2NO2SPurity:Min. 95%Molecular weight:344.26 g/molLysine-methotrexate
CAS:<p>Lysine-methotrexate is a monoclonal antibody that binds to the DNA template of Leishmania. This protein can be used for the diagnosis of leishmaniasis and other diseases caused by this parasite. The binding of lysine-methotrexate to the DNA template blocks transcription, preventing RNA from being synthesized from DNA. Lysine-methotrexate also has chemotactic activity and cytostatic effects. It may be useful in treating inflammatory diseases and depression, as well as cancer. Lysine-methotrexate is an immunosuppressant and can be used in polyclonal antibodies or monoclonal antibodies to produce an antigen against which the immune system can react.</p>Formula:C21H27N9O3Purity:Min. 95%Molecular weight:453.5 g/molAllopurinol Sodium
CAS:<p>Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.</p>Formula:C5H4N4NaOPurity:99.93%Color and Shape:SolidMolecular weight:159.1(S)-Tenofovir
CAS:<p>(S)-Tenofovir ((S)-PMPA) is the less active S-enantiomer of Tenofovir which is a nucleotide reverse transcriptase inhibitor.</p>Formula:C9H14N5O4PPurity:99.9%Color and Shape:SolidMolecular weight:287.21Palonosetron
CAS:Palonosetron, a 5-HT3 antagonist with Ki of 0.17 nM, is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).Formula:C19H24N2OPurity:98%Color and Shape:SolidMolecular weight:296.41Tenofovir diphosphate
CAS:<p>TFV-DP inhibits DNA polymerases, mimics dATP, and is used by HIV-1's reverse transcriptase.</p>Formula:C9H16N5O10P3Color and Shape:SolidMolecular weight:447.17Migalastat
CAS:<p>Migalastat (GR181413A free base) is an orally administered, competitive inhibitor of α-galactosidase A (α-Gal A), demonstrating an IC50 value of 0.04 μM against</p>Formula:C6H13NO4Color and Shape:SolidMolecular weight:163.17Neopterin
CAS:<p>D-(+)-Neopterin (D-(+)-Neopterin) is produced by human monocytes/macrophages upon stimulation with the cytokine interferon-γ.</p>Formula:C9H11N5O4Purity:99.54%Color and Shape:SolidMolecular weight:253.21OXSI-2
CAS:OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM.Formula:C18H15N3O3SPurity:98%Color and Shape:Dark Orange SolidMolecular weight:353.39Ormetoprim
CAS:Ormetoprim (Ro 5-9754), an antibiotic approved for use in the United States, is used to prevent the spread of disease in freshwater aquaculture.Formula:C14H18N4O2Purity:99.92%Color and Shape:SolidMolecular weight:274.32Tenofovir exalidex
CAS:Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistantFormula:C28H52N5O5PPurity:99.83%Color and Shape:SolidMolecular weight:569.72N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-γ-glutamyl-L-glutamic acid
CAS:<p>N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-gamma-glutamyl-L-glutamic acid is used as a research and development purity standard. It is a white crystalline powder that is soluble in water and ethanol. N-[4-[2-(2Amino 4,7dihydro 4oxo 3Hpyrrolo 2,3d]pyrimidin 5yl)ethyl]benzoyl]-L gamma glutamyl L glutamic acid has CAS number 144051 68 3. The drug product is a synthetic compound with high purity. It has been shown to be an analytical reference substance for HPLC standards and to have niche applications in metabolism studies of other drugs.</p>Formula:C25H28N6O9Purity:Min. 95%Molecular weight:556.52 g/molErgotamine Tartrate
CAS:Controlled ProductErgotamine and its saltsFormula:(C33H35N5O5)2·C4H6O6Color and Shape:White Yellow PowderMolecular weight:1162.52764N-Hydroxymethyl Sumatriptan
CAS:<p>N-Hydroxymethyl Sumatriptan is an analytical standard and a research and development impurity. It is also used as an API impurity in drug product manufacturing. N-Hydroxymethyl Sumatriptan can be synthesized by reacting the parent drug with hydroxyl radicals, which is a process that yields no side products. N-Hydroxymethyl Sumatriptan can be found in the following pharmacopoeia: United States Pharmacopoeia (USP) 11>, European Pharmacopoeia (EP), Japanese Pharmacopoeia (JP)13>, British Pharmacopoeia (BP), and Chinese Pharmacopiae (CPC).</p>Formula:C15H23N3O3SPurity:Min. 95%Molecular weight:325.43 g/molCodeine Phosphate CII
CAS:Controlled ProductConcentrates of poppy straw; buprenorphine (inn) codeinFormula:C18H21NO3·H3O4PH2OColor and Shape:White Crystalline PowderMolecular weight:406.37 g/molButalbital CIII
CAS:Controlled ProductAllobarbital (inn), amobarbital (inn), barbital (inn), butalbital (inn), butobarbital, cyclobarbital(inn), methylphenobarbital (inn), etc.Formula:C11H16N2O3Color and Shape:White PowderMolecular weight:224.11609Methotrexate-1-monomethyl ester
CAS:<p>Methotrexate-1-monomethyl ester is an impurity found in methotrexate, a drug used to treat cancer and autoimmune disorders. Methotrexate-1-monomethyl ester is a white to off-white crystalline solid that has been synthesized as a custom synthesis. It is used as an analytical standard for the determination of methotrexate in biological fluids and tissues. The chemical purity of this compound can be determined by HPLC, which allows for the identification of any impurities that may be present. Methotrexate-1-monomethyl ester is also used as a pharmacopoeia standard for methotrexate and its metabolites.</p>Formula:C21H24N8O5Purity:Min. 95%Molecular weight:468.47 g/mol1-Bromo-3,5-dimethyladamantane
CAS:Intermediate in the synthesis of memantineFormula:C12H19BrPurity:Min. 95%Molecular weight:243.18 g/molSumatriptan EP Impurity A
CAS:<p>Sumatriptan EP Impurity A is a metabolite of sumatriptan, a drug product that is used for the treatment of migraine headaches. Sumatriptan EP Impurity A is a natural metabolite of sumatriptan and has been found to be an analytical impurity in the drug product. It has been shown to have anti-inflammatory properties and may be useful for treating arthritis. This impurity can also be synthesized by chemical synthesis or recombinant DNA technology.</p>Formula:C27H37N5O2SPurity:Min. 95%Molecular weight:495.68 g/molClopidogrel EP Impurity B hydrochloride
CAS:<p>Please enquire for more information about Clopidogrel EP Impurity B hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>Formula:C16H16ClNO2S•HClPurity:Min. 95%Molecular weight:358.28 g/molFrovatriptan
CAS:Frovatriptan, potent 5-HT 1B/D agonist, shows high cerebroselectivity and efficacy for migraine with aura.Formula:C14H17N3OColor and Shape:SolidMolecular weight:243.3Miglustat hydrochloride
CAS:Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an inhibitor of glucosylceramide synthase and can be used for studies about Type I GaucherFormula:C10H22ClNO4Purity:99.85%Color and Shape:SolidMolecular weight:255.74Sumatriptan 3-hydroxy-2-oxo impurity
CAS:<p>Please enquire for more information about Sumatriptan 3-hydroxy-2-oxo impurity including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>Formula:C14H21N3O4SPurity:Min. 95%Molecular weight:327.4 g/molSorivudine
CAS:Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.Formula:C11H13BrN2O6Purity:99.74%Color and Shape:SolidMolecular weight:349.13Porphobilinogen
CAS:<p>Porphobilinogen act as a phytotoxin, a metabotoxin, and a neurotoxin.</p>Formula:C10H14N2O4Purity:98%Color and Shape:SolidMolecular weight:226.23MRS2500
CAS:MRS2500 is a highly potent and selective platelet P2Y1 receptor antagonist.Formula:C13H18IN5O8P2Purity:98%Color and Shape:SolidMolecular weight:561.161-Benzyl-5-phenylbarbituric acid, 98+%
CAS:<p>1-Benzyl-5-phenylbarbituric acid is useful as a pharmaceutical intermediate in organic synthesis. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar p</p>Formula:C17H14N2O3Purity:98+%Color and Shape:Powder, White to creamMolecular weight:294.31Ergotaminine
CAS:Alkaloids of rye ergot and their derivatives; salts thereof, nesoiFormula:C33H35N5O5Color and Shape:White Off-White Light Grey Crystalline PowderMolecular weight:581.26382Open Ring N-Methyl Clopidogrel Hydrochloride (methyl (S)-2-(2-chlorophenyl)-2-(methyl(2-(thiophen-2-yl)ethyl)amino)acetate, hydrochloride) (DISCONTINUED)
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C16H18ClNO2S·HClColor and Shape:White Off-White SolidMolecular weight:359.05136Ref: 4Z-T-3415
Discontinued productRef: 4Z-G-2434
Discontinued productRef: 4Z-P-6839
Discontinued productRef: 4Z-O-1126
Discontinued productRef: 4Z-C-1815
Discontinued productRef: 4Z-P-7153
Discontinued productRef: 4Z-O-11173
Discontinued productRef: 4Z-G-178017
Discontinued productRef: 4Z-F-3922
Discontinued productRef: 4Z-T-144031
Discontinued productRef: 4Z-I-064016
Discontinued productRef: 4Z-P-10312
Discontinued productRef: 4Z-G-178013
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Discontinued productRef: 4Z-P-7155
Discontinued productRef: 4Z-C-1358
Discontinued productRef: 4Z-O-11101
Discontinued productRef: 4Z-M-107004
Discontinued productRef: 4Z-T-8427
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Discontinued productRef: 4Z-C-13102
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Discontinued productRef: 4Z-O-0324
Discontinued productRef: 4Z-D-129017
Discontinued productRef: 4Z-G-178018
Discontinued productRef: 4Z-M-7034
Discontinued productRef: 4Z-I-064020
Discontinued product3-Des[2-(Dimethylamino)ethyl]-3-[1-methyl-1-(Methylamino)ethyl]-Almotriptan
Formula:C17H25N3O2SMolecular weight:335.47Ref: 4Z-A-056
Discontinued productRef: 4Z-T-6039
Discontinued productRef: 4Z-U-0615
Discontinued productRef: 4Z-T-3411
Discontinued productRef: 4Z-P-5325
Discontinued productRef: 4Z-O-0333
Discontinued productRef: 4Z-M-7036
Discontinued productClopidogrel Impurity 17
CAS:Formula:C7H11NOSColor and Shape:White To Off-White SolidMolecular weight:157.23Ref: 4Z-C-1346
Discontinued productRef: 4Z-N-056026
Discontinued productRef: 4Z-T-8432
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Discontinued productRef: 4Z-P-127057
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Discontinued productRef: 4Z-P-7154
Discontinued productRef: 4Z-P-10309
Discontinued productRef: 4Z-T-422
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Discontinued productRef: 4Z-O-11138
Discontinued productRef: 4Z-P-10304
Discontinued productRef: 4Z-T-4222
Discontinued product2-Fluoroacetaldehyde 2,4-Dinitrophenylhydrazone
CAS:Formula:C8H7FN4O4Color and Shape:Off-White SolidMolecular weight:242.17Ref: 4Z-P-10303
Discontinued productRef: 4Z-P-5317
Discontinued productRef: 4Z-T-02120
Discontinued productDiamino-L-Tyrosine
CAS:Formula:C9H13N3O3Color and Shape:White To Off-White SolidMolecular weight:211.22Ref: 4Z-T-144006
Discontinued productRef: 4Z-L-153058
Discontinued productRef: 4Z-S-3120
Discontinued productRef: 4Z-P-212041
Discontinued productRef: 4Z-A-6916
Discontinued productSapropterin Related Compound ((6S)-5,6,7,8-Tetrahydro-L-Biopterin Sulfate)
CAS:Formula:C9H15N5O3·H2SO4Molecular weight:241.25 98.08Ref: 4Z-S-313
Discontinued productRef: 4Z-T-0220
Discontinued productRef: 4Z-L-153027
Discontinued productRef: 4Z-E-1235
Discontinued productRef: 4Z-T-0289
Discontinued productRef: 4Z-M-3812
Discontinued productRef: 4Z-I-064019
Discontinued productTenofovir Impurity 58 ([N1,N3-15N2]) Adenine
CAS:Formula:C5H5N315N2Color and Shape:Off-White SolidMolecular weight:137.12Ref: 4Z-T-02102
Discontinued productRef: 4Z-L-123002
Discontinued productRef: 4Z-T-6057
Discontinued productRef: 4Z-O-11136
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Discontinued productRef: 4Z-L-153069
Discontinued productTemozolomide Impurity 18
CAS:Formula:C4H3N4O2·ClColor and Shape:Pale Pink SolidMolecular weight:139.09 35.45Ref: 4Z-T-3427
Discontinued productRef: 4Z-P-127005
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Discontinued productRef: 4Z-U-069
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Discontinued productRef: 4Z-U-0649
Discontinued productSodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
CAS:Purity:95.0%Molecular weight:367.16101074218754-Chloro-2-fluoropyrimidine
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:132.52000427246094Ref: 10-F326777
Discontinued productN-Des[1-(3-methoxypropyl)-4-piperidinyl] Prucalopride
CAS:Controlled Product<p>Applications N-Des[1-(3-methoxypropyl)-4-piperidinyl] Prucalopride is an impurity of Prucalopride (P838950), a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe.<br>References Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008), McKinnell, R., et al.: J. Med. Chem., 52, 5330 (2009), Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008),<br></p>Formula:C9H9ClN2O2Color and Shape:NeatMolecular weight:225.3831-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylic acid
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:170.12399291992188Ref: 10-F313154
Discontinued productmethyl 2-amino-6-[4-(trifluoromethyl)pyrimidin-2-yl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
Molecular weight:358.3399963378906Ref: 10-F478254
Discontinued product4-(DIMETHOXYMETHYL)-2-(TRIFLUOROMETHYL)PYRIMIDINE
CAS:Purity:97.0%Molecular weight:222.16700744628906(S)-2-(1-((9H-Purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:415.4320068359375








