Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65630 products of "Quinazoline and Quinoline Derivatives"
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6-(Naphthalen-2-yl)-5-(pyridin-4-yl)pyridazin-3(2H)-one
CAS:Purity:95.0%Molecular weight:299.3330078125rac Kynurenine
CAS:Controlled Product<p>Applications A tryptophan metabolite, is a precursor of kynurenic acid, which is an antagonist of N-methyl-aspartate receptor. An amino acid produced in the body from tryptophan.<br>References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990), Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003), Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003), Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007),<br></p>Formula:C10H12N2O3Color and Shape:NeatMolecular weight:208.21Lenalidomide Lactosamine Adduct
Controlled Product<p>Stability Hygroscopic<br>Applications Lenalidomide Lactosamine Adduct is a derivative of Lenalidomide (L328000), an oral immunomodulatory agent for the management of myelodysplastic syndromes.<br>References Bartlett, J.B., et al.: Nature Rev., 4, 314 (2004); Mitsiades, C.S., et al.: Curr. Opin. Invest. Drugs, 5, 635 (2004); List, A., et al.: N. Engl. J. Med., 352, 549 (2005)<br></p>Formula:C25H33N3O13Color and Shape:NeatMolecular weight:583.54Reserpine-d9
CAS:Controlled Product<p>Applications Labelled Reserpine (R144600). An indole alkaloid found in Rauwolfia serpentina. Inhibits vesicular uptake of catecholamines and serotonin. Reserpine is reasonably anticipated to be a human carcinogen. Antihypertensive.<br>References Muller, J.M., et al.: Experientia, 8, 338 (1952), Schirmer, R.E., et al.: Anal. Profiles Drug Subs., 4, 384 (1975), Diener, R.M., et al.: Toxicol. Pathol., 8, 1 (1980),<br></p>Formula:C332H9H31N2O9Color and Shape:NeatMolecular weight:617.731-Cyclopropylmethyl-1H-pyrazole-4-carboxylic acid
CAS:Color and Shape:Solid, White solidMolecular weight:166.17999267578125Trametinib
CAS:Controlled Product<p>Applications Used in the systematic treatment of advanced cutaneous melanoma. An EGFR kinase inhibitor and potent MEK inhibitor.<br>References Ercan, D. et al.: Canc. Disc., 2, 934 (2012); Mackiewicz-Wysocka, M. et al.: Exp. Opin. Investig. Drugs., 22, 181 (2013);<br></p>Formula:C26H23FIN5O4Color and Shape:Off-WhiteMolecular weight:615.39Alogliptin-d3
CAS:Controlled Product<p>Applications Labelled Alogliptin (A575425). It is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Antidiabetic agent.<br>References Lynn, F., et al.: Diabetes, 50, 1004 (2001), Trumper, A., et al.: J. Endocrinol., 174, 233 (2002), Vollmer, K., et al.: J. Clin. Endocrinol. Metab., 94, 1379 (2009),<br></p>Formula:C182H3H18N5O2Color and Shape:NeatMolecular weight:342.41Ondansetron Hydrochloride Dihydrate
CAS:Formula:C18H19N3O·ClH·2H2OColor and Shape:Off-WhiteMolecular weight:365.856-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione
CAS:Purity:98%Molecular weight:230.14599609375Trimetazidine Dihydrochloride
CAS:Controlled Product<p>Applications Coronary vasodilator. Antianginal.<br>References Fujita, et al.: Jpn. J. Pharmacol., 17, 19 (1967), Harpey, C., et al.: Cardiovasc. Drug Rev., 6, 292 (1989),<br></p>Formula:C14H22N2O3·2ClHColor and Shape:Off WhiteMolecular weight:339.26N-Desmethyl Asenapine Hydrochloride
CAS:<p>Applications Asenapine (A788000) metabolite.<br>References Lobell, M., et al.: J. Pharm., Sci., 92, 360 (2003), Zhang, L., et al.: Pharm. Res., 25, 1902 (2008), Toulmin, A., et al.: J. Med. Chem., 51, 3720 (2008),<br></p>Formula:C16H14ClNO·ClHColor and Shape:NeatMolecular weight:308.20Tilidine Impurity D Hydrochloride
CAS:Controlled Product<p>Applications Tilidine Impurity D Hydrochloride is an imourity of Tilidine, which is a controlled substance (opiate). Analgesic. It is used in clinical trial in comparison with Nefopam. Tilidine is one of the most widely used narcotics in Germany and Belgium.<br>References Vollmer, K.-O., et al.: Arzneim.-Forsch., 20, 990 (1970), Abeloos, J., et al.: Acta Anaesthesiol. Belg., 34, 283 (1983), Van Cauwenberge, H., et al.: Int. J. Clin. Pharmacol. Res., 12, 1 (1992),<br></p>Formula:C13H19NO2·ClHColor and Shape:NeatMolecular weight:257.76[4-(5-pyridin-3-yl-1H-1,2,4-triazol-3-yl)phenyl]amine
CAS:Purity:95.0%Molecular weight:237.26600646972656Vismodegib
CAS:Controlled Product<p>Applications Vismodegib targets the Hedgehog (Hh) pathway. Inhibition of the Hh signaling may be effective in the treatment and prevention of many types of human cancers. Potent Hedgehog inhibitor.<br>References Gupta, S. et al.: Ther. Advances in Med. Oncology 2,237(2010)<br></p>Formula:C19H14Cl2N2O3SColor and Shape:Off-WhiteMolecular weight:421.30Alfuzosin
CAS:<p>Alfuzosin (SL 77499) is an alpha-1 adrenergic antagonist used to treat benign prostatic hypertrophy and urethral dysfunction.</p>Formula:C19H27N5O4Purity:99.64%Color and Shape:White Crystaline PowderMolecular weight:389.45Diminazene-13C2,15N4 Dihydrochloride (major)
CAS:<p>Applications Labelled Diminazene (D479550). Antiprotozoal (Trypanosoma, Babesia).<br>References Braithwaite, A.W.<br></p>Formula:C1213C2H17Cl2N315N4Color and Shape:Yellow To Dark YellowMolecular weight:360.2Dolutegravir Sodium
CAS:<p>Applications Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.<br>References Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011)<br></p>Formula:C20H18F2N3O5·NaColor and Shape:NeatMolecular weight:441.36Nimodipine
CAS:<p>Applications A dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral). Neuroprotective & Neuroresearch products.<br>References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),<br></p>Formula:C21H26N2O7Color and Shape:NeatMolecular weight:418.44Levofloxacin-d3 Sodium Salt
CAS:Controlled Product<p>Applications Levofloxacin-d3 Sodium Salt, is the labeled analogue of Levofloxacin (L360000), an antibiotic used against gram-negative organisms.<br>References Kato, M., et al.: Arzneim.-Forsch., 42, 365 (1992), North, D.S., et al.: Pharmacotherapy, 18, 915 (1998), Hwang, D.G., et al.: Br. J. Ophthalmol., 87, 1004 (2003),<br></p>Formula:C18H16D3FN3NaO4Color and Shape:NeatMolecular weight:386.376-Benzyloxy-7-methoxy-2-methyl-quinoline-3-carboxylic acid p-tolylamide
Purity:95.0%Molecular weight:412.4890136718752-Phenylbutyric Acid
CAS:Controlled ProductFormula:C10H12O2Color and Shape:White To Off-WhiteMolecular weight:164.21-(tert-Butoxycarbonyl)-4-(1H-pyrazol-1-yl)piperidine-4-carboxylic acid
CAS:Purity:95%Molecular weight:295.3389892578125[4-(difluoromethyl)-3-methyl-6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid
CAS:Purity:95.0%Molecular weight:321.28799438476564-Chloro-2-(4-chlorobenzoyl)-1-(4-methoxyphenyl)hydrazide Benzoic Acid
CAS:<p>Applications An impurity of the anti-inflammatory drug indomnethacin (I641000). Indomethacin inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.<br>References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)<br></p>Formula:C21H16Cl2N2O3Color and Shape:NeatMolecular weight:415.27Diethyl (S)-(2-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate
CAS:Purity:98%Molecular weight:552.91998291015622-methyl-4-(2-(4-phenylcyclohexylidene)hydrazinyl)quinoline hydrochloride
CAS:Purity:95.0%Molecular weight:365.91000366210942-(2,4-Dimethoxybenzoyl)-5-(1,3-dioxolan-2-yl)thiophene
CAS:Purity:97.0%Molecular weight:320.3599853515625N-Chloro Ethyl ThioTEPA
CAS:Controlled Product<p>Stability Hygroscopic, Moisture Sensitive<br>Applications N-Chloro Ethyl ThioTEPA is an impurity of ThioTEPA which is an alkylating agent used to treat cancer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Maanen, M., et al.: Cancer Treatment Rev., 26, 257 (2000); Sykes, M., et al.: Cancer, 6, 142 (1953)<br></p>Formula:C6H13ClN3PSColor and Shape:White To Off-WhiteMolecular weight:225.682-Amino-5-methylthiazole
CAS:Controlled Product<p>Impurity Meloxicam EP Impurity B<br>Applications 2-Amino-5-methylthiazole (Meloxicam EP Impurity B) is an aminothiazole derivative used in characterization and DNA-interaction studies via formation of metal complexes that bind competitively to DNA. 2-Amino-5-methylthiazole can be used in solar cells to influence the interaction with the TiO2 photoelectrode, which in turn alters the dye-sensitized solar cell performance.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kusama, H. et al.: Sol. Energy Mat. Sol. Cells, 82, 457 (2004); Cox, P.J. et al.: Bioorg. Med. Chem., 17, 6054 (2009);<br></p>Formula:C4H6N2SColor and Shape:Brown To Dark BrownMolecular weight:114.17Ondansetron
CAS:Controlled Product<p>Applications Ondansetron is a specific serotonin (5-HT3) receptor antagonist. Antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988); Faris, P..L., et al.: Lances, 355, 792 (2000)<br></p>Formula:C18H19N3OColor and Shape:White To Light BeigeMolecular weight:293.36Benzocaine
CAS:Controlled Product<p>Applications Benzocaine is used as an anesthetic (local).<br>References Kholod, Y., et al.: Environ. Sci. Technol., 43, 9208 (2009), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Perez-Garrido, Alfonso; Helguera, A., et al.: J. Pharm. Sci., 98, 4557 (2009), Onoue, S., et al.: J. Pharm. Sci., 98, 3647 (2009),<br></p>Formula:C9H11NO2Color and Shape:NeatMolecular weight:165.19Oxethazaine
CAS:Oxethazaine (Oxetacaine), a topical anesthetic, is used to prevent acid-induced esophageal pain.Formula:C28H41N3O3Purity:99.875% - 99.94%Color and Shape:Physical Description White Powder (Ntp 1992)Molecular weight:467.64Retigabine N-β-D-Glucuronide Sodium Salt
CAS:Controlled Product<p>Applications Sodium salt of Retigabine N-β-D-Glucuronide is the major metabolite of the antiepileptic drug Retigabine (R189050) that is produced via N-glucuronidation in humans.<br>References Hiller, A. et al.: Drug Metab. Dispos., 27, 605 (1999); Borlak, J. et al.: Metab. Clin. Exp., 55, 711 (2006); McNeilly, P.P. et al.: Zenobiotica, 27, 431 (1997);<br></p>Formula:C22H25FN3NaO8Color and Shape:NeatMolecular weight:501.445-Hydroxy Omeprazole (~5% Triethylamine as stabilizer)
CAS:<p>Stability Hygroscopic, Temperature Sensitive<br>Applications 5-Hydroxy Omeprazole is the main metabolite of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>Formula:C17H19N3O4SColor and Shape:NeatMolecular weight:361.424-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-[4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]phenyl]-1-butanone
CAS:<p>Applications 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-[4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]phenyl]-1-butanone is an impurity of Haloperidol (H103700), an antipsychotic agent.<br>References Morris, A.P., et al.: Drug. Meta. Lett., 2, 275 (2008); Morris, A.P., et al.: Int. J. Pharma., 367, 44 (2009);<br></p>Formula:C32H36Cl2N2O3Color and Shape:NeatMolecular weight:567.55Ref: 10-F340506
1gTo inquire5gTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire250mgTo inquire(6-bromo-2-methoxyquinolin-3-yl)(3-chloro-4-fluorophenyl)methanol
CAS:Purity:95.0%Molecular weight:396.6400146484375Risperidone N-Oxide
CAS:Controlled Product<p>Applications Risperidone (R525000) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References El-Sherif, Z., et al.: J. Pharm. Biomed. Anal., 36, 975 (2005), Sattanathan, P., et al.: J. Pharm. Biomed. Anal., 40, 598 (2006),<br></p>Formula:C23H27FN4O3Color and Shape:WhiteMolecular weight:426.48
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