Sulfonamides and Derivatives
Sulphonamides are compounds that contain a sulphonamide functional group (-SO₂NH₂), where a sulphur atom is bonded to an amino group. They were among the first synthetic antibiotics used in medicine, inhibiting folic acid synthesis in bacteria, which gives them antimicrobial properties. They are mainly used to treat bacterial infections, although their use has declined due to antimicrobial resistance. In addition to their use as antibiotics, sulphonamides also have applications in the treatment of diseases such as malaria and inflammatory bowel diseases.
At CymitQuimica, we offer high-purity sulphonamides and their derivatives for research in microbiology and pharmaceutical development.
Found 2592 products of "Sulfonamides and Derivatives"
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4-Acetaminophen-d3 Sulfate Potassium Salt
CAS:Controlled Product<p>Applications 4-Acetaminophen-d3 Sulfate Potassium Salt is a deuterium labeled metabolite of Acetaminophen (A161220) (1,2,3).<br>References (1) Lloyd, A., et al.: Biochim. Biophys. Acta., 52, 413 (1961)(2) Purohit, A., et al.: J. Steroid Biochem. Mol. Biol., 86, 423 (2003) (3) Winum, J., et al.: J. Med. Chem., 46, 2197 (2003)<br></p>Formula:C8H5D3KNO5SColor and Shape:NeatMolecular weight:272.33Saccharin-13C6
CAS:<p>Applications It is a labelled non-nutritive sweetener; pharmaceutic aid (flavor). Saccharin was formerly listed as reasonably anticipated to be a human carcinogen; delisted because the cancer data are not sufficient to meet the current criteria for this listing.<br>References Taylor, J.D., et al.: Food Cosmet. Toxicol., 6, 313 (1968), Arnold, D.L., et al.: Fundam. Appl. Toxicol., 4, 674 (1984),<br></p>Formula:C13C6H5NO3SColor and Shape:Off-WhiteMolecular weight:189.14Glyburide-d11
CAS:Controlled ProductFormula:C23D11H17ClN3O5SColor and Shape:Off-WhiteMolecular weight:505.072-Chloronicotinic Acid
CAS:Controlled Product<p>Applications 2-Chloronicotinic Acid is used in the preparation of 4-thiazolidinone derivatives and Schiff bases displaying antimicrobial activity.<br>References Patel, N. et al.: Saudi Pharm. J., 18, 129 (2010); Patel, N. et al.: J. Sci. Islam Repub. Iran., 21, 121 (2010);<br></p>Formula:C6H4ClNO2Color and Shape:NeatMolecular weight:157.55N-Desbutyl-N-propyl Bumetanide
CAS:Controlled Product<p>Applications Bumetanide (B689550) analogue as diuretic and antihypertensive. Bumetanide impurity.<br>References Feit, P.W., et al.: J. Med. Chem., 14, 432 (1971),<br></p>Formula:C16H18N2O5SColor and Shape:NeatMolecular weight:350.3894-desamino Dapsone
CAS:<p>Applications 4-Phenylsulfonylaniline is used in the preparation of novel Flufenamic acid analogues as inhibitors of androgen receptor mediated transcription.<br>References Kemppainen, J., et al.: J. Biol. Chem., 267, 968 (1992), Amler, L., et al.: Cancer Res., 60, 6134 (2000), Klotz, L., et al.: Clin. Prostate Cancer, 3, 215 (2005),<br></p>Formula:C12H11NO2SColor and Shape:White To Off-WhiteMolecular weight:233.293-Hydroxyacetaminophen-D3
CAS:Controlled Product<p>Applications 3-Hydroxyacetaminophen-d3 is deuterium labeled 3-Hydroxyacetaminophen (H714750). 3-Hydroxyacetaminophen is a metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) Chen, C., et al.: J. Biol. Chem., 283, 4543 (2008)(2) Reith, D., et al.: Clin. Exper. Pharmacol. Physiol., 36, 35 (2009) (3) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)<br></p>Formula:C82H3H6NO3Color and Shape:NeatMolecular weight:170.18N-(2,3-Dimethylphenyl) Mefenamic Acid Carboxamide
CAS:Controlled Product<p>Impurity Mefeneic Acid EP Impurity B<br>Applications N-(2,3-Dimethylphenyl) Mefenamic Acid Carboxamide is a derivative of Mefenamic Acid (M205050); an anti-inflammatory agent and analgesic.<br>References Winder, C.V., J. Pharmacol. Exp. Ther., 138, 405 (1962)<br></p>Formula:C23H24N2OColor and Shape:NeatMolecular weight:344.454-(2-Aminoethyl)benzenesulfonamide
CAS:Controlled ProductFormula:C8H12N2O2SColor and Shape:NeatMolecular weight:200.26Zonisamide N,N-Dimethylformimidamide
CAS:<p>Applications Zonisamide related compound C.<br></p>Formula:C11H13N3O3SColor and Shape:White To Off-WhiteMolecular weight:267.30Acemetacin
CAS:Controlled Product<p>Applications Acemetacin is a non-steroidal anti-inflammatory agent and used to treat rheumatic disease and other musculoskeletal disorders (1,2).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Jacobi, H. and Dell, H. D.: Arzneimittelforschung 30, 1398 (1980) (2) Moore, R. A., et al.: Cochrane Database Syst Rev. 8,CD007589 (2009)<br></p>Formula:C21H18ClNO6Color and Shape:YellowMolecular weight:415.82Sulfadiazine-d4
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications The isotopically labelled drug Sulfadiazine. Antibacterial.<br>References Bohni, et al.: Chemotherapy, 14, 195 (1969), Carr, et al.: Antimicrob. Agents Chemother., 4, 585 (1973), Stober, H., et al.: Anal. Profiles Drug Subs., 11, 523 (1982),<br></p>Formula:C10D4H6N4O2SColor and Shape:Light YellowMolecular weight:254.35-(3,4,5-Trimethoxybenzoyl)-2,4-pyrimidinediamine
CAS:<p>Stability Hygroscopic<br>Applications 5-(3,4,5-Trimethoxybenzoyl)-2,4-pyrimidinediamine, is a derivative of Trimethoprim (T795615), an antibacterial agent. 5-(3,4,5-Trimethoxybenzoyl)-2,4-pyrimidinediamine, is a possible potent and selective inhibitor targeting dihydrofolate reductase of C. hominis, used for the treatment of Cryptosporidiosis.<br>References Popov, V. M., et al.: Bioorg. Med. Chem. Lett., 16, 4366 (2006); Brogden, R.N., et al.: Drugs, 23, 405 (1982);<br></p>Formula:C14H16N4O4Color and Shape:Light Yellow To OrangeMolecular weight:304.30Sulfasalazine
CAS:Controlled Product<p>Applications Sulfasalazine is an anti-inflammatory (gastrointestinal). Sulfasalazine has been used in granulomatous colitis.<br>References Schroder, H., et al.: Clin. Pharmacol. Ther.,13, 539 (1972), McDonnell, J.P., et al.: Anal. Profiles Drug Subs., 5, 515 (1976), Klotz, U., et al.: Clin. Pharmacokinet.,10, 285 (1985),<br></p>Formula:C18H14N4O5SColor and Shape:Yellow To Dark OrangeMolecular weight:398.394-Carboxy-a-methylbenzeneacetic Acid
CAS:Controlled ProductFormula:C10H10O4Color and Shape:WhiteMolecular weight:194.18Sulfamonomethoxine-d4
CAS:Controlled Product<p>Applications Labelled Sulfamonomethoxine. Protein binding. Inhibitor of enzyme. Sulfamonomethoxine and Trimethoprim are used for treating porcine unknown hyperpyrexia.<br>References Bridges, et al.: Biochem. J., et al.: 96, 829 (1965), Hong, Y.-L., et al.: Antimicrob. Agents Chemother., 39, 1756 (1995)<br></p>Formula:C11H8D4N4O3SColor and Shape:NeatMolecular weight:284.33Mefenamic Acid-d3 (major)
CAS:Controlled ProductFormula:C15H12D3NO2Color and Shape:Light YellowMolecular weight:244.32-Phenoxylaniline
CAS:Controlled Product<p>Impurity Nimesulide EP Impurity C<br>Stability Hygroscopic<br>Applications 2-Phenoxylaniline (Nimesulide EP Impurity C) is an impurity of Nimesulide (N477500) which is an antiinflammatory agent that preferentially inhibits COX-2 over COX-1.<br>References Pairet, M., et al.: Inflamm. Res., 47, S93 (1998), Fukutake, M., et al.: Carcinogenesis, 19, 1939 (1998), Okajima., E., et al.: Cancer Res., 58, 3028 (1998), Azab, A., et al.: Life Sci., 63, 323 (1998)<br></p>Formula:C12H11NOColor and Shape:Off-WhiteMolecular weight:185.22Sulfachlorpyridazine-d4
CAS:Controlled Product<p>Applications Labelled analogue of Sulfachlorpyridazine, an antibacterial compound.<br>References Wammer, K.: Environ. Toxicol. Chem. 25, 1480 (2006);<br></p>Formula:C10H5D4ClN4O2SColor and Shape:NeatMolecular weight:288.754-Chloro-2-(4-chlorobenzoyl)-1-(4-methoxyphenyl)hydrazide Benzoic Acid
CAS:<p>Applications An impurity of the anti-inflammatory drug indomnethacin (I641000). Indomethacin inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.<br>References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)<br></p>Formula:C21H16Cl2N2O3Color and Shape:NeatMolecular weight:415.27p-Butyl Ibuprofen
CAS:Controlled Product<p>Applications p-Butyl Ibuprofen (cas# 3585-49-7) is a useful research chemical.<br></p>Formula:C13H18O2Color and Shape:Light YellowMolecular weight:206.28Xipamide-d6
CAS:Controlled Product<p>Applications A labelled diuretic and antihypertensive.<br>References Wagieh, N., et al.: Drug Test. Anal., 2, 113 (2010), Prado-Prado, F., et al.: Bioorg. Med. Chem., 18, 2225 (2010), Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010),<br></p>Formula:C15H9D6ClN2O4SColor and Shape:NeatMolecular weight:360.854-Nitroso Sulfamethoxazole, > 90%
CAS:Controlled Product<p>Applications A Sulfamethoxazole metabolite.<br>References Gill, H., et al.: Br. J. Clin. Pharmacol., 42, 347 (1996), Winter, H., et al.: Clin. Pharmacol. Ther., 76, 579 (2004), Vyas, P., et al.: Biochem. Pharmacol., 70, 275 (2005), Vyas, P., et al.: Drug Metab. Dispos., 34, 16 (2006),<br></p>Formula:C10H9N3O4SPurity:>90%Color and Shape:NeatMolecular weight:267.26Limaprost-d3 (>90%)
CAS:Controlled Product<p>Applications Labelled Limaprost (L461500). Limaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tsuboi, T., et al.: Arch. Int. Pharmacodyn., 247, 89 (1980), Adaikan, P.G., et al.: Prostaglandins Med., 6, 449 (1981), Kottegoda, S.R., et al.: Prostaglandins Leukotrienes Med., 8, 343 (1982), Ishizaki, T., et al.: Chest, 85, 382 (1984),<br></p>Formula:C22H33D3O5Purity:>90%Color and Shape:NeatMolecular weight:383.54N-Acetyl Sulfamethoxazole
CAS:<p>Impurity Sulfamethoxazole EP Impurity A<br>Applications A metabolite of Sulfamethoxazole.<br>References Ciolino, H., et al.: Cancer Res., 58 , 2754 (1998), Larsen, T., et al.: Environ. Sci. Technol., 35, 192 (2001), Heberer, T., et al.: Toxicol. Lett., 131, 5 (2002), Larsen, T., et al.: J. Biotechnol., 113, 295 (2004),<br></p>Formula:C12H13N3O4SColor and Shape:Off-WhiteMolecular weight:295.31Mefruside
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Mefruside is a diuretic used for the treatment of edema and hypertension.<br>References Johansen, A., et al.: Euro. J. Epidemiol., 27, 63 (2012); Hasegawa, Y., et al.: Blood. Press. Supple., 1, 10 (2010);<br></p>Formula:C13H19ClN2O5S2Color and Shape:Off-WhiteMolecular weight:382.88Ibuprofen Related Compound (2,3-Dihydroxypropyl 2-(4-Isobutylphenyl)Propanoate)
CAS:Controlled Product<p>Applications Ibuprofen Related Compound is used for research purposes on Ibuprofen soft capsules for the investigation of unknown impurities.<br>References Bao, S., et al.: Yaowu Fenxi Zazhi, 35, 97 (2015)<br></p>Formula:C16H24O4Color and Shape:ColourlessMolecular weight:280.36Ethyl 4-Hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide(Piroxicam Impurity H)
CAS:Controlled Product<p>Impurity Piroxicam EP Impurity H<br>Applications Piroxicam Impurity H.<br>References Lombardino, J., et al.: J. Med. Chem., 14, 1171 (1971), Turck, D., et al.: Clin. Drug Invest., 9, 270 (1995),<br></p>Formula:C11H11NO5SColor and Shape:White To Off-WhiteMolecular weight:269.271,3-Dipalmitoyl-2-chloropropanediol-d5
CAS:Controlled Product<p>Applications Labelled 1,3-Dipalmitoyl-2-chloropropanediol is used in the synthesis of some prodrugs of Piroxicam and Lornoxicam to improve their bioavailability.<br>References Passarotti, C.M., et al.: Bollettino Chimico Farmaceutico, 134, 161 (1995),<br></p>Formula:C352H5H62ClO4Color and Shape:WhiteMolecular weight:592.39Hydrochlorothiazide-d2
CAS:Controlled Product<p>Applications Hydrochlorothiazide-d2 is the labeled analogue of Hydrochlorothiazide (H714560), a carbonic anhydrase inhibitor as a diuretic.<br>References Piala, J.J., et al.: J. Pharmacol. Exp. Ther., 134, 273 (1961); Deppeler, H.P., et al.: Anal. Profiles Drug Subs., 10, 405 (1981)<br></p>Formula:C72H2H6ClN3O4S2Color and Shape:WhiteMolecular weight:299.752-(p-Tolyl)propionic Acid
CAS:Controlled Product<p>Impurity Ibuprofen EP Impurity D<br>Applications 2-(p-Tolyl)propionic acid (Ibuprofen EP Impurity D) is an impurity of Ibuprofen (I140000). Ibuprofen impurity D.<br>References Jia, C., et al.: Science, 287, 1992 (2000), Yu, J., et al.: Org. Biomol. Chem., 4, 4041 (2006),<br></p>Formula:C10H12O2Color and Shape:White To Off-WhiteMolecular weight:164.20N-(5-Chloro-1,3,4-thiadiazol-2-yl)acetamide
CAS:Controlled Product<p>Impurity Acetazolamide EP Impurity A<br>Applications N-(5-Chloro-1,3,4-thiadiazol-2-yl)acetamide is an impurity of Acetazolamide (A161500). Acetazolamide EP Impurity A<br>References Zarghi, A., et al.: J. Pharm. Biomed. Anal., 28, 169 (2002), Subbarao, D., et al.: J. Chromatogr., 67, 841 (2008),<br></p>Formula:C4H4ClN3OSColor and Shape:White To Off-WhiteMolecular weight:177.61Descyclohexylformamide Glipizide
CAS:Controlled Product<p>Impurity Glipizide EP Impurity D<br>Applications 4-[β-(6-Methylpyrazinyl-2-carboxamido)ethyl]benzene Sulfonamide (Glipizide EP Impurity D) is an intermediate in the synthesis of the impurity 5-Desmethyl-6-methyl Glipizide (D292550).<br></p>Formula:C14H16N4O3SColor and Shape:NeatMolecular weight:320.37Acetazolamide-d3
CAS:Controlled Product<p>Applications Carbonic anhydrase inhibitor. Diuretic.<br>References Parasrampuria, J., et al.: Anal. Profiles Drug Subs. Excip. 22, 1 (1993),<br></p>Formula:C4H3D3N4O3S2Color and Shape:Off White To Light YellowMolecular weight:225.26Acetaminophen-d3
CAS:Controlled Product<p>Applications Acetaminophen-d3 is deuterium labeled Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>Formula:C82H3H6NO2Color and Shape:WhiteMolecular weight:154.18Sulfadimethoxine-d4
CAS:Controlled Product<p>Applications Sulfadimethoxine-d4 is a isotope labeled version of Sulfadimethoxine (S699060), a sulfonamide antibiotic.<br>References Seki, et al.: Arzneim.-Forsch., 15, 1441 (1965), Bohni, et al.: Chemotherapy, 14, 195 (1969),<br></p>Formula:C12H10D4N4O4SColor and Shape:NeatMolecular weight:314.35Acetaminophen-d4 (major)
CAS:Controlled Product<p>Applications Acetaminophen-d4 (major) is deuterium labeled Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974)(3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>Formula:C82H4H5NO2Color and Shape:Off-WhiteMolecular weight:155.19rac-Acetaminophen Mercapturate-d5 (Major)
CAS:Controlled Product<p>Applications rac-Acetaminophen Mercapturate-d5 (Major), is a labeled analogue and free acid of 3-(N-Acetyl-L-cystein-S-yl) Acetaminophen Disodium Salt (A172100), which is a metabolite of Acetaminophen (A161220). Acetaminophen is an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References van der Hooft, J.,et al.: Metabolomics, 12, 1 (2016)<br></p>Formula:C13H11D5N2O5SColor and Shape:NeatMolecular weight:317.37Hydrochlorothiazide Dimer
CAS:<p>Impurity Hydrochlorothiazide EP Impurity C<br>Applications N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide (Hydrochlorothiazide EP Impurity C) is an impurity in bulk Hydrochlorothiazide. Dimer Impurity C.<br>References Daniels, S.L., et al.: J. Pharm. Sci., 70, 211 (1981), Fang, X., et al.: Pharm. Res., 14, 691 (1997),<br></p>Formula:C15H16Cl2N6O8S4Color and Shape:Off-WhiteMolecular weight:607.498-Methyl Etodolac
CAS:Controlled Product<p>Impurity Etodolac EP Impurity B<br>Applications 8-Methyl Etodolac (Etodolac EP Impurity B) is an impurity of Etodolac (E933100) which was examined for mutagenicity in reverse mutation tests on bacteria. Etodolac impurity B.<br>References Franke, L., et al.: J. Med. Chem., 48, 6997 (2005), Fox, T., et al.: Curr. Top Med. Chem., 6, 1579 (2006),<br></p>Formula:C16H19NO3Color and Shape:WhiteMolecular weight:273.334-Chloro-benzoic Acid 1-(4-Methoxyphenyl)hydrazide Hydrochloride
CAS:<p>Applications 4-Chloro-benzoic Acid 1-(4-Methoxyphenyl)hydrazide Hydrochloride is a derivative of (4-Methoxyphenyl)hydrazine Hydrochloride (M265880). It is a useful synthetic intermediate for the preparation of Indomethacin (I641000); a potent, time-dependent, nonselective inhibitor of the cyclooxygenase enzymes COX-1 and COX-2.<br>References Blobaum, Anna L., et al.: ACS Med. Chem. Lett., 4(5), 486-490 (2013); Prusakiewicz, Jeffery J., et al.: Biochemistry, 43(49), 15439-15445 (2004)<br></p>Formula:C14H13ClN2O2·HClColor and Shape:NeatMolecular weight:313.18Sulfadiazine Sodium Salt
CAS:Controlled Product<p>Applications Sulfadiazine Sodium Salt can be used as reactant/reagent in preparation and crystal structure of aminophenyl sulfonamide tetrahalides, hydrochloride and hydrobromide cocrystals with iodine.<br>References Pan, F., et al.: CrystEngComm, 17, 6641 (2015)<br></p>Formula:C10H9N4NaO2SColor and Shape:Off-WhiteMolecular weight:272.264-Deschloro-4-(2-furanylmethyl)amino Furosemide
CAS:<p>Impurity Furosemide EP Impurity D<br>Applications 4-Deschloro-4-(2-furanylmethyl)amino Furosemide (Furosemide EP Impurity D) is a Furosemide (F865000) Impurity.<br>References Goldenthal, E.I.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Benet, L.Z.: J. Pharmacokinet. Biopharm., 7, 1 (1979)<br></p>Formula:C17H17N3O6SColor and Shape:White To Dark BrownMolecular weight:391.405-Amino-1,3,4-thiadiazol-2-sulfonamide
CAS:Controlled ProductFormula:C2H4N4O2S2Purity:99%Color and Shape:NeatMolecular weight:180.21N-Acetyl Sulfadiazine
CAS:Controlled ProductFormula:C12H12N4O3SColor and Shape:Off-WhiteMolecular weight:292.313-(p-Chlorophenyl)-3-hydroxyphthalimidine
CAS:Controlled Product<p>Applications 3-(p-Chlorophenyl)-3-hydroxyphthalimidine is an analog of Chlorthalidone (C427500) and has potential antidiuretic and hyperglycemic activities.<br>References Wales, J.K., et al.: P. Soc. Exp. Biol. Med., 128, 581 (1968)<br></p>Formula:C14H10ClNO2Color and Shape:White To Off-WhiteMolecular weight:259.69rac cis-3-Hydroxy Glyburide
CAS:Controlled Product<p>Applications rac cis-3-Hydroxy Glyburide is a metabolite of Glyburide which is used as an antidiabetic (MII-metabolite).<br>References Heptner, W., et al.: Pharmaceut. Res., 5, 215 (1984), Rydberg, T., et al.: Br. J. Clin. Pharm., 43, 373 (1997),<br></p>Formula:C23H28ClN3O6SColor and Shape:NeatMolecular weight:510.00
