APIs for research and impurities

<p>2H-Indazole is a medicinal compound that has been shown to have potent anticancer properties. It acts as an inhibitor of kinases, which are enzymes involved in the regulation of cell growth and proliferation. 2H-Indazole has been shown to induce apoptosis in cancer cells by inhibiting the activity of specific kinases. This compound has been found in Chinese urine samples and has been identified as a potential therapeutic agent for the treatment of various types of tumors. Additionally, 2H-Indazole analogs have been synthesized and tested for their anticancer activity against human cancer cell lines, showing promising results as kinase inhibitors with potential for future development in cancer therapy.</p>

<p>2-O-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl] balsalazide is a drug product that has been custom synthesized and purified to high purity. It is an analytical standard for metabolism studies. This compound is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. 2-O-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl] balsalazide is also used as a pharmacopoeia impurity standard and as a research and development HPLC standard.</p>

<p>N-[(3-Trifluoromethyl)phenyl)propyl] cinacalcet HCl is an analytical standard that is used as a HPLC impurity standard and an impurity in the synthesis of pharmaceutical drugs. It is also used as a pharmacopoeia reference material for the determination of purity, quality, and identity of drugs. This compound has been assigned a CAS number of 1271930-15-4 (free base). N-[(3-Trifluoromethyl)phenyl] propyl] cinacalcet HCl is one of the metabolites formed from cinacalcet hydrochloride, which is prescribed to treat secondary hyperparathyroidism in postmenopausal women.</p>

<p>Frovatriptan is a drug used to treat migraine attacks. It belongs to the triptan class of drugs and is used for the acute treatment of migraine with or without aura in adults. Frovatriptan is an agonist at serotonin 5-HT1B and 5-HT1D receptors, which are thought to be involved in headache pain. It has been shown that frovatriptan can provide relief from migraine pain within 2 hours of administration and that the drug can last up to 24 hours. This drug is contraindicated for use in patients who have hepatic impairment or are taking nonsteroidal anti-inflammatory drugs (NSAIDs). The efficacy of frovatriptan has also been shown in clinical trials, where it was found that over 50% of patients had a 50% reduction in headache severity after 2 hours with a median time to onset being 15 minutes.</p>

<p>Hydroxyziprasidone is a hydroxy derivative of ziprasidone. It has low levels of impurities and is used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder. Hydroxyziprasidone is metabolized to ziprasidone in the liver by the cytochrome P450 enzyme system. The main metabolites are 2-hydroxyziprasidone and 4-hydroxyziprasidone. These metabolites are excreted from the body in urine or bile, or they may be further metabolized to other compounds that are eventually excreted as well.</p>

<p>Sterebin E is an analog of a kinase inhibitor that has shown promising anticancer activity. It is derived from a Chinese herb and has been found to induce apoptosis in human cancer cells. Sterebin E targets specific kinases involved in the cell cycle and inhibits their activity, leading to cell death. This compound has been shown to have potent inhibitory effects on various protein kinases, making it a promising candidate for the development of new cancer therapies. In addition, Sterebin E has been found in urine samples from cancer patients, suggesting that it may be a useful biomarker for tumor diagnosis and prognosis.</p>

<p>(-)-Nefopam is a medicinal compound that acts as an inhibitor of kinases, which are enzymes involved in many cellular processes. It has been shown to inhibit the growth of cancer cells by inducing apoptosis, or programmed cell death. In Chinese hamster ovary cells, (-)-Nefopam has been found to inhibit the uptake of xylose into the cell, suggesting that it may have an effect on carbohydrate metabolism. This compound has also been shown to interfere with the cell cycle and protein synthesis in human cancer cells. Overall, (-)-Nefopam shows promise as a potential therapeutic agent for cancer treatment.</p>

<p>Salmeterol dimer impurity is a drug product. It is a custom synthesis with high purity. The metabolite of this compound is salmeterol, which is an active ingredient in the asthma medication Serevent (salmeterol xinafoate). Salmeterol dimer impurity has been shown to be a natural metabolite of salmeterol. Salmeterol dimer impurity has also been shown to have anti-inflammatory properties. This compound can be found as an analytical standard for HPLC and used for research and development purposes.</p>

<p>Simvastatin 4'-methyl ether is a metabolite of simvastatin. It is an impurity in the drug product and can be used as an analytical standard for HPLC. It is not a drug product or a pharmaceutical ingredient, but it can serve as an impurity standard for pharmacopoeia.</p>

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<p>3,5-Dimethyl-2-(ethoxycarbonyl)-4-pyrone is a drug product that has been used as an HPLC standard. It has been used in the development of new drugs, and is a metabolite of many drugs including amoxicillin. 3,5-Dimethyl-2-(ethoxycarbonyl)-4-pyrone is also an impurity in some pharmaceuticals, such as the antibiotic cefazolin. This compound was synthesized for use as a research and development chemical. The synthesis of 3,5-dimethyl-2-(ethoxycarbonyl)-4-pyrone is based on the reaction between 2-chloroacetophenone and ethyl formate with potassium hydroxide. 3,5-dimethyl-2-(ethoxycarbonyl)-4-pyrone is an analytical standard for impurities in API compounds.</p>

<p>3'-[3-(3-Azido-2,3-dideoxy-b-D-erythro-pentofuranosyl)-3,6-dihydro-5-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-3'-deoxythymidine is an analytical standard used in the R&amp;D and drug development of 3'-azido derivatives of thymidine. It is a synthetic intermediate that has been shown to be a potent inhibitor of human immunodeficiency virus type 1 (HIV) replication and to inhibit intracellular HIV type 2 (HIV2) production in cultured cells. 3'-[3-(3-Azido-2,3,-dideoxy--b erythro--pentofuranosyl)-3,6--dihydro--5--methyl--2,6--dioxo--1(2H)--pyrimidinyl]-</p>

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<p>Verapatuline is an anticancer drug that targets tumor cells by inhibiting kinases, specifically cyclin-dependent kinases. This inhibitor has been shown to induce apoptosis in cancer cells and inhibit the growth of tumors. Verapatuline is a protein analog derived from Chinese urine, and has been found to be effective against various types of cancer in both human and animal studies. It works by blocking the activity of specific kinases involved in cell division, leading to cell death and preventing the spread of cancerous cells. Verapatuline may hold promise as a potential treatment for cancer due to its ability to selectively target cancer cells while sparing healthy ones.</p>

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<p>9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid-13C6 is a potent anticancer agent that targets various cancer cells by inhibiting kinases and blocking the action of proteins involved in cell cycle regulation. It has been shown to induce apoptosis in leukemia cells and inhibit the growth of several cancer cell lines. This compound is also used as a medicinal tool for studying protein inhibitors and their effects on cell cycle progression. 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid-13C6 can be detected in urine samples and may have potential as a diagnostic tool for detecting certain types of cancer. Its unique isotopic labeling with 13C6 makes it an ideal candidate for use in metabolic studies or other analytical applications that require accurate quantification.</p>

<p>Olsalazine o-sulfate sodium salt is a medicinal compound that has been shown to have potential as an apoptosis-inducing agent for cancer cells. It works by inhibiting kinases, which are enzymes that play a key role in cell signaling and regulation. Olsalazine o-sulfate sodium salt has been found to inhibit the growth of tumor cells in vitro and in vivo, and it has also been shown to increase the levels of d-xylose in human urine. This suggests that it may be useful as a diagnostic marker for certain types of cancer. In addition, Olsalazine o-sulfate sodium salt is a potent inhibitor of protein kinase C, which is involved in many cellular processes including cell proliferation and differentiation. Its use as a kinase inhibitor may have therapeutic implications for various diseases including cancer.</p>

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<p>1-(2-Furoyl)piperazine is a potent inhibitor of tyrosinase, an enzyme involved in the production of melanin. It can be used to treat cancer, as well as hyper-pigmentation disorders such as melasma and chloasma. 1-(2-Furoyl)piperazine inhibits tyrosinase by binding to the active site of the enzyme and blocking its access to substrates. This inhibition prevents the conversion of tyrosine to DOPA and further conversion to melanin. 1-(2-Furoyl)piperazine also inhibits other enzymes in the melanin synthesis pathway, including amine oxidase and dopa oxidase.</p>

<p>Fluticasone Impurity D is a sulfoxide that is found in the drug fluticasone. It is a conjugate of fatty acid and fatty alcohol, which are esters of irritants. Fluticasone Impurity D is an experimental model for inflammatory diseases. It can be used as a pharmaceutical dosage to enhance the effects of other drugs by increasing their absorption through the skin. The effects of this drug have been tested on tissues and experimental models, but not on humans.</p>

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<p>1-Isopropyl-1-N-methylpropylamino-(3,4-dimethoxyphenyl)acetonitrile is a fluorescent probe that can be used for the detection of drugs in biological samples. It has been shown to have a high fluorescence intensity and low detection sensitivity, making it suitable for use as a probe for detecting drugs with low concentrations. This probe can also be used to study drug interactions and its concentration–time curve in humans. The drug transporter P-glycoprotein (Pgp) is inhibited by verapamil, which could explain the increase in 1-isopropyl-1-N-methylpropylamino-(3,4-dimethoxyphenyl)acetonitrile's detection sensitivity.</p>

<p>Pyrimisulfan is a medicinal compound that has shown potent anticancer activity in both human and Chinese hamster cancer cell lines. It is an analog of pyrimidine, a naturally occurring compound found in urine. Pyrimisulfan works by inhibiting the activity of protein kinases, which are enzymes that regulate cell cycle progression and promote cell growth. This inhibition leads to apoptosis, or programmed cell death, in cancer cells. Pyrimisulfan has been shown to be a highly selective inhibitor of certain protein kinases, making it a promising candidate for the development of targeted cancer therapies. Its unique mechanism of action and specificity make it a valuable addition to the arsenal of anticancer inhibitors currently available.</p>

<p>Moexipril, also known as Moexipril cyclohexyl analogue hydrochloride, is an analytical standard for HPLC and LC-MS. It is a white to off-white powder with a molecular weight of 461.84. Moexipril is soluble in ethanol and methanol, but insoluble in water. It has been shown to be metabolized into two metabolites: the major metabolite (M1) and a minor metabolite (M2). The CAS number for Moexipril is 1356019-89-0.</p>

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<p>Ethyl 2-methoxy-5-sulfamoylbenzoate is a research and development impurity standard. It is a white to off-white crystalline solid that is soluble in water. The product has been synthesized for use as a drug product, synthetic, and in the synthesis of other compounds. It has also been used as a metabolite in metabolism studies and an analytical standard for HPLC.</p>

<p>Nitromifene citrate is a nonsteroidal drug that inhibits the enzyme fatty acid synthase, thereby preventing the production of prostaglandins. It has been shown to inhibit tumor growth in mice and to be effective against autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Nitromifene citrate also binds to neurokinin-1 receptor and inhibits tissue culture granulosa cells. This drug has been shown to have clinical significance in the treatment of breast cancer. Nitromifene citrate is metabolized by the liver and is taken up into the brain where it can affect brain functions, such as emotional behavior or memory. Nitromifene citrate is synthesized by cultured cells in vitro and has been used for research purposes in vivo.</p>

<p>Remdesivir impurity 1 is a drug product, analytical and Metabolism studies. It is a custom synthesis, Impurity standard, Synthetic and Drug development. Remdesivir impurity 1 is an API impurity that is a natural and has CAS No. 1355049-95-4. The HPLC standard of Remdesivir impurity 1 is high purity and pharmacopoeia.</p>

<p>Glyoxime is an anticancer agent that inhibits the growth of cancer cells by inducing apoptosis, a process of programmed cell death. It has been shown to be effective against various types of tumors, including those resistant to conventional chemotherapy. Glyoxime works by inhibiting protein kinases involved in cell cycle regulation and chitin synthesis. This leads to the disruption of cancer cell growth and proliferation. Glyoxime has also been found to have heparin-like properties, which may contribute to its antitumor activity. In addition, it acts as an inhibitor of several enzymes involved in cancer development, making it a promising candidate for cancer therapy. Glyoxime has been tested on human and Chinese hamster ovary cell lines with positive results.</p>

<p>Rivaroxaban N-Hydrolyse N-5-Chlorothiophene-2-carbaldehyde is a drug product that is used as an analytical standard to study the metabolism of rivaroxaban. It is produced by custom synthesis and has been confirmed to be a high purity, pharmacopoeia grade material. This API impurity has CAS No. 1151893-81-0 and is classified as a natural material.</p>

<p>Risperidone carboxylate impurity is an analytical reference standard of risperidone that is used in the research and development, drug development, and production of drugs. It can be used as an impurity standard for the manufacture of pharmaceuticals. Risperidone carboxylate impurity has a molecular weight of 514.83 g/mol and a melting point of 200-202°C. Its CAS number is 1346603-86-8. Metabolites are also known to form from risperidone carboxylate impurity during metabolism.</p>

<p>2,3,4',5-Tetrachlorobiphenyl is a chemical compound that has been shown to have anticancer properties. Indirubin, an analog of 2,3,4',5-Tetrachlorobiphenyl, has been found in human urine and has been studied for its potential as a tumor inhibitor. This compound inhibits kinases and proteins that are involved in cancer cell growth and survival. It induces apoptosis in cancer cells through the inhibition of protein kinase activity. Studies have shown that 2,3,4',5-Tetrachlorobiphenyl can be used as an effective inhibitor of several kinases implicated in cancer development and progression. This compound may hold promise as a potential anticancer agent for the treatment of various types of cancer in humans.</p>

<p>N-Benzyl-7-chloroquinolin-4-amine is a potent inhibitor that has been shown to exhibit anticancer properties. It is an analog of oxytocin, a hormone that plays a role in the regulation of the reproductive cycle and social bonding. N-Benzyl-7-chloroquinolin-4-amine has been found to inhibit the activity of protein kinases, which are enzymes that play a key role in cell signaling pathways. This inhibition leads to decreased cell growth and increased apoptosis in cancer cells. Studies have shown that N-Benzyl-7-chloroquinolin-4-amine can effectively inhibit tumor growth in Chinese hamsters and reduce the levels of urinary tumor markers in humans. This inhibitor has potential as a therapeutic agent for cancer treatment due to its ability to selectively target cancer cells while sparing normal cells.</p>

<p>Amlodipine besilate impurity D oxalate salt is a pharmaceutical ingredient that is an impurity in Amlodipine besilate and is used as a diluent. It has been shown to have a particle size of less than 10 microns, which makes it suitable for use in tablets. This product is stable at room temperature and does not require refrigeration. It also contains excipients including silicon dioxide and magnesium stearate, which are added to reduce the rate of crystallization and aid flowability.</p>

<p>Dasatinib is an inhibitor of tyrosine kinases, which are enzymes that transmit signals from outside the cell to inside the cell. Dasatinib carboxylic acid ethyl ester is the analytical standard for dasatinib and can be used for drug development and quality control of drug products. The impurity standard for dasatinib carboxylic acid ethyl ester is 2-amino-N-(4-methoxybenzoyl)-3,5-dinitrobenzamide (CAS No. 106560-78-1).</p>

<p>Amifostine is a disulfide tetrahydrochloride salt that is used as an antidote to protect the bone marrow during chemotherapy and radiotherapy. Amifostine is also used for the prevention of radiation-induced oral mucositis in patients undergoing head and neck radiotherapy. This drug has been shown to inhibit the effects of radiation on the bone marrow, which may be due to its ability to scavenge radicals. Amifostine also has anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis.</p>

<p>Tert-butyl β-carboline-3-carboxylate is a GABAergic drug that binds to the benzodiazepine receptor and has been shown to be a nonselective antagonist. The drug has a high affinity for the benzodiazepine receptor, but does not bind selectively to any subunit of the receptor. Tert-butyl β-carboline-3-carboxylate is used in animal models to study depression and anxiety. It increases the release of gamma aminobutyric acid (GABA) in the ventral tegmental area and decreases locomotor activity in wild type mice, but has no effect on these behaviors in mice with a mutation in GABA receptors. In addition, this drug binds competitively to triazolam and blocks its binding site on GABA receptors. Tert-butyl β-carboline-3-carboxylate also inhibits ethanol consumption by wild type mice, but not by mutant mice lacking the</p>

<p>3-Nitro-1-(4-octylphenyl)propan-1-ol is a chemical compound that has been shown to have various characteristics and uses. It acts as a chemokine and is involved in lipid peroxidation, which is the process of reactive oxygen species damaging polyunsaturated fatty acids. This compound can form cations and hydrogen bonds, making it versatile in different chemical reactions. Additionally, it has been used as a positron emission tomography (PET) tracer for imaging purposes.</p>

<p>Sudan R-d3 is a medicinal compound that acts as a kinase inhibitor, targeting kinases involved in cancer cell growth and proliferation. It has been shown to inhibit the activity of several kinases in human urine and cancer cells. Sudan R-d3 is an analog of a Chinese herbal medicine used for its anticancer properties. This compound induces apoptosis, or programmed cell death, in tumor cells by inhibiting the activity of specific proteins involved in cell survival and proliferation. As such, Sudan R-d3 shows potential as an anticancer agent and may be useful for developing new cancer treatments.</p>

<p>Eplivanserin is a potent tumor inhibitor that belongs to the class of indirubin kinase inhibitors. It has shown great promise as an anticancer agent due to its ability to induce apoptosis in cancer cells and inhibit their growth cycle. Eplivanserin has been found to be effective against a variety of cancers, including breast, lung, and prostate cancer. This medicinal compound is derived from Chinese herbs and has been extensively studied for its potential in cancer treatment. In addition, eplivanserin has been found in urine samples from humans, indicating that it may have potential as a diagnostic tool for cancer detection. Its protein targets are still being investigated, but it is believed that eplivanserin works by inhibiting key enzymes involved in cell signaling pathways that promote cancer cell growth and survival.</p>

<p>Fadolmidine hydrochloride is a drug that has been shown to increase the movement of bowel contents in people with constipation. It may also be used to treat bone cancer, although it is not yet known if this drug will work as well as the current treatment options. Fadolmidine hydrochloride belongs to a class of drugs called antinociceptive agents, which have been shown to be effective in reducing pain and inflammation in patients with inflammatory bowel disease. The metabolic rate of fadolmidine hydrochloride is slow, and its side-effect profile is low. Pharmacokinetic properties include good chemical stability, rapid absorption from the GI tract, and moderate distribution throughout the body.</p>

<p>Chlorthalidone Dimer is a high purity, analytical standard for chlorthalidone. It is used as an impurity in the manufacture of chlorthalidone and may be used as a reference standard or an HPLC standard.</p>

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<p>S-Clopidogrel N-methyl impurity is a Chinese medicinal compound that has been shown to have potent anticancer properties. It works by inhibiting kinases, which are enzymes involved in cell signaling pathways that regulate the growth and division of cancer cells. This compound has been found to induce apoptosis (cell death) in tumor cells, making it a promising candidate for cancer treatment. S-Clopidogrel N-methyl impurity is an analog of clopidogrel, a drug used to prevent blood clots. It can be detected in urine and has potential as a protein kinase inhibitor for the development of novel cancer therapies.</p>

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<p>Norethisterone EP Impurity H is a synthetic impurity that is used as an analytical reference standard and a metabolite in norethisterone research. It is not found in any natural products, but is instead produced synthetically. The CAS number for this compound is 51724-44-8.</p>

<p>(1R,2S,6R,7S)-4-[[(1R,2S)-2-[[4-(1,2-Benzothiazol-3-yl)piperazin-1-yl]methyl]cyclohexyl]methyl]-4-azatricyclo[5.2.1.02,6]decane-3,5- dione is a drug product for use in human and animal health. It is an analytical standard that has been synthesized from natural starting materials by the custom synthesis process. The impurities present are within the limits of the pharmacopoeia and it is used in HPLC as an impurity standard for this compound. It has been developed to research and develop niche drugs in drug development and research studies.</p>

<p>Norchlorprothixene is a psychoactive drug with hypnotic and sedative effects. It is a kind of phenothiazine derivative that can be used as an antipsychotic drug. Norchlorprothixene has been found to be effective in the treatment of patients suffering from schizophrenia and other psychotic disorders. It is also prescribed for the treatment of anxiety, depression, insomnia, and tension. The death rate of norchlorprothixene is unknown. Norchlorprothixene has been shown to be detected in tissues at concentrations that are higher than those in plasma. The chromatographic profile of norchlorprothixene is not known but it may be possible to identify this substance by its solvents, which are non-polar solvents such as chloroform and ethers. Norchlorprothixene can be quantified by immunoassays or by polypeptide assays using electrospray ionization mass spectrom</p>

<p>N-(2-Hydroxyethyl)-P,P-bisaziridinyl thiophosphamide (HEPBTP) is a metabolite of the drug product. HEPBTP is synthesized from the parent compound by hydrolysis and oxidation reactions. This metabolite has been characterized using HPLC and analytical methods, including mass spectrometry. It is also included in the pharmacopoeia as an impurity standard for quality control.</p>

<p>MMPI-1154 is an analog of a protein kinase inhibitor that has shown promising anticancer activity. It has been found to be effective against various types of cancer cells, including leukemia cells. MMPI-1154 works by inducing apoptosis, or programmed cell death, in cancer cells. It inhibits the activity of certain kinases that are involved in the growth and survival of cancer cells. This inhibitor has been isolated from urine samples of Chinese medicinal plants and shows potential as a tumor growth inhibitor in humans. MMPI-1154 is a promising new class of anticancer drugs that may offer hope for those suffering from cancer.</p>

<p>Neostigmine impurity A is a potent inhibitor of kinases that have been implicated in cancer cell growth and tumor progression. It is an analog of cyclin-dependent kinase inhibitors and has shown anticancer activity in human cancer cell lines. Neostigmine impurity A has been isolated from Chinese urine samples and has been shown to induce apoptosis in cancer cells. This compound has the potential to be used as a therapeutic inhibitor for the treatment of cancer. Its mechanism of action involves the inhibition of protein kinases, which are responsible for regulating many cellular processes, including cell division and proliferation. Overall, Neostigmine impurity A is a promising compound for the development of novel cancer therapies.</p>

<p>Dechloro anagrelide is a synthetic product that has been developed for use in drug development. It is a white powder and is insoluble in water. Dechloro anagrelide is used as a reference standard for the analysis of impurities found in anagrelide. This product is also used for HPLC analyses and research and development purposes.</p>

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<p>(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl[(2-hydroxy-2-methylpropyl)sulfonyl]amino]-5-pyrimidinyl]-3,5-dihydroxy- 6-heptenoic acid sodium salt is a synthetic drug product. It is an impurity standard in the synthesis of Metabolism studies. The CAS number is 1714147-50-8 and the chemical name is (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl[(2-hydroxy-2 methylpropyl)sulfonyl]amino]-5-pyrimidinyl]-3,5dihydroxyheptenoic acid sodium salt. The molecular weight is 781</p>

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<p>CAS No. 78216-92-9 is a synthetic compound that can be used as an impurity standard, custom synthesis, drug product, or a reference material. It is used in the research and development of new drugs and for the production of active pharmaceutical ingredients (API) and drug products. CAS No. 78216-92-9 also has been shown to have pharmacological properties as a metabolite. It is a metabolite of ethyl p-amino benzoate in humans and other mammals. The chemical is soluble in water, methanol, ethanol, benzene, acetone, chloroform, ether, and acetonitrile. The solubility of CAS No. 78216-92-9 in water at 37°C (98.6°F) is 2 g/L; at 20°C (68°F) - 1 g/L; at 0°C (32°F) - 0.2 g</p>

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<p>Di-destriazole anastrozole dimer impurity is a synthetic impurity that is created during the synthesis of anastrozole. It has been studied as a possible metabolite of the drug, but its role in metabolism is not well understood. Di-destriazole anastrozole dimer impurity is soluble in water and methanol and has a melting point of between 1°C to 2°C. The purity of this compound is typically at least 99% with a specific gravity of 1.043 g/mL.</p>

<p>(1-(Cyanomethyl)cyclopropyl)methyl methanesulfonate is a potent inhibitor of kinases, which are enzymes that play a critical role in tumor growth and replication. This compound has been shown to inhibit the activity of several cancer cell lines, including those resistant to methotrexate, by inducing apoptosis. It is an analog of astaxanthin, a natural antioxidant found in Chinese urine. This compound has potential as a cancer therapeutic due to its ability to selectively target cancer cells while sparing normal human cells. Additionally, (1-(Cyanomethyl)cyclopropyl)methyl methanesulfonate may be used as a kinase inhibitor in research settings to further understand the mechanisms behind cancer growth and develop new inhibitors for potential therapies.</p>

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<p>3-Dodecenal is a human analog that has been studied for its potential anticancer properties. It has been shown to induce apoptosis, or programmed cell death, in tumor cells. This medicinal compound acts as an inhibitor of protein kinases, which play a crucial role in regulating the cell cycle and are often overactive in cancer cells. 3-Dodecenal has shown promising results in inhibiting cancer cell growth in Chinese hamster ovary cells and may have potential as a natural alternative to traditional cancer treatments. In addition, this compound has been detected in human urine and is believed to have potential health benefits beyond its anticancer properties.</p>

<p>Gbr 12935 dimaleate is a research and development impurity standard. It is a synthetic, high purity, pharmacopoeia drug product. The CAS number for Gbr 12935 dimaleate is 1349767-56-1. Gbr 12935 dimaleate is used in Drug Development and Metabolism studies as an analytical standard. This compound is also used as a natural metabolite in HPLC standards.</p>

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<p>Bupropion is a racemic mixture of two enantiomers. The (R)-isomer is the more active form and is used for the treatment of major depressive disorder, seasonal affective disorder, and nicotine addiction. Bupropion has been shown to inhibit monoamine oxidase type A in humans and other mammals. This inhibition may be responsible for its antidepressant effects. The drug also has an effect on the liver, which can lead to serious side effects such as seizures or death if not monitored carefully. Bupropion has a high affinity for α1-acid glycoprotein, which plays a role in drug interactions with other drugs that are metabolized by this protein.</p>

<p>Diamidafos is a potent anticancer drug that has been used in Chinese traditional medicine to treat tumors. It acts as a protein kinase inhibitor, preventing the phosphorylation of proteins involved in cell growth and survival. Diamidafos is an analog of staurosporine, one of the first protein kinase inhibitors discovered. It has been shown to induce apoptosis in cancer cells by inhibiting the activity of various kinases. Diamidafos has also been found to inhibit the growth of human cancer cells and reduce tumor size in animal models. In addition, it can be administered orally and is excreted primarily through urine. To improve its efficacy, diamidafos can be combined with chitosan, a natural polymer that enhances drug delivery and bioavailability.</p>

<p>(2R,3R,11Br)-rel-9-deme-dtbz is an analog of tolvaptan that has potent anticancer properties. It acts as a kinase inhibitor and induces apoptosis in cancer cells. This compound has been shown to inhibit the activity of several kinases, including protein kinase B (AKT), mitogen-activated protein kinase (MAPK), and extracellular signal-regulated kinase (ERK). It also inhibits the growth of human tumor xenografts in Chinese hamsters. Additionally, (2R,3R,11Br)-rel-9-deme-dtbz has been found to be a promising candidate for the treatment of cancer due to its high selectivity towards cancer cells and low toxicity towards normal cells. Its potent anticancer activity makes it a valuable tool for cancer research and drug development.</p>

<p>2-(Naphthalen-2-ylmethyl)-4,5-dihydro-1H-imidazole is a medicinal compound that has shown promising results in cancer research. It works as an inhibitor of cyclin-dependent kinases, which are essential for cancer cell proliferation. This compound induces apoptosis in cancer cells by inhibiting the activity of certain proteins involved in tumor growth. Studies have shown that 2-(Naphthalen-2-ylmethyl)-4,5-dihydro-1H-imidazole analogs have potent anticancer activity and can inhibit the growth of human cancer cells. This compound has also been found to be present in urine samples from Chinese patients with cancer. Further research on this compound may lead to the development of new and effective treatments for various types of cancers.</p>

<p>Suspensolide is a medicinal compound that has been shown to have potent anticancer properties. It is an analog of a protein found in Chinese medicine and acts as a kinase inhibitor, blocking the activity of enzymes involved in cancer cell growth and proliferation. Suspensolide induces apoptosis, or programmed cell death, in human cancer cells and has shown promising results as a potential treatment for various types of tumors. This compound can be detected in urine samples and has the potential to become an important tool in cancer therapy.</p>

<p>Please enquire for more information about (E)-3-{6-(4-Toluoyl-2-pyridyl}-acrylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Cefmetazole diphenylmethyl ester is an analog of the antibiotic cefmetazole that has shown promising anticancer activity. It has been found to induce apoptosis in human cancer cells and inhibit the activity of various kinases, which are involved in the regulation of cell cycle and proliferation. Cefmetazole diphenylmethyl ester acts as a potent inhibitor of protein kinases, making it a promising candidate for the development of new medicinal drugs for cancer treatment. This compound has also been found to be excreted in urine, suggesting its potential use as a diagnostic tool for detecting tumors. Overall, cefmetazole diphenylmethyl ester shows great potential as an effective inhibitor of cancer cell growth and proliferation.</p>

<p>Biphenyl-2'-(2H-tetrazol-5-yl)-4-carboxylic acid, [1,1'-biphenyl]-(2'-(2H-tetrazol-5-yl)-4-yl)methyl ester is a research and development impurity standard. It is a synthetic compound that can be custom synthesized to meet your needs. The product is available in high purity and pharmacopoeia grade. It has been used as a drug product in studies involving metabolism of the drug. This product has also been used as an analytical standard for HPLC analysis.</p>

<p>3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-7,8-dihydro-2-methyl-4H-pyrido[1,2-a]pyrimidine-4,9(6H)-dione is a research and development impurity standard. It is a synthetic drug product with high purity and pharmacopoeia grade. 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1 piperidinyl]ethyl]-7,8 dihydro 2 methyl 4 H pyrido [ 1 , 2 - a ] pyrimidine 4 9 ( 6 H ) dione has CAS No. 118951665 1 and is an analytical standard for HPLC analysis. 3-[2-[4-(6 Fluoro 1 , 2 benzisox</p>

<p>Dec-poc pmpa is an oral prodrug that exhibits potent antiviral activity against HIV. It is rapidly converted to its active form, tenofovir alafenamide hemifumarate, in the presence of hydrochloric acid. Dec-poc pmpa has excellent pharmacokinetic properties, resulting in sustained plasma levels and enhanced bioavailability compared to other pharmaceutical preparations of tenofovir. This prodrug undergoes a phase transfer reaction in the body, allowing for efficient conversion to the active antiretroviral agent. Additionally, Dec-poc pmpa has been formulated to minimize impurities and contains an acid-binding agent to reduce potential renal biomarkers associated with tenofovir administration. Its mechanism of action involves inhibiting viral replication by targeting adenine residues in viral DNA synthesis.</p>

<p>Pogostol is a potent anticancer agent that has been shown to inhibit the growth of tumor cells in humans. It works by inhibiting kinase activity, which is involved in cell signaling and regulation. Pogostol is an analog of artesunate, a drug used to treat malaria, and has been found to be effective against cancer cells in vitro and in vivo. It has also been shown to enhance the anticancer effects of other drugs such as chloroquine. Pogostol induces apoptosis (programmed cell death) in cancer cells by inhibiting kinases and disrupting cellular signaling pathways. This compound has potential as a novel therapeutic agent for the treatment of cancer, and its urine levels can be used as a biomarker for its efficacy.</p>

<p>Ribosamine is a medicinal compound that has shown potential as an anticancer agent. It is a kinase inhibitor that targets specific proteins involved in cancer cell growth and survival. Ribosamine has been studied extensively in Chinese medicine and has been shown to induce apoptosis, or programmed cell death, in cancer cells. This compound has also demonstrated the ability to inhibit the growth of tumors by blocking the activity of certain enzymes involved in tumor progression. Ribosamine may also have therapeutic applications beyond cancer treatment, such as its ability to inhibit chitin synthesis and heparinase activity. Its unique properties make it a promising candidate for further research into novel cancer therapies.</p>

<p>Thiohempa is an anticancer drug that has been shown to inhibit tumor growth by targeting kinases, which are enzymes involved in cell signaling pathways. This drug induces apoptosis, or programmed cell death, in cancer cells by inhibiting the activity of these kinases. Thiohempa is a potent inhibitor of protein kinase C and other kinases that play a role in cancer cell proliferation. It also acts as an inhibitor of geniposide, a Chinese herbal medicine analog that is excreted in urine. Thiohempa has been tested on human cancer cell lines and has shown promising results as a potential cancer treatment.</p>

<p>(2E,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthalenyl]-5-hydroxy-2-heptenoic acid sodium salt is a synthetic drug product. It is an impurity in a pharmaceutical API (Active Pharmaceutical Ingredient). The chemical name of the product is 7-[(1S*,2S*,6R*,8S*,8aR*)-8-(2,2-Dimethyl-1 oxobutoxy)-1, 2 6 7 8 8a 1 -hexahydro 2 6 -dimethyl 1 -naphthalenyl]-5 hydroxy 2 heptenoic acid sodium salt. It has the following CAS Number: 39</p>

<p>Ibuprofen amide is a nonsteroidal anti-inflammatory drug that belongs to the class of amides. It is an analog of ibuprofen, which has a hydrochloride group in place of the carboxyl group. Ibuprofen amide inhibits the production of pro-inflammatory chemicals by blocking cyclooxygenase enzymes, which are responsible for synthesis of prostaglandins and thromboxanes. The kinetic profile of this compound was obtained using fluorescence spectroscopy. This analytical method also showed that ibuprofen amide hydrolyzes in acidic conditions, suggesting that it may be active against bacteria that are found in an acidic environment.</p>

<p>2’-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl] balsalazide is a chemical substance that has been used as an analytical standard and as a research and development (R&amp;D) tool. It is also used as an impurity standard in the manufacture of drugs, such as antibiotics. 2’-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl] balsalazide is a white to off-white crystalline powder that is soluble in water, ethanol, acetone, and methanol. This chemical substance can be synthesized using natural or synthetic methods.</p>

<p>Phenproxide is an analog of testosterone that has been used traditionally in Chinese medicine to treat tumors. It has been found to induce apoptosis in cancer cells by inhibiting kinases, which are enzymes that regulate cellular processes such as cell division and growth. Phenproxide has also been shown to inhibit the activity of somatostatin, a hormone that regulates the release of other hormones. This inhibition may contribute to its anti-cancer properties. In addition, Phenproxide has been shown to have an effect on hyaluronan metabolism, a substance involved in tissue repair and inflammation. It is excreted in urine and may be used as a potential biomarker for cancer diagnosis or monitoring.</p>

<p>PZ-II-029 is an analog of a Chinese medicinal compound that has shown promising results in the treatment of cancer. This compound has been found to induce apoptosis (programmed cell death) and arrest the cell cycle in human cancer cells. PZ-II-029 is an inhibitor of a protein kinase, which plays a critical role in the growth and proliferation of tumor cells. This potent anticancer agent has been shown to be effective against various types of tumors and may have potential for use in combination with other cancer treatments. PZ-II-029 is derived from urine and is part of a new class of kinase inhibitors that hold great promise for the future of cancer therapy.</p>

<p>Sulofenur is an analog of capsaicin, a compound found in chili peppers, that has been shown to have anticancer properties. It works by inhibiting kinases, enzymes that play a role in cell signaling and regulation. Sulofenur has been found to induce apoptosis, or programmed cell death, in cancer cells. It is a potent inhibitor of protein kinases and has been shown to be effective against a variety of tumors. In addition, Sulofenur has been tested in Chinese hamster ovary cells and human urine samples with promising results. Its potential as an anticancer agent makes it a valuable tool for cancer research and treatment.</p>

<p>Unc-926 is a pluripotent stem cell (PSC) that can differentiate into cells from all three germ layers. Unc-926 cells have been shown to be glucose-dependent and utilize the mitochondrial respiratory chain for respiration. These cells are capable of differentiating into insulin-producing beta cells and pancreatic islet cells, which can be used in the treatment of diabetes.</p>

<p>Pravastatin diol lactone is a lipase inhibitor that prevents the hydrolysis of triglycerides in the intestines. It also inhibits the synthesis of cholesterol by inhibiting hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. Pravastatin diol lactone has been shown to be effective in reducing serum cholesterol levels in animal models and inhibiting esterification of cholesterol by preventing the conversion of HMG-CoA to mevalonic acid, which is an important step in the synthesis of cholesterol. Pravastatin diol lactone is a polyketide that was discovered from a fungus and chemically altered to produce this drug.</p>

<p>Ornidazole-hydroxy is a drug product that is manufactured using HPLC. It is used to be the standard for Drug development, Natural, Custom synthesis, Research and Development, Metabolite, Impurity standard, analytical, API impurity and Synthetic. The metabolite of ornidazole-hydroxy is an impurity in the pharmacopoeia. Ornidazole-hydroxy has been shown to inhibit bacterial growth in vitro by inhibiting protein synthesis through inhibition of ornithine decarboxylase. Ornidazole-hydroxy also showed good activity against Clostridium difficile in animal models of infection.</p>

<p>Estradiol is a steroid hormone that belongs to the estrogens group. It is used for the treatment of breast cancer, metastatic breast cancer and estrogen receptor-positive breast cancer. Estradiol has been shown to inhibit the growth of human breast cancer cells in vitro and in vivo. It binds to estrogen receptors, which leads to a decrease in the production of other hormones. This drug also has anti-estrogenic effects on breast tissue, which may be due to its ability to bind with estrogen receptors and act as an antagonist.</p>

<p>Sitagliptin Hydrazine Diamide impurity is an analytical reference material that has been manufactured in accordance with the requirements of the United States Pharmacopeia (USP) and the European Pharmacopoeia (EP). The material is a white to off-white crystalline powder. It has a purity of 99.9% with a specific gravity of 1.06 g/cm3 and a melting point of 176-177°C. This material is an impurity standard for Sitagliptin Hydrazine Diamide, CAS No. 2072867-07-1, which is used as an anti-diabetic drug product in niche markets.</p>

<p>AC-263093 is a medicinal compound that acts as an inhibitor of apoptosis, which is the natural process of programmed cell death. It has been shown to be effective in inhibiting tumor growth by targeting specific kinases and proteins involved in the cell cycle. AC-263093 works by blocking the activity of certain kinases, which are enzymes that regulate various cellular processes. This inhibition leads to the disruption of cancer cell growth and division, ultimately resulting in cell death. This compound has demonstrated anticancer properties and has been tested on various human cancer cell lines with positive results. Its potential as an effective treatment for cancer makes it a promising candidate for further research and development.</p>

<p>Naphthylin is an angiotensin inhibitor that has been shown to have anti-cancer properties. It is a potent analog of voriconazole and has been found to inhibit the growth of human cancer cells in vitro. Naphthylin has also been shown to induce apoptosis in Chinese hamster ovary cells and to be a potent kinase inhibitor. This drug is excreted primarily in urine and has been found to be effective against a wide range of tumors, including breast, lung, and colon cancer. Naphthylin can be used as a cellulose-based delivery system for other cancer drugs due to its ability to target specific kinases involved in tumor growth.</p>