Amino Acids (AA)

<p>Applications A reagent used to synthesize 5-HT2A and 5-HT3 receptor ligands for use in treating CNS-related disorders.<br>References Bermudez, J., et al.: J. Med. Chem., 33, 1924 (1990),<br></p>

<p>Stability Hygroscopic<br>Applications 2,2-Diselanediyldiethanamine dihydrochloride (cas# 3542-13-0) is a useful research chemical.<br></p>

<p>Applications 2,4,8,10-Tetraoxaspiro[5.5]undecane-3,9-diylbis(2-methylpropane-2,1-diyl) bis(3-(3-(tert-butyl)-4-hydroxy-5-methylphenyl)propanoate) (cas# 90498-90-1) is a useful compound used as a modifier for the thermo-oxidative stabilization of synthesized meterials such as polypropylene-based materials, and spider silk.<br>References Matta, A.; et al.: Polym. Degrad. Stab., 142, 50 (2017); Dao, A. T.; et al.: Polym. Degrad. Stab., 153, 37 (2018).<br></p>

<p>Applications N-Methylaniline is used as an additive in gasoline because of its antiknock properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, Li-jun, et al.: Huaxue Shiji, 37(1), 53-55, 96 (2015); Qin, Li-xia, et al.: Guangzhou Huagong, 43(8), 138-139, 148 (2015);<br></p>

<p>Applications 4-Methyl-2(5H)-furanone (cas# 6124-79-4) is a useful research chemical.<br></p>

<p>Applications (S)-2-Amino-4-[(3-aminopropyl)amino]-butanoic Acid is used in the reaction of carboxynorspermidine decarboxylase of Vibrio alginolyticus.<br>References Nakao, H., et al.: J. Gen. Microbiol. 136, 1699-704 (1990)<br></p>

<p>Stability Hygroscopic<br>Applications Chlorobutanol is used as a preservative and sedative. It has also been shown to exhibit antibacterial properties.<br>References Dutta, T., et al.: PCT Int. Appl., 22, (2020); Ibibia, E., et al.: Asian. J. Pharm. Clin. Res., 9, 179-182 (2016)<br></p>

<p>Applications Dl-valine<br></p>

<p>Applications Labelled 4-Methoxyestrone (M226135). An endogenous estrogen metabolite, risk-factor for development of breast cancer.<br>References Beral, V., et al.: Lancet, 362, 419 (2003), Nelson, R., et al.: Clin. Chem., 50, 373 (2004), Malekinejad, H., et al.: J. Agric. Food Chem., 54, 9785 (2006),<br></p>

<p>Applications It can be degraded efficiently by the QL-degrading bacteria.<br>References Shukla, O., et al.: Microbios., 59, 47 (1989), Oh, Y; Biotechnol Bioeng 1994, 44, 533,,,<br></p>

<p>Applications Caerulein is a ten amino acid oligopeptide that stimulates smooth muscle and increases digestive secretions. It is similar in action and composition to cholecystokinin. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction. It is used to induce pancreatitis in experimental animal models.<br>References Anastasi,E., et al.: Ep., 23, 699 (1997); De Caro, G., et al.: Br. J. Pharmac Chemother., 33, 48 (1968)<br></p>

<p>Applications 2-Methoxy-5-(methylsulfonyl)benzoic acid (cas# 50390-76-6) is a useful research chemical.<br></p>

<p>Applications 4-Methyl-1-octanol is an intermediate in the synthesis of 1,2-Cyclohexanedicarboxylic Acid Mono 4-Methyloctan-1-ol Ester which is a possible metabolite of the di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) monoester (MINCH).<br>References Koch, H., et al.: Arch. Toxicol., 87, 799 (2013)<br></p>

<p>Applications 4-Methoxy-6-(trifluoromethyl)-1,3,5-triazin-2-amine can be used as reactant/reagent in preparation of N-phenylsulfony-N'-pyrimidinylureas as herbicides.<br>References Hamprecht, G., et al.: Ger. Offen., DE 4322726 A1 19950112 (1995)<br></p>

<p>Applications N-Boc-L-Allylglycine is a boc-protected allylglycine used in the preparation of arginine analogues including the natural amino acid enduracididine.<br>References Saniere, L. et al.: Tetrahedron, 60, 5889 (2004): Leman, L. et al.: ARKIVOC, 6, 126 (2003);<br></p>

<p>Applications 2-hydroxy-3-methylpentanoic acid (cas# 488-15-3) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxy-3-methylpyridine, is an building block used in the chemical synthesis of various pharmaceutical and biologically active compounds. It is an intermediate for the synthesis of second generation agonist of the orphan G-protein coupled receptor GPR119, for the treatment of diabetes.<br>References Graeme, S., et al.: Bioorg. Med. Chem. Lett., 22, 1750 (2012);<br></p>

<p>Stability Light Sensitive<br>Applications 3-Methyl-diazirine-3-propanoic Acid is a reagent used in crosslinking sugars and photoactivatable crosslinking.<br>References Tanaka, Y. et al.: J. Am. Chem. Soc., 130, 3278 (2008);<br></p>

<p>Applications N-(4-Bromo-2-methylphenyl)-2-chloroacetamide (cas# 96686-51-0) is a useful research chemical.<br></p>

<p>Applications Dl-lysine monohydrate<br></p>

<p>Applications Pteroyltri-γ-L-glutamic acid is a folate derivative found in various foods such as yeast, spinach, beef liver, beef fillet and peas.<br>References Tamura, T., et al.: Br. J. Haematol., 25, 513 (1973); Ndaw, S., et al.: J. Chromatogr. A, 928, 77 (2001)<br></p>

<p>Applications D-LEUCYL-L-TYROSINE (cas# 3303-29-5) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Isotope labelled N-Acetyl-S-(2-cyanoethyl)-L-cysteine Ammonium Salt is a metabolite of Acrylonitrile (AN) and acrylamide (AM). Are commonly used in the synthesis of plastics and polymers.<br>References van Bladeren, P., et al.: Drug Metab. Dispos., 9, 246 (1981), Guengerich, F., et al.: Chem. Res. Toxicol., 4, 168 (1991),<br></p>

<p>Applications A labelled metabolite of Crotonaldehyde.<br>References Gray, J.M., et al.: Xenobiotica, 1, 55 (1971), Chung, F., et al.: Mutat. Res., 424, 71 (1999), Smith, C., et al.: Food Chem. Toxicol., 38, 637 (2000), Pan, J., et al.: Chem. Res. Toxicol., 15, 367 (2002),<br></p>

<p>Applications Norvaline, a hydrogen analogs of an amino acid, was found to be racemates from the Murchison meteorite show. Norvaline was used in chiral separation by electrokinetic chromatography.<br>References Cronin, J., et al.: Science, 275, 951 (1997); Pizzarello, S., et al.: Geochim. Cosmochim. Acta., 64, 329 (2000); Gerabe, S., et al.: J. Chromatogr., 480, 403 (1989);<br></p>

<p>Applications (±)-3-Amino-iso-butyric-2,3,3-d3 Acid is the labeled version of DL-3-Aminoisobutyric Acid (A603043(P)), which is a useful compound for suppressing atherosclerosis in apolipoprotein E-knockout mouse.<br>References Shimba, Y., et al.: Bio. Pharma. Bull., 43, 1016 (2020)<br></p>

<p>Applications Labelled DL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer’s treatment.<br>References Tanaka, M. et al.: Bioorg. Med. Chem., 21, 1159 (2013);<br></p>

<p>Applications 6-Methylpurine (cas# 2004-03-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Air Sensitive, Moisture Sensitive<br>Applications (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate hydrate (cas# 41468-25-1) is a useful research chemical.<br></p>

<p>Applications 3-Ethyl-2-methyl-2-(3-methylbutyl)-oxazolidine is a oxazolidine-based moisture scavenger for use in urethane coatings, sealants and elastomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Substrate for TenA enzyme in the thiamin salvage pathway<br>References Jenkins, A., et al.: Nat. Chem. Biol., 3, 492 (2007), Jenkins, A., et al.: Bioorg. Chem., 36, 29 (2008),<br></p>

<p>Applications 4,4'-Methylenedianiline is used in the production of polyurethane foams and epoxy resins (1). Potential contributor in pulmonary arterial hypertension (PAH) in rats through alteration of the serotenergic transport system (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Dyes and metabolites, Environmental Testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Hebert V. et al.: Cardiovas. Toxicol., 2011 Dec;11(4):316-24.2. Carroll-Turpin, M. et al.: Toxicol. Sci. 2015 Sep;147(1):235-45<br></p>

<p>Applications L-Hydroxyprolylglycine_x000D__x000D (cas# 7672-35-7) is a useful research chemical.<br></p>

<p>Applications 2-Methoxyphenylsulfate is used in the analysis of alkylsulfatases and their kinetics.<br>References Bateman, T. et al.: Biochem. J., 236, 401 (1986);<br></p>

<p>Stability Hygroscopic<br>Applications (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride is an important co-factor of mammalian mitochondrial energy metabolism. It is also a good active ingredient for dry-skin.<br>References Geier, David A., et al.: Neurochem. Res., 38(11), 2336-2341 (2013);Tanno, Osamu, et al.: Fragrance J., 33(8), 82-85 (2005);<br></p>

<p>Applications A protected glutamic acid for use in peptide synthesis.<br>References Takahashi, M., et al.: J. Exp. Biol., 200, 401 (1997), Michaelis, E., et al.: Prog. Neurobiol., 54, 369 (1998), Koch, H., et al.: Mol. Pharmacol., 55, 1044 (1999), O'Kane, R., et al.: J. Biol. Chem., 274, 31891 (1999),<br></p>

<p>M02979 - H-Glu-OH</p>

<p>Applications 4,4'-Methylene-d2-dianiline (CAS# 215590-72-0) is a useful isotopically labeled research compound.<br></p>

<p>Stability Very Hygroscopic<br>Applications 6-N-Trimethyl L-Lysine-d9, is the labeled analogue of Nε,Nε,Nε-Trimethyllysine, a metabolite and cofactor on the metabolic pathways.<br>References Rebouche C.J., et. al, J. Nutrition, 116(5), 751-759 (1986); Vaz, F.M et. al, J. Bio. Chem., 276(36), 33512-33517 (2001);<br></p>

<p>Applications L-Aspartyl-L-phenylalanine is an impurity of Thiamine (T344185). Thiamine Impurity B.<br>References Aluwihare, L., et al.: Science, 308, 1007 (2005), Koch, B., et al.: Anal. Chem., 79, 1758 (2007), Reemtsma, T., et al.: Environ. Sci. Technol., 42, 1430 (2008),<br></p>

<p>Applications L-Abrine is an indoleamino acid that displays radical scavenging and antioxidant properties.<br>References Yang, M., et al.: Food. Funct., 5, 2268 (2014);<br></p>

<p>Impurity Azathioprine EP Impurity C<br>Applications 5-Chloro-1-methyl-4-nitroimidazole (cas# 4897-25-0) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications 4-(4-Methylpiperazinomethyl)benzoic Acid, Dihydrochloride (cas# 106261-49-8) is a compound useful in organic synthesis.<br></p>

<p>Stability Air Sensitive<br>Applications L-Homocysteine is the hydrolysis product of adenosine (A280400), a purine nucleoside. Metabolic fate of L-Homocysteine is converted back to L-Methionine( M260440) via tetrahydrofolate.<br>References Liu, X.D., et al.: Org. BIomolec. Chem., 11, 4258 (2013); Chen, C.S., et al.: Nueroendocrinol., 97, 232 (2013);<br></p>

<p>Applications H-D-Ala-D-Leu-OH (cas# 67392-69-2) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Labelled N-Acetyl-S-(carbamoylethyl)-L-cysteine (A171870). N-Acetyl-S-(carbamoylethyl)-L-cysteine is the urinary metabolite of Acrylamide (AA). Acrylamide is formed during the heating of food and is classified as a genotoxic carcinogen.<br>References Besaratinia, A., et al.: Mutat. Res., 80, 31 (2005), Bjellaas, T., et al.: Xenobiotica, 35, 1003 (2005), Bjellaas, T., et al.: Food Chem. Toxicol., 45, 1020 (2007), Bjellaas, T., et al.: Toxicol. Sci., 98, 110 (2007),<br></p>

<p>Applications 3-Methyl-1,2,3-butanetricarboxylic Acid Trimethyl Ester is an intermediate in the synthesis of derivatives of α-pinene, a tracer compound for atmospheric terpene secondary organic aerosol (SOA) particles.<br>References Dette, H.P., et. al.: J. Phys. Chem. A., 118, 7024 (2014)<br></p>

<p>Applications Used in the synthesis of DMPO-type spin traps.<br>References Konaka, R., et al.: Free Radical Res., 23, 15 (1995),<br></p>

<p>Applications (4R, 2S)-4-Hydroxy-1-(9-phenyl-9H-fluoren-9-yl)-proline Methyl Ester (cas# 179990-59-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Labelled 1-Methyl-2-pyrrolidinone (M326120). It is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.<br>References Southwell, D., et al.: J. Pharm. Pharmacol., 33, 3 (1981), Barry, W., et al.: J. Invest. Dermatol., 82, 49 (1984),<br></p>

<p>Applications Labeled Sucrose (S697000). Yuanzhen sugar is a polysaccharide polymer, containing a certain amount of fructooligosaccharides.<br>References Watanabe, T., et al.: Biosci. Biotech. Biochem., 72, 3167 (2008), You, Y., et al.: J. Agric. Food Chem., 57, 709 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications 1,2-Cyclohexanedicarboxylic Acid Mono 4-Methyl-7-carboxy-heptyl Ester is a possible metabolite of the di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) monoester (MINCH).<br>References Koch, H., et al.: Arch. Toxicol., 87, 799 (2013)<br></p>

<p>Applications Used for the synthesis of Bortezomib from L-phenylalanine via dipeptidyl boronic acid ester intermediates.<br>References Zhu, Y., et al.: J. Med. Chem., 52, 4192 (2009),<br></p>

<p>Stability Unstable in Aqueous Solution<br>Applications 2-METHYL-1,4-BUTANEDIOL (cas# 2938-98-9) is a useful research chemical.<br></p>

<p>Applications 5-((2-Hydroxyethyl)amino)-2-methylphenol (cas# 55302-96-0) is a useful research chemical.<br></p>

<p>Applications N-Benzyloxycarbonyl L-Threonine Amide O-Methanesulfonate (cas# 80082-51-5) is a compound useful in organic synthesis.<br></p>

<p>Impurity Cefalexin EP Impurity D<br>Applications 3-Hydroxy-4-methyl-2(5H)-thiophenone (Cefalexin EP Impurity D) is an acid degradation product of Cephalexin (C256800) and Cefaclor (C235250), antibiotics.<br>References Dinner, A.: J. Med. Chem. 20, 963 (1977); Baetschi, S.W., et. al.: J. Pharmaceut., Sci., 86, 526 (1997)<br></p>

<p>Stability Light sensitive, Temperature Sensitive<br>Applications 3-Methyl-1,5-pentanediol Diacrylate is a useful chemical reagent.<br></p>

<p>Applications Sinorphan is an inhibitor of angiotensin-converting enzyme and neutral endopeptidase.<br>References Sulpizio, A.C., et al.: J. Pharmacol. Exp. Therap., 209, 1141 (2004); Takeda, Y., et al.: J. Hyper., 18, 927 (2000); Monteil, T., et al.: Syn. Comm., 31, 211 (2001);<br></p>

<p>Applications It is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.<br>References Southwell, D., et al.: J. Pharm. Pharmacol., 33, 3 (1981), Barry, W., et al.: J. Invest. Dermatol., 82, 49 (1984),<br></p>

<p>Impurity Iohexol EP Impurity K<br>Applications 5-Amino-2,4,6-triiodoisophthalic Acid (Iohexol EP Impurity K) is an intermediate for nonionic iodinated X-ray contrast agents.<br></p>

<p>Applications N-(2-Hydroxyethyl)glycine (~90%) (cas# 5835-28-9) is a compound useful in organic synthesis.<br></p>

<p>Applications An essential amino acid found in naturally produced peptides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins.<br>References Karunakaran, S.et al.: Bochem. J., 414, 343 (2008); Pallaghy, P.K. et al.: Biochem., 38, 11553 (1999);<br></p>

<p>Applications potassium 4-hydroxy-4-methylpentanoate (cas# 1607261-66-4) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Cysteine is a non-essential amino acid that can be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. Cysteine is commonly used as a precursor in the food and pharmaceutical industries. Cysteine is used as a processing aid for baking, as an additive in cigarettes, as well as in the preparation of meat flavours.<br>References Hui, N. et al.: Meat Sci. Appl., 74 (2001); Kiviharju, K. et al.: J. Biotechnol., 117, 299 (2005); Pecivova, P. et al.: J. Sci. Food Agric., 90, 1681 (2010);<br></p>