Flavonoids and Polyphenols

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications Xanthophyll is one of the most widespread carotenoid alcohols in nature. Originally isolated from egg yolk, also isolated by chromatography from nettles, algae, and petals of many yellow flowers.<br>References van het Hof, K., et al.: J. Nutr., 130, 503 (2000), Cooper, D., et al.: J. Nutr., 134, 221S (2004), Faulks, R., et al.: Biochim. Biophys. Acta, 1740, 95 (2005), Rao, A., et al.: Pharmacol. Res., 55, 207 (2007), Tuberoso, C., et al.: Food Chem., 103, 149 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Urolithin M7 is an intestinal microbial metabolite of ellagitannins.<br>References Garcia-Villalba, R., et al.: J. Agr. Food Chem., 61, 8797 (2013);<br></p>

<p>Applications It was isolated from Garcinia mangostana Linn (Guttiferae). It is an anti-inflammatory agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chairungsrilerd, N., et al.: Planta Med., 62, 471 (1996), Chen, Y., et al.: Biochem. Pharmacol., 59, 1445 (2000), Matsumoto, K., et al.: Bioorg. Med. Chem., 12, 5799 (2004), Ramprasath, V., et al.: Biol. Pharm. Bull., 27, 2028 (2004),<br></p>

<p>Applications Labelled Hesperetin (H289500). The aglucon of Hesperidin (H281185), a flavanone found in citrus fruits.<br>References Tsujimoto, M., et al.: Biol. Pharm. Bull., 32, 671 (2009), Wang, H., et al.: J. Pharm. Biomed. Anal., 49, 1157 (2009), Lee, S,. et al.: Bioorg. Med. Chem. Lett., 19, 2116 (2009),<br></p>

<p>Stability Light Sensitive<br>Applications Chlorophyll A is a photosynthetic pigment that is essential for photosynthesis of eukaryotes and cyanobacteria, acting as a primary donor in the electron transport chain. Dyes and metabolites.<br>References Prasad, K., et al.: Curr. Res. Chem., 3, 98 (2011); Shanab, S.M., et al.: Int. J. Electrochem. Sci., 6, 3017 (2011); Ajayan, K.V., et al.: Biores. Techol., 102, 7591 (2011); Felming, I.: Nature, 216, 151 (1967); Woodward, R.B. et al.: Tetrahedron, 46, 7599 1990); Chen, M. et al.: Sciemce, 319, 1318 (2010); Gitelson, A.A. et al.: Rem. Sens. Environ., 69, 296 (1999);<br></p>

<p>Stability Hygroscopic<br>Applications Feruloylputrescine is an effector of plant root systems, influencing development of nutrient gathering root systems. Inhibition of the formation of this compound causes the development of a dominant or ‘tap’ root.<br>References Ben-Hayyim G. et al.: FEBS Lett., 4, 145 (1994);<br></p>

<p>Applications A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.Curcumin is currently being examined as a possible therapeutic for the treatment of Alzheimers disease. Neuroprotective. Dyes and metabolites.<br>References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007), Chem. and Eng. News 90(31), 44 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications (+)-Gallocatechin is antioxidant isomer of (-)-Gallocatechin (G188990), a potential cancer chemopreventive agent that inhibits the growth and adherence of P. gingivalis onto the buccal epithelial cells. An epimer of (-)-Epigallocatechin (E588940).<br>References Rychlik, J., et. al: J. Sci. Food Agr., 95, 1892 (2015); Guo, Q. et al.: Biochim. Biophys. Acta, 1427, 13 (1999); Sakanaka, S. et al.: Biosci. Biotechnol. Biochem., 60, 745 (1996)<br></p>

<p>Applications Isoferulic Acid 3-O-β-D-Glucuronide is the glucuronide conjugate of Isoferulic Acid (H946180). Isoferulic Acid 3-O-β-D-Glucuronide is one of the circulating metabolites in human plasma after coffee consumption.<br>References Fumeaux, R. et al.: Org. Biomol. Chem., 8, 5199 (2010); Redeuil, K. et al.: J. Chrom. A, 1218, 4678 (2011);<br></p>

<p>Stability Light Sensitive<br>Applications Minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression.<br>References Powell, R.G., et al.: Phytochemistry, 35, 335 (1994), Jeandet, P., et al.: J. Phytopathol., 143, 135 (1995), Mattivi, F., et al.: J. Agric. Food Chem., 43, 1820 (1995),<br></p>

<p>Applications The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/β-catenin pathway through down-regulation of the transcriptional coactivator p300.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ryu, M.J. et al.: Biochem. Biophys. Res. Comm., 377, 1304 (2008); Sandur, S.K. et al.: Carcinogenesis, 28, 1765 (2007); Huang, T. et al.: J. Agric. Food. Chem., 58, 10639 (2010);<br></p>

<p>Applications [6]-Shogaol is an aromatic constituent of ginger and the chain-dehydroxylated analog of [6]-Gingerol. [6]-Shogaol has activity very similar to [6]-Gingerol and produced an inhibition of spontaneous motor activity, antipyretic and analgesic effects, and prolonged hexobarbital-induced sleeping time. [6]-Shogaol also has potent antitussive activity and affected the cortical EEG.<br>References Suekawa, M. et al.: J. Pharm-Dyn., 7, 836 (1984); Yoshikawa, M. et al.: Chem. Pharmac. Bull., 40, 2239 (1992);<br></p>

<p>Applications Chrysoeriol is a methoxyflavonoid that selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells. A metabolite of Luteolin (L475000).<br>References Takemura, H. et al.: J. Steroid Biochem. Mol. Biol., 118, 70 (2010); Petroianu, G. et al.: Open Med. Chem. J., 3, 1 (2009); Takemura, H. et al.: Toxicology, 274, 42 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications (-)-Riboflavin is a nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor).<br>References Unna, K., et al.: J. Pharmacol. Exp. Ther., 76, 75 (1942), Rivlin, et al.: N. Engl. J. Med., 283, 463 (1970), Al-Shammary, F.J., et al.: Anal. Profiles Drug Subs., 19, 429 (1990),<br></p>

<p>Applications Chloroxylenol is an antiseptic and germicide. Chloroxylenol is used for mildew prevention. Chloroxylenol is also an antibacterial; antiseptic (topical and urinary).<br>References Heberer, T., et al.: Toxicol. Lett., 131, 5 (2002), Nikolaou, A., et al.: Anal. Bioanal. Chem., 387, 1225 (2007), Focazio, M., et al.: Sci. Total Environ., 402, 201 (2008), Miege, C., et al.: Environ. Pollut., 157, 1721 (2009),<br></p>

<p>Applications Labelled 2-tert-Butyl-4-hydroxyanisole (B699300). 2-tert-Butyl-4-hydroxyanisole shows insecticidal activity.<br>References Newberne, P., et al.: Food Technol., 54, 66 (2000), Passone, M., et al.: Food Control, 19, 364 (2008),<br></p>

<p>Applications Matairesinol is a principle plant lignan consituent of dietary fiber.<br>References Dang, P. H., et al.: J. Nat. Prod., 80, 1876 (2017); Hu, C., et al.: Nat. Prod. Res., 31, 1358 (2017)<br></p>

<p>Applications trans-Resveratrol Triacetate is the acetylated analogue of Resveratrol (R150000) that is a natural antioxidant and a potential radioprotective agent. trans-Resveratrol Triacetate induces p53 activity and inhibits proliferation in breast and prostate tumor cell lines.<br>References Torres, P. et al.: J. Agric. Food Chem., 58, 807 (2010); Kotagiri, S. et al.: J. Chem. Pharmac. Sci., 3, 191 (2010); Koide, K. et al.: ACS Med. Chem. Chem. Lett., 2, 270 (2011);<br></p>

<p>Applications (+)-[6]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with antioxidant activity, which functions as an anti-inflammatory and antitumor agent. (+)-[6]-Gingerol down regulates proinflammatory cytokine release by macrophages. (+)-[6]-Gingerol has been shown to inhibit COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Aeschbach, R. et al.: Food Chem. Toxicol., 32, 31 (1994); Tripathi, S. et al.: J. Surg. Res., 130, 318 (2006); Kim, S.O., et al.: Oncogene 24, 2558 (2005);<br></p>

<p>Stability Hygroscopic<br>Applications Eupatilin maintains anticoagulant and antiplatelet activity isolated from the Artemisia princeps Pampanini flower.<br>References Ryu, R. et al.: Prev. Nutr. Food Sci., 18, 181 (2013);<br></p>

<p>Applications Sinensetin exhibits anti-fungal, anti-histamine activity; induce cell differentiation, inhibition of linoleic acid oxidation, inhibition of white blood cells in the human zona protein Interleukin -1-induced expression of tissue factor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Elliott, A., et al.: Biochem. Pharmacol., 44, 1603 (1992), Furuta, S., et al.: J. Food Sci., 62, 526 (1997),<br></p>