Monosaccharides

<p>1,3,4,6-Tetra-O-acetyl-N-azidoacetylgalactosamine is an azido-tagged analogue of N-acetylgalactosamine. It features azide functionality on the N-acyl side chain and is acetylated to aid in cell membrane permeation. It is metabolised by mammalian cells and incorporated into mucin-type-O-linked glycoproteins. The azide functionality is exploited as a biorthogonal functional group that can be reacted with phosphine probes by the Staudinger ligation.</p>

<p>Ethyl 4,6-O-benzylidene-β-D-galactopyranoside is a carbohydrate that belongs to the monosaccharide class. It is glycosylated with an ethyl group at the hydroxyl group at the 6th position and methylated on the benzene ring at the 4th position. This modification has been shown to increase its solubility in water and its stability in basic solutions. The synthesis of this compound is performed through a click reaction, which allows for high purity and custom synthesis. Ethyl 4,6-O-benzylidene-β-D-galactopyranoside can be used as a sugar substitute or in pharmaceuticals for treatment of diabetes mellitus type 2.</p>

<p>Neoandrographolide is a diterpene compound that has been shown to have a significant cytotoxic effect on HL-60 cells. It also shows matrix effects in body formation and chemiluminescence. Neoandrographolide is extracted from the plant Andrographis paniculata, which belongs to the family Acanthaceae. This plant has been used historically as a medical herb in China and India for centuries. The extract of this plant has shown anti-inflammatory properties and can be used to treat infectious diseases such as bowel disease.</p>

<p>Voglibose is a competitive inhibitor of α-glucosidase used for the control of blood sugar levels in patients with type 2 diabetes mellitus. The compound binds reversibly to intestinal carbohydrate-active digestive enzymes with α-glucosidase activity, inhibits breakdown of complex sugars and consequently delays the absorption of glucose into blood.</p>

<p>3-Azido-1-O-t-butyldimethylsilyl-2,3,6-trideoxy-b-L-arabinohexopyranose is a modified sugar. It is used as a building block in the synthesis of oligosaccharides and polysaccharides. This product is custom synthesized to customer's specifications and is available in high purity.</p>

<p>2-Methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-a-D-glucopyrano)-[2,1-d]-2-oxazoline (TAO) is a molecule that is produced during the glycosylation of proteins. TAO has been shown to enhance chemotherapy by targeting and inhibiting the growth of cancer cells. TAO binds to the epidermal growth factor receptor (EGFR), which is a protein that regulates cell proliferation. TAO inhibits cancer cell growth by blocking the activation of EGFR and its downstream signaling pathways. This inhibition leads to tumor regression in xenografts in mice. TAO also blocks o-glycosylation, which is a process that enhances cancer therapy resistance.</p>

<p>Ethyl 2-O-benzoyl-4,6-O-benzylidene-β-D-galactopyranoside (E2B) is a fluorinated oligosaccharide that has been synthesized using the Click chemistry. The synthesis proceeds via an oxidative coupling of benzoyl chloride and 4,6-O-benzylidene β-D galactopyranose. The product was purified by crystallization from methanol.<br>E2B is a complex carbohydrate that can be modified to suit your needs. It is used in research as a model for glycosylation and polysaccharides with methylation or sugar modification.</p>

<p>2-Azido-3,5-di-O-benzoyl-2-deoxy--C-methyl-D--ribonic acid g--lactone is a methylated saccharide that can be used for the synthesis of polysaccharides. The 2'-azido group in this compound can be used to modify oligosaccharides and glycosylations. This compound is a custom synthesis and is not commercially available. It has been shown to have high purity and a yield of 99%.</p>

<p>Cotinine-N-b-glucuronide-D3 is a modification of the natural product cotinine, which is a methylated form of nicotine and can be synthesized from the plant Nicotiana tabacum. Cotinine-N-b-glucuronide-D3 is a complex carbohydrate that has been custom synthesized for the purpose of modifying an oligosaccharide. This modification will allow for the synthesis of high purity monosaccharides. Cotinine has been shown to have antiinflammatory properties, which may be due to its inhibition of prostaglandin synthesis.</p>

<p>2-O-Acetyl-3,4,6-tri-O-benzyl-a-D-glucopyranosyl trichloroacetimidate is a custom synthesis. It is a modified oligosaccharide with a fluorinated carbon atom in the 2 position of the acetyl group. This chemical has been shown to be effective for click modification and glycosylation reactions. The CAS number for this chemical is 108869-64-3.</p>

<p>3,4-Di-O-acetyl-L-arabinal is a synthetic compound that belongs to the class of monofluorides. It has been synthesized from l-arabinose by a stereoselective process, with triflic acid as the catalyst and propargylation as the key step. The synthetic pathway starts from an acid hydrolysis of L-arabinose to yield 3,4-di-O-acetyl-L-arabinonic acid. This acid is then converted to 3,4 diacetyl L arabinonic acid with acetic anhydride and acetic acid in the presence of triethylamine. The final product is then obtained by reacting this intermediate with 1 equivalent of sodium fluoride in tetrahydrofuran (THF) using catalytic reduction with sodium borohydride at 0 °C. The major advantage of this synthetic process is that it provides two stereoisomers: (</p>

<p>6-O-Acetyl-D-glucose is a natural sugar that is found in Holothuria, a sea cucumber. It has been shown to have anti-cancer and anti-inflammatory properties. 6-O-Acetyl-D-glucose inhibits the production of extracellular Ca2+ and has shown therapeutic effects against colorectal carcinoma. This active substance also exhibits allergenic reactions, which may be due to its ability to bind to IgE antibodies on mast cells and basophils. 6-O-Acetyl-D-glucose is a glycoside that contains an acetate group linked by an O atom to the hydroxyl residue of glucose. The glycosidic bond can be hydrolyzed with the enzyme β glucosidase, releasing the aglycone (sugar) and β glucosidase.</p>

<p>Competitive inhibitor of glucosylceramidase (GlcCer), which catalyses the first step in glycosphingolipid (GSL) synthesis. This compound is a promising candidate for substrate reduction therapy in Sandhoff disease, where it decreases the rate of GSL biosynthesis and counterbalances the impaired rate of ganglioside catabolism.</p>

<p>5-S-Methyl-5-thio-D-xylose is a carbohydrate that can be synthesized from 5,5’ -dithiobis(2-nitrobenzoic acid) and D-xylose. It is a high purity, custom synthesis product. This carbohydrate has been modified with fluorination at the 5 position of the sugar ring and methylation of the alpha carbon to form a methylated xylose. The molecular weight is 488.1 g/mol and it has a CAS number of 53458-58-5. This product can be used to modify saccharides and oligosaccharides with fluorination and methylation reactions.</p>

<p>Used in culture medium to differentiate bacteria on the basis of carbohydrate fermentation abilities.</p>

<p>D-Galactose-1-phosphate disodium is an organic compound that is used as a methylation and glycosylation reagent. It can be used in the synthesis of oligosaccharides, polysaccharides, and other complex carbohydrates. D-Galactose-1-phosphate disodium is a fluorinated saccharide that can be custom synthesized to order. It is also available in high purity and has CAS No. 147072-63-7.</p>

<p>Delphinidin 3-glucoside chloride is a natural, water-soluble compound that exhibits antimicrobial activity against Staphylococcus aureus. It has been shown to inhibit the growth of this bacteria by inhibiting detoxification enzymes and intracellular cGMP production. Delphinidin 3-glucoside chloride also inhibits uptake of this bacterium by human cells, which may be due to its synergistic interaction with other compounds such as cinnamic acid derivatives. This compound has been shown to have cardiac effects in animals and is being studied for its potential use in treating heart disease.</p>

<p>Resource for the 6-O-modification of Glc e.g. in glucuronic acid synthesis</p>

<p>Synthetic building block for nucleic acid research</p>

<p>2,3,4,6-Tetra-O-acetyl-β-D-galactopyranosyl azide is a catalyst that has been used in the production of carbonate catalysts. It can also be used to reoxidize metallic catalysts.</p>