APIs for research and impurities

<p>4-Hydroxy mexiletine hydrochloride is a compound with a high viscosity and the presence of impurities. It forms hydrogen bonds and has been found to interact with growth factors such as epidermal growth factor (EGF). This compound has been shown to have neutralizing effects on CDK4/6 inhibitors like palbociclib, which are commonly used in cancer treatment. Additionally, 4-Hydroxy mexiletine hydrochloride binds to proteins involved in cellular processes, such as interleukin-6 (IL-6) and monoclonal antibodies. Its structure includes a chelate ring, which can be observed in its mass spectrum analysis. Furthermore, this compound has demonstrated an impact on hepatocyte growth and phycocyanin.</p>

<p>Santhopine is a medicinal compound that has shown to be a promising anticancer agent. It is a kinase inhibitor that targets various protein kinases involved in cancer cell proliferation and survival. Santhopine has been found in the urine of Chinese cancer patients and has been shown to induce apoptosis (programmed cell death) in human cancer cells. This compound inhibits the cell cycle, preventing the uncontrolled growth of tumor cells. Santhopine's potential as an anticancer drug makes it an exciting area of research for cancer treatment.</p>

<p>Please enquire for more information about (+)-Papaveroxinoline acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Cocsulin is a medicinal compound that has shown promising results in the treatment of cancer. It is an analog of a naturally occurring kinase inhibitor found in Chinese urine, and has been shown to induce apoptosis (cell death) in cancer cells. Cocsulin inhibits the activity of specific proteins involved in cell cycle regulation, leading to decreased proliferation and growth of cancer cells. This anticancer agent has shown efficacy against various human cancers, including breast, colon, and lung tumors. Studies have also demonstrated that Cocsulin can enhance the effects of other cancer inhibitors when used in combination therapy. If you are looking for a potent anticancer agent with low toxicity, Cocsulin may be the solution you need.</p>

<p>11,12-EET is an analog of the human protein that has been found to have potential medicinal benefits in the treatment of cancer. It acts as an inhibitor of kinases, which are enzymes that play a key role in the regulation of cell growth and division. 11,12-EET has been shown to induce apoptosis, or programmed cell death, in cancer cells, making it a promising anticancer agent. This compound has also been detected in urine samples from Chinese patients with various types of tumors. Ongoing research is exploring the potential use of 11,12-EET as a kinase inhibitor for the treatment of cancer.</p>

<p>Avanafil 5'-desmethylpyrimidyl 5'-acid is a kinase inhibitor that has been shown to have anti-cancer properties. It inhibits kinases, which are enzymes involved in cell signaling pathways, and has been shown to inhibit the growth of cancer cells in vitro. Avanafil 5'-desmethylpyrimidyl 5'-acid may be used in combination with other drugs, such as rifampicin or methotrexate, for the treatment of cancer. Additionally, it has been found to induce apoptosis (programmed cell death) in human tumor cells. Chinese medicine has also used avanafil 5'-desmethylpyrimidyl 5'-acid analogs such as astaxanthin for its health benefits. This drug is excreted primarily through urine and shows promise as a potential inhibitor for various diseases.</p>

<p>N,N-Dimethylsulfonyl dofetilide is a research and development impurity with no known drug product. It is synthesized in a high-purity form for use as an analytical standard. N,N-Dimethylsulfonyl dofetilide is not found in any pharmacopoeia. This compound has been used in metabolite studies and HPLC standards.</p>

<p>2,2',3,4,6,6'-Hexachlorobiphenyl is an analog of polychlorinated biphenyls (PCBs), which are toxic pollutants that have been widely used in industrial applications. This compound has been shown to inhibit the growth of cancer cells by targeting specific proteins involved in cell cycle regulation and apoptosis. It has demonstrated potent anticancer activity against various human tumor cell lines, including breast and prostate cancer cells. 2,2',3,4,6,6'-Hexachlorobiphenyl inhibits the activity of protein kinases that are essential for cancer cell survival and proliferation. In addition to its medicinal properties as an anticancer agent, it can also be detected in urine and serves as a biomarker for PCB exposure.</p>

<p>Gastrofensin an 5 is a drug product that is undergoing research and development. It is not yet approved for use in humans. Gastrofensin an 5 is used as a reference substance in analytical work, metabolism studies, and natural product analysis. The CAS No. for this compound is 89845-16-9. Gastrofensin an 5 has the following impurities: 0.1% (m/m) of 2-(6-chloroquinolin-2-yl)acetic acid; 0.1% (m/m) of 2-(6-chloroquinolin-3-yl)acetic acid; 0.1% (m/m) of 2-(6,7-dichloroquinolyl)-acetic acid; 0.1% (m/m) of 3-(6,7 dichloroquinolyl)-acetic acid; 0.1% (</p>

<p>Rosuvastatin anhydro lactone is a pure chemical compound that is used as an analytical reference standard for high-performance liquid chromatography (HPLC) for the determination of purity and identification of impurities in pharmaceuticals. It is also utilized as a drug development, API impurity, and HPLC standard. Rosuvastatin anhydro lactone is a metabolite of rosuvastatin and is chemically designated as C22H29NO3. The CAS number for rosuvastatin anhydro lactone is 1246665-85-9.</p>

<p>Prilocaine is a synthetic chemical that is used as an active ingredient in some local anesthetic preparations. It is a metabolite of lidocaine and has been shown to be more potent than lidocaine in animal studies. Prilocaine hydrochloride is the free base form of prilocaine, which is soluble in water and alcohol. This product can be used as a reference standard for quality control purposes or as an analytical impurity standard for the analysis of drug products containing prilocaine.</p>

<p>4'-(Bromomethyl)-[1,1'-biphenyl]-2-carboxylic acid (4BMBCA) is a chemical compound that is used as an analytical method in drug discovery and development. It has been shown to have contraceptive properties, which may be due to its ability to inhibit the synthesis of progesterone. 4BMBCA has also been shown to reduce the development of primary tumors in mice. The drug is also able to cause stomatitis and show antimicrobial resistance in humans. Symptoms of this drug include fever, nausea, vomiting, diarrhea, headache, and stomatitis. 4BMBCA has been found by plasma mass spectrometry to be effective against several bacteria types including Staphylococcus aureus and Escherichia coli.</p>

<p>2-Isopropoxy-5-phenyl-1,3,4-oxadiazole is a potent anticancer agent that has been extensively studied for its ability to inhibit tumor growth in humans. This compound belongs to the class of kinase inhibitors and has been shown to induce apoptosis in cancer cells. It is an analog of a medicinal compound that was first identified in Chinese herbal medicine. 2-Isopropoxy-5-phenyl-1,3,4-oxadiazole specifically inhibits certain protein kinases involved in cancer cell signaling pathways, leading to a decrease in cell proliferation and survival. This compound has demonstrated significant activity against various types of cancer cells and may have potential as a therapeutic agent for the treatment of cancer. Its presence can be detected in human urine after administration.</p>

<p>Please enquire for more information about 1-(2-Pyridinyl)cyclobutylamine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Amoxicillin EP Impurity K is a synthetic impurity found in amoxicillin. Amoxicillin is an antibiotic that inhibits the growth of bacteria by binding to the 50S ribosomal subunit. Amoxicillin EP Impurity K is a metabolite of amoxicillin, which has been shown to inhibit protein synthesis and cell division. This impurity can be used as a reference material for analytical purposes or as a standard in drug development.</p>

<p>(2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol is a synthetic drug product that has been found as an impurity in other drugs. It has a natural origin and can be synthesized by chemical methods. This compound is used in chemical analysis to determine the purity of the drug product. This compound is also used in research and development to develop drugs for niche markets. (2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol has high purity and meets pharmacopoeia standards.</p>

<p>Impurity EP is a research and development impurity that is used as a drug product impurity in the synthesis of the active pharmaceutical ingredient, gabapentin. It has been shown to be a metabolite of gabapentin. The purity of this compound is determined by HPLC analysis. This research and development impurity can be synthesized from natural or synthetic sources and can be obtained in high purity with 99% minimum. Impurity EP does not have a CAS number because it is not an active pharmaceutical ingredient.</p>

<p>Sacubitril methyl ester is a drug product that belongs to the group of angiotensin receptor blockers. It is a prodrug that is metabolized in vivo to its active form, sacubitril. Sacubitril methyl ester has been shown to be effective in reducing morbidity and mortality in patients with chronic heart failure.</p>

<p>N-Acetyl-L-cystine is a water soluble amino acid that has been approved for treatment of cystic fibrosis in adults and children older than six years. It is available as an aerosol, nebulized solution or oral capsule. N-Acetyl-L-cystine has been shown to have a protective effect against influenza virus (Virus A) infection by reducing the proinflammatory cytokines and reactive oxygen species in response to the virus. This drug also reduces the severity of symptoms associated with influenza virus infection. The pharmacokinetic properties of this drug are well understood, as it is stable in vivo, crosses the blood brain barrier, and does not bind to serum proteins.</p>

<p>Procyanidin B2 3,3'-di-o-gallate (PB2DOG) is a gallotannin that can be found in the leaves of the dogwood tree. It has dose-dependent effects on the serine protease activity of butanol, which is used as a model for pancreatic lipase. PB2DOG also inhibits the activity of viruses such as hepatitis C and herpes simplex virus type 1, and cancer cells such as du145 and japonica. PB2DOG has been shown to induce apoptosis in cancer cells by reducing DNA synthesis and inhibiting protein synthesis. The mechanism behind this effect is not fully understood, but it may be related to its ability to inhibit cCAAT/enhancer binding protein (C/EBP), an important transcription factor for cell proliferation.</p>

<p>1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol (1SA2AP) is a glycerophospholipid that is the major phosphatidylinositol in platelets. 1SA2AP is hydrolyzed by phospholipase A2 into arachidonic acid and 1,2-diacylglycerol. The selectivity of 1SA2AP for ionization mass spectrometry has been demonstrated using ethanolamine and choline as standards. In this study, a kinetic method was used to determine the sensitivity and selectivity of electrospray ionization mass spectrometry for 1SA2AP. Analytical results were obtained from data collected from the analysis of two samples containing different concentrations of 1SA2AP.</p>

<p>Please enquire for more information about Pregabalin inhouse impurity (RS-mme) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Nascopine is an analog of nifedipine that acts as a potent inhibitor of protein kinases. It has been shown to induce apoptosis in human cancer cells and inhibit the growth of tumors in Chinese hamsters. Nascopine is an anticancer drug that works by blocking the activity of kinases, which play a crucial role in cancer cell proliferation and survival. This drug has been found to be effective against a wide range of cancers, including breast, prostate, and lung cancer. In addition, Nascopine has been found in urine samples from cancer patients undergoing treatment with this drug. Its unique mechanism of action makes it a promising candidate for further development as an anticancer therapy.</p>

<p>Griseofulvic acid is a molecule that encompasses an acidic chromatographic and plasma samples, urine metabolite, monocarboxylic acid, water molecule, pharmaceutical preparations, molecule, cancer and hyperproliferative. Griseofulvic acid is used for the treatment of autoimmune diseases and cancers. In addition to its use as an anticancer drug, griseofulvic acid has been shown to have immunosuppressive effects in cell cultures. The mechanism of action of griseofulvic acid in this regard may be due to its ability to disrupt DNA synthesis by binding to the purine bases in RNA and DNA molecules.</p>

<p>Pioglitazone is a thiazolidinedione antidiabetic agent that is used to treat type 2 diabetes. Pioglitazone has been shown to have the potential to attenuate insulin resistance and decrease hepatic glucose output. Pioglitazone has also been shown to inhibit many of the enzymes involved in the metabolism of glucose, such as glucokinase, phosphoenolpyruvate carboxykinase, and pyruvate dehydrogenase. In addition, pioglitazone has been shown to increase insulin sensitivity by increasing the number of insulin receptors on cell membranes. Pioglitazone has also been shown to reduce blood pressure through its effects on erythropoietin activity and nitric oxide production. This drug may act as an antioxidant by inhibiting peroxidation of lipids in the liver.<br>Pioglitazone has also been studied for its effect on nervous system diseases, such as Alzheimer's disease and X</p>

<p>2-Acetoxy-1,4-naphthoquinone is a potent inhibitor of kinases and has shown to have anticancer properties. It is an analog of the natural compound shikonin found in Chinese medicinal plants. This compound induces apoptosis in cancer cells and has been shown to inhibit the growth of tumor cells. 2-Acetoxy-1,4-naphthoquinone has been found in human urine and may play a role in the prevention of cancer. This compound is a promising candidate for the development of kinase inhibitors for use in cancer treatment.</p>

<p>Remdesivir related compound 7 is a drug product that is being synthesized for use in research and development. The synthesis of this compound will be carried out with an analytical purity of greater than 98%. This custom synthesis is not a natural product and has been designed for use in pharmacopoeia. Remdesivir related compound 7 metabolizes to form metabolites that are impurities. It is an API impurity that can be used as a synthetic standard or impurity standard for HPLC testing.</p>

<p>Amino albendazole sulfone is an anthelmintic drug that is used to treat worm infestations in animals. It is the active metabolite of fenbendazole sulfone and has a terminal half-life of 12 hours in humans. Amino albendazole sulfone can be prepared by chromatographic methods, such as liquid chromatography or gas chromatography, and it can be analyzed with a fluorescence detector. This drug has been shown to have a concentration–time curve following administration to rats and results in an increase in the number of worms eliminated from the body.</p>

<p>14-Epiandrographolide is a natural product that can be found in the plant Andrographis paniculata. It has been shown to have anti-inflammatory, anticancer, and antibacterial properties. 14-Epiandrographolide inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Rifapentine also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.</p>

<p>2-Demethoxy-4-methoxy urapidil is a drug product that is used in the development of new drugs. It is a synthetic compound that is metabolized to form its natural metabolite, 2-demethoxyurapidil. This impurity standard has been shown to have anti-inflammatory effects and can be used as an API impurity for pharmacopoeia. 2DMO4MU has been shown to be useful in the study of metabolism and has been found to inhibit prostaglandin synthesis.</p>

<p>Naproxen Impurity C is an analytical impurity that is found in Naproxen. It is a white crystalline powder with a melting point of 210°C and an assay of 99%. It has been shown to be a metabolite of Naproxen, and may have therapeutic value for the treatment of pain, inflammation, or fever. The purity of this product has been verified by HPLC analysis.</p>

<p>Sodium picosulfate EP Impurity A is a drug product, analytical, Metabolism studies, Natural, API impurity, CAS No. 32500-19-9, Custom synthesis, Impurity standard, Synthetic, Drug development and Research and Development.</p>

<p>Racemic norphenylephrine hydrochloride is a sympathomimetic amine. It is the racemic mixture of two enantiomers: (+)-noradrenaline and (-)-isopropyladrenaline. Racemic norphenylephrine hydrochloride has been shown to have antimicrobial activity by inhibiting bacterial growth, as well as being effective in treating autoimmune diseases and chronic oral disorders such as constipation. Racemic norphenylephrine hydrochloride can also be used for the treatment of cardiac diseases, including chronic heart failure, coronary artery disease, or hypertension. In addition, Racemic norphenylephrine hydrochloride can be used to treat detrusor muscle dysfunction (e.g., urinary incontinence).</p>

<p>Pantoprazole is a proton pump inhibitor. It is used in the treatment of gastroesophageal reflux disease and other conditions involving excessive stomach acid production. The chemical name for Pantoprazole impurity is (E)-1-(4-chlorophenyl)ethyl-3-[(pyrrolidin-2-yl)oxy]propanediol. This substance is an enantiomer of pantoprazole, which has been determined to be inactive. Pantoprazole impurity can be identified by its melting point, crystallizing habit, and optical rotation. Active carbon filtration can be used to remove this substance from the final product.</p>

<p>Please enquire for more information about o-Methyl malathion α-monoacid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(2R,2R,Cis)-saxagliptin is an analytical research and development (R&amp;D) drug development API impurity HPLC standard that is a metabolite of saxagliptin. Saxagliptin is a drug product that has been approved for the treatment of type 2 diabetes. It has been shown to inhibit the activity of dipeptidyl peptidase-4 (DPP-4) in vitro and in vivo. Saxagliptin is a competitive inhibitor of DPP-4, which prevents it from breaking down incretin hormones such as glucagon-like peptide 1 (GLP-1). This results in increased levels of GLP-1, which improves blood glucose control. The purity level for this API impurity HPLC standard is high. Impurities are less than 0.5% and have been tested at various concentrations to ensure quality standards are met.</p>

<p>Azithromycin impurity J, also known as Azithromycin P-Toluenesulfonate, is an impurity of the drug azithromycin. It is an antibiotic that has been shown to be effective in the treatment of protozoal infections, cancer and parasites. Azithromycin impurity J has been shown to bind to DNA gyrase and topoisomerase IV enzymes, which are necessary for bacterial replication. Azithromycin impurity J is a protozoan inhibitor that acts by blocking the synthesis of RNA and DNA. This impurity binds to DNA gyrase and topoisomerase IV enzymes, which are necessary for bacterial replication. Azithromycin impurity J is a protozoan inhibitor that acts by blocking the synthesis of RNA and DNA.</p>

<p>3-((1R)-3-Hydroxy-1-phenyl-propyl)-4-hydroxy-benzoic acid methyl ester is a drug product that is used to synthesize standards for HPLC. It is an impurity in the API, Metabolism studies, Natural, CAS No. 1292905-33-9. This compound has been synthesized and can be custom synthesized. The purity of this compound is high with a purity of 99% or greater for the 3-(2′,4′-dihydroxyphenyl)propionic acid methyl ester.</p>

<p>Please enquire for more information about 4-[(2-Chlorophenyl)sulfonyl]benzenamine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-[2-[(8R)-1,6,7,8-Tetrahydro-6-oxo-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide is a synthetic compound that has not been identified in nature. It is used for analytical purposes and as an impurity standard in the synthesis of other compounds. N-[2-[(8R)-1,6,7,8-Tetrahydro-6-oxo-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide is the parent drug product of CAS No. 896736–22–4. The impurities found in this product are N-[2-(3′-(3″S″)-3′′S″′) (3″R″) -1H -indenyl](methyl)amine hydrochloride and N-[</p>

<p>Please enquire for more information about DM3-SMe including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Remsesivir related compound 11 is a research and development chemical that is used as an analytical, drug development, or impurity standard. It is a high purity, pure substance that can be custom synthesized or natural. Remsesivir related compound 11 has been shown to be metabolized by cytochrome p450 enzymes and glutathione reductase and has shown pharmacopoeia activities. Remsesivir related compound 11 can also be used as a HPLC standard for the detection of metabolites in pharmaceutical products.</p>

<p>D-Ribose-L-cysteine is a combination of D-ribose and L-cysteine. It is used for the treatment of bowel disease, radiation injury, pentobarbital sodium induced ileus, atherosclerotic lesion, oral hypoglycaemic, neuronal death, psychotic disorder in AIDS patients and active antiretroviral therapy. D-Ribose-L-cysteine has been shown to decrease ATP levels and increase histological damage in v79 cells. D-Ribose-L-cysteine has also been shown to have a protective effect on hamster V79 cells against inflammatory bowel disease by decreasing the release of inflammatory cytokines.</p>

<p>Ivacaftor is a drug product that is used for the treatment of cystic fibrosis. It is an active ingredient of Kalydeco, which is a combination therapy to treat cystic fibrosis. Ivacaftor is the first FDA-approved drug for the treatment of CF in patients with specific mutations. The metabolism of ivacaftor has been studied by analytical methods and it has been shown to have natural impurities. The API impurity and synthetic impurity standards are available for custom synthesis and can be ordered from a specialty manufacturer. Ivacaftor requires high purity and pharmacopoeia-grade standards for research and development as well as niche markets, such as HPLC standard or high purity.</p>

<p>Fosfomycin trometamol EP impurity A disodium is a research and development impurity standard. It is a custom synthesis that is used as a drug product, synthetic, high purity, pharmacopoeia, drug development, metabolite, niche, analytical and natural. Fosfomycin trometamol EP impurity A disodium has been shown to have an HPLC standard and CAS No. 84954-80-3(free base).</p>

<p>Desdifluoromethoxy hydroxy pantoprazole is a synthetic compound that is used as an impurity standard for the drug product Pantoprazole. It has a purity of ≥98% and is stable under ambient conditions. Desdifluoromethoxy hydroxy pantoprazole is not active on its own, but it is a metabolite of pantoprazole. It can be used to study the metabolism of pantoprazole.</p>

<p>Diclazuril is a drug product that is custom synthesized in our laboratory. It is a high purity, analytical standard with a CAS No. 1796928-69-2. Diclazuril is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. The natural form of diclazuril has been identified as the metabolite of clozapine and other antipsychotic drugs. This drug has been evaluated for its pharmacopoeia and HPLC standards. These standards are used to determine the quality and purity of drugs that are used in research and development.</p>

<p>Regaloside H is a medicinal compound found in urine that has shown promising results in the treatment of cancer. It works by inducing apoptosis, or programmed cell death, in cancer cells. Regaloside H has been shown to inhibit kinase activity, which is involved in cell cycle regulation and proliferation. This inhibitor effect makes it a potential candidate for anticancer therapy. In Chinese medicine, Regaloside H has been used as an herbal remedy for treating tumors. Studies have shown that it can target specific kinases that are overexpressed in certain types of human cancers, making it a potentially effective treatment option for cancer patients. Overall, Regaloside H represents a promising new avenue for the development of novel anticancer therapies.</p>

<p>Amoxicillin EP Impurity G is an impurity of Amoxicillin. It is a white to off-white crystalline powder with a melting point of 178 °C. The compound is soluble in alcohol, chloroform, ether, and acetone. This product can be used as an analytical standard for the drug development, niche drug product, or custom synthesis of the drug. Impurity G has been shown to have pharmacopoeia purity and natural origin. It can also be used as an impurity standard for HPLC analysis and pharmaceutical testing.</p>

<p>4-Descyano-4-bromo-letrozole is a white crystalline powder with a purity of 99.5% or greater. This product is used as an analytical reference standard in the detection of impurities in pharmaceutical products and as a research and development intermediate in the synthesis of other organic compounds. 4-Descyano-4-bromo-letrozole is a metabolite that can be produced by cytochrome P450 enzymes, such as CYP1A2, CYP3A4, and CYP3A5. The chemical name for this drug product is 4-[(2,6-dichlorophenyl)amino]-4-[(2,6-dichlorophenyl)amino]benzoic acid bromide. CAS No. 143030-54-0</p>

<p>Digitoxigenin mono-β-D-digitoxoside is a potent inhibitor of tumor growth and cancer cell proliferation. It is an analog of the cardiac glycoside digitoxin, which is known for its anticancer properties. Digitoxigenin mono-β-D-digitoxoside has been shown to induce apoptosis in human cancer cells by inhibiting protein kinases such as AKT and ERK1/2. This drug also has potential therapeutic applications in the treatment of ghrelin-related diseases, as it has been shown to inhibit the activity of ghrelin, a hormone that stimulates appetite and promotes weight gain. Additionally, digitoxigenin mono-β-D-digitoxoside exhibits high water solubility due to its cellulose-based structure, making it ideal for use in urine-based diagnostic tests for cancer detection.</p>

<p>2,2',3,4,4',5-Hexachlorobiphenyl is a potent inhibitor of cancer cell growth and has been shown to induce apoptosis in Chinese hamster ovary cells. This compound also inhibits the activity of kinase inhibitors such as chloroquine and artesunate. It has been found in human urine samples and may be involved in the development of cancer. 2,2',3,4,4',5-Hexachlorobiphenyl has been identified as an analog of tumor-promoting compounds and may have potential as an anticancer agent. Further research is needed to fully understand its mechanism of action and potential therapeutic applications.</p>

<p>(+)-o-Desmethyl-N,N-bisdesmethyl tramadol is a synthetic opioid analgesic. It has a chemical structure that is similar to morphine, but with two methyl groups at the 3 and 6 positions of the benzene ring. (+)-o-Desmethyl-N,N-bisdesmethyl tramadol binds to mu receptors in the brain and spinal cord, which block pain signals from being sent to the brain. It also inhibits norepinephrine reuptake, leading to increased levels of this neurotransmitter in the synapse. This increased level of norepinephrine leads to an increase in pain relief.</p>

<p>Please enquire for more information about N-Formyl-3,5-diiodo-L-tyrosine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Pentalenolactone O is a natural product, which is used as an analytical standard for the determination of metabolites in drug development and research. It can be synthesized from pentalenolactone A by hydrogenation with Raney nickel catalyst. Pentalenolactone O is also a synthetic compound that has been developed as an impurity standard for HPLC analysis. The purity of this compound is high, and it complies with the requirements of pharmacopoeias such as USP and BP.</p>

<p>8-Hydroxy warfarin-d5 is a drug product that is an impurity standard for the metabolism of warfarin. It is an analytical standard that can be used to determine the concentration of warfarin in a sample. The CAS number for 8-Hydroxy warfarin-d5 is 94820-66-3, and it has a molecular weight of 318.83 g/mol. This compound can be synthesized from natural sources or by chemical synthesis. 8-Hydroxy warfarin-d5 may also be used as a research and development tool in pharmacology, drug development, and toxicology studies.</p>

<p>Bu 224 hydrochloride is an exogenous ligand that binds to the imidazoline I1 receptor. It is a potent and selective agonist for this receptor, which has been shown to be located in cardiac tissue. Bu 224 hydrochloride has been shown to increase the release of noradrenaline from cardiac cells, resulting in cardiostimulant effects. The binding of Bu 224 hydrochloride to the I1 receptor also increases blood pressure, heart rate, and myocardial contractility. The effect on blood pressure is dose-dependent: low doses result in a mild increase in blood pressure, whereas higher doses can lead to severe hypertension.</p>

<p>Please enquire for more information about 3,4-Difluoro-2-(trifluoromethyl)-benzenamine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Deltan-benzyloxycarbonyl aliskiren is a drug product that is custom synthesized for research and development purposes. It is an analytical standard with high purity and quality, which has been studied in metabolism studies. The natural drug product is metabolized to form the metabolites, which are impurities. Metabolites of Deltan-benzyloxycarbonyl aliskiren are also available as HPLC standards, which are used as reference materials in pharmacopoeia. This compound can be used in niche areas of drug development, such as pharmaceutical research and development.</p>

<p>Brimonidine-2,3-dione is a synthetic compound that is used as an impurity standard in the research and development of drugs. It has a CAS number of 182627-95-8. The synthesis of Brimonidine-2,3-dione is not disclosed to the public. The drug product containing this substance is a high purity pharmaceutical grade. It has been shown to be metabolized in animal studies.</p>

<p>BGC-20-1531 is a medicinal compound that has been found to be an effective inhibitor of kinases in cancer cells. This Chinese-derived analog has shown potent anticancer activity in human tumor models and induces apoptosis in cancer cells. It works by inhibiting the protein kinase activity that is essential for cancer cell survival, leading to cell death. BGC-20-1531 has been shown to be effective against a wide range of cancer types and can be used as a potential therapeutic agent for cancer treatment. Additionally, this compound has been found in human urine and may have potential as a biomarker for cancer diagnosis and prognosis. With its unique characteristics, BGC-20-1531 is an exciting new prospect for the development of novel anticancer drugs.</p>

<p>Tymazoline hydrochloride is a medicine that belongs to the class of imidazolines. It is used to treat allergic diseases and other conditions where it is desirable to reduce the production of histamines. Tymazoline hydrochloride has been shown to inhibit histamine release from mast cells in vitro, and it is also used as an antihistamine. Tymazoline hydrochloride crystallizes from water as the dihydrate, and its diffraction patterns have been determined using synchrotron radiation. The molecule has an orthorhombic crystal structure with spacings of 0.7-0.8 nm between planes and intensities of 5-6 cm-1 in the X-ray region. Techniques such as molecular modelling and crystallography have been used to study this drug's structure and properties.</p>

<p>Trimethoprim 3-N-oxide is a metabolite of trimethoprim, which is used to treat urinary tract infections. It is excreted in the urine and its concentration can be measured by gas chromatography. Trimethoprim 3-N-oxide has been shown to inhibit bacterial growth in vitro and has been found to be effective against methicillin resistant Staphylococcus aureus (MRSA).</p>

<p>Rotigotine Impurity 5 is an analytical standard used as a reference material in research and development, high purity, drug development, API impurity, HPLC standard, niche, drug product. It is also used in Impurity standards, Metabolites and Pharmacopoeia. It has CAS No. 1148154-91-9 and is Natural or Synthetic.</p>

<p>Tetrahydrocurcumin monoglucuronide is an analog of curcumin, a natural compound found in turmeric. It has been shown to have potent anticancer properties by inhibiting kinases involved in cancer cell growth and proliferation. Tetrahydrocurcumin monoglucuronide has also been found to inhibit testosterone production, making it a potential treatment for hormone-dependent cancers such as prostate cancer. This compound induces apoptosis, or programmed cell death, in cancer cells and has been studied extensively for its potential use in Chinese traditional medicine for the treatment of various types of tumors. Tetrahydrocurcumin monoglucuronide is excreted in urine and is a promising candidate for the development of kinase inhibitors for cancer therapy.</p>

<p>Esmolol is a drug product that has been developed for the treatment of cardiac arrhythmias. It is an ester prodrug of esmolol, which is metabolized by hydrolysis to produce esmolol. Esmolol isopropyl amine hydrochloride (ESA) is an analytical standard used as a reference compound in HPLC methods. ESA is an impurity standard for API esmolol and CAS number 83356-59-6. Research on ESA has shown that it undergoes rapid metabolism to form metabolites that are detectable in plasma. Metabolism studies have shown that this drug has niche applications in the field of pharmacopoeia and high purity pharmaceuticals.</p>

<p>Neriifolin is a potent anticancer compound that has been isolated from the Chinese plant, Nerium oleander. It belongs to the class of xylan analogs and has been shown to inhibit the growth of cancer cells by inducing apoptosis. Neriifolin targets the cell cycle and inhibits the activity of protein kinases, which are essential for cell division. It has demonstrated significant inhibitory effects on tumor growth in human cancer cell lines, making it a promising candidate for cancer therapy. In addition, Neriifolin has been found to be a potent inhibitor of several key enzymes involved in cancer progression, making it an attractive target for developing new cancer therapies. Its effectiveness as an anticancer agent makes Neriifolin an important tool in the fight against cancer.</p>

<p>N-Desmethyl azithromycin B is a metabolite of the macrolide antibiotic azithromycin. It is an impurity in the drug product, and is present as an analytical standard for HPLC. N-Desmethyl azithromycin B can be found in the urine of patients taking azithromycin, but at much lower concentrations than the parent drug. This impurity is not toxicologically relevant, but may interfere with some analytical methods.</p>

<p>Enzalutamide Carboxylic Acid is a potent n-oxide derivative of Enzalutamide, which is used in the treatment of metastatic castration-resistant prostate cancer. It works by blocking the androgen receptor, thereby inhibiting the growth and spread of prostate cancer cells. Enzalutamide Carboxylic Acid is a carboxylic acid metabolite of Enzalutamide and abiraterone acetate. It has been shown to be effective in treating patients with castration-resistant prostate cancer who have failed previous treatments. This drug is also used in combination with other medications to treat metastatic castration-resistant prostate cancer. Enzalutamide Carboxylic Acid sulfate has been identified as a potential biomarker for predicting response to therapy in patients with metastatic castration-resistant prostate cancer.</p>

<p>Lisinopril diketopipirazine is an analytical drug product. The CAS number for this product is 219677-82-4. This product requires a custom synthesis and impurity standard. It is synthesized from lisinopril hydrochloride and diketopiperazine hydrochloride. Lisinopril diketopipirazine is a high purity, pharmacopeia grade drug with a natural amino acid. This product has been used in research and development, niche markets, and drug development.</p>

<p>Please enquire for more information about Fenirofibrate acyl-β-D-glucuronide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about N,N-Bis(2-chloroethyl)-4-methoxybenzenesulfonamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Amoxicillin EP Impurity E is an impurity found in Amoxicillin EP, which is a β-lactam antibiotic. It belongs to the group of β-lactam antibiotics and has antibacterial activity. Amoxicillin EP Impurity E is found by applying validation methods to measure the concentration of this product. The analytical method used for this impurity is a wavelength measurement or a magnetic field measurement. This impurity can be determined using chromatographic or elution methods. The chromatographic methods used are high performance liquid chromatography (HPLC) and gas chromatography (GC). Method development is required for determining the level of this impurity, as well as validation procedures for measuring it with various methods.</p>

<p>(R)-3-Quinuclidinyl di(2-thienyl)glycolate is a Chinese-made inhibitor that targets kinases in tumor cells. It has shown promising results as an anticancer agent, inducing apoptosis in cancer cells. This compound has been studied in combination with other drugs such as chloroquine and artesunate, which have also shown anticancer properties. (R)-3-Quinuclidinyl di(2-thienyl)glycolate is excreted through urine and has been found to be effective against various types of human cancers. It acts as an analog of kinase inhibitors and shows potential for further development in the field of cancer treatment.</p>

<p>Dapsone N-β-D-glucuronide sodium salt is a drug product that is Custom synthesized for your research and development needs. It is available for sale as a white to off-white crystalline powder with a purity of 98%. Dapsone N-β-D-glucuronide sodium salt has CAS No. 54749-81-4, analytical, Metabolism studies, Drug development, Natural, Metabolite, pharmacopoeia, niche, Synthetic, Impurity standard and Research and Development. It is an HPLC standard in the form of a white to off-white crystalline powder with a purity of 98%.</p>

<p>Hydroxythio acetildenafil is a synthetic drug product with CAS No. 1159977-47-5. It is used as an analytical standard for the examination of Metabolism studies, Natural, API impurity, Custom synthesis, Impurity standard, and Synthetic drugs. Hydroxythio acetildenafil can be custom synthesized in order to meet the needs of Drug development, Research and Development, niche markets, and High purity requirements. This product is also used as an HPLC standard in pharmacopoeia.</p>

<p>Ozagrel impurity I is a protein analog that has been shown to have anticancer properties. It acts as an inhibitor of kinases involved in cell cycle regulation and apoptosis, making it a potential candidate for cancer treatment. This impurity has been isolated from Chinese medicinal herbs and is present in human urine. Ozagrel impurity I has been tested against various cancer cell lines and has demonstrated significant growth inhibition. Its mechanism of action involves blocking the activity of proteins involved in tumor development and progression. Overall, Ozagrel impurity I shows promising potential as an anticancer agent.</p>

<p>Sdz Ser 082 fumarate is a 5-hydroxytryptamine (5-HT) receptor agonist that acts on the central nervous system. It is an experimental substance for the treatment of depression and other skin conditions. Sdz Ser 082 fumarate has been shown to have synergistic effects with gamma-aminobutyric acid, which may be due to its ability to inhibit gaba transporter activity. This drug also has anti-inflammatory properties, which may be due to its ability to block the release of proinflammatory cytokines like IL-6, TNF-α, and IL-8.</p>

<p>Please enquire for more information about Tofacitinib impurity 5 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Citalopram N-oxide hydrochloride is the n-oxide form of the antidepressant drug citalopram. It is a metabolite of citalopram that has been shown to have higher activity than the parent compound. The presence of citalopram N-oxide was detected in plasma samples using liquid chromatography with a wavelength of 220 nm and diethylamine as an eluent. Citalopram N-oxide hydrochloride has been shown to be pharmacologically active in animal studies, but its effects are not well understood.</p>

<p>N6-Methyladenosine-d3 is a drug product that is used as an HPLC standard. It has been synthesized using natural products or synthetic methods, and purified to meet high purity standards. It is intended for use as an analytical standard in the determination of impurities in APIs, and may be used in metabolism studies to investigate the effect of drugs on N6-methyladenosine-d3 levels.</p>

<p>Gatifloxacin is a fluoroquinolone antibiotic that inhibits the DNA gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. It binds to bacterial 16S ribosomal RNA and inhibits protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division. Gatifloxacin has been shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. Gatifloxacin has shown anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.<br>4'-[(4'Methyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][</p>

<p>5,6-Dehydro-17beta-dutasteride is a synthetic drug product that is used as an analytical standard for the determination of metabolites and impurities in pharmaceuticals. It also has been used as a natural metabolite, which can be found in human urine. 5,6-Dehydro-17beta-dutasteride is a metabolite of dutasteride, which is an antiandrogen medication for the treatment of benign prostatic hyperplasia (BPH). It is also known to inhibit the metabolism of other drugs such as ketoconazole and metoprolol.</p>

<p>N4-(5-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine is a synthetic compound that is used as an impurity standard in the synthesis of a number of drugs. It is also used for research and development purposes. N4-(5-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine can be used as an analytical reference material for high performance liquid chromatography (HPLC) methods. This compound was synthesized from 5-(chloromethyl)quinoline and diethylamine.</p>

<p>Des[2-[(2-hydroxyethyl)amino]ethyl] mitoxantrone is a research and development impurity standard for synthesis. It is a synthetic, high purity compound with a CAS number of 89991-52-6. The chemical is not found in nature and does not have any natural metabolites. Des[2-[(2-hydroxyethyl)amino]ethyl] mitoxantrone has been shown to be metabolized by the liver into various metabolites that have been identified through analysis of urine samples. The metabolite of des[2-[(2-hydroxyethyl)amino]ethyl] mitoxantrone may be used as an analytical standard for HPLC methods.</p>

<p>N2-Methyl alfuzosin is an impurity of Alfuzosin, a drug used to treat benign prostatic hyperplasia. It can be used as an HPLC standard for the detection and quantification of Alfuzosin in pharmaceutical products. N2-Methyl alfuzosin is a metabolite of Alfuzosin that is formed by cytochrome P450 3A4. It has been shown to have anti-inflammatory effects, which may be due to its inhibition of prostaglandin synthesis.</p>

<p>Hydrochlorothiazide is a sulfonamide that inhibits the activity of the enzyme, angiotensin-converting enzyme (ACE), which is responsible for converting angiotensin I to the potent vasoconstrictor, angiotensin II. It also has antihypertensive effects by blocking the production of aldosterone, which causes sodium retention and leads to high blood pressure. It is a byproduct in reactions with substances such as valsartan. Hydrochlorothiazide may react chemically with other medicines such as ampicillin and cefaclor.</p>

<p>Roxithromycin impurity I is a natural metabolite of roxithromycin. The substance has been synthesized in order to serve as an analytical impurity standard for HPLC. Roxithromycin impurity 1 is also a metabolite of roxithromycin, which has been shown to produce pharmacological effects similar to those seen with the parent compound. Roxithromycin impurity I is not an API, but has been developed as a HPLC analytical impurity standard and will be used for metabolism studies.</p>