Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65578 products of "Quinazoline and Quinoline Derivatives"
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rac-trans-Ambroxol-d5
CAS:Controlled Product<p>Applications A labelled metabolite of Bromohexine. Ambroxol Hydrochloride is a bronchosecretolytic drug.<br>References Jauch, R., et al.: Arzneim-Forsch., 13, 474 (1963)<br></p>Formula:C13H13D5Br2N2OColor and Shape:NeatMolecular weight:383.13Meloxicam
CAS:<p>Applications Preferential cyclooxygenase (COX-2) inhibitor. Sudoxicam and Meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs) from the enol-carboxamide class.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hawkey, C., et al.: Br. J. Rheumatol., 35, Suppl. 1, 1 (1996), Fleischmann, R., et al.: Expert Opin. Pharmacother., 3, 1501 (2002),<br></p>Formula:C14H13N3O4S2Color and Shape:Light YellowMolecular weight:351.40Risperidone EP Impurity J
CAS:<p>Impurity Risperidone EP Impurity J<br>Applications 3-[2-[4-[(Z)-(4-Fluoro-2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)phenyl](hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (Risperidone EP Impurity J) is a Risperidone (R525000) impurity.<br></p>Formula:C35H40F2N6O3Color and Shape:White To YellowMolecular weight:630.72732-(1-Nitroso-4-piperidinyl)-1H-benzimidazole
CAS:Controlled ProductFormula:C12H14N4OColor and Shape:NeatMolecular weight:230.266(S)-(-)-4’-Hydroxyphenyl Carvedilol
CAS:Controlled Product<p>Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α1-blocking activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),<br></p>Formula:C24H26N2O5Color and Shape:NeatMolecular weight:422.47Iso Sildenafil
CAS:Controlled Product<p>Applications Iso Sildenafil is the isomer of Sildenafil methylated at N-2 position of the pyrazolo[4,3-d]pyrimidin-7-one nucleus.<br>References Sheldrick, G., et al.: Acta Crystallogr., A46, 467 (1990), Terrett, N., et al.: Bioorg. Med. Chem. Lett., 6, 1819 (1996),<br></p>Formula:C22H30N6O4SColor and Shape:NeatMolecular weight:474.582-Amino-4-thiazoleacetic Acid
CAS:Controlled ProductFormula:C5H6N2O2SColor and Shape:NeatMolecular weight:158.18Levomepromazine EP Impurity D
Controlled ProductFormula:C32H33N3O2S2Color and Shape:NeatMolecular weight:555.81-(3-Cyano-2-pyridyl)-4-methyl-2-phenylpiperazine
CAS:<p>Applications Used in the preparation of Mirtazapine (M365000) impurities.<br></p>Formula:C17H18N4Color and Shape:Light Yellow To BrownMolecular weight:278.35(2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications (2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile is a key intermediate for dipeptidyl peptidase IV inhibitor Vildagliptin (V305000).<br>References Singh, S.K., et al.: Beil. J. Org. Chem., 4, 20 (2008);<br></p>Formula:C7H9ClN2OColor and Shape:NeatMolecular weight:172.614’-O-Benzyloxy Ezetimibe
CAS:Controlled Product<p>Impurity Ezetimibe Benzyl Ether Impurity<br>Applications Protected Ezetimibe, used for the synthesis of related derivatives.<br>References Raman, B., et al.: J. Pharm. Biomed. Anal., 52, 73 (2010),<br></p>Formula:C31H27F2NO3Color and Shape:NeatMolecular weight:499.55N-Desmethyl Diphenhydramine Hydrochloride
CAS:<p>Applications N-Desmethyl Diphenhydramine is an impurity of Diphenhydramine (D486900) with antihistaminic activity.<br>References Nauta, W. T. et al.: Med. Chem., Spec. Contrib. Int. Symp., 3rd, 125 (1973);<br></p>Formula:C16H19NO·ClHColor and Shape:White To Light BeigeMolecular weight:277.79Iso Loratadine
CAS:Controlled Product<p>Impurity Loratadine EP Impurity E<br>Applications Iso Loratadine (Loratadine EP Impurity E) is a Loratadine (L469575) impurity. An isomer of Loratadine used for preparation of tricyclic amides and ureas useful for inhibition of G-protein function and for treatment of proliferative diseases.<br>References Billah., et al.: Lipids, 26, 1172 (1991), Piwinski., et al.: J. Med. Chem., 34, 457 (1991),<br></p>Formula:C22H23ClN2O2Color and Shape:NeatMolecular weight:382.88Minoxidil Sulfate-d10
CAS:Controlled Product<p>Stability Light Sensitive - Protect from Light, Store in Freezer<br>Applications Labelled Minoxidil sulfate (M345100). Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14µM) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener.<br>References Nakaya, Y., et al.: J. Dermatol. Sci., 7 (Suppl.), S104-S108 (1994), Ohtsuyama, M., et al.: J. Pharmacol. Exp. Ther., 269(2), 823 (1994), Andersson, K.E., et al.: Pharmacol. Toxicol., 70, 244 (1992), Bray, K.M., et al.: J. Biol. Chem., 267, 11689 (1992), Saitoh, M. et al.: Biochem. Biophys. Res. Commun., 140, 280 (1986)<br></p>Formula:C9H5D10N5O4SColor and Shape:NeatMolecular weight:299.372-(Aminomethyl)-1-ethylpyrrolidine
CAS:Controlled ProductFormula:C7H16N2Color and Shape:Colourless To Light YellowMolecular weight:128.222-Nitrobenzaldehyde
CAS:<p>Applications 2-Nitrobenzaldehyde is a benzaldhyde with a nitro group substituted in the ortho position. 2-Nitrobenzaldehyde is used in the preparation of dyes and colorants such as Indigo carmine. 2-Nitrobenzaldehyde gas been shown to be a useful photoremovable protecting group as well as in the preparation of more effective ones such as o-Nitrophenylethylene glycol.<br>References Gravel, D. et al.: Can. J. Chem., 61, 400 (1983); Sebej, P. et al.: J. Org. Chem., 74, 8647 (2009); Das, A. et al.: J. Ind. Che,. Soc., 49, 993 (1972);<br></p>Formula:C7H5NO3Color and Shape:NeatMolecular weight:151.129-Piperazino Levofloxacin Impurity
CAS:Controlled Product<p>Applications A degradation product of Levofloxacin (L360000). Levofloxacin impurity.<br>References ierens, C., et al.: J. Pharm. Biomed. Anal., 22, 763 (2000), Kitade, T., et al.: Chem. Pharm. Bull., 51, 53 (2003), Liang, Y., et al.: Anal. Chim. Acta, 510, 21 (2004),<br></p>Formula:C18H20FN3O4Color and Shape:NeatMolecular weight:361.3685-Hydroxy Omeprazole-d3 Sodium Salt
CAS:Controlled ProductFormula:C17H15D3N3NaO4SColor and Shape:White To Light YellowMolecular weight:386.42Gabapentin-d4
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.<br>References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>Formula:C9D4H13NO2Color and Shape:Off-WhiteMolecular weight:175.26Celecoxib
CAS:Controlled Product<p>Applications Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.Celecoxib is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain. Celecoxib is also used in the treatment of hereditary polyps in the colon<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>Formula:C17H14F3N3O2SColor and Shape:NeatMolecular weight:381.37Dolutegravir O-b-D-Glucuronide Sodium salt
Formula:C26H26F2N3NaO11Color and Shape:White To Off-WhiteMolecular weight:617.49(S)-Naproxen
CAS:<p>Applications (S)-Naproxen is a a nonsteroidal anti-inflammatory compound with analgesic and antipyretic properties (1,2). (S)-Naproxen is also a potent COX1 inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Harrison, I.T., et al.: J. Med. Chem., 13, 203 (1970)(2) Scott, W. W., et al.: World Neurosurg. 82, e633 (2014)<br></p>Formula:C14H14O3Color and Shape:Off-WhiteMolecular weight:230.266-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
CAS:Controlled Product<p>Applications An Intermediate in the synthesis of risperidone and iloperidone.<br></p>Formula:C12H13FN2OColor and Shape:NeatMolecular weight:220.245-Aminoimidazole-4-carboxamide
CAS:<p>Applications A metabolite of Temozolomide.<br>References Jaeken, J., et al.: Lancet, 2, 1058 (1984), Baggott, J., et al.: Biochem. J., 236, 193 (1986), Baggott, J., et al.: Arch. Dermatol., 135, 813 (1999),<br></p>Formula:C4H6N4OColor and Shape:White To Off-WhiteMolecular weight:126.122,2'-Dithiobis[N-methyl-benzamide]
CAS:<p>Applications Benzamide, 2,2'-dithiobis[N-methyl- (cas# 2527-58-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C16H16N2O2S2Color and Shape:Light Yellow To Light BeigeMolecular weight:332.444-Anilino-4-oxobutanoic Acid
CAS:Controlled Product<p>Applications The metabolite (MII) of Suberoylanilide Hydroxamic Acid (S688700).<br>References Sun, W.S., et al.: J. Med. Chem., 46, 5619 (2003)<br></p>Formula:C10H11NO3Color and Shape:NeatMolecular weight:193.20Maraviroc
CAS:Controlled ProductFormula:C29H41F2N5OColor and Shape:White To Off-WhiteMolecular weight:513.67Methyl 4’-[[2-n-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]methyl]biphenyl-2-ca
CAS:Formula:C34H32N4O2Color and Shape:YellowMolecular weight:528.64Nifursol (~90%)
CAS:Controlled Product<p>Applications A medicinal, prophylactic additive in animal feeds, protecting poultry from histomoniasis.Environmental contaminants; Food contaminants; Heat processing contaminants<br>References Kowalski, P., et al.: J. Pharm. Biomed. Anal., 32, 937 (2003), Khlebnikov, A., et al.: Bioorg. Med. Chem., 16, 9302 (2008), Schepetkin, I., et al.: Mol. Pharmacol., 74, 392 (2008),<br></p>Formula:C12H7N5O9Purity:~90%Color and Shape:NeatMolecular weight:365.21Vildagliptin Amide
CAS:Controlled Product<p>Impurity Vildagliptin Amide Impurity<br>Applications N-(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl-L-prolinamide is an impurity of Vildagliptin (V305000) which is an oral anti-hyperglycemic agent that inhibit dipeptidyl peptidase 4 (DPP-4).<br>References Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),<br></p>Formula:C17H27N3O3Color and Shape:Off-WhiteMolecular weight:321.41Felbamate-d4
CAS:Controlled Product<p>Applications Antiepileptic, structurally similar to meprobamate.<br>References Swinyard, E.A., et al.: Epilepsia, 27, 27 (1986), Remmel, R.P., et al.: Ther. Drug Monit., 12, 90 (1990), Sofia, R.D., et al.: Epilepsy Res. Suppl., 3, 103 (1991),<br></p>Formula:C11H10D4N2O4Color and Shape:NeatMolecular weight:242.267Irbesartan-d4
CAS:Controlled Product<p>Applications Irbesartan-d4 is the labeled analogue of Irbesartan (I751000), an angiotensin II type 1 (AII1)-receptor antagonist.<br>References Gillis, J.C. and Markham, A.: Drugs, 54, 885 (1997); Chando, T.J., et al.: Drug. Metabol. Dispos., 26, 408 (1998); Massie, B., et al.: New Eng. J. Med., 359, 2456 (2008); Ren, X., et al.: Pharmacol., 83, 80 (2009)Aromatics, Heterocycles, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals<br></p>Formula:C25H24D4N6OColor and Shape:NeatMolecular weight:432.55Trametinib
CAS:Controlled Product<p>Applications Used in the systematic treatment of advanced cutaneous melanoma. An EGFR kinase inhibitor and potent MEK inhibitor.<br>References Ercan, D. et al.: Canc. Disc., 2, 934 (2012); Mackiewicz-Wysocka, M. et al.: Exp. Opin. Investig. Drugs., 22, 181 (2013);<br></p>Formula:C26H23FIN5O4Color and Shape:Off-WhiteMolecular weight:615.39Alogliptin-d3
CAS:Controlled Product<p>Applications Labelled Alogliptin (A575425). It is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Antidiabetic agent.<br>References Lynn, F., et al.: Diabetes, 50, 1004 (2001), Trumper, A., et al.: J. Endocrinol., 174, 233 (2002), Vollmer, K., et al.: J. Clin. Endocrinol. Metab., 94, 1379 (2009),<br></p>Formula:C182H3H18N5O2Color and Shape:NeatMolecular weight:342.41Vismodegib
CAS:Controlled Product<p>Applications Vismodegib targets the Hedgehog (Hh) pathway. Inhibition of the Hh signaling may be effective in the treatment and prevention of many types of human cancers. Potent Hedgehog inhibitor.<br>References Gupta, S. et al.: Ther. Advances in Med. Oncology 2,237(2010)<br></p>Formula:C19H14Cl2N2O3SColor and Shape:Off-WhiteMolecular weight:421.30Nimodipine
CAS:<p>Applications A dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral). Neuroprotective & Neuroresearch products.<br>References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),<br></p>Formula:C21H26N2O7Color and Shape:NeatMolecular weight:418.44N-Chloro Ethyl ThioTEPA
CAS:Controlled Product<p>Stability Hygroscopic, Moisture Sensitive<br>Applications N-Chloro Ethyl ThioTEPA is an impurity of ThioTEPA which is an alkylating agent used to treat cancer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Maanen, M., et al.: Cancer Treatment Rev., 26, 257 (2000); Sykes, M., et al.: Cancer, 6, 142 (1953)<br></p>Formula:C6H13ClN3PSColor and Shape:White To Off-WhiteMolecular weight:225.68O3-Desethyl Apremilast
CAS:Controlled ProductFormula:C20H20N2O7SColor and Shape:NeatMolecular weight:432.45Riociguat-13C-d3
CAS:Controlled Product<p>Applications Riociguat-13C-d3 is the labelled analogue of Riociguat (R520000), which is used in the treatment for pulmonary hypertension.<br>References Frey, R. et al.: J. Clin. Pharmacol., 51, 1051 (2011);<br></p>Formula:C1913CH16D3FN8O2Color and Shape:NeatMolecular weight:426.43Netupitant
CAS:Controlled Product<p>Applications Netupitant is a potent and selective neurokinin-1 receptor (NK1) receptor antagonist. It is achiral and orally active.<br>References Hoffmann, T., et al.: Bioorg. Med. Chem. Lett., 16, 1362 (2006); Di Fabio, R., et al.: Bioorg. Med. Chem., 21, 6264 (2013)<br></p>Formula:C30H32F6N4OColor and Shape:NeatMolecular weight:578.59Butoxy Olopatadine Hydrochloride
CAS:Controlled ProductFormula:C25H31NO3•HClColor and Shape:NeatMolecular weight:429.98Irbesartan-d6
CAS:Controlled Product<p>Applications Irbesartan-d6 is deuterium labelled Irbesartan (I751000) which is an angiotensin II type 1 (AII1)-receptor antagonist.<br>References Gillis, J.C. and Markham, A.: Drugs, 54, 885 (1997); Chando, T.J., et al.: Drug. Metabol. Dispos., 26, 408 (1998),<br></p>Formula:C25D6H22N6OColor and Shape:White SolidMolecular weight:434.57N-Demethyl Ondansetron
CAS:<p>Applications A metabolite of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bayliss, M., et al: Xenobiotica, 24, 231 (1994), Atkins, W., et al.: J. Biol. Chem., 277, 33258 (2002), De Graaf, I., et al.: Drug Metab. Dispos., 30, 1129 (2002),<br></p>Formula:C17H17N3OColor and Shape:White To BrownMolecular weight:279.342-(Chloromethyl)-4-methylquinazoline
CAS:Controlled Product<p>Impurity Linagliptin 2-Chloromethyl Impurity<br>Applications 2-(Chloromethyl)-4-methylquinazoline, is a building block used for the preparation of Linagliptin (L465900), and its impurities, acting as type 2 diabetes drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011);<br></p>Formula:C10H9ClN2Color and Shape:NeatMolecular weight:192.64Oxaprozin-d10
CAS:Controlled Product<p>Applications Oxaprozin-d10 is the labeled analogue of Oxaprozin (O845400), an anti-inflammatory drug. Oxaprozin was comparable to Aspirin (A687780).<br>References Whitehouse, M.W., et al.: Biochem. Pharmacol., 20, 2309 (1971); Janssen, F.W., et al.: Drug Metab. Dispos., 6, 465 (1978); Shriver, D.A., et al.: Toxicol. Appl. Pharmacol., 42, 75 (1977)<br></p>Formula:C18H5D10NO3Color and Shape:NeatMolecular weight:303.38Ethyl 6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
CAS:Controlled Product<p>Applications Ethyl 6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate is an impurity of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Nevuluri, N. et al.: Monat. fuer Chem., 148, 1477 (2017);<br></p>Formula:C22H22N4O4Color and Shape:NeatMolecular weight:406.43C-Desmethyl Metoprolol
CAS:Controlled Product<p>Impurity Metoprolol EP Impurity A<br>Applications C-Desmethyl Metoprolol (Metoprolol EP Impurity A) is a new byproduct detected in Metoprolol tartrate. Metoprolol impurity.<br>References Erickson, M., et al.: J. Pharma. Biomed. Analysis, 13, 567 (1995), Phinney, K., et al.: Chirality, 15, 287 (2003), Zheng, J., et al.: Anal. Chem., 78, 1535 (2006),<br></p>Formula:C14H23NO3Color and Shape:NeatMolecular weight:253.34
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