Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65615 products of "Quinazoline and Quinoline Derivatives"
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Rilpivirine-d6
CAS:Controlled Product<p>Applications A labelled novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.<br>References Sun, et al.: J. Med. Chem., 41, 4648 (1998); Kashiwada, et al.: Bioorg. Med. Chem. Lett., 11, 183 (2001);<br></p>Formula:C222H6H12N6Color and Shape:White To YellowMolecular weight:372.46Prochlorperazine Sulfoxide-d3
CAS:Controlled Product<p>Applications A labelled metabolite of Prochlorperazine.<br>References Finn, A., et al.: J. Clin. Pharmacol., 45, 1383 (2005),<br></p>Formula:C202H3H21ClN3OSColor and Shape:Off WhiteMolecular weight:392.96Vortioxetine Hydrobromide-D8
CAS:Controlled Product<p>Applications Vortioxetine Hydrobromide-D8 is deuterium labeled Vortioxetine Hydrobromide (V766000), a multimodal serotonergic agent that inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT (1,2,3).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011)(2) Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012) (3) Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013)<br></p>Formula:C18D8H14N2S·BrHColor and Shape:Off White PowderMolecular weight:387.4069Adrafinil
CAS:Controlled ProductFormula:C15H15NO3SColor and Shape:Off-White Light Orange ColourMolecular weight:289.35TERT-BUTYL (4-(6-(1-METHYL-1H-PYRAZOL-4-YL)PYRROLO[2,1-F][1,2,4]TRIAZIN-4-YL)PHENYL)CARBAMATE
Purity:95.0%Molecular weight:390.4469909667969N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:352.2200012207031Cycloheptyl 5-(1,3-dioxolan-2-yl)-2-thienyl ketone
CAS:Purity:97.0%Molecular weight:280.38000488281252,6-Dimethylaniline-d6
CAS:Controlled Product<p>Applications Labelled Bupivacaine (B689560) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lepage, F., et al.: Eur. J. Med. Chem., 27, 581 (1992), Thummel, K.E., et al.: Drug Metab. Dispos., 21, 350 (1993)<br></p>Formula:C82H6H5NColor and Shape:BrownMolecular weight:127.224-(3-Aminophenyl)-3-morpholinone
CAS:Controlled Product<p>Applications 4-(3-Aminophenyl)-3-morpholinone is an intermediate during the preparation of imidazothiazoles as protein kinase inhibitors for treating cancers.<br>References Bamaung, N., et al.: PCT Int. Appl. (2009), WO 2009070516 A1 20090604.<br></p>Formula:C10H12N2O2Color and Shape:NeatMolecular weight:192.2142-(4-(3-(2',8-Bis(trifluoromethyl)-10H-[3,10'-biphenothiazin]-10-yl)propyl)piperazin-1-yl)ethanol
Controlled ProductFormula:C35H32F6N4OS2Color and Shape:NeatMolecular weight:702.78Lansoprazole Sulfone-d4
CAS:Controlled ProductFormula:C16H10D4F3N3O3SColor and Shape:NeatMolecular weight:389.38Bupivacaine N-Oxide Hydrochloride Salt
CAS:Controlled Product<p>Applications The N-oxide of the local anesthetic Bupivacaine (B689546).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C18H29ClN2O2Color and Shape:White To BeigeMolecular weight:340.89Phenylephrone-d3 Hydrochloride
CAS:Controlled Product<p>Applications Labelled impurity C of Phenylephrine.<br>References Bodor, N., et al.: J. Med. Chem., 31, 100 (1988), Goskonda, V., et al.: J. Pharm. Sci., 88, 180 (1999),<br></p>Formula:C9H9D3ClNO2Color and Shape:NeatMolecular weight:204.675-Desbromo, 5-Chloro Brimonidine
CAS:Controlled Product<p>Impurity Brimonidine EP Impurity H<br>Applications UK 14819 is a quinoxalinyl imidazolidine α2-adrenoceptor agonist and is structurally related to Brimonidine (B677520).<br>References Thaina, P., et al.: J. Auton. Pharmacol., 19, 185 (1999)<br></p>Formula:C11H10ClN5Color and Shape:Light Yellow To YellowMolecular weight:247.68364,4',4''-(2,4,6-Trimethylbenzene-1,3,5-triyl)tripyridine
CAS:Purity:97%Molecular weight:351.45300292968751-Bis(4-fluorophenyl)methyl Piperazine
CAS:Controlled Product<p>Impurity Flumazenil EP Impurity A<br>Stability Hygroscopic<br>Applications 1-Bis(4-fluorophenyl)methyl Piperazine (Flumazenil EP Impurity A) is a chemical reagent used in the synthesis of novel tubulin polymerization inhibitors. Also used in the synthesis of novel benzhydrylpiperazine carboxamide derivatives. Impurity of F455200<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yin, Y. et al.: Bioorg. Med. Chem., 22, 2409 (2014); Gurdal, E. et al.: J. Enz. Inhib. Med. Chem., 29, 205 (2014);<br></p>Formula:C17H18F2N2Color and Shape:White To Light YellowMolecular weight:288.34Ethyl 3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylate
CAS:Controlled Product<p>Impurity Dutateride EP Impurity C<br>Applications Ethyl 3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylate (Dutateride EP Impurity C) is a compound synthesized in the production of azasteroids. Used in the inhibition of 5α-reductase and of androgen receptor binding, both major effecters in the male hormonal system.<br>References Ramusson, G. et al.: J. Med. Chem., 29, 2298 (1986);<br></p>Formula:C21H31NO3Color and Shape:White To Off-WhiteMolecular weight:345.48(3R,4R,3’R)-Ezetimibe
CAS:Controlled Product<p>Applications (3’R,3R,4R)-Ezetimibe is a structural analog of Ezetimibe (E975000); an antihyperlipoproteinemic and a cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formula:C24H21F2NO3Color and Shape:NeatMolecular weight:409.431,2:4,5-bis-O-(1-Methylethylidene)-β-D-Fructopyranose
CAS:Controlled Product<p>Applications 1,2:4,5-bis-O-(1-Methylethylidene)-β-D-Fructopyranose is a reagent in the synthesis of antibacterial/antifungal monosaccaride esters. Also used in the synthesis of antihyperlipidemic novel compounds involving glycosyl fructose derivatives.<br>References Shen, Y. et al.: Molecules, 17, 8661 (2012); Tiwari, P. et al.: Bioorg. Med. Chem. Lett., 16, 6028 (2006);<br></p>Formula:C12H20O6Color and Shape:NeatMolecular weight:260.28METHYL 4-((1-CYCLOBUTYL-4-OXO-4,5,6,7,8,9-HEXAHYDRO-3H-PYRAZOLO[3,4-C]QUINOLIN-3-YL)METHYL)PICOLINATE
CAS:Purity:95.0%Molecular weight:392.4590148925781Dehydro Nisoldipine
CAS:Controlled Product<p>Applications A metabolite of Nisoldipine (N489125).<br>References Grossi, P., et al.: Xenobiotica, 22, 899 (1992), Hayase, N., et al.: J. Pharm. Sci., 83, 532 (1994), Barlett, M., et al.: J. Pharm. Biomed. Anal., 18, 335 (1998), Nayler, W., et al.: J. Clin. Basic Cardiol., 2, 155 (1999), Mielcarek, J., et al.: J. Pharm. Biomed. Anal., 24, 71 (2000),<br></p>Formula:C20H22N2O6Color and Shape:NeatMolecular weight:386.40N-Hydroxy Norfloxacin
CAS:<p>Applications A metabolite of Norfloxacin (N681000).<br>References Uno, T., et al.: J. Med. Chem., 33, 2929 (1990),<br></p>Formula:C16H18FN3O4Color and Shape:NeatMolecular weight:335.33Dermofungin
CAS:Controlled Product<p>Applications Dermofungin, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug.<br>References Hongchao, J., et al.: Cancer Lett., 312, 11 (2011); LeVine, H., et al.: Neuroscience Lett., 465, 99 (2009);<br></p>Formula:C9H6ClNOColor and Shape:NeatMolecular weight:179.602-[5-amino-3-(2-furyl)-1H-pyrazol-1-yl]-6-isopropylpyrimidin-4(3H)-one
CAS:Purity:95.0%Molecular weight:285.3070068359375DL-Norepinephrine Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Antagonist of dibutyryl cyclic-AMP in the regulation of narcosis.Norepinephrine modulates human dendritic cell activation by altering cytokine release.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Piguet, P., et al.: J. Exp. Med., 173, 673 (1991), Hosoi, J., et al.: Nature, 363, 159 (1993), Elenkov, I., et al.: Pharmacol. Rev., 52, 595 (2000), Kaplan, D., et al.: Immunity, 23, 611 (2005),<br></p>Formula:C8H11NO3·ClHColor and Shape:NeatMolecular weight:205.643-Acetylthio-2-methylpropionic Acid
CAS:Controlled Product<p>Impurity Captopril EP Impurity G<br>Applications 3-Acetylthio-2-methylpropionic Acid (Captopril EP Impurity G) is a key intermediate for Captopril (C175750) and other hypertension drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cushman, D., et al.: Biochem., 16, 5484 (1977), Ondetti, M., et al.: J. Med. Chem., 24, 355 (1981), Tseng, T., et al.: Cancer Lett., 62, 233 (1992),<br></p>Formula:C6H10O3SColor and Shape:NeatMolecular weight:162.21Cabozantinib N-oxide
CAS:Controlled Product<p>Applications Cabozantinib N-oxide is a impurity of Cabozantinib (X745500), a medication used to treat medullary thyroid cancer. As well, it can be used in biological study. Computational network biological approach based on pathway cross-talk inhibition identified new synergistic drug combinations using raloxifene and cabozantinib for treatment of human breast cancer in xenograft mouse model. Potent c-MET inhibitor.<br>References Jaeger, S., et al.: Cancer Res, 77, 459-469 (2017)<br></p>Formula:C28H24FN3O6Color and Shape:Off-WhiteMolecular weight:517.51rac-cis-7-Hydroxy Pramipexole
CAS:Controlled Product<p>Impurity Pramipexole Related Compound G<br>Applications Pramipexole derivative used for the preparation of (S)-Pramipexole via resolution of 2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole derivatives.<br>References Validation of a column liquid chromatographic method for the analysis of pramipexole and its 5 impurities. Journal of AOAC International (2010), 93(4), 1102-1112. Gegoe, Csaba Lehel; Fejes, Imre; Garaczi, Sandor; Kovacs, Imre; Lukacs, Ferenc; Majercsik, Orsolya; Schneider, Geza. Process for preparation of (S)-pramipexole via resolution of 2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole derivatives. Eur. Pat. Appl. (2008), 26pp. CODEN: EPXXDW EP 1878731<br></p>Formula:C10H17N3OSColor and Shape:NeatMolecular weight:227.33Gabapentin-d4 (100 μg/mL in Methanol)
CAS:Controlled ProductFormula:C9D4H13NO2Color and Shape:Single SolutionMolecular weight:175.261-Deoxy-1-(octylamino)-D-glucitol
CAS:Controlled ProductFormula:C14H31NO5Color and Shape:White To Off-WhiteMolecular weight:293.40(5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone
CAS:Controlled Product<p>Applications (5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone is an intermediate used in the synthesis of dronedarone hydrochloride (I), a class III antiarrhythmia drug for the prevention of cardiac arrhythmias such as atrial fibrillation.<br>References Mali, A. C., et al.: Org. Proc. Res. Dev., 17, 863 (2013)<br></p>Formula:C30H42N2O3Color and Shape:NeatMolecular weight:478.672-Isoniazid
CAS:Controlled Product<p>Applications An impurity of Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis and inhibits mycolic acid biosynthesis. Intermediate used for the synthesis of analogs of antitumor agent 1-acetyl-2-picolinoylhydrazine.<br>References Brewer, G.A., et al.: Anal. Profiles. Drug. Subs., 6, 183 (1977), Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979); Rutner, H., et al.: Cancer. Chem. Rep., 58, 803 (1974)<br></p>Formula:C6H7N3OColor and Shape:WhiteMolecular weight:137.14Dehydro Felodipine Ester Lactone
CAS:Controlled Product<p>Applications A metabolite of Felodipine (F232375).<br>References Wang, S.X. et al.: J. Pharmacol. Exp. Therap., 250, 632 (1989); Baeaernhielm, C. et al.: Drug Metab. Disp., 14, 613 (1986);<br></p>Formula:C17H13Cl2NO4Color and Shape:NeatMolecular weight:366.20(2R,4R)-rel-1,2,3,4-Tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-5-pyrimidinecarboxylic Acid Methyl Ester
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications (2R,4R)-rel-1,2,3,4-Tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-5-pyrimidinecarboxylic Acid Methyl Ester is an impurity of Nifedipine (N457000); a dihydropyridine calcium channel blocker. Also used as an antihypertensive and antianginal.<br>References Karancsi, T., et al.: Acta Pharm. Hung., 66, 21 (1996); Poetter, H., et al.: J. Pharmaceut. Biomed., 6, 115 (1988); Ali, S.L., et al.: Anal. Profiles Drug Subs., 18, 221 (1989); Soons, P.A., et al.: J. Pharm. Biomed. Anal., 9, 475 (1991); Brown, M.J., et al.: Lancet, 356, 366 (2000)<br></p>Formula:C19H18N4O6Color and Shape:NeatMolecular weight:398.37Tezacaftor-D4
CAS:Controlled ProductFormula:C26D4H23F3N2O6Color and Shape:NeatMolecular weight:524.52Loxapine N-Oxide
CAS:<p>Stability Hygroscopic, Light Sensitive<br>Applications Loxapine N-Oxide is a metabolite of Loxapine (L472750), a D2/D4-Dopamine receptor antagonist. It is a serotonergic receptor antagonist that acts as a dibenzoxazepine antipsychotic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shen, Y., et al.: J. Biol. Chem., 268, 18200 (1993), Fiorella, D., et al.: Psychopharmacology, 121, 347 (1995), Glusa, E., et al.: Br. J. Pharmacol., 130, 692 (2000)<br></p>Formula:C18H18ClN3O2Color and Shape:NeatMolecular weight:343.81N-Acetyl-(+)-Pseudoephedrine
CAS:Controlled Product<p>Applications N-Acetyl-(+)-Pseudoephedrine is the N-acetylated analogue of the non-selective adrenergic agonist (+)-Pseudoephedrine (P839350).<br>References Tanaka, K.: Yakug. Zas., 70, 220 (1950); Rodriguez, M. et al.: Org. Biomol. Chem., 3, 2026 (2005);<br></p>Formula:C12H17NO2Color and Shape:WhiteMolecular weight:207.27Ticagrelor Acetonide
CAS:<p>Stability Hygroscopic<br>Applications 2-[[(3aS,4R,6S,6aa)-4-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl]oxy]ethanol is an intermediate in the synthesis of Ticagrelor (T437700) which is an anticoagulant.<br>References Qiao, D., et al.: Preparation of anticoagulant Ticagrelor, China Patent 104592237, May 6, 2015;<br></p>Formula:C26H32F2N6O4SColor and Shape:NeatMolecular weight:562.63Ethyl 2-(2-(4-methoxyphenoxy)acetamido)-4-methyl-5-(o-tolylcarbamoyl)thiophene-3-carboxylate
CAS:Purity:98%Molecular weight:482.54998779296875N-Formyl Mirabegron
CAS:Controlled ProductFormula:C22H24N4O3SColor and Shape:NeatMolecular weight:424.516
![TERT-BUTYL (4-(6-(1-METHYL-1H-PYRAZOL-4-YL)PYRROLO[2,1-F][1,2,4]TRIAZIN-4-YL)PHENYL)CARBAMATE](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb-webp%2FF530508.webp&w=3840&q=75)
![2-(4-(3-(2',8-Bis(trifluoromethyl)-10H-[3,10'-biphenothiazin]-10-yl)propyl)piperazin-1-yl)ethanol](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FB586700.webp&w=3840&q=75)
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![METHYL 4-((1-CYCLOBUTYL-4-OXO-4,5,6,7,8,9-HEXAHYDRO-3H-PYRAZOLO[3,4-C]QUINOLIN-3-YL)METHYL)PICOLIN…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb-webp%2FF332700.webp&w=3840&q=75)
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![(5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FA617575.webp&w=3840&q=75)
