Sulfonamides and Derivatives
Sulphonamides are compounds that contain a sulphonamide functional group (-SO₂NH₂), where a sulphur atom is bonded to an amino group. They were among the first synthetic antibiotics used in medicine, inhibiting folic acid synthesis in bacteria, which gives them antimicrobial properties. They are mainly used to treat bacterial infections, although their use has declined due to antimicrobial resistance. In addition to their use as antibiotics, sulphonamides also have applications in the treatment of diseases such as malaria and inflammatory bowel diseases.
At CymitQuimica, we offer high-purity sulphonamides and their derivatives for research in microbiology and pharmaceutical development.
Found 2584 products of "Sulfonamides and Derivatives"
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Glimepiride-d4 (phenylethyl-a,a,b,b-d4) (cis/trans)
CAS:Controlled Product<p>Applications Glimepiride-d4 (phenylethyl-a,a,b,b-d4) (cis/trans) is a useful isotopically labeled compound of Glimepiride (G410150)<br></p>Formula:C24H30D4N4O5SColor and Shape:NeatMolecular weight:244.2Tiafenacil
CAS:<p>Applications Tiafenacil is a uracil herbicide used as a pesticide for the prevention and control of plants.<br>References Peng, X., et al. Faming Zhuanli Shenqing, 68pp Patent 2018 CODEN:CNXXEV<br></p>Formula:C19H18ClF4N3O5SColor and Shape:Off White SolidMolecular weight:511.874-Nitro-2-phenoxyphenol
CAS:<p>Applications 4-Nitro-2-phenoxyphenol is a impurity of Nimesulide (N477500), antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production. Also used in the preparation of benzoxirenes and the synthesis of trioxonins.<br>References Pairet, M., et al.: Inflamm. Res., 47, S93 (1998), Fukutake, M., et al.: Carcinogenesis, 19, 1939 (1998), Okajima., E., et al.: Cancer Res., 58, 3028 (1998), Azab, A., et al.: Life Sci., 63, 323 (1998)<br></p>Formula:C12H9NO4Color and Shape:Light YellowMolecular weight:231.205-Nitroso-2,4,6-triaminopyrimidine
CAS:Controlled ProductFormula:C4H6N6OColor and Shape:NeatMolecular weight:154.13N-Nitroso Aceclofenac
Controlled ProductFormula:C16H12Cl2N2O5Color and Shape:NeatMolecular weight:383.183N-Nitroso Furosemide-d5
Controlled ProductFormula:C12D5H5ClN3O6SColor and Shape:NeatMolecular weight:364.773O-Desmethyl Indomethacin-d4
CAS:Controlled Product<p>Applications The major labelled metabolite of Indomethacin.<br>References Lewis, R., et al.: J. Clin. Invest., 53, 1607 (1974), Alvan, G., et al.: Clin. Pharmacol. Ther., 18, 364 (1975), Mungall, D., et al.: J. Pharm. Sci., 73, 1000 (1984), Baldwin, S., et al.: Xenobiotica, 25, 261 (1995),<br></p>Formula:C18H10D4ClNO4Color and Shape:NeatMolecular weight:347.79N-Acetylsulfathiazole-d4 (Major)
CAS:Controlled Product<p>Applications A deuterated metabolite of the drug Sulfathiazole.<br></p>Formula:C112H4H7N3O3S2Color and Shape:NeatMolecular weight:301.388-Propyl Etodolac
CAS:Controlled Product<p>Impurity Etodolac EP Impurity E<br>Applications 8-Propyl Etodolac (Etodolac EP Impurity E) is an impurity in the synthesis of Etodolac (E933100), may have use in the treatment of myeloma. COX-1/COX-2/β-catenin inhibitors.<br>References Humber, L.G., et al.: Med. Res. Rev., 7, 1 (1987); Balfour, J.A, et al.: Drugs, 42, 274 (1991); Kato, et al.: J. Pharm. Pharmacol., 53 1679 (2001);<br></p>Formula:C18H23NO3Color and Shape:NeatMolecular weight:301.384-Carboxy Tolbutamide-d9
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A labelled metabolite of Tolbutamide. Formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes.<br>References Relling, etl al.: J. Pharmacol. Exp. Ther., 252, 442 (1990), Parent, et al.: J. Pharmacol. Exp. Ther., 261, 780 (1992), Ho, et al.: Life Sci., 52, 21 (1993),<br></p>Formula:C12D9H7N2O5SColor and Shape:NeatMolecular weight:309.395-Amino-3-(4-sulfonylphenyl)salicyclic Acid Sodium Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 5-Amino-3-(4-sulfonylphenyl)salicyclic Acid Sodium Salt is an impurity of mesalamine (M258100), which is the active metabolite of Sulfasalazine (S699084). Anti-inflammatory (gastrointestinal).<br>References Friedman, G., et al.: Am. J. Gastroenterol., 81, 141 (1986); Tursi A., Expert Opin. Pharmacother., 6, 69 (2005);<br></p>Formula:C13H11NO6S•x(Na)Color and Shape:NeatMolecular weight:309.29 + x(22.99)3-[(4-Aminophenyl)sulfonyl]benzenamine
CAS:Controlled Product<p>Applications 3-[(4-Aminophenyl)sulfonyl]benzenamine is an impurity of Dapsone (D193250), an antibacterial used in the treatment of dermatitis herpetiformis.<br>References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950); Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009); Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009);Varma, M., et al.: J. Med. Chem., 52, 4844 (2009)<br></p>Formula:C12H12N2O2SColor and Shape:NeatMolecular weight:248.301(S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide
CAS:Controlled Product<p>Applications (S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide has been used as a reactant for the preparation of Brinzolamide (AL-4862) [B677600], a topical carbonic anhydrase inhibitor.<br>References Conrow, R.E., et. al.: Org. Process Res. Dev., 3, 114 (1999)<br></p>Formula:C10H16N2O6S3Color and Shape:NeatMolecular weight:356.44N-Desethyl-N-(2-boronoethyl) Dorzolamide Hydrochloride
Formula:C10H17BN2O6S3•(HCl)Color and Shape:NeatMolecular weight:368.263646rac-trans Dorzolamide Hydrochloride
CAS:Controlled Product<p>Applications rac-trans Dorzolamide is an impurity of Dorzolamide (D535100).<br>References Casini, A., et al.: Bioorg. Med. Chem. Lett., 13, 841 (2003), Clare, B., et al.: Bioorg. Med. Chem., 13, 2197 (2005),<br></p>Formula:C10H17ClN2O4S3Color and Shape:NeatMolecular weight:360.94-Amino-4'-chlorodiphenyl Sulfone
CAS:Controlled Product<p>Applications 4-Amino-4'-chlorodiphenyl sulfone is a substituted 4-aminodiphenylsulfone as Escherichia coli dihydropteroate synthase inhibitor.<br>References Lopez de Compadre, R.L., et al.: J. Med. Chem., 31, 2315 (1988),<br></p>Formula:C12H10ClNO2SColor and Shape:Off-White To Light YellowMolecular weight:267.73Indomethacin 1-Glycerin Ester
CAS:<p>Applications Indometacin 1-Glycerin Ester was synthesized and evaluated for anti-flammatory activity in the rate paw carrageenin edema essay.<br>References Paris, Gerard. , et al.: J. Med. Chem, 23, 9 (1980)<br></p>Formula:C22H22ClNO6Color and Shape:NeatMolecular weight:431.87Mefruside-d3
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Isotope labelled analogue of Mefruside (M205150), a diuretic used for the treatment of edema and hypertension.<br>References Johansen, A., et al.: Euro. J. Epidemiol., 27, 63 (2012); Hasegawa, Y., et al.: Blood. Press. Supple., 1, 10 (2010);<br></p>Formula:C13H16D3ClN2O5S2Color and Shape:White To Light BeigeMolecular weight:385.90Bumetanide 3-(Butyl(nitroso)amino)-d5
CAS:Controlled ProductFormula:C17D5H14N3O6SColor and Shape:NeatMolecular weight:398.445Metolazone
CAS:Controlled Product<p>Applications A diruetic. An antihypertensive.<br>References Curry, C.L., et al.: Clin. Ther., 9, 47 (1986), Kiyingi, A., et al.: Lancet, 335, 29 (1990)<br></p>Formula:C16H16ClN3O3SColor and Shape:NeatMolecular weight:365.83Benzoxazolemethanesulfonamide-N-(6-methyl-hexanoate)
CAS:Controlled Product<p>Applications Intermediate of Zonisamide-N-(6-hexanoic acid).<br></p>Formula:C15H20N2O5SColor and Shape:NeatMolecular weight:340.391-[1-(4-Chlorobenzoyl)-5-hydroxy-2-methyl-1H-indole-3-acetate]β-D-Glucopyranuronic Acid
CAS:Controlled Product<p>Stability Hygroscopic, Moisture Sensitive<br>Applications 1-[1-(4-Chlorobenzoyl)-5-hydroxy-2-methyl-1H-indole-3-acetate]β-D-Glucopyranuronic Acid is an analog of Indomethacin Acyl-β-D-glucuronide a metabolite of Indomethacin (I641000). Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs.<br>References Abid, A., et al.: Biochem. Pharmacol., 50, 557 (1995), Gamage, N., et al.: Toxicol. Sci., 90, 5 (2006), Cerveny, L., et al.: Drug Metab. Dispos., 35, 1032 (2007), Hayeshi, R., et al.: Eur. J. Pharm. Sci., 35, 383 (2008),<br></p>Formula:C24H22ClNO10Color and Shape:NeatMolecular weight:519.894-Hydroxy Triamterene Sulfate-d4, Sodium Salt
CAS:Controlled Product<p>Applications Isotope labelled 4-hydroxy triamterene sulfate sodium salt a metabolite of Triamterne, a diuretic agent.<br>References Vollmer, G., et al.: Arzneim.-Forsch., 31, 529 (1981), Gilfrich, H.J., et al.: Eur. J. Clin. Pharmacol., 25, 237 (1983),<br></p>Formula:C12H6D4N7NaO4SColor and Shape:NeatMolecular weight:375.33Bumetanide 3-(Butyl(nitroso)amino) (1 mg/mL in Methanol)
CAS:Controlled ProductFormula:C17H19N3O6SColor and Shape:ColourlessMolecular weight:393.41Benzeneacetonitrile
CAS:Controlled Product<p>Applications Benzeneacetonitrile is a volatile compound released from apple trees infested with light brown apple moth larvae. It is also used in the synthesis of phenobarbital (P316760), methylphenidate (M325880), and other amphetamines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Suckling, D. et al.: J. Agr. Food. Chem., 60, 9562 (2012); Cuevas-G. et al.: Int. J. Food. Sci. Technol., 47, 1378 (2012)<br></p>Formula:C8H7NColor and Shape:NeatMolecular weight:117.15Sulfadiazine Silver Salt
CAS:Controlled Product<p>Applications Coordination compound. Antibacterial.<br>References Bohni, et al.: Chemotherapy, 14, 195 (1969), Carr, et al.: Antimicrob. Agents Chemother., 4, 585 (1973), Stober, H., et al.: Anal. Profiles Drug Subs., 11, 523 (1982),<br></p>Formula:C10H9N4O2S·AgColor and Shape:NeatMolecular weight:357.14Sulfamethoxazole-d4 β-D-Glucuronide
CAS:Controlled Product<p>Applications The main labelled metabolite of Sulfamethoxazole.<br>References Altenburger, R., et al.: Environ. Toxicol. Chem., 19, 2341 (2000), Pascoe, R., et al.: Anal. Chem., 73, 6014 (2001), Zhaohua, H., et al.: Eur. J. Med. Chem., 36, 863 (2001),<br></p>Formula:C16H15D4N3O9SColor and Shape:NeatMolecular weight:433.43(4R,6S)-5,6-Dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-ol 7,7-Dioxide
CAS:Controlled Product<p>Applications (4R,6S)-4H-Thieno[2,3-b]thiopyran-4-ol, 5,6-dihydro-6-methyl-,7,7-dioxide is an analog of topically-active carbonic anhydrase inhibitor MK-507 also commonly known as Dorzolamide (D535100).<br>References Blacklock, T., et al.: J. Org. Chem., 58, 1672 (1993); Tempkin, O., et al.: Tetrahedron: Asym., 7, 2721 (1996)<br></p>Formula:C8H10O3S2Color and Shape:NeatMolecular weight:218.29N-(4-Chloro-3-sulfamoylbenzoyl)-2-methylindoline
CAS:Controlled Product<p>Applications N-(4-Chloro-3-sulfamoylbenzoyl)-2-methylindoline is an impurity of Indapamide (I500100).<br></p>Formula:C16H15ClN2O3SColor and Shape:Light YellowMolecular weight:350.82Etodolac Ethyl Ester
CAS:Controlled Product<p>Applications Etodolac Ethyl Ester is a useful intermediate in the preparation of the new antiinflammatory drug Etodolac. Etodolac Impurity.<br>References Mizuguchi, E., et al.: Heterocycles, 46, 149 (1997); Woods, M., et al.: Org. Process Res. Dev., 4, 418 (2000)<br></p>Formula:C19H25NO3Color and Shape:NeatMolecular weight:315.41Sulfamethizole-d4
CAS:Controlled Product<p>Applications Isotope Labelled Sulfamethizole is a sulfonamide based antibiotic that exhibit bactericidal activities towards gram-negative bacteria. Sulfamehizole was shown to be effective in treating gram-negative Bacillus AmpC enzyme in elderly patients with lower respiratory tract infection and as well as against microbs responsible for tuberculosis.<br>References Mondelli, M., et al.: J. Molec. Struct., 1036, 180 (2013); Leelakrishnana, S., et al.: Adv. App. Sci. Res., 3, 3502 (2012); Ghoreishi, S.M., et al.: Anal. Lett., 46, 323 (2012);<br></p>Formula:C92H4H6N4O2S2Color and Shape:NeatMolecular weight:274.368-Isopropyl Etodolac
CAS:Controlled Product<p>Impurity Etodolac EP Impurity D<br>Applications 8-Isopropyl Etodolac (Etodolac EP Impurity D) is an impurity in the synthesis of Etodolac (E933100), may have use in the treatment of myeloma. COX-1/COX-2/β-catenin inhibitors, or anti-inflammatory agent.<br>References Humber, L.G., et al.: Med. Res. Rev., 7, 1 (1987); Balfour, J.A, et al.: Drugs, 42, 274 (1991); Kato, et al.: J. Pharm. Pharmacol., 53 1679 (2001);<br></p>Formula:C18H23NO3Color and Shape:NeatMolecular weight:301.38Dehydro Indapamide-d3
CAS:Controlled ProductFormula:C16H11D3ClN3O3SColor and Shape:NeatMolecular weight:366.84N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N-methylnitrous amide
CAS:Controlled ProductFormula:C12H14N4O2Color and Shape:NeatMolecular weight:246.273-Azabicyclo[3.3.0]octane Hydrochloride
CAS:Controlled Product<p>Applications 3-Azabicyclo[3.3.0]octane Hydrochloride is a reactant in the preparation of substituted pyrimidines derivatives as novel hedgehog signaling pathway inhibitors.<br>References Xin, M. et al.: Med. Chem. Res., 23, 3784 (2014); Xin, M. et al.: Bioorg. Med. Chem. Lett., 24, 983 (2014);<br></p>Formula:C7H13N·ClHColor and Shape:White To Light YellowMolecular weight:147.652,3-Dimethylaniline
CAS:Controlled Product<p>Impurity Mefenamic Acid EP Impurity A<br>Applications Reagent used in the preparation of non-steroidal anti-inflammatory drugs, dyes and pesticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ivachtchenko, A., et al.: Bioorg. Med. Chem., 18, 5282 (2010), Rais, R., et al.: J. Med. Chem., 53, 4749 (2010),<br></p>Formula:C8H11NColor and Shape:BrownMolecular weight:121.18Dapsone N-β-D-Glucuronide Sodium Salt
CAS:Controlled Product<p>Stability Hygroscopic, unstable in solution<br>Applications Dapsone N-β-D-Glucuronide is the glucuronide conjugate and main urinary metabolite of the antibacterial Dapsone (D193250).<br>References Andoh, B.Y.A. et al.: Xenobiotica, 4, 571 (1974); Ogiya, S. et al.: Yakug. Zas., 81, 349 (1961);<br></p>Formula:C18H19N2NaO8SColor and Shape:NeatMolecular weight:446.41Ibuprofen Ethyl Ester
CAS:Controlled Product<p>Applications Ibuprofen Ethyl Ester is a derivative of Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID) that is known to inhibit PGH synthase-1 and PGH synthase-2 with comparable potency.<br>References Gnanarajan, G., et al.: Int. J. Pharma. Sci. Rsch., 1, 27 (2010); Busson, M., et al.: J. Int. Med Res., 14, 53 (1986); Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993); Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998);<br></p>Formula:C15H22O2Color and Shape:Colourless To Light YellowMolecular weight:234.33Indomethacin 1-Menthol ester
CAS:Controlled Product<p>Applications Indomethacin terpenoids' esters were synthesized and assessed both in vitro and in vivo as indomethacin dermal prodrugs.<br>References Bonina,, Francesco. , et al.: European Journal of Pharmaceutical Sciences, 14, 123 (2001),<br></p>Formula:C29H34ClNO4Color and Shape:NeatMolecular weight:496.038N-Des(5-methylpyrazinecarbonyl)-N-ethylcarboxyl Glipizide
CAS:Controlled Product<p>Impurity Glipizide EP Impurity C<br>Applications N-Des(5-methylpyrazinecarbonyl)-N-ethylcarboxyl Glipizide (Glipizide EP Impurity C) is an impurity of Glipizide (G410225).<br></p>Formula:C18H27N3O5SColor and Shape:NeatMolecular weight:397.496-Methylpyrazinecarboxylic Acid
CAS:Controlled Product<p>Applications 6-Methylpyrazinecarboxylic Acid can be used to synthesize compounds that are active against M.tuberculosis H37Rv. Similarly, it can be used to synthesize compounds that are useful for the inhibition, prevention or therapy of tumor cell invasion, metastasis, inflammation, hepatitis, or liver dysfunction.<br>References Vontor, T., et al.: Cesk. Farm., 34, 441 (1985); Oka, K., et al.: Jpn. Kokai Tokkyo Koho, JP 2007210926 A 20070823 (2007)<br></p>Formula:C6H6N2O2Color and Shape:NeatMolecular weight:138.12(4-Trideuteromethoxy) Trimethoprim N1-Oxide, ~90%
CAS:Controlled ProductFormula:C14H15D3N4O4Purity:~90%Color and Shape:NeatMolecular weight:309.34Indomethacin Ethyl Ester
CAS:Controlled ProductFormula:C21H20ClNO4Color and Shape:Off-WhiteMolecular weight:385.84Ibuprofen-13C6
CAS:<p>Applications Labelled Ibuprofen, a selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency.<br>References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986), Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993), Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998),<br></p>Formula:C713C6H18O2Color and Shape:NeatMolecular weight:212.24trans-Carboxy Glimepiride-d5
CAS:Controlled Product<p>Applications An active labelled metabolite of Glimepiride (G410150).<br>References Groop, L., et al.: Diabetes Care, 15, 737 (1992), Muller, G., et al.: Diabetes, 42, 1852 (1993), Kramer, W., et al.: Biochem. Biophys. Acta, 119, 278 (1994),<br></p>Formula:C24H27D5N4O7SColor and Shape:NeatMolecular weight:525.63Gliclazide Impurity D
CAS:<p>Applications Gliclazide Impurity D is a manufacturing impurity of the drug Gliclazide (G409875) which is a sulfonylurea hypoglycemic agent and is used as an antidiabetic.<br>References Duhault, J., et al.: Arzneimittel-Forsch., 22, 1686 (1972), Holmes, B., et al.: Drugs, 27, 301 (1984),<br></p>Formula:C15H20N2O3SColor and Shape:NeatMolecular weight:308.3959
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