Amino Acids (AA)

<p>Applications 3-Methyl-2-hexanamine HCl Salt is more stable and easier to purify compared to the free base.<br></p>

<p>Stability Hygroscopic<br>Applications 1-(2-Methoxyphenyl)piperazine Hydrobromide is a useful reagent for improving the synthesis of Eapidil.<br>References Wang, H., et al.: Anhui Huagong, 37, 23 (2011)<br></p>

<p>Stability Unstable in methanol solution<br>Applications 4-Chloro-2-methylphenol Sulfate Sodium Salt is a halogenated derivative of o-toluenesulfonate, present in landfill leachates. o-Toluenesulfonate is an analog of the strong organic acid p-Toluenesulfonate.<br>References Riediker, S. et al.: Environ. Sci. Tech., 34, 2156 (2000);<br></p>

<p>Applications N-Succinimidyl 3-Methoxy-4-nitrobenzoate (cas# 2006277-78-5) is a useful research chemical.<br></p>

<p>Applications 7-Chloro-8-methylquinoline (cas# 78941-93-2) is a compound useful in organic synthesis.<br></p>

<p>Applications N-PHENYL-4-METHOXYBENZYLAMINE (cas# 3526-43-0) is a useful research chemical.<br></p>

<p>Applications 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is a reagent in the synthesis and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone which is an antibacterial agent. Benzoxazinyl-oxazolidinone had potent activity against Gram-positive pathogens. 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is also an intermediate in the synthesis of Tedizolid (T013750).<br>References Xin, Q., et al.: J. Med. Chem., 54, 7493 (2011)<br></p>

<p>Applications 3-Methylindole metabolite.<br>References Skordos, K., et al.: Chem. Res. Toxicol., 11, 741 (1998), Lanza, D., et al.: Drug Metab. Disposition, 29, 950 (2001), Hoenicke, K., et al.: J. Agric. Food Chem., 50, 4303 (2002),<br></p>

<p>Applications A red azoic dye. Dyes and metabolites, Environmental Testing<br>References Hoover, K., et al.: Chem. Res. Toxicol., 18, 1497 (2005), Altenburger, R., et al.: Environ. Toxicol. Chem., 24, 324 (2005), Gonzalez, M., et al.: Bioorg. Med. Chem., 13, 1775 (2005),<br></p>

<p>Applications 1-BOC-2,3-Dihydropyrrole-4-boronic acid, pinacol ester is a useful research chemical for organic synthesis and other chemical processes.<br>References Lewis, R. T., et al.: From PCT Int. Appl. (2017), WO 2017004359 A1 20170105<br></p>

<p>Stability Light Sensitive<br>Applications 4-Methoxyphenylhydrazine hydrochloride was used in the preparation of 5-cyano-3-(5-methoxy-2-methylindol-3-yl)-1,2,4-thiadiazole. It was also used to synthesize diarylpyrazoles as possible cyclooxygenase 2 ((COX-2)) inhibitors.<br>References Iwakawa, T., et al.: Chem. Pharm. Bull., 48, 160 (2000); Penning, T., et al.: J. Med. Chem., 40, 1347 (1997)<br></p>

<p>Applications: Isotope labelled analogue of 2-Methoxyacetic Acid, a synthetic intermediate in the synthesis of dimethyl(alkyloxy)[(methylsulfonyl)phenyl]furanones as COX-2 inhibitors.<br>Dangerous Goods Info: Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leblanc, Y., et al.: Bioorg. Med. Chem. Lett., 9, 2207 (1999);<br></p>

<p>Applications 3,5-Diiodo-DL-tyrosine is used for diagnosis of hypothyroidism caused by DEHAL1 gene defects.<br>References Encinas, S., et al.: Chem. Res. Toxicol., 11, 946 (1998), Daneshvar, A., et al.: Chemosphere, 80, 301 (2010), Eriksson, J., et al.: Photochem. Photobiol., 86, 528 (2010),<br></p>

<p>Applications 5-Methyl-3,4-diphenylisoxazole is a reagent for the preparation of valdecoxib and valdecoxib analogues.<br>References Di Nunno, L., et al.: J. Med. Chem., 47, 4881 (2004); Reddy, A. R., et al.: Synth. Commun., 42, 639 (2012); Huang, Y., et al.: Zhongguo Xiandai Yingyong, 26, 456 (2009)<br></p>

<p>Applications 1-Methoxy-4-(1E)-1-propen-1-ylbenzene is a component of essential oils extracted from natural sources. It is also a possible inhibitor of protein kinase CK2α and CK2α’.<br>References Liang, Zhi-yuan, et al.: Shizhen Guoyi Guoyao, 25(7), 1602-1604 (2014);Benelli, Giovanni, et al.: Indus. Crops and Prod., 124, 236-243 (2018);Baier, Andrea, et al.: Phytochem., 136, 39-45 (2017)<br></p>

<p>Applications 3-Methylnonane-2,4-dione is a compound that possesses a butter-like and beany off flavour that is a result of flavour reversion of soya-bean oil. 3-Methylnonane-2,4-dione is also present in Japanese green tea and pressure-cooked hen meat.<br>References Farkaš, P., et al.: Food Chem., 60, 617 (1997); Guth, H. &amp; Grosch, W.: Flav. Chem., No vol. given, 377 (1999); Kumazawa, K. &amp; Masuda, H.: J. Agr. Food Chem., 47, 5169 (1999)<br></p>

<p>Applications Ethametsulfuron-methyl is a regulator of the early steps of complement activation on mucosal surfaces. It can be used in combination treatment of ohmic heating with various essential oil components for inactivation of food-​borne pathogens in buffered peptone water and salsa.<br>References Kim, S. S., et al.: Food Control, 80, 29 (2017); Reichhardt, M. P., et al.: Front Immunol, 7, 85 (2016)<br></p>

<p>Applications 3-Formyl-5-methylbenzoic Acid<br></p>

<p>Applications Isotope labelled N-Isovalerylglycine is a useful diagnostic tool in the diagnosis of many organic acidemias and mitochondrial fatty acid β-oxidation defects. N-Isovalerylglycine is found in the urine of patients with isovaleric acidemia, an inborn error of leucine metabolism.<br>References Tanaka, K. et al.: J. Biol. Chem., 242, 2966 (1967); Bonafe, L. et al.: Mol. Gen. Metab., 69, 311 (2000);<br></p>

<p>Applications Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (cas# 27143-07-3) is a useful research chemical.<br></p>

<p>Applications N-Methylcytisine (cas# 486-86-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Intermediate in transsulfuration whereby the mammal transfers the sulfur of methionine via homocysteine to cysteine.<br>References Prochazka, Z., et al.: Collection Czechoslov. Chem. Commun., 45, 1982 (1980), Yorek, M.A. &amp; Spector, A.A.: Prog. Clin. Biol. Res., 179, 361 (1985)<br></p>

<p>Applications 2-Methyl-4-oxo-4-phenylbutyric Acid is a chemical reagent used in the synthesis of various pharmaceutically active compounds. Used in the synthesis of Minozac, a suppressor of brain proinflammatory cytokine up-regulation.<br>References Hu, W. et al.: Bioog. Med. Chem. Lett., 17, 414 (2007); Qabaja, G. ET AL.: J. ORG. CHEM., 80, 133 (2015);<br></p>

<p>Applications 5-(2-Hydroxyethylamino)-2-methoxylaniline sulfate (cas# 83763-48-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications This not naturally occurring amino acid was first observed after alkali treatment of different proteins. Synthetic Lysinoalanine was found to have a strong chelating ability for metals.<br>References Schwass, D., et al.: J. Agric. Food Chem., 32, 1377 (1984), Ahmed, M., et al.: J. Biol. Chem., 261, 8816 (1986), Wells-Knecht, K., et al.: Biochem., 34, 3702 (1995),<br></p>

<p>Applications 4-Hydroxy-3-methylpyridine, is an building block used in the chemical synthesis of various pharmaceutical and biologically active compounds. It is an intermediate for the synthesis of second generation agonist of the orphan G-protein coupled receptor GPR119, for the treatment of diabetes.<br>References Graeme, S., et al.: Bioorg. Med. Chem. Lett., 22, 1750 (2012);<br></p>

<p>Applications Bisphenol B Mono-β-D-glucuronide is a metabolite of Bisphenol B (B519565), which is the analogue of Bisphenol A (B519495), that is used to make certain plastic an epoxy resins. BPA and its analogs, are also shown to activate human pregnane X receptor (PXR), a nuclear receptor that functions as a master regulator of xenobiotic metabolism.<br>References Krishnan, A.V., et al.: Endocrinology, 132, 2279 (1993); Steinmetz, R., et al.: Trends Endocrinol. Metab., 9, 124 (1998); Petersen, H., et al.: Eur. Food Res. Technol., 216, 355 (2003); Yipeng, S., et al.: Env Hea. Pers., 120, 399 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520).<br>References Mochizuki, A., et al.: Jpn. Kokai Tokkyo Koho. JP 2010120852 A 20100603. Jun 3, 2010; Mochizuki, A., et al.: PCT Int. Appl. WO 2008123017 A1 20081016. Oct 16, 2008<br></p>

<p>Applications 4-methoxy-3-methylaniline (cas# 136-90-3) is a useful research chemical.<br></p>

<p>Applications 2-Hydroxy-5-methylpyridine (cas# 1003-68-5) is a useful compound for organic synthesis. In particular it has been used for the diastereoselective preparation of cyclobutane-fused pyridinyl sulfonyl fluorides.<br>References Liu, J., et al.: Org. Biomol. Chem., 18, 4019 (2020)<br></p>

<p>Applications N-(5-Methyl-3-isoxazolyl)benzenesulfonamide is used in the preparation of isoxazolecarboxylic acid derivatives as agricultural fungicides.<br>References Gomes, J.R.B., et al.: Tetrahedron, 61, 2705 (2005),<br></p>

<p>Applications 2-(4-Hydroxyphenyl)-3-methyl-1H-indol-5-ol is used as a reagent in the synthesis of tethered indoles as functionalizable ligands for estrogen receptor.<br>References Trogden, B.G., et al.: Bioorg. Med. Chem. Lett., 19, 485 (2009)<br></p>

<p>Applications 3-Hydroxy-2-methylbutanoic Acid (cas# 473-86-9) is a compound useful in organic synthesis.<br></p>

<p>Applications DL-2-aminobutyric acid<br></p>

<p>Stability Hygroscopic<br>Applications 3-Chloro-L-tyrosine was used in the enzymatic synthesis of halogen derivatives of aromatic amino acids labeled with hydrogen isotope. 3-Chloro-L-tyrosine exhibited stronger antioxidant properties in Hb-induced oxidative stress as was evident by higher efficiency of reduction of ferryl species.<br>References Winnicka, E., et al.: J. Chem. Eng., 8, 54 (2014); Lu, N., et al.: Toxicol. In Vitro, 28, 847 (2014);<br></p>

<p>Stability Light Sensitive<br>Applications 2-Methoxyphenol (CAS# 90-05-1) is useful for testing ruthenium- and palladium-containing catalysts activity via guaiacol hydrogenation.<br>References Shakirov, I. I., et al.: Pet. Chem., 60, 1136 (2020)<br></p>

<p>Applications N-Acetyl-L-Tryptophan, is a derivative of L-Tryptophan (T947210), that can be used as competitive inhibitor to identify and characterize tryptophanases. It can also be used as an NK1 tachykinin receptor antagonist, that may help to develop a novel therapeutic intervention for the treatment of reperfusion injury in acute ischemic stroke.<br>References Turner, R. J., et al.: Neuroscience, 220, 1 (2012);<br></p>

<p>Applications L-Abrine is an indoleamino acid that displays radical scavenging and antioxidant properties.<br>References Yang, M., et al.: Food. Funct., 5, 2268 (2014);<br></p>

<p>Stability Moisture Sensitive<br>Applications 3-Glycidoxypropyltrimethoxysilane (cas# 2530-83-8) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Dityrosine (DY), a tyrosine dimer formed by 3,3’-biaryl bond formation can be used as a biomarker to detect oxidative protein damage and selective proteolysis. Fluorescence intensity decays of Dityrosine are generally characterized by two decay components, one with a lifetime in the range of 150 to 800 ps and another between 2.5 and 4.5 ns.<br>References Libertini, L., et al.: Biophys. J., 47, 765 (1985), Huggins, T., et al.: J. Biol. Chem., 268, 12341 (1993), Malencik, D., et al.: Biochemistry, 35, 4375 (1996),<br></p>

<p>Applications 4-Aminohippuric Acid is used in the measurement of renal plasma flow as a diagnostic tool which may be applied towards kidney disorders.<br>References Phillips, R. et al.: Am. J. Physiol., 152, 523 (1948);<br></p>

<p>Applications 1-Bromo-3-methylbutane, is used as an extraction solvent to determine various polycyclic aromatic hydrocarbons in water samples though dispersive liquid-liquid microextraction along with GC-MS (gas chromatography- mass spectrometry).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rezaee, M., et al.: J. Chromat. A., 1116, 1 (2006)<br></p>

<p>Applications Protected (S) enantiomer of the amino acid Phenylalanine.<br>References Zhu, P., et al.: Bioorg. Med. Chem. Lett., 19, 6966 (2009), Cramer, B., et al.: Bioorg. Med. Chem., 18, 343 (2010),<br></p>

<p>Applications 1,3,5-Trichloro-2-methylbenzene can be used as reactant/reagent in hydrodechlorination process and catalysts for the production of 2,​6-​dichlorotoluene from polychlorotoluene-​containing mixtures. Also, it is derived from 2,4,6-Trichlorobenzoic Acid (T774715), which is a possible degradation intermediate of Polychlorinated Biphenyls (PCBs) in contaminated soil, suggesting the occurrence of microbial transformation processes over time.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Eichinger, W., et al.: PCT Int. Appl., WO 2001017932 A1 20010315 (2001); Stella, T., et al.: Sci Total Environ, 533, 177-186 (2015)<br></p>

<p>Applications (R)-N-(1-Carboxyethyl)-D-norvaline 1-Ethyl Ester is an intermediate in the synthesis of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.<br>References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Melatonin (M215000).<br>References Reiter, R.J., et al.: J. Biomed. Sci., 7, 444 (2000), Chen, Z., et al.: Am. J. Physiol, 284, 1618 (2003), Barrenetxe, J., et al.: J. Physiol. Biochem., 60, 61 (2004),<br></p>

<p>Applications N-Methyl-N-nitroso-1-octadecylamine was found to present in various hair-care products when investigated through thermal energy analyzer.<br>References Morrison, J.B., et al.: Food. Chem. Toxicol., 21, 69 (1983); Rainey, W.T., et al.: Biomed. Mass. Spec., 5, 395 (1978);<br></p>

<p>Applications Intermediate in the production of anti-cancer quinoline derivatives and antibacterial agents<br>References Zhao, H., et al.: Bioorg. Med. Chem. Lett., 12, 3105 (2002),<br></p>

<p>Applications 3-Methyl-2-furoic Acid-d is a deuterated version of 3-Methyl-2-furoic Acid (M219553), a useful reactant in the synthesis of therapeutic agents.<br>References Dragovich, Peter S., et al.: Bioorg. &amp; Med. Chem. Let., 24(3), 954-962 (2014);Garcia-Barrantes, Pedro M., et al.: J. of Med. Chem., 58(20), 7959-7971 (2015)<br></p>

<p>Applications 2-Methoxy-1-[4-(oxiranylmethoxy)phenyl]ethanone (cas# 110458-44-1) is a compound useful in organic synthesis.<br></p>

<p>Applications An efficient reagent for aminoacylations. Used in the synthesis of chiral Pilocarpine analogs via a C-8 ketone intermediate.<br>References Enz, A., et al.: Life Sci., 52, 513 (1993), Felder, C., et al.: J. Med. Chem., 43, 4333 (2000),<br></p>

<p>Applications 3-(methyl-d3)-1H-Indole-2,4,5,6,7-d5 is the labeled analogue of 3-Methylindole (M313470), a naturally abundant pneumotoxin, found primarily in mammalian feces providing its strong fecal odor; however in lower concentrations the compound has a pleasent aroma, giving orange blossoms and jasmine their pleasing scent. It is often a component of commercial fragrances and perfumes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nakashima, T., et al.: Biol. Pharm. Bull., 32, 832 (2009), Xu, H., et al.: Chem. Pharm. Bull., 57, 321 (2009), Bodoor, K., et al.: J. Med. Chem., 52, 3753 (2009), Naskar, S., et al.: J. Chem. Res., 3, 174 (2009), Sollner, K., et al.: J. Agric. Food Chem., 57, 4319 (2009),<br></p>

<p>Impurity Fluorouracil EP Impurity D<br>Applications 5-Methoxyuracil (Fluorouracil EP Impurity D) is methoxylated uracil, a component of nucleid acid. 5-Methoxyuracil is used in the preparation of nucleosides.<br>References Vorbrueggen, H. et al.: Chem. Ber., 114, 1279 (1981); Novacek, A. et al.: Coll. Czech. Chem. Comm., 32, 1045 (1967);<br></p>

<p>Applications (2E)-3-Methyl-1,3-benzothiazol-2(3H)-one Hydrazone Hydrochloride is used in method for synthesizing Methylbenzothiazolinone Hydrazone Hydrochloride Hydrate.<br>References Chen, W., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-chloro-5-fluoro-2-methoxypyrimidine (cas# 1801-06-5) is a useful research chemical.<br></p>

<p>Applications 2'-Deoxy-N-methyl-cytidine is a nucleotide derivative used as an analytical reagent.<br>References Dupret, D.: Biomed. Health. Res., 23(Human Genome Analysis), 244-255 (1998)<br></p>