Amino Acids (AA)

<p>Applications (E)-4-methoxy-2,3,6-trimethyl-5-(3,7,11,15-tetramethylhexadec-2-en-1-yl)phenol is a useful chemical reagent.<br></p>

<p>Applications Ethyl 2-[3-Fluoro-(trifluoromethyl)phenyl]-4-methyl-thiazole-5-carboxylate (cas# 317319-21-4) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Methylaniline Hydrochloride (cas# 2739-12-0) is a useful research chemical.<br></p>

<p>Applications 10-(t-Boc-amino)-1-decanol (cas# 173606-54-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(2-methylphenyl)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 101273-81-8) is a useful research chemical.<br></p>

<p>Applications 4-Chloro-2-methylphenol is a transformation/degredation product of herbicides found in the environment through landfills and runoff.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lagana, A. et al.: Anal. Chim. Acta., 462, 187 (2002); Irmak, S. et al.: App. Catal. B. Environ.., 63, 243 (2006);<br></p>

<p>Applications L-Leucine-2-d1 (CAS# 89836-93-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Nepsilon-Benzyloxycarbonyl-L-lysine-2,6,6-d3 is a useful isotopically labeled compound of N6-(Benzyloxycarbonyl)-L-lysine (B286220)<br></p>

<p>Applications N-(4-Chlorophenyl)-O-methylisourea Sulfate Salt (~90%) is a cytotoxic agent which displays tumor inhibitory activity.<br>References Hendry, J. et al.: Brit. J. Pharmacol. Chemother., 6, 201 (1951);<br></p>

<p>Applications Secobarbital-d5 (1-methyl-d3-butyl-2,2-d2) (CAS# 1219803-94-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-(n-Butylamino-2,2,3,3,4,4,4-d7)benzoic Acid (CAS# 1219803-44-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-methylpyrrolidin-3-ol hydrochloride (cas# 921592-91-8) is a useful research chemical.<br></p>

<p>Applications 7-Methyl-1-phenylpyrazolo[1,5-a]pyrimidine-2,5(1H,4H)-dione, is a building block used in the synthesis of various 5-pyrazolone derivatives.<br>References El-Zanfally, S. et al.: Indian Journal of Chemistry, Vol. 16B, Iss. 6, P: 496-8 (1978);<br></p>

<p>Applications Bis(3-methylpentyl) Phthalate, is used as a plasticizer to impart softness and flexibility to PVC products.<br>References Pierson, J. F., et al.: Angewandte Makromolekulare Chemie, 38, 167 (1979); Kaya, T., et al.: Chem. Res. Toxic., 19 (8), 999 (2006); Matter, H., et al.: Bioorg. Med. Chem., 20 (18), 5352 (2012);<br></p>

<p>Applications L-Methionine-d3 (S-methyl-d3) Methyl-d3 Sulfonium Chloride (CAS# 362049-54-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-methyl-1H-pyrazole hydrochloride (cas# 119760-62-2) is a useful research chemical.<br></p>

<p>Applications (1E,4E)-1-(4-Hydroxy-3-methoxyphenyl)-5-(4-hydroxyphenyl)-1,4-pentadien-3-one is used for preparation of anti-oxidative and anti-inflammatory curcumin0related phenolics.<br>References Masuda, T., et al.: Phytochem., 32, 1557 (1993);<br></p>

<p>Applications 4’-Chloro-2’-fluoro-5’-methylacetophenone is used as a reagent in the synthesis of 3-Aryl-5-hydroxyl-5-trifluoromethylisoxazolines which are important intermediates of protox-inhibiting herbicides.<br>References Zhou, Y., et al.: Jingxi Huagong, 21, 785 (2004)<br></p>

<p>Applications Glycerol 2-Methyl Ether is an derivative of Glycerol (G598400), used both in sample preparation and gel formation for polyacrylamide gel electrophoresis.<br>References Murata, M., et al.: Chem. Pharma. Bull., 37, 2670 (1989);<br></p>

<p>Applications Potassium Trifluoro(5-methoxy-2-pyridinyl)-borate-d3 is labelled Potassium Trifluoro(5-methoxy-2-pyridinyl)-borate (P698600) which is a useful synthetic intermediate.<br></p>

<p>Applications An intermediate in the production of Rosuvastatin (R700500) derivatives.<br>References Liu, Y. et al.: Guang. Huag., 39, 54 (2011);<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Methyl-7-nitroisatoic Anhydride is a reagent for RNA SHAPE-MaP experiments. Enables analysis of RNA secondary structures at single nucleotide resolution in &lt;70 seconds.<br></p>

<p>Applications 6-Chloro1,4-dihydro-1-methyl-4-phenyl-4-quinazolinol-13CD3 is the isotope labelled analog of 6-Chloro1,4-dihydro-1-methyl-4-phenyl-4-quinazolinol. 6-Chloro1,4-dihydro-1-methyl-4-phenyl-4-quinazolinol is used in hydroxyglycine reactions in determining a new synthetic route for phenylquinazoline derivatives.<br>References Hoefnagel, A.J., et al.: Tetrahedron, 49, 6899 (1993)<br></p>

<p>Applications An intermediate used in the synthesis of fluorescent indicators and various inhibitors<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Suzuki, T., et al.: Bioorg. Med. Chem. Lett., 17, 4208 (2007), Woodroofe, C., et al.: Biochem., 47, 10383 (2008),<br></p>

<p>Applications Heptyl 5-Methyl-2-hexyl Phthalate-d4, is the labeled analogue of Heptyl 5-Methyl-2-hexyl Phthalate, a phthalate ester used as plasticizers and additives.<br>References Peterson, J.C., et al.: Int. J. Envrion. Anal. Chem., 18, 237 (1984);<br></p>

<p>Applications N2-Cbz-D-glutamine is an N-Cbz-protected form of D-Glutamine (G597295). D-Glutamine is an unnatural isomer of L-Glutamine (G597000) that is present in human plasma an is a source of liberated ammonia. D-Glutamine can be synthesized by enzymatic means or can be found in cheeses, wine and vinegars as well. It is often used to determine the activity of Glutamine synthetase, an enzyme that is commonly found in the mammalian liver and brain that controls the use of nitrogen in cells.<br>References Almassy, R., et al.: Nature, 323, 304 (1986); Frank, H., et al.: J. Chromatog. B: Biomed. Sci. Appl., 224, 177 (1981); Jayme, D.: Cytotechnology, 5, 15 (1991); Kagan, H. &amp; Meister, A.: Biochemistry, 5, 725 (1966); Levintow, L. &amp; Meister, A.: J. Am. Chem. Soc., 75, 3039 (1953); Raj, D., et al.: Am. J. Phys. Endo. Metab., 280, E214 (2001); Varadi, M., et al.: Biosens. Bioelect., 14, 335 (1999)<br></p>

<p>Applications Ethyl 2-[5-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridyl]acetate (cas# 1076198-08-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-methyl[1,2,4]triazolo[1,5-a]pyridin-8-amine acts as a reagent in the one step synthesis of C-nucleosides s-triazolo[4,3-a]- and [1,5-a]pyridine using 2-pyridylhydrazines and ribofuranosyl thioformimidate.<br>References Huynh D. T., et al.: J. Org. Chem., 41, 3124 (1976)<br></p>

<p>Applications (S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide has been used as a reactant for the preparation of Brinzolamide (AL-4862) [B677600], a topical carbonic anhydrase inhibitor.<br>References Conrow, R.E., et. al.: Org. Process Res. Dev., 3, 114 (1999)<br></p>

<p>Applications N-Acetyl-L-alanine-3,3,3-d3 (CAS# 1485548-36-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(2,5-dimethoxy-4-methylphenyl)-2-propanone Oxime is a reagent used in research.<br>References Gal, J., et al.: J. Med. Chem., 18, 683 (1975);Weinkam, R., et al.: Anal. Chem., 48, 203(1976);Coutts, R.T., et al.: Org. Mass Spec., 7, 985 (1973)<br></p>

<p>Applications 4-Anilinomethylenepentenedioic Acid-d5 5-Methyl Ester (cas# 1185237-80-2) is a compound useful in organic synthesis.<br></p>

<p>Applications α-Methylstyrene-d5 Oxide is labelled α-Methylstyrene Oxide (M325390) which is structurally similar to rac Styrene Oxide (S687795), a major (toxic) metabolite of Styrene (S687790), catalyzed by epoxide hydrolase.<br>References Shen, S. et al.: Drug Metab. Disp., 38, 1934 (2010); Carlson, G.P. et al.: J. Toxicol. Env. Health, 73, 1689 (2010)<br></p>

<p>Applications 2-[[(4-Fluorophenyl)methyl]amino]-1,7-dihydro-5-methyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidine-6-propanoic Acid (cas# 1281266-20-3) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Methyl 6-Oxo Naltrexone Bromide is an intermediate used in the synthesis of (4R,4aS,6S,6aR,11bS)-6-Carboxy-3-(cyclopropylmethyl)-1,2,3,4,4a,5,6,6a-octahydro-4a,6,8-trihydroxy-3-methyl-4,11-methanobenzofuro[3',2':2,3]cyclopenta[1,2-c]pyridinium Bromide (C176950), which is an impurity/degradation of N-methyl Naltrexone (M320350), a metabolite of Naltrexone (N285750).<br>References Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007); Chem. and Eng. News p.4 Jan. 23, (2017)<br></p>

<p>Applications 3-Methylpentyl Chloroformate is an isomer of 2-Methylpentyl Chloroformate (M324735) which is an intermediate used to prepare azidoformates in a high yield.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wu, P., et al.: J. Chinese Chem. Soc., 47, 271 (2000)<br></p>

<p>Applications Phenyl 2-Hydroxy-4-methoxy-5-sulfobenzoate is synthesized from 4-Methoxysalicylic acid which is a reagent for chloropyridine oxadiazoles as potential antitumor agents.<br>References Zheng, Q., et al.: Bioorg. Med. Chem., 18, 7836 (2010);<br></p>

<p>Applications 2-Chloro-4-methylaniline is an intermediate used to prepare reverse transcriptase inhibitors of HIV-1.<br>References Chan, J., et al.: J. Med. Chem., 44, 1866 (2001);De La Rosa, M., et al.: Bioorg. Med. Chem. Lett., 16, 4444 (2006)<br></p>

<p>Applications 3-Chloro-2-(2-methoxyphenyl)-6-[N-(2-methylaminoethyl)pyperidin-4-yl]indole is used in the preparation of heterocyclic inhibitors of protein argenine methyltransferases; compounds which are used for treating hyperproliferative, inflammatory, infectious, and immunoregulatory disorders and diseases.<br>References Purandare, A. V., et al. Preparation of heterocyclic inhibitors of proteine arginine methyltransferases for treating hyperproliferative, inflammatory, infectious, and immunoregulatory diseases. U.S. Pat. Appl. 20060235037. Oct 19, 2006<br></p>

<p>Applications Used for the preparation of N-sulfonylamino acid derivatives as metalloproteinase inhibitors.<br>References Reed, R., et al.: Biochem. J., 191, 867 (1980), Fehske, K., et al.: Biochem. Pharm., 30, 687 (1981),<br></p>

<p>Applications 1-Methyl-3-Phenyl-1h-Pyrazol-5-Amine (cas# 10199-50-5) is a useful research chemical.<br></p>

<p>Applications m-Tyramine Hydrochloride affects the firing pattern of Heobania vermiculata. Potential organ or tumor imaging agent.<br>References Avoli, M., et al.: Comp. Biochem. Physiol. C: Pharmacol., 59C, 173-175 (1978); Counsell, R. E., et al.: J. Med. Chem., 16, 684-687 (1973);<br></p>

<p>Applications 4-(3-Fluoro-4-((2-(methyl-d3-carbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpicolinamide is the labeled analogue of 4-(3-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpicolinamide (F593180), an impurity of Regorafenib (R143000), which inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent.<br>References Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000)<br></p>

<p>Applications A labelled alanine derivative.<br></p>

<p>Applications 4-Methylcinnamic acid (cas# 1866-39-3) is a useful research chemical.<br></p>

<p>Applications 1-Carboxy-1-methylethoxyammonium Hydrochloride is used as a reactant in the synthesis of carbon-11 labeled celecoxib derivatives as new candidate PET radioligands for imaging of inflammation.<br>References Gao, M., et al.: Appl. Radiat. Isot., 67, 2019 (2009);<br></p>

<p>Applications N-Boc-D-tyrosine is an N-Boc-protected form of D-Tyrosine (T899970). D-Tyrosine is an unnatural isomer of L-Tyrosine (T899975) that inhibits metabolic activity of Bacillus subtilis. It is known to exhibit antimetabolic effects on rats as well, inhibiting growth and development. D-Tyrosine is also a chiral precursor to biosynthesized inhibitors that have antiinflammatory effects in humans.<br>References Champney, W. &amp; Jensen, R.: J. Bacteriol., 98, 205 (1969); Friedman, M.: Nut. Toxicol. Conseq. Food Proc., No vol. given, 447 (1991); Hansford, K., et al.: Chembiochem, 4, 181 (2003)<br></p>

<p>Applications 3-Methoxy-2,2-dimethylpropylamine Hydrochloride (cas# 171268-71-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Methyl-1-pentanol, occurs naturally in Capsicum frutescens, the tabasco pepper. It is also an intermediate in the manufacture of other chemicals, such as novel branched alkyl carbamates, having anticonvulsant activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gary, R., et al.: Source book of Flavors, (2 ed), 268 (1998); Hen, N., j. Med. Chem., 55 (6), 2835 (2012);<br></p>

<p>Applications 5-Octyl L-Glutamate is a stable cell-permeable molecule which generates free glutamic acid upon hydrolysis of the ester bond by cytoplasmic esterase.<br>References Chin, R.M., et al.: Nature, 509, 397 (2014)<br></p>

<p>Applications Fmoc-Aph(Hor)-OH (CAS# 1253282-31-3) is an intermediate of degarelix, a pharmeceutical hormone used in the treatment of prostate cancer. Fmoc-Aph(Hor)-OH has been used as a building block in peptide elongation reactions.<br>References Guryanov, I.; et al.: WO 2017103275 (2017); Takahashi, D.; et al.: Angew. Chem. Int. Ed., 56, 7803 (2017).<br></p>

<p>Applications 3-Methylbenzenesulfonamide (cas# 1899-94-1) is a useful research chemical.<br></p>

<p>Applications 5-Amino-2-methylene-1,3,3-trimethylindoline (cas# 6872-05-5) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Methylacetamide-2,2,2-d3 (CAS# 3669-69-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-Bromo-6-methoxynicotinic acid (cas# 1186194-46-6) is a useful research chemical.<br></p>

<p>Applications 5-Hydroxy-6-methoxy-1-indanone (cas# 127399-78-4) is a compound useful in organic synthesis.<br></p>

<p>Impurity Anastrozole 1,3-Dicyanomethyl Impurity<br>Applications 5-Methyl-1,3-benzenediacetonitrile is an Anastrozole intermediate. Anastrozole 1,3-Dicyanomethyl Impurity. Anastrozole is an aromatase inhibitor and used as an antineoplastic.<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>

<p>Applications 6-Methyl-3,6-diazabicyclo[3.1.1]heptane is a useful research chemical.<br></p>

<p>Applications N-Acetyl-L-arginine Methyl Ester is used in the synthetic route to biologically important L-arginine peptides.<br>References Levison, P.R., et al.: Synthetic Communic., 13, 167 (1983),<br></p>

<p>Applications n-Pentyl 3-Methyl-2-pentyl Phthalate-d4, is the labeled form of n-Pentyl 3-Methyl-2-pentyl Phthalate (P283625), a phthalate ester, which are ubiquitous environmental contaminants that interact with peroxisome proliferator-activated receptors (PPARs), a family of nuclear receptors. It is used as a plasticizer to impart softness and flexibility to PVC products.<br>References Kaya, T., et al.: Chem. Res. Toxic., 19 (8), 999 (2006); Matter, H., et al.: Bioorg. Med. Chem., 20 (18), 5352 (2012);<br></p>