Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65497 products of "Quinazoline and Quinoline Derivatives"
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5-(p-Methylphenyl)-5-phenylhydantoin
CAS:<p>Applications An antibody agent.<br>References Rowell, F. J., et al.: Immunochemistry, 13, 891 (1976),<br></p>Formula:C16H14N2O2Color and Shape:NeatMolecular weight:266.292-Hydroxymethyl Olanzapine
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A minor metabolite of Olanzapine.<br>References Moore, N., et al.: J. Pharmacol. Exper. Ther., 262, 545 (1992), Chiu, J., et al.: J. Pharmaceut. Biomed. Anal., 14, 609 (1996), Kassahun, K., et al.: Drug Metab. Dispos., 25, 81 (1997),<br></p>Formula:C17H20N4OSColor and Shape:NeatMolecular weight:328.43(S)-4-Hydroxy Mephenytoin
CAS:Controlled Product<p>Applications The S-enantiomer metabolite of Mephenytoin (M225000).<br>References Boobis, A., et al.: Cancer Res., 54, 89 (1994), Beresford, A., et al.: Xenobiotica, 27, 159 (1997), Zhu, B., et al.: Clin. Pharmacol. Ther., 70, 455 (2001), Jerdi, M., et al.: J. Pharm. Biomed. Anal., 35, 1203 (2004),<br></p>Formula:C12H14N2O3Color and Shape:White To Off-WhiteMolecular weight:234.25Isoleucine Valsartan
CAS:<p>Applications Isoleucine Valsartan is a Valsartan (V095750) impurity. Valsartan is A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Formula:C25H31N5O3Color and Shape:NeatMolecular weight:449.55Afatinib Dimaleate
CAS:Controlled Product<p>Applications Afatinib Dimaleate is a salt of Afatinib {BIBW 2992) (B377000), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. An anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity.<br>References D, Li. et al.: Oncogene., 27, 4702 (2008); Wang, X. et al.: Cancer Res., 74, 4431 (2014);<br></p>Formula:C24H25ClFN5O3·2C4H4O4Color and Shape:NeatMolecular weight:718.08Haloperidol Hydrochloride
CAS:Controlled ProductFormula:C21H23ClFNO2·HClColor and Shape:NeatMolecular weight:412.325Abemaciclib-d5
CAS:Controlled ProductFormula:C27D5H27F2N8Color and Shape:NeatMolecular weight:511.624TERT-BUTYL 2-CHLORO-4-MORPHOLINO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE
CAS:Purity:95.0%Molecular weight:340.80999755859375O-Desethyl Dapagliflozin tetraacetate)
CAS:<p>Applications Empagliflozin Tetraacetate is an Empagliflozin (E521510) impurity and is a reagent used to design and synthesize nitric oxide releasing derivatives of dapagliflozin which has potential antidiabetic and antithrombotic agents.<br>References Zheng, L., et al.: Bioorg. Med. Chem., 26, 3947 (2018)<br></p>Formula:C27H29ClO10Color and Shape:White To Off-WhiteMolecular weight:548.97(S)-2-((tert-Butoxycarbonyl)amino)pentane-1,5-diyl Dimethanesulfonate
CAS:Controlled ProductFormula:C12H25NO8S2Color and Shape:NeatMolecular weight:375.4591,2,3,9-Tetrahydro-3-(1H-imidazol-1-ylmethyl)-9-methyl-4H-carbazol-4-one (Ondansetron Impurity G)
CAS:Controlled Product<p>Applications 1,2,3,9-Tetrahydro-3-(1H-imidazol-1-ylmethyl)-9-methyl-4H-carbazol-4-one is an metabolite of Ondansetron (O655000), is a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist that has been introduced to clinical practice as an antiemetic for cancer treatment-induced and anesthesia-related nausea and vomiting.<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988), Faris, P..L., et al.: Lances, 355, 792 (2000), Ye, J.H., et al.: CNS Drug Reviews., 7, 199 (2001);<br></p>Formula:C17H17N3OColor and Shape:White To Off-WhiteMolecular weight:279.348-Bromo-3-methyl-7-(2-butynyl)-xanthine
CAS:Controlled ProductFormula:C10H9BrN4O2Color and Shape:NeatMolecular weight:297.108N-Des-(2-chloroethyl) Chlorambucil
CAS:Controlled Product<p>Applications N-Des-(2-chloroethyl) Chlorambucil is the half-mustard analog of Chlorambucil (C325050) and exhibits mutagenic activity.<br>References Ferguson, L.R., et al.: Anti-Cancer Drug Des., 3, 67 (1988)<br></p>Formula:C12H16ClNO2Color and Shape:Off WhiteMolecular weight:241.714PTC-124
CAS:Controlled Product<p>Applications PTC-124 is a nonaminoglycoside that has been reported to induce ribosomes to read through premature nonsense stop signals on mRNA, allowing the production of full-length functional proteins,<br>References Yu, H. et al.: Int. J. Mol. Med., 33, 729 (2014); Aditya, S. et al.: J. Biomed. Pharm. Res., 2, 21 (2013);<br></p>Formula:C15H9FN2O3Color and Shape:White To Off-WhiteMolecular weight:284.24cis-(Z)-Flupentixol Dihydrochloride
CAS:Controlled Product<p>Applications Neuroleptic agent related structurally to thiothixene. Antipsychotic; neuroleptic agent; dopamine receptor antagonist.<br>References Nielsen, et al.: Acta Pharmacol. Toxicol., 32, 363 (1973), Post, M.L., et al.: Nature, 256, 342 (1975), Peuch, et al.: Neuropharmacology, 20, 1279 (1981),<br></p>Formula:C23H27Cl2F3N2OSColor and Shape:NeatMolecular weight:507.442-[(1S,3R)-3-Hydroxycyclopentyl]-9-methoxy-1,8-dioxo-N-[(2,4,6-trifluorophenyl)methyl]pyrido[1,2-a]pyrazine-7-carboxamide
CAS:Formula:C22H20F3N3O5Color and Shape:NeatO-Desmethyl Everolimus (Technical Grade)
CAS:Controlled Product<p>Applications O-Desmethyl Everolimus is an impurity of Everolimus (E945400). Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001), Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001), Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002),<br></p>Formula:C52H81NO14Color and Shape:NeatMolecular weight:944.2Ondansetron
CAS:Controlled Product<p>Applications Ondansetron is a specific serotonin (5-HT3) receptor antagonist. Antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988); Faris, P..L., et al.: Lances, 355, 792 (2000)<br></p>Formula:C18H19N3OColor and Shape:White To Light BeigeMolecular weight:293.36N1-Ethylcarbamoyl Cabergoline (>90%)
CAS:Formula:C29H42N6O3Color and Shape:Off White SolidMolecular weight:522.68Baricitinib
CAS:Controlled Product<p>Applications Baricitinib is a JAK1 and JAK2 inhibitor and have been used as a promising treatment for rheumatoid arthritis.<br>References Greenwald, L.J., et al.: Int. J. Clin. Rheumatol., 6, 401 (2011); Fridman, J.S., et al.: J. Immunol., 184, 5298 (2010);<br></p>Formula:C16H17N7O2SColor and Shape:White SolidMolecular weight:371.424-(3-Thien-2-yl-1,2,4-oxadiazol-5-yl)butanoic acid
CAS:Formula:C10H10N2O3SPurity:95.0%Molecular weight:238.26rac-Epinephrine-3-O-sulfate
CAS:Formula:C9H13NO6SColor and Shape:White To Off-WhiteMolecular weight:263.268Rebamipide 3-Chloro Impurity (>80%)
CAS:Controlled Product<p>Applications Rebamipide 3-Chloro Impurity (CAS# 90098-05-8) is a useful research chemical compound.<br></p>Formula:C19H15ClN2O4Purity:>80%Color and Shape:White To Off-WhiteMolecular weight:370.78646-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione
CAS:Purity:98%Molecular weight:230.145996093752-(1-Nitroso-4-piperidinyl)-1H-benzimidazole
CAS:Controlled ProductFormula:C12H14N4OColor and Shape:NeatMolecular weight:230.266(S)-(-)-4’-Hydroxyphenyl Carvedilol
CAS:Controlled Product<p>Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α1-blocking activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),<br></p>Formula:C24H26N2O5Color and Shape:NeatMolecular weight:422.47Iso Sildenafil
CAS:Controlled Product<p>Applications Iso Sildenafil is the isomer of Sildenafil methylated at N-2 position of the pyrazolo[4,3-d]pyrimidin-7-one nucleus.<br>References Sheldrick, G., et al.: Acta Crystallogr., A46, 467 (1990), Terrett, N., et al.: Bioorg. Med. Chem. Lett., 6, 1819 (1996),<br></p>Formula:C22H30N6O4SColor and Shape:NeatMolecular weight:474.583-[4-(2-Methoxyethyl)phenoxy]-1,2-propanediol
CAS:Controlled Product<p>Impurity Metoprolol EP Impurity D<br>Applications 3-[4-(2-Methoxyethyl)phenoxy]-1,2-propanediol (Metoprolol EP Impurity D) is a new byproduct detected in Metoprolol tartrate. Metoprolol (M338790) impurity.<br>References Erickson, M., et al.: J. Pharmac. Biomed. Anal., 13, 567 (1995),<br></p>Formula:C12H18O4Color and Shape:WhiteMolecular weight:226.274’-O-Benzyloxy Ezetimibe
CAS:Controlled Product<p>Impurity Ezetimibe Benzyl Ether Impurity<br>Applications Protected Ezetimibe, used for the synthesis of related derivatives.<br>References Raman, B., et al.: J. Pharm. Biomed. Anal., 52, 73 (2010),<br></p>Formula:C31H27F2NO3Color and Shape:NeatMolecular weight:499.55Valsartan-d3
CAS:Controlled ProductFormula:C24H26D3N5O3Color and Shape:Off-WhiteMolecular weight:438.542N-Desmethyl Diphenhydramine Hydrochloride
CAS:<p>Applications N-Desmethyl Diphenhydramine is an impurity of Diphenhydramine (D486900) with antihistaminic activity.<br>References Nauta, W. T. et al.: Med. Chem., Spec. Contrib. Int. Symp., 3rd, 125 (1973);<br></p>Formula:C16H19NO·ClHColor and Shape:White To Light BeigeMolecular weight:277.79Iso Loratadine
CAS:Controlled Product<p>Impurity Loratadine EP Impurity E<br>Applications Iso Loratadine (Loratadine EP Impurity E) is a Loratadine (L469575) impurity. An isomer of Loratadine used for preparation of tricyclic amides and ureas useful for inhibition of G-protein function and for treatment of proliferative diseases.<br>References Billah., et al.: Lipids, 26, 1172 (1991), Piwinski., et al.: J. Med. Chem., 34, 457 (1991),<br></p>Formula:C22H23ClN2O2Color and Shape:NeatMolecular weight:382.88(5,5’-Bis(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6,6’-dichloro-3-hydroxy-3,3’-biindoline-2,2’-dione)
CAS:<p>Impurity Ziprasidone EP Impurity D<br>Applications (5,5’-Bis(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6,6’-dichloro-3-hydroxy-3,3’-biindoline-2,2’-dione) (Ziprasidone EP Impurity D) is a compound related to Ziprasidone (Z485000), which is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist. Used as an antipsychotic.<br>References Bench, C.J., et al.: Psychopharmacology, 112, 308 (1993), Goldstein, J.M.: Exp. Opin. Invest. Drugs, 4, 291 (1995)<br></p>Formula:C42H40Cl2N8O3S2Color and Shape:NeatMolecular weight:839.852-(Descyclohexylcarbonyl)-2-benzoyl Praziquantel
CAS:Controlled Product<p>Impurity Praziquantel USP Related Compound A<br>Applications 2-(Descyclohexylcarbonyl)-2-benzoyl Praziquantel is used in the synthesis of Praziquantel (P702095), anthelmintic, effective against flatworms. Praziquantel USP Related Compound A<br>References Liu, H. et al.: Chem. Biol. Drug Des., 79, 470 (2012);<br></p>Formula:C19H18N2O2Color and Shape:NeatMolecular weight:306.36Efavirenz Pent-3-ene-1-yne (cis/trans Mixture)
Controlled Product<p>Applications Efavirenz Pen-3-ene-1-yne is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor and antiviral agent.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Formula:C14H9ClF3NO2Color and Shape:NeatMolecular weight:315.67N-(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl-L-proline
CAS:Controlled Product<p>Applications N-(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl-L-proline, is a metabolite of Vildagliptin (V305000), a class of oral anti-hyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase.<br>References Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),<br></p>Formula:C17H26N2O4Color and Shape:NeatMolecular weight:322.3995-Amino-1-(5-chloro-2-pyridinyl)-1H-pyrazole-4-carbonitrile
CAS:Formula:C9H6ClN5Purity:95.0%Color and Shape:SolidMolecular weight:219.636β-Hydroxy Dutasteride
<p>Applications 6β-Hydroxy Dutasteride is a hydroxylated derivative of Dutasteride (D735000).<br></p>Formula:C27H30F6N2O3Color and Shape:NeatMolecular weight:544.43Udenafil
CAS:Controlled Product<p>Applications Udenafil is an oral phosphodiesterase 5 inhibitor used for the treatment of erectile dysfunction.<br>References Kim, T. et al.: Br. J. Clin. Pharmacol., 68, 43 (2009); Lee, C. et al.: J. Sex Med., 7, 2564 (2010); Bae, S.K. et al.: Biomed. Chrom., 22, 939 (2008);<br></p>Formula:C25H36N6O4SColor and Shape:Off White SolidMolecular weight:516.66(4-(3-Methoxypropoxy)-3-methylpyridin-2-yl)methanol Hydrochloride
CAS:Controlled ProductFormula:C11H17NO3·HClColor and Shape:NeatMolecular weight:211.26 + 36.46O-Desmethyl Felodipine
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications O-Desmethyl metabolite of the calcium channel blocker Felopidine (F232375).<br>References Uno, K. et al.: Yakub. Dotai, 7, 243 (1992);<br></p>Formula:C17H17Cl2NO4Color and Shape:NeatMolecular weight:370.23
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