Monosaccharides

2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl-N'-(2-aminophenyl)thiourea is a fluorinated glycoside that is synthesized by the coupling of an acetyl group with an aminophenylthiourea. The synthesis of this compound can be customized for specific carbohydrate requirements. This product has been shown to be effective in the modification of complex carbohydrates such as polysaccharides and glycans. It is also useful for applications involving glycosylation and methylation reactions.

Chromogenic substrate targeting beta-glucuronidase

1,2:5,6-Di-O-isopropylidene-alpha-D-glucofuranose, also known as diacetone-D-glucose (DAG), is a partially protected D-glucose sugar locked in the furanose form with isopropylidene protecting groups on the 1,2 and 5,6 positions. The unprotected 3 position is ready for a variety of chemical manipulations, such as alkylation, acylation or stereo-inversion. An orthogonal protecting group could be added to the 3 position to allow deprotection of an isopropylidene and therefore manipulations of the other hydroxyl groups. Diacetone-D-glucose has been used to make fluorinated hexopyranose glycolysis inhibitors useful in the treatment of brain tumours.

1,2-Dideoxy-5-O-DMT-D-ribose is a methylation inhibitor that inhibits the transfer of a methyl group from S-adenosylmethionine to a substrate. This modification can be found in many biological systems, including DNA and RNA. It is also used as an intermediate in the synthesis of other compounds such as oligosaccharides and polysaccharides. 1,2-Dideoxy-5-O-DMT-D-ribose has been shown to inhibit the growth of bacteria by inhibiting bacterial cell wall synthesis. It is believed to work by binding to glycosidic bonds in bacterial cell walls, preventing the formation of new bonds and therefore inhibiting cell wall biosynthesis.
1,2 - Dideoxy - 5 - O - DMT - D - ribose can be used for fluorination reactions with various types of compounds, including sugars and other complex carbohydrates.

2-Chloro-2-deoxy-D-glucose (2CDG) is a chemical compound that has been shown to be an effective inhibitor of hypoxic tumor growth. 2CDG inhibits the production of fatty acids, which are required for cell proliferation and survival. It also has inhibitory properties on the chromatographic system and can be used as a detector in electrochemical methods. The detection of 2CDG in blood serum is used as a diagnostic tool for cancer, with a sensitivity and specificity of up to 100%. This compound has shown promising results for the treatment of hypertension and diabetes.

Glycol ethers are compounds that are used as solvents and plasticizers. They have been shown to inhibit the activity of enzymes, such as glucose-6-phosphate dehydrogenase, which is involved in the conversion of glucose to phosphate. Glycol ethers also promote sugar transport by inhibiting the sodium-dependent glucose transporter (SGLT). This transport mechanism is important for maintaining normal blood sugar levels and preventing diabetic neuropathy. Glycol ethers are also anti-diabetic agents that can increase insulin sensitivity by stimulating insulin release from pancreatic beta cells and improving the response of peripheral tissues to insulin stimulation.