Flavonoids and Polyphenols

Applications The aglucon of Phlorizin. A glucose transport inhibitor. Also inhibits protein kinase C and has been shown to inhibit the entry of five enveloped viruses into human fibroblasts.
References Constantinescu, S.N., et al.: FEBS Lett., 292, 31 (1991), Mann, J., et al.: Appl. Physiol., 71, 410 (1991), Benga, G., et al.: Eur. J. Cell Biol., 59, 219 (1992), Kitanaka, J., et al.: J. Neurochem., 60, 704 (1993), Wang, X., et al.: Biochem. J., 290, 249 (1993)

Stability Light Sensitive, Temperature Sensitive
Applications A metabolite of cis Resveratrol.
References Schroder, H., et al.: Clin. Nutr., 20, 429 (2001), Yu, C., et al.: Pharm. Res., 19, 1907 (2002), Rimando, A., et al.: J. Agric. Food Chem., 52, 4713 (2004), Walle, T., et al.: Drug Metab. Dispos., 32, 1377 (2004), Ito, H., et al.: Br. J. Nutr., 94, 500 (2005),

Applications A metabolite of trans Resveratrol (150000).
References Schroder, H., et al.: Clin. Nutr., 20, 429 (2001), Yu, C., et al.: Pharm. Res., 19, 1907 (2002), Rimando, A., et al.: J. Agric. Food Chem., 52, 4713 (2004), Walle, T., et al.: Drug Metab. Dispos., 32, 1377 (2004), Ito, H., et al.: Br. J. Nutr., 94, 500 (2005),

M06038 - BACKUCHIOL

Applications Silydianin is an active constituent of Silybium marianum and is known the exhibit anti-inflammatory activity which regulates caspase-3 activation which affects cell membranes and acts as a free radical scavenger.
References Zlelinska-Przyyjemska, M., et al.: Phytother. Res., 20, 115 (2006); Milan, M., et al.L Anal. Chimica. Acta., 486, 125 (2003); Liu, Y.Z., et al.: Chin. Herb. Med., 4, 237 (2012);

Applications Chlorophyllin Copper Trisodium Salt, is a water soluble derivative of Chlorophyll (C379880), which has shown to have has been shown to have both anticarcinogenic and antigenotoxic properties.
References Grossi, M., et al.: Toxicology Lett., et al.: 214, 235 (2012); Prasad, K., et al.: Curr. Res. Chem., 3, 98 (2011);

Applications (S)-Naringenin, an active flavanone, maintains antioxidative, anti-inflammatory and antitumorigenic activities. Used in the treatment of praquat (PQ)-induced oxidative stress.
References Podder, B. et al.: J. Microbiol. Biotech., 24, 605 (2014); Abd El Azim, M. et al.: Org. Chem. An Ind. J., 10,410 (2014);

Stability Light Sensitive, Temperature Sensitive
Applications A metabolite of cis Resveratrol.
References Schroder, H., et al.: Clin. Nutr., 20, 429 (2001), Yu, C., et al.: Pharm. Res., 19, 1907 (2002), Rimando, A., et al.: J. Agric. Food Chem., 52, 4713 (2004), Walle, T., et al.: Drug Metab. Dispos., 32, 1377 (2004), Ito, H., et al.: Br. J. Nutr., 94, 500 (2005),

Applications Anisole is used in perfumery.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Taylor, J.M., et al.: Toxicol. Appl. Pharmacol., 6, 378 (1964),

Applications 2-Phenyl-2-propanol is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
References Kostjuk, S.V., et al.: Eur. Polym. J., 43, 968-979 (2007); Liu, X., et al.: J. Mol. Catal. A: Chem., 252, 176-180 (2006);

Applications Paeoniflorin is an active compound of the Paeonia root. Paeoniflorin inhibits Aβ25-35-induced mitochondrial dysfunction, which includes decreased mitochondrial membrane potential, increased Bax/Bcl-2 ratio, cytochrome c release and activity of caspase-3 and caspase-9. Paeoniflorin could attenuate or restore the viability loss, apoptotic increase, and ROS production induced by Aβ25-35 in SH-SY5Y cells.
References Yuan,Y., et. al.: Int. J. Mol. Sci., 14, 18502 (2013); Wang, K., et. al.: Cell Mol. Neurobiol., 34, 227 (2014)

BR1235 - 4-Hydroxybenzaldehyde

Applications Neoponcirin is a flavonoid that was shown to exhibit anticancer properties by inducing apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma.
References Singhai, J., et al.: Cancer. Prev. Res., 5, 473 (2012); Sdiri, S., et al.: Postharv. Biol. Techol., 65, 13, (2012);