Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65924 products of "Quinazoline and Quinoline Derivatives"
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Desmethyl 2N-Nitroso Mirtazapine-d6 (major)
Controlled ProductFormula:C16D6H10N4OColor and Shape:Neat6-chloro-2-(4-methylphenyl)quinoline-4-carboxylic acid
CAS:Purity:95.0%Molecular weight:297.739990234375p-Nicorandil
CAS:<p>Applications A positional isomeric impurity of the antianginal Nicorandil (N398500).<br>References Fedorov, B.S. et al.: Pharmac. Chem. J., 43, 134 (2009); Tatyanenko, L.V. et al.: Biomed. Khim., 52, 174 (2006);<br></p>Formula:C8H9N3O4Color and Shape:BeigeMolecular weight:211.17(4S)-4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Monomethyl Ester
CAS:Controlled ProductFormula:C16H15Cl2NO4Color and Shape:NeatMolecular weight:356.201Nilotinib-d3
CAS:Controlled Product<p>Applications Labelled analog of Nilotinib (AMN1O7), which might be useful in treatment of chronic myelogenous leukemia. It is a COVID19-related research product.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>Formula:C282H3H19F3N7OColor and Shape:Off-White To Light YellowMolecular weight:532.53N-Nitrosoephedrine
CAS:Controlled ProductFormula:C10H14N2O2Color and Shape:NeatMolecular weight:194.23Danofloxacin
CAS:<p>Applications Danofloxacin is a broad spectrum fluoroquinolone antibacterial compound.<br>References Golet, E., et al.: Anal. Chem., 73, 3632 (2001); Golet, E., et al.: Environ. Sci. Technol., 36, 3645 (2002); Huet, A., et al.: J. Agric. Food Chem., 54, 2822 (2006);<br></p>Formula:C19H20FN3O3Color and Shape:Off-WhiteMolecular weight:357.384,5-Dichloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
CAS:<p>Applications 4,5-Dichloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide is an impurity of Rivaroxaban (R538000), a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C19H17Cl2N3O5SColor and Shape:NeatMolecular weight:470.33Dibenzazepine-10,11-dione
CAS:Controlled Product<p>Applications Dibenzazepine-10,11-dione is an impurity of Oxcarbazepine (O869250). Dibenzazepine-10,11-dione is used as a reagent in the preparation of bifunctional dipolar electroluminescent template for optoelectronic applications.<br>References Chen, C.-T. et al.: Chem. Comm., 31, 3980 (2005); Heckendorn, R. et al.: Helv, Chim. Acta, 70, 1955 (1987);<br></p>Formula:C14H9NO2Color and Shape:NeatMolecular weight:223.23Norneo Vardenafil
CAS:Controlled Product<p>Applications Norneo Vardenafil is a related compound of Vardenafil (V098001) as phosphodiesterase inhibitor.<br></p>Formula:C18H20N4O4Color and Shape:Off White SolidMolecular weight:356.38Acetyl Isoniazid-d4
CAS:Controlled Product<p>Applications A labelled metabolite of Isoniazid (I821450) in plasma.<br>References Peloquin, C., et al.: Antimicrob. Agents Chemother., 41, 2670 (1997), Peloquin, C., et al.: Drugs, 62, 2169 (2002),<br></p>Formula:C8H5D4N3O2Color and Shape:Off-WhiteMolecular weight:183.2Isoleucine Valsartan
CAS:<p>Applications Isoleucine Valsartan is a Valsartan (V095750) impurity. Valsartan is A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Formula:C25H31N5O3Color and Shape:NeatMolecular weight:449.554-Dechloro-4-hydroxy Diclazuril
CAS:<p>Applications 4-Dechloro-4-hydroxy Diclazuril is an impurity of Diclazuril (D436200), a nucleotide analog with broad-spectrum anticoccidial activity.<br>References Fodey, T.L., et al.: J. Immunol. Meth., 323, 31 (2007);<br></p>Formula:C17H10Cl2N4O3Color and Shape:NeatMolecular weight:389.19(R)-2-((4-Aminophenethyl)amino)-1-phenylethanol Hydrochloride
CAS:Controlled ProductFormula:C16H21ClN2OColor and Shape:NeatMolecular weight:292.8Levosimendan Triazene Impurity
CAS:<p>Stability Light Sensitive<br>Applications Levosimendan Triazene is an impurity of Levosimendan (L378000); a positive inotropic agent with vasodilating activity. Also cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995); Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996)<br></p>Formula:C22H23N7O2Color and Shape:NeatMolecular weight:417.46Haloperidol Hydrochloride
CAS:Controlled ProductFormula:C21H23ClFNO2·HClColor and Shape:NeatMolecular weight:412.325Clofedanol Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A centrally-acting cough suppressant. It has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.<br>References Yuizono, T., et al.: Yakugaku Zasshi, 87, 915 (1967), Nomura, A., et al.: Oyo Yakuri, 8, 119 (1974),<br></p>Formula:C17H20ClNO·ClHColor and Shape:White To Off-WhiteMolecular weight:326.26Abemaciclib-d5
CAS:Controlled ProductFormula:C27D5H27F2N8Color and Shape:NeatMolecular weight:511.624Carvedilol-d5
CAS:Controlled Product<p>Applications Carvedilol-d5 is the labelled analog of Carvedilol, a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990), Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996),<br></p>Formula:C24H21D5N2O4Color and Shape:NeatMolecular weight:411.51Olanzapine - d8
CAS:Controlled ProductFormula:C172H8H12N4SColor and Shape:NeatMolecular weight:320.482-[3,5-Dichloro-4-(4-chlorobenzoyl)phenyl]-1,2,4-triazine-3,5(2H,4H)-dione
CAS:Controlled Product<p>Applications An anticoccidal triazine used for the treatment of coccidiosis in chickens. An impurity of Diclazuril (D436200).<br>References McFarland, J. et al.: J. Med. Chem., 35, 2543 (1992);<br></p>Formula:C16H8Cl3N3O3Color and Shape:NeatMolecular weight:396.61O-Desethyl Dapagliflozin tetraacetate)
CAS:<p>Applications Empagliflozin Tetraacetate is an Empagliflozin (E521510) impurity and is a reagent used to design and synthesize nitric oxide releasing derivatives of dapagliflozin which has potential antidiabetic and antithrombotic agents.<br>References Zheng, L., et al.: Bioorg. Med. Chem., 26, 3947 (2018)<br></p>Formula:C27H29ClO10Color and Shape:White To Off-WhiteMolecular weight:548.97Triallate
CAS:Controlled Product<p>Applications Triallate is a pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schneider, M., et al.: J. Environ. Qual., 42, 844 (2013); Busi, R., et al.: Pest Manag. Sci., 69, 1379 (2013)<br></p>Formula:C10H16Cl3NOSColor and Shape:Light Brown To BrownMolecular weight:304.66N-Desmethyl Regorafenib (Pyridine)-N-oxide
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications N-Desmethyl Regorafenib (Pyridine)-N-oxide is a synthetic metabolite of Regorafenib (R143000) and is used for treatment and prevention of cancer.<br>References Wilhelm, S.: PCT Int. Appl. WO 2011130728 A1 20111020. Oct 20, 2011<br></p>Formula:C20H13ClF4N4O4Color and Shape:NeatMolecular weight:484.792-Amino-5-methylpyridine
CAS:Controlled Product<p>Applications 2-Amino-5-methylpyridine (cas# 1603-41-4) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Francotte, P., et al.: Bioorg. Med. Chem., 16, 9948 (2008), Sundaraganesan, N., et al.: J. Mol. Struc., 891, 284 (2008), Caleta, I., et al.: J. Med. Chem., 52, 1744 (2009),<br></p>Formula:C6H8N2Color and Shape:NeatMolecular weight:108.14Cimetidine Sulfoxide
CAS:Controlled Product<p>Impurity Cimetidine EP Impurity E<br>Applications Cimetidine Sulfoxide (Cimetidine EP Impurity E) is a metabolite of the H2-receptor antagonist Cimetidine (C441650). Cimetidine Sulfoxide is detected in the blood and urine of patients with kidney diseases.<br>References Luksa, J. et al.: J. Chrom. B Biomed. Appl., 667, 321 (1995); Lee, R.M. et al.: J. Chrom. Biomed. Appl., 146, 354 (1978);<br></p>Formula:C10H16N6OSColor and Shape:NeatMolecular weight:268.34Methylfelbamate
CAS:Controlled Product<p>Applications Methylfelbamate is a methyl impurity of felbamate (F231000), which is antiepileptic, structurally similar to meprobamate.<br>References Swinyard, E.A., et al.: Epilepsia, 27, 27 (1986), Remmel, R.P., et al.: Ther. Drug Monit., 12, 90 (1990), Sofia, R.D., et al.: Epilepsy Res. Suppl., 3, 103 (1991),<br></p>Formula:C12H16N2O4Color and Shape:NeatMolecular weight:252.274-Chloro-2-(4-chlorobenzoyl)-1-(4-methoxyphenyl)hydrazide Benzoic Acid
CAS:<p>Applications An impurity of the anti-inflammatory drug indomnethacin (I641000). Indomethacin inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.<br>References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)<br></p>Formula:C21H16Cl2N2O3Color and Shape:NeatMolecular weight:415.27Levofloxacin-d3 Sodium Salt
CAS:Controlled Product<p>Applications Levofloxacin-d3 Sodium Salt, is the labeled analogue of Levofloxacin (L360000), an antibiotic used against gram-negative organisms.<br>References Kato, M., et al.: Arzneim.-Forsch., 42, 365 (1992), North, D.S., et al.: Pharmacotherapy, 18, 915 (1998), Hwang, D.G., et al.: Br. J. Ophthalmol., 87, 1004 (2003),<br></p>Formula:C18H16D3FN3NaO4Color and Shape:NeatMolecular weight:386.372-METHOXY-5-(5-(PYRIDIN-4-YL)-1H-BENZO[D]IMIDAZOL-1-YL)PHENOL
CAS:Purity:95.0%Molecular weight:317.3479919433594Omeprazole-d3 (benzimidazole-4,6,7-d3)
CAS:Controlled Product<p>Applications Omeprazole-d3 (benzimidazole-4,6,7-d3) (CAS# 934293-92-2) is a useful isotopically labeled research compound.<br></p>Formula:C17H16D3N3O3SColor and Shape:Light BrownMolecular weight:348.4410,11-Dihydro-10-hydroxy Carbamazepine-d3
CAS:Controlled Product<p>Applications A labelled metabolite of Oxcarbazepine (O869250).<br>References Burkhart, C., et al.: Clin. Exp. Allergy, 32, 1635 (2002), Pearce, R., et al.: Drug Metab. Dispos., 30, 1170 (2002), Naisbitt, D., et al.: Mol. Pharmacol., 63, 732 (2003), Farrell, J., et al.: Br. J. Clin. Pharmacol., 57, 690 (2004),<br></p>Formula:C152H3H11N2O2Color and Shape:Off WhiteMolecular weight:257.30Vortioxetine Sulfone
CAS:<p>Applications Vortioxetine Sulfone is a derivative of Vortioxetine (V766000), a multimodal serotonergic agent that inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT (1,2,3).<br>References Paunovic, A. et al.: ACS Chem. Biol., 12, 132 (2017);<br></p>Formula:C18H22N2O2SColor and Shape:NeatMolecular weight:330.44Empagliflozin α-Anomer
CAS:Controlled ProductFormula:C23H27ClO7Color and Shape:White To Off-WhiteMolecular weight:450.909Levetiracetam-d3
CAS:Controlled ProductFormula:C8H11D3N2O2Color and Shape:White To Off-WhiteMolecular weight:173.23N-Demethyl Ondansetron
CAS:<p>Applications A metabolite of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bayliss, M., et al: Xenobiotica, 24, 231 (1994), Atkins, W., et al.: J. Biol. Chem., 277, 33258 (2002), De Graaf, I., et al.: Drug Metab. Dispos., 30, 1129 (2002),<br></p>Formula:C17H17N3OColor and Shape:White To BrownMolecular weight:279.34Dimethylaminomethylfurylmethylthioethyl Ranitidine
CAS:Controlled Product<p>Impurity Ranitidine EP impurity A<br>Applications Dimethylaminomethylfurylmethylthioethyl Ranitidine (Ranitidine EP impurity A) is a Ranitidine (R120000) impurity.<br>References Evans, M., et al.: J. Pharm. Biomed. Anal., 7, 1 (1989), Mellors, J., et al.: Anal. Chem., 76, 5441 (2004),<br></p>Formula:C22H35N5O4S2Color and Shape:NeatMolecular weight:497.675-Methyl-2-phenoxypyridine
CAS:Controlled ProductFormula:C12H11NOColor and Shape:NeatMolecular weight:185.23Dolutegravir Sodium
CAS:<p>Applications Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.<br>References Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011)<br></p>Formula:C20H18F2N3O5·NaColor and Shape:NeatMolecular weight:441.36Diminazene-13C2,15N4 Dihydrochloride (major)
CAS:<p>Applications Labelled Diminazene (D479550). Antiprotozoal (Trypanosoma, Babesia).<br>References Braithwaite, A.W.<br></p>Formula:C1213C2H17Cl2N315N4Color and Shape:Yellow To Dark YellowMolecular weight:360.2Tilidine Impurity D Hydrochloride
CAS:Controlled Product<p>Applications Tilidine Impurity D Hydrochloride is an imourity of Tilidine, which is a controlled substance (opiate). Analgesic. It is used in clinical trial in comparison with Nefopam. Tilidine is one of the most widely used narcotics in Germany and Belgium.<br>References Vollmer, K.-O., et al.: Arzneim.-Forsch., 20, 990 (1970), Abeloos, J., et al.: Acta Anaesthesiol. Belg., 34, 283 (1983), Van Cauwenberge, H., et al.: Int. J. Clin. Pharmacol. Res., 12, 1 (1992),<br></p>Formula:C13H19NO2·ClHColor and Shape:NeatMolecular weight:257.76N-Methyl Pantoprazole(Mixture of 1 and 3 isomers)
CAS:<p>Impurity Pantoprazole EP Impurity D;<br>Applications N-Methyl Pantoprazole (Pantoprazole EP Impurity D) is an impurity of Omeprazole and Pantoprazole. Mixture of 1 and 3 isomers (mixture of impurity D and F).<br>References McClean, S., et al.: Anal. Chim. Acta, 292, 81 (1994), Besancon, M., et al.: J. Biol. Chem., 272, 22438 (1997), Avgerinos, A., et al.: Eur. J. Drug Metab. Pharmacokinet., 23, 329 (1998), Wahbi, A., et al.: J. Pharm. Biomed. Anal., 30, 1133 (2002),<br></p>Formula:C17H17F2N3O4SColor and Shape:Light RedMolecular weight:397.40
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