Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65578 products of "Quinazoline and Quinoline Derivatives"
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O-Desethyl Dapagliflozin tetraacetate)
CAS:<p>Applications Empagliflozin Tetraacetate is an Empagliflozin (E521510) impurity and is a reagent used to design and synthesize nitric oxide releasing derivatives of dapagliflozin which has potential antidiabetic and antithrombotic agents.<br>References Zheng, L., et al.: Bioorg. Med. Chem., 26, 3947 (2018)<br></p>Formula:C27H29ClO10Color and Shape:White To Off-WhiteMolecular weight:548.97(S)-2-((tert-Butoxycarbonyl)amino)pentane-1,5-diyl Dimethanesulfonate
CAS:Controlled ProductFormula:C12H25NO8S2Color and Shape:NeatMolecular weight:375.4591,2,3,9-Tetrahydro-3-(1H-imidazol-1-ylmethyl)-9-methyl-4H-carbazol-4-one (Ondansetron Impurity G)
CAS:Controlled Product<p>Applications 1,2,3,9-Tetrahydro-3-(1H-imidazol-1-ylmethyl)-9-methyl-4H-carbazol-4-one is an metabolite of Ondansetron (O655000), is a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist that has been introduced to clinical practice as an antiemetic for cancer treatment-induced and anesthesia-related nausea and vomiting.<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988), Faris, P..L., et al.: Lances, 355, 792 (2000), Ye, J.H., et al.: CNS Drug Reviews., 7, 199 (2001);<br></p>Formula:C17H17N3OColor and Shape:White To Off-WhiteMolecular weight:279.34(2-Ethoxy-4-methylpyridin-3-yl)boronic acid
CAS:Purity:95+%Color and Shape:SolidMolecular weight:181.02-(4-Chloro-3-difluoromethyl-5-methyl-pyrazol-1-yl)-propionic acid
CAS:Formula:C8H9ClF2N2O2Color and Shape:SolidMolecular weight:238.625,5-Diphenyl Hydantoin Sodium
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 5,5-Diphenyl Hydantoin Sodium salt reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Faucette, S., et al.: J. Pharmacol. Exp. Ther., 320, 72 (2007), Guo, D., et al.: J. Biol. Chem., 282, 36766 (2007), Merrell, M., et al.: Drug Metab. Dispos., 36, 1716 (2008),<br></p>Formula:C15H11N2O2·NaColor and Shape:NeatMolecular weight:274.25N-Des-(2-chloroethyl) Chlorambucil
CAS:Controlled Product<p>Applications N-Des-(2-chloroethyl) Chlorambucil is the half-mustard analog of Chlorambucil (C325050) and exhibits mutagenic activity.<br>References Ferguson, L.R., et al.: Anti-Cancer Drug Des., 3, 67 (1988)<br></p>Formula:C12H16ClNO2Color and Shape:Off WhiteMolecular weight:241.7141-(4-Chloromethyl-2-thiazoyl)guanidine Hydrochloride Salt
CAS:Controlled Product<p>Stability Moisture Sensitive<br>Applications Reagent used to produce many guanidine based pharmaceuticals<br></p>Formula:C5H7ClN4S·ClHColor and Shape:White To Light BrownMolecular weight:227.11Tebufenozide
CAS:Controlled Product<p>Applications Tebufenozide is a synthetic nonsteroidal ecdysone agonist used in pesticide formulations (1) that causes premature molting; novel insect growth regulator (2,3,4) specific to lepidopteran species. Drinking water Contaminant Candidate List 3 (CCL3) as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Jordan T, et al.: Anal Bioanal Chem. 2009 Aug;394(8):2257-66 2. Vianna U. Et al.: Ecotoxicology. 2009 Feb;18(2):180-6. 3. Rose, G. et al. Food. Chem. 2009 Dec;117(4) pp634-6404. Wang, J. et al.: J. Agric. Food Chem. 2009 Mar 25;57(6):2162-73.<br></p>Formula:C22H28N2O2Color and Shape:Off-WhiteMolecular weight:352.47Methyl-(1-methyl-1H-pyrazol-3-ylmethyl)-amine
CAS:Purity:95.0%Color and Shape:Liquid, liquidMolecular weight:125.175003051757812-[(1S,3R)-3-Hydroxycyclopentyl]-9-methoxy-1,8-dioxo-N-[(2,4,6-trifluorophenyl)methyl]pyrido[1,2-a]pyrazine-7-carboxamide
CAS:Formula:C22H20F3N3O5Color and Shape:NeatO-Desmethyl Everolimus (Technical Grade)
CAS:Controlled Product<p>Applications O-Desmethyl Everolimus is an impurity of Everolimus (E945400). Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001), Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001), Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002),<br></p>Formula:C52H81NO14Color and Shape:NeatMolecular weight:944.2[1,1'-Biphenyl]-4-yl(phenyl)methanol
CAS:Controlled Product<p>Impurity Bifonazole EP Impurity A<br>Applications [1,1'-Biphenyl]-4-yl(phenyl)methanol (Bifonazole EP Impurity A) is a Bifonazole (B383400), an anti-fungal agent used in the treatment of skin diseases. Causes an increase in Ca2+ concentration and triggers cell death in PC3 human prostate cancer cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cheng, J. et al.: J. Recep. Sign. Transduct., 34, 493 (2014); Chen, Z. et al.: Mol. Pharm., 12, 590 (2015);<br></p>Formula:C19H16OColor and Shape:NeatMolecular weight:260.334-Methyl-3-(morpholine-4-sulfonyl)benzoic acid
CAS:Formula:C12H15NO5SPurity:95%Color and Shape:SolidMolecular weight:285.313-Amino-5-(4-fluorophenyl)thiophene-2-carboxamide
CAS:Formula:C11H9FN2OSColor and Shape:SolidMolecular weight:236.26Rabeprazole
CAS:<p>Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells and can be used in the study of gastric ulcers.</p>Formula:C18H21N3O3SPurity:97.06%Color and Shape:White To Yellowish Crystalline PowderMolecular weight:359.444-(Trifluoromethyl)aniline
CAS:Controlled Product<p>Impurity Leflunomide EP Impurity A; Leflunomide USP Related Compound A<br>Applications 4-(Trifluoromethyl)aniline (Leflunomide EP Impurity A; Leflunomide USP Related Compound A) is a 4-Substituted aniline derivatives exert special hematotoxicity on the red blood cells and induce leukocytosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Weber, W., et al.: Pharmacol. Rev., 37, 25 (1985), Hein, D., et al.: Carcinogenesis, 14, 1633 (1993), Payton, M., et al.: Microbiology, 147, 1137 (2001), Mushtaq, A., et al.: J. Biol. Chem., 277, 12175 (2002),<br></p>Formula:C7H6F3NColor and Shape:NeatMolecular weight:161.125-Methylisoxazole-4-carboxylic Acid
CAS:Controlled ProductFormula:C5H5NO3Color and Shape:NeatMolecular weight:127.10Desmethylene Tadalafil
CAS:<p>Stability Hygroscopic<br>Applications Tadalafil. A phosphodiesterase 5 inhibitor.<br></p>Formula:C21H19N3O4Color and Shape:Off White PowderMolecular weight:377.39(R)-Pramipexole Dihydrochloride
CAS:Controlled Product<p>Impurity Pramipexole EP Impurity D; Pramipexole BP Impurity D; Pramipexole USP Related Compound D<br>Applications (R)-Pramipexole Dihydrochloride (Pramipexole EP Impurity D; Pramipexole BP Impurity D; Pramipexole USP Related Compound D) is the opposite enantiomer of Pramipexole (P700755), a dopamine-D2-receptor agonist. Dexpramipexole is a low-molecular-weight, water-soluble, orally bioavailable, renally excreted compound with linear pharmacokinetics.<br>References Mierau, J., et al.: J. Med. Chem., 30, 494 (1987), Schilling, J.C., et al.: Clin. Pharmacol. Ther., 51, 541 (1992), Kieburtz, K., et al.: J. Am. Med. Assoc., 278, 125 (1997)<br></p>Formula:C10H17N3S·2ClHColor and Shape:NeatMolecular weight:284.254-Phenyl-2-(3-pyridyl)thiazole-5-carboxylic acid
CAS:Color and Shape:SolidMolecular weight:282.320007324218751-Isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
CAS:Purity:98%Color and Shape:SolidMolecular weight:569.754028320313N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide
CAS:Purity:97.0%Molecular weight:390.7600097656254-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is used in the preparation of (pyridinyl)-N-[(triazolyl)phenyl]pyrimidinamine derivatives and (pyridinyl)-N-[oxadiazolyl)phenyl]pyrimidinamine derivatives, and can be used in the detection of their activity as antileukemia agents (neoplastic stem cell leukemia). 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is also a Nilotinib (N465300) intermediate, which might be useful in treatment of chronic myelogenous leukemia.<br>References Li, Y., et al.: Bioorg. Med. Chem. Lett., 26, 1419-1427 (2016)<br></p>Formula:C17H14N4O2Color and Shape:NeatMolecular weight:306.32Tofacitinib impurity L
CAS:Controlled Product<p>Impurity Tofacitinib Impurity (T528000)<br>Applications Tofacitinib impurity L is an impurity of Tofacitinib (T528000), an enantiopure stereoisomer of the drug, Janus kinase 3(Jak3) inhibitor (CP-690,550) that has been found to inhibit selected members of the STE7 and STE20 subfamily of kinases.<br>References Jiang, J., et. al.: J. med. Chem., 51, 8012 (2008)<br></p>Formula:C16H22N6O2Color and Shape:NeatMolecular weight:330.38N-nitroso-Ritalinic Acid
CAS:Controlled ProductFormula:C13H16N2O3Color and Shape:NeatMolecular weight:248.284-Methoxy-2-(((5-methoxy-1H-benzo[d]imidazol-2-yl)sulfinyl)methyl)-3,5-dimethylpyridine 1-oxide
CAS:Purity:95.0%Molecular weight:361.4200134277344Carisoprodol
CAS:Controlled Product<p>Applications Muscle relaxant (skeletal).<br>References Musso, D., et al.: J. Med. Chem. 46, 399 (2003), Newman, P., et al.: Eur. J. Clin. Pharm., 23, 31 (1982).<br></p>Formula:C12H24N2O4Color and Shape:White To Off-WhiteMolecular weight:260.334-Hydroxy Benzeneacetic Acid 2-(Dimethylamino)-2-oxoethyl Ester
CAS:Controlled Product<p>Applications Impurity of Camostat (C150300).<br>References Bodor, N., et al.: Pharm. Res., 3, 120 (1984), Han, L., et al.: Biochem., 46, 1432 (2007),<br></p>Formula:C12H15NO4Color and Shape:NeatMolecular weight:237.25Phenformin Hydrochloride
CAS:<p>Applications It is an anti-diabetic drug from the biguanide class.<br>References Moody, J.E., Anal. Profiles Drug Subs., 4, 319 (1975),<br></p>Formula:C10H15N5·ClHColor and Shape:NeatMolecular weight:241.72Diclazuril 6-Carboxylic Acid
CAS:Controlled Product<p>Applications Diclazuril 6-Carboxylic Acid is an impurity of Diclazuril (D436200), a nucleotide analog with broad-spectrum anticoccidial activity.<br>References Fodey, T.L., et al.: J. Immunol. Meth., 323, 31 (2007);<br></p>Formula:C18H9Cl3N4O4Color and Shape:NeatMolecular weight:451.65Indomethacin-d4
CAS:Controlled Product<p>Applications Nonsteroidal anti-inflammatory agent (NSAID).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)<br></p>Formula:C192H4H12ClNO4Color and Shape:White To Off-WhiteMolecular weight:361.812,5-Bis(2-hexyldecyl)-3,6-di(thiophen-2-yl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione
CAS:Purity:99%Molecular weight:749.21002197265624-Chloro-1-chloromethyl-1H-pyrazole
CAS:Formula:C4H4Cl2N2Color and Shape:LiquidMolecular weight:150.992-[1-Methyl-5-(trifluoromethyl)pyrazol-3-yl]-thiophene-5-carboxaldehyde
CAS:Formula:C10H7F3N2OSColor and Shape:SolidMolecular weight:260.23Rivastigmine-d4 Tartrate Salt
CAS:Controlled Product<p>Applications Rivastigmine-d4 Tartrate Salt, is the labeled analogue of Rivastigmine Tartrate Salt (R541000), a brain selective acetylcholinesterase inhibitor. Nootropic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999), Enz, A., et al.: Prog. Brain Res., 98, 431 (1993),<br></p>Formula:C18H24D4N2O8Color and Shape:NeatMolecular weight:404.454-Methylbenzenesulfonic Acid Monohydrate
CAS:Controlled Product<p>Impurity Lisinopril EP Impurity B/ Anastrozole EP Impurity F<br>Applications 4-Methylbenzenesulfonic Acid Monohydrate (Lisinopril EP Impurity B) is used in the synthesis of resveratrol. Also used in the synthesis of oxane derivatives as antimalarial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Davis, M. et al.: Org. Prep. Proc. Int., 45, 304 (2013); Wang, X. et al.: J. Med. Chem., 56, 2547 (2013);<br></p>Formula:C7H8O3S·H2OColor and Shape:WhiteMolecular weight:190.222-(2-Nitrobenzylidene)-3-oxobutanoic Acid, Methyl Ester
CAS:Controlled Product<p>Applications 2-(2-Nitrobenzylidene)-3-oxobutanoic Acid, Methyl Ester (cas# 39562-27-1) is a compound useful in organic synthesis.<br></p>Formula:C12H11NO5Color and Shape:NeatMolecular weight:249.22Chlorambucil 2-Chloroethyl Ester
CAS:Controlled Product<p>Applications Chlorambucil 2-Chloroethyl Ester is a derivative of Chlorambucil (C325050); an alkylating agent that is used as a chemotherapy drug in the treatment of chronic lymphocytic leukemia.<br>References Cogia, A., et al.: Leuk. Lymph., 53, 1961 (2012); Tonino, S.H., et al.: Leuk. Lymph., 53, 1785 (2012); Smolej, L., et al.: Curr. Pharma. Design., 18, 3399 (2012)<br></p>Formula:C16H22Cl3NO2Color and Shape:NeatMolecular weight:366.71Lercanidipine-d3 Hydrochloride
CAS:Controlled ProductFormula:C36D3H38N3O6·HClColor and Shape:NeatMolecular weight:651.21
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