Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65576 products of "Quinazoline and Quinoline Derivatives"
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Olanzapine 4'-N-Glucuronide
CAS:Controlled ProductFormula:C23H28N4O6SColor and Shape:NeatMolecular weight:488.557Dehydro Felodipine Ester Lactone
CAS:Controlled Product<p>Applications A metabolite of Felodipine (F232375).<br>References Wang, S.X. et al.: J. Pharmacol. Exp. Therap., 250, 632 (1989); Baeaernhielm, C. et al.: Drug Metab. Disp., 14, 613 (1986);<br></p>Formula:C17H13Cl2NO4Color and Shape:NeatMolecular weight:366.201-Deoxy-1-(octylamino)-D-glucitol
CAS:Controlled ProductFormula:C14H31NO5Color and Shape:White To Off-WhiteMolecular weight:293.40Rilpivirine-d6
CAS:Controlled Product<p>Applications A labelled novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.<br>References Sun, et al.: J. Med. Chem., 41, 4648 (1998); Kashiwada, et al.: Bioorg. Med. Chem. Lett., 11, 183 (2001);<br></p>Formula:C222H6H12N6Color and Shape:White To YellowMolecular weight:372.46N-Nitroso Terbutaline
Controlled ProductFormula:C12H18N2O4Color and Shape:NeatMolecular weight:254.282Afatinib
CAS:<p>Applications An aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.<br>References Nakao, K., et al.: Sci. Rep., 9, 18202 92019); Ebert, K, PLoS One, 14, 0223225 (2019)<br></p>Formula:C24H25ClFN5O3Color and Shape:NeatMolecular weight:485.941,1'-[(5E)-5-Methyl-7-oxo-5-undecene-1,11-diyl] Bis[Theobromine]
CAS:Formula:C26H34N8O5Color and Shape:NeatMolecular weight:538.60Aprepitant-d4
CAS:Controlled Product<p>Applications Aprepitant-d4 is a labeled analogue of Aprepitant (A729800), A novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Aprepitant-d4 is a potential treatment for chemotherapy induced nausea and vomiting.<br>References Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998); Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001); Van Belle, S., et al.: Cancer, 94, 3032 (2002); Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006)<br></p>Formula:C23H17D4F7N4O3Color and Shape:NeatMolecular weight:538.45DL-Erythro Ritalinic Acid
CAS:Controlled Product<p>Applications A major metabolite of Methylphenidate.<br>References Redalieu, E., et al.: Drug Metab. Dispos., 10, 708 (1982), Brewer, E., et al.: J. Pharm. Sci., 87, 395 (1998), Shah, V., et al.: Pharm. Res., 17, 1551 (2000), Tanaka, N., et al.: Anal. Chem., 73, 420 (2001),<br></p>Formula:C13H17NO2Color and Shape:WhiteMolecular weight:219.283-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinemethanol
CAS:Controlled ProductFormula:C9H10F3NO2Color and Shape:Light Beige To Light BrownMolecular weight:221.07Sulindac Acyl-β-D-Glucuronide
CAS:Controlled Product<p>Applications Sulindac Acyl-β-D-Glucuronide is the major metabolite of the non-steroidal anti-inflammatory drug Sulindac (S699215) in plasma and urine.<br>References Hucker, H.B., et al.: Drug Metab. Dispos., 1, 721 (1973),<br></p>Formula:C26H25FO9SColor and Shape:NeatMolecular weight:532.534’-Hydroxyphenyl Carvedilol-d3
CAS:Controlled Product<p>Applications A labelled metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),<br></p>Formula:C242H3H23N2O5Color and Shape:NeatMolecular weight:425.49Risperidone Carboxylate Impurity
CAS:Controlled Product<p>Impurity Risperidone EP Impurity F<br>Applications Risperidone Carboxylate Impurity (Risperidone EP Impurity F) is a Risperidone (R525000) impurity.<br></p>Formula:C24H27FN4O4Color and Shape:NeatMolecular weight:454.49Vildagliptin Racemic
CAS:<p>Applications Vildagliptin Racemic is an impurity of Vildagliptin (V305000),a class of oral anti-hyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase. Aside from their use in type 2 diabetes, gliptins have positive cardiovascular and anti-inflammtatory effects. Antidiabetic.<br>References Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),<br></p>Formula:C17H25N3O2Color and Shape:NeatMolecular weight:303.3994-(2-(4-CHLORO-5H-PYRROLO[2,3-D]PYRIMIDIN-7(6H)-YL)ETHYL)MORPHOLINE
CAS:Purity:95.0%Molecular weight:268.754’-O-Benzyloxy Ezetimibe
CAS:Controlled Product<p>Impurity Ezetimibe Benzyl Ether Impurity<br>Applications Protected Ezetimibe, used for the synthesis of related derivatives.<br>References Raman, B., et al.: J. Pharm. Biomed. Anal., 52, 73 (2010),<br></p>Formula:C31H27F2NO3Color and Shape:NeatMolecular weight:499.55N-Desmethyl Diphenhydramine Hydrochloride
CAS:<p>Applications N-Desmethyl Diphenhydramine is an impurity of Diphenhydramine (D486900) with antihistaminic activity.<br>References Nauta, W. T. et al.: Med. Chem., Spec. Contrib. Int. Symp., 3rd, 125 (1973);<br></p>Formula:C16H19NO·ClHColor and Shape:White To Light BeigeMolecular weight:277.79Iso Loratadine
CAS:Controlled Product<p>Impurity Loratadine EP Impurity E<br>Applications Iso Loratadine (Loratadine EP Impurity E) is a Loratadine (L469575) impurity. An isomer of Loratadine used for preparation of tricyclic amides and ureas useful for inhibition of G-protein function and for treatment of proliferative diseases.<br>References Billah., et al.: Lipids, 26, 1172 (1991), Piwinski., et al.: J. Med. Chem., 34, 457 (1991),<br></p>Formula:C22H23ClN2O2Color and Shape:NeatMolecular weight:382.884,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-Pyrazolo[3,4-c]pyridine-3-carboxylic Acid Methyl Ester
CAS:Controlled ProductFormula:C26H26N4O5Color and Shape:NeatMolecular weight:474.508(2S,3S,5S)-5-Amino-1,6-diphenyl-2-([[thiazol-5-ylmethoxy)carbonyl]amino]hexan-3-yl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoate Hydrochloride
CAS:Controlled Product<p>Applications (2S,3S,5S)-5-amino-1,6-diphenyl-2-([[thiazol-5-ylmethoxy)carbonyl]amino]hexan-3-yl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoate Hydrochloride, is a prodrug of Ritonavir (R535000), which is a selective HIV protease inhibitor.<br>References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788 (2006);<br></p>Formula:C37H48N6O5S2•xHClColor and Shape:NeatMolecular weight:720.94Levetiracetam
CAS:<p>Applications The (S)-enantiomer of Etiracetam (E932970) and the ethyl analog of Piracetam (P500800). Used as an anticonvulsant. Neuroprotective & Neuroresearch Product.<br>References Gower, A.J., et al.: Eur. J. Pharmacol., 222, 193 (1992); Kasteleijn-Noist Trenite, D.G.A., et al.: Epilepsy Res., 25, 225 (1996); Patsalos, P.N., et al.: Pharmacol. Ther., 85, 77 (2000)<br></p>Formula:C8H14N2O2Color and Shape:NeatMolecular weight:170.21Stiripentol-d9
CAS:Controlled Product<p>Applications An labelled epilepsy drug. It has been used as co-therapy for treatment of epilepsy. It inhibits the enzymes responsible for metabolism of other anti-convulsant agents.<br>References Laurie, D., et al.: J. Neurosci., 12, 4151 (1992), Smith, A., et al.: J. Pharmacol. Exp. Therap., 311, 601 (2004), Trojnar, M., et al.: Pharm. Rep., 57, 154 (2005), Drafts, B., et al.: J. Pharm. Exp. Ther., 318, 1094 (2006), Picton, A., et al.: Brain Res., 1165, 40 (2007),<br></p>Formula:C14H9D9O3Color and Shape:White SolidMolecular weight:243.35Macitentan
CAS:Controlled Product<p>Applications Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension.<br>References Emoto, N. Ensho to Men'eki, 20, 487 (2012);<br></p>Formula:C19H20Br2N6O4SColor and Shape:White To Off-WhiteMolecular weight:588.278-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane Bromide
CAS:Controlled Product<p>Impurity Aripiprazole Impurity 12<br>Applications 8-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane Bromide is an intermediate used in the preparation of Aripiprazole (A771000), a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity. Antipsychotic. Aripiprazole Impurity 12<br>References Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998), Oshiro, Y., et al.: J. Med. Chem., 41, 658 (1998),<br></p>Formula:C14H19Cl2N2·BrColor and Shape:NeatMolecular weight:366.122-Amino-2-[2-(4-hexylphenyl)ethyl]-1,3-propanediol
CAS:Controlled ProductFormula:C17H29NO2Color and Shape:NeatMolecular weight:279.42Piribedil
CAS:Controlled Product<p>Applications Piribedil is an antiparkisonian agent that acts as a dopamine agonist. Piribedil also displays α2-adrenergic antagonist properties. Piribedil has also been shown to counteract age-related memory impairment by improving memory and attention as well as increasing the velocity of psychomotor reactions and lability of nervous processes.<br>References Millan, M.J. et al.: J. Pharmacol. Exp. Therap., 297, 876 (2001); Gobert, A. et al.: J. Pharmacol. Exp. Therap., 305, 338 (2003); Bochkarev, V.K. et al.: Zh. Nevrol. Psikhiatr. Im. S.S. Korsakova, 105, 46 (2005);<br></p>Formula:C16H18N4O2Color and Shape:WhiteMolecular weight:298.34N-Nitroso Nebivolol-D₄
CAS:Controlled ProductFormula:C22D4H20F2N2O5Color and Shape:Off-WhiteMolecular weight:438.458Dehydro Felodipine
CAS:Controlled Product<p>Impurity Felodipine EP Impurity A<br>Applications Dehydro Felodipine (Felodipine EP Impurity A) is the primary metabolite of Felodipine.<br>References Bailey, D.G., et al.: Clin. Pharmacol. Ther., 60, 25 (1996), Lundahl, J., et al.: Eur. J. Clin. Pharmacol., 52, 139 (1997),<br></p>Formula:C18H17Cl2NO4Color and Shape:NeatMolecular weight:382.244’-Hydroxymethyl 5’-Desmethyl Meloxicam
CAS:Controlled Product<p>Applications Meloxicam (M216100) derivative.<br></p>Formula:C14H13N3O5S2Color and Shape:NeatMolecular weight:367.4N-Nitroso-metoprolol-D6
Controlled ProductFormula:C15H18D6N2O4Color and Shape:NeatMolecular weight:302.39903Etomidate Acid
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Etomidate Acid is a metabolite and carboxylic acid analogue of the short-acting hypnotic drug, Etomidate (E933310).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Heykants, J.J. et al.: Arch. Int. Pharnacodyn. Ther., 216, 113 (1975); Hammitzsch, M. et al.: Electrophoresis, 27, 4334 (2006);<br></p>Formula:C12H12N2O2Color and Shape:White To Off-WhiteMolecular weight:216.24Atrazine-d5
CAS:Controlled Product<p>Applications Labelled selective herbicide. Potential symptoms of overexposure are irritation of eyes and skin<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dalgaard-Mikkelsen, S., et al.: Pharmacol. Rev., 14, 225 (1962), Muller, K., et al.: J. Environ. Qual., 31, 309<br></p>Formula:C82H5H9ClN5Color and Shape:Off-WhiteMolecular weight:220.71rac trans-Loxoprofen-d3 Alcohol
CAS:Controlled Product<p>Applications The cis-alcohol metabolite of Loxoprofen (L472900).<br>References Terada, A., et al.: J. Med. Chem., 27, 212 (1984), Sugimoto, M., et al.: Biochem. Pharmacol., 42, 2363 (1991), Riendeau, D., et al.: Bioorg. Med. Chem. Lett., 14, 1201 (2004)<br></p>Formula:C15H17D3O3Color and Shape:NeatMolecular weight:251.34rac Sulpiride
CAS:Controlled Product<p>Applications An antipsychotic drug used in the treatment of Schozophrenia and depression.<br>References Kramer, P., et al.: J. Neurosci., 31, 126 (2011), Alelyunas, Y., et al.: Bioorg. Med. Chem. Lett., 20, 7312, (2010),<br></p>Formula:C15H23N3O4SColor and Shape:Off-WhiteMolecular weight:341.43Famotidine Sulfoxide
CAS:Controlled Product<p>Applications An intermediate in the synthesis of the metabolite of the drug Famotidine (F102250(P)), which is a histamine H2-receptor antagonist and an antiulcerative.<br>References Takeda, M., et al.: Arzneim.-Forsch., 32, 734 (1982), Miwa, M., et al.: J. Clin. Pharmacol. Ther. Toxicol., 22, 214 (1984), Takabatke, T., et al.: Eur. J. Clin. Pharmacol., 28, 327 (1985),<br></p>Formula:C8H15N7O3S3Color and Shape:NeatMolecular weight:353.44rac Efavirenz-d4
CAS:Controlled ProductFormula:C14H5D4ClF3NO2Color and Shape:NeatMolecular weight:319.70Ethionamide Sulfoxide
CAS:Controlled Product<p>Applications The major metabolite of Ethionamide.<br>References Rivera-Marrero, C., et al.: Microb. Pathog., 25, 307 (1998), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Cole, S., et al.: Nature, 409, 1007 (2001), Liang, X., et al.: Bacteriology, 183, 843 (2001),<br></p>Formula:C8H10N2OSColor and Shape:NeatMolecular weight:182.24Ketoconazole-d3
CAS:Controlled Product<p>Applications Ketoconazole-d3 is the labeled analogue of Ketoconazole (K186000), which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986); Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989); Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988); Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)<br></p>Formula:C26H25D3Cl2N4O4Color and Shape:NeatMolecular weight:534.45N-Nitroso Silodosin
Controlled ProductFormula:C25H31F3N4O5Color and Shape:NeatMolecular weight:524.5334,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (Loratadine Impurity)
CAS:Controlled Product<p>Impurity Loratadine USP Related Compound E<br>Applications Loratadine impurity. Loratidine impurity E. Loratadine USP Related Compound E.<br>References Villani, et al.: J. Med. Chem., 15, 750 (1972), Zhong, D., et al.: Pharmazie, 49, 736 (1994), Ruperez, F., et al.: J. Pharm. Biomed. Anal., 29, 35 (2002),<br></p>Formula:C14H9Cl2NOColor and Shape:NeatMolecular weight:278.136,7-Dimethoxy-N2,N2-dimethylquinazoline-2,4-diamine
CAS:Controlled ProductFormula:C12H16N4O2Color and Shape:NeatMolecular weight:248.281Brivaracetam
CAS:Controlled Product<p>Applications Brivaracetam, is a 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.<br>References Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007); Malawska, B., et al.:, Curr. Opin. Investig. Drugs, 6(7), 740 (2005);<br></p>Formula:C11H20N2O2Color and Shape:Off-WhiteMolecular weight:212.29trans-Amorolfine
CAS:Controlled Product<p>Applications trans-Amorolfine is an analog / impurity of Amorolfine (A634170, HCl); a morpholine antifungal drug and topical solution for the treatment of toenail infections.<br>References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)<br></p>Formula:C21H35NOColor and Shape:NeatMolecular weight:317.51A 77-1726
CAS:<p>Impurity Leflunomide EP Impurity B<br>Applications A77 1726 (Leflunomide EP Impurity B) is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®).<br>References Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)<br></p>Formula:C12H9F3N2O2Color and Shape:White To Off-WhiteMolecular weight:270.21Deschloro Dasatinib
CAS:Controlled ProductFormula:C22H27N7O2SColor and Shape:BrownMolecular weight:453.56rac Metanephrine-d3 Hydrochloride Salt
CAS:Controlled Product<p>Applications A labelled metabolite of Epinephrine (E588585). A naturraly occurring derivative of Epinephrine, found in urine and in certain tissues.<br>References Eisenhofer, G., et al.: J. Clin. Endocrinol. Metab., 82, 3864 (1997), Akiyama, T., et al.: Cardiovasc. Res., 49, 78 (2001), Burke, W., et al.: Brain Res., 891, 218 (2001),<br></p>Formula:C102H3H12NO3·ClHColor and Shape:BeigeMolecular weight:236.71
![1,1'-[(5E)-5-Methyl-7-oxo-5-undecene-1,11-diyl] Bis[Theobromine]](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FM270000.webp&w=3840&q=75)
![4-(2-(4-CHLORO-5H-PYRROLO[2,3-D]PYRIMIDIN-7(6H)-YL)ETHYL)MORPHOLINE](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb-webp%2FF473991.webp&w=3840&q=75)
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![8-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane Bromide](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FD436070.webp&w=3840&q=75)
![2-Amino-2-[2-(4-hexylphenyl)ethyl]-1,3-propanediol](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FA611073.webp&w=3840&q=75)
![4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (Loratadine Impurity)](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FD434160.webp&w=3840&q=75)
