Enzyme Modulators
Subcategories of "Enzyme Modulators"
Found 691 products for "Enzyme Modulators".
Nafamostat mesylate - Bio-X ™
CAS:Nafamostat is a broad-spectrum serine protease inhibitor produced by chemical synthesis. Nafamostat is effective through its antioxidant and anti-inflammatory activity. This drug is involved in inhibiting various enzyme systems such as coagulation and fibrinolytic systems.
Formula:C19H17N5O2•(CH4O3S)2Purity:Min. 95%Color and Shape:PowderMolecular weight:539.58 g/molTofacitinib citrate
CAS:Inhibits Jak kinases; immunosuppressive; anti-inflammatory
Formula:C16H20N6O·C6H8O7Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:504.49 g/molBAY 73-6691
CAS:Potent inhibitor of phosphodiesterase type 9 (PDE9), tested in human and murine in vitro assays (IC50 values: 55 nM and 100 nM, respectively). BAY 73-6691 induces long-term potentiation and improves memory in rodents. BAY 73-6691 has been studied as a potential therapy for Alzheimer’s disease.
Formula:C15H12ClF3N4OPurity:Min. 95%Color and Shape:PowderMolecular weight:356.73 g/molCilastatin
CAS:Cilastatin is a renal dehydropeptidase inhibitor, which is a compound sourced from synthetic processes designed to augment the pharmacokinetic profile of certain beta-lactam antibiotics. Its primary mode of action is to inhibit the enzyme dehydropeptidase I (DHP-I), located in the renal brush border. This enzyme typically degrades antibiotics, like imipenem, within the renal tubules. By inhibiting DHP-I, cilastatin prevents the inactivation of these antibiotics, thereby prolonging their active presence in the body and enhancing their antimicrobial efficacy.Formula:C16H26N2O5SPurity:Min. 95%Color and Shape:PowderMolecular weight:358.45 g/molJTZ 951
CAS:Inhibitor of HIF prolyl hydroxylaseFormula:C17H16N4O4Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:340.33 g/molPD 98059
CAS:MAP kinase kinase (MEK) inhibitor. Binds to MEK-1, preventing phosphorylation and activation by Raf or MEK kinase. PD 098059 enhances self-renewal in stem cells. Has anti-growth and anti-proliferative effects on AML cells. Anti-apoptotic effect on AML cells observed in synergy with Nutlin-3a.
Formula:C16H13O3NPurity:Min. 95%Color and Shape:Off-White PowderMolecular weight:267.28 g/molIrsogladine maleate - Bio-X ™
CAS:Irsogladine is a gastroprotective drug that is used for the treatment of GERD and gastric ulcers. This drug also has antioxidant properties. Irsogladine is a phosphodiesterase-4 inhibitor and increases levels of cAMP. It helps to prevent and heal damage to the stomach lining.Formula:C13H11Cl2N5O4Purity:Min. 95%Color and Shape:PowderMolecular weight:372.16 g/molLU 005i
CAS:Potent inhibitor of β5i subunit of immunoproteasomes (IC50 = 6.6 nM), selective over β5c subunit (IC50 = 287 nM). The β5i subunit of immunoproteasomes (iCPs) is the chymotrypsin-like active sites that have implications on anti-cancer affects. On the other hand, β5c subunits are found in constitutive proteasomes (cCPs).Formula:C31H46N4O7Purity:Min. 95%Color and Shape:PowderMolecular weight:586.72 g/molVeliparib
CAS:Potently inhibits PARP-1 and PARP-2 enzymes, orally bioavailable and crosses blood-brain barrier. Sensitises cancer cells to DNA-damaging chemotherapy and radiotherapy. Combination therapies investigated in clinical trials for solid and blood malignancies.
Formula:C13H16N4OPurity:Min. 95%Color and Shape:White PowderMolecular weight:244.29 g/molCilastatin sodium salt - Bio-X ™
CAS:Cilastatin is a renal dehydropeptidase inhibitor drug that is used to prevent degradation of imipenem. It is used to treat a variety of infections in combination with imipenem. This drug blocks the mechanism of imipenem which is hydrolyzed by dehydropeptidase-I.
Formula:C16H26N2O5S•NaPurity:Min. 95%Color and Shape:PowderMolecular weight:381.44 g/molT 3364366
CAS:A potent, reversible and slow-binding inhibitor of delta-5 desaturases (D5Ds), by binding to the desaturase domain. Inhibiting D5D has therapeutic applications in inflammatory diseases. This is due to the increase in anti-inflammatory DGLA-derived eicosanoids and decrease in pro-inflammatory AA-derived eicosanoids.
Formula:C18H16F3N3O3S2Purity:Min. 95%Color and Shape:SolidMolecular weight:443.47 g/mol1,3,4,6-Tetra-O-acetyl-2-deoxy-2-(2,2,2-trifluoroacetylamino)-D-glucopyranoside
CAS:Potent, selective and cell-permeable tool for modulation of O-GlcNAcylation. Ac4GlcNAcF3 is a dual modulator of O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Ac4GlcNAcF3 perturbates the GlcNAc cycling as OGT can incorporate GlcNAcF3 onto proteins but subsequently, it cannot be removed by OGA. In a mouse embryogenic fibroblast cell line, Ac4GlcNAcF3 increased the level of protein O-GlcNAcylation.Formula:C16H20F3NO10Purity:Min. 95%Color and Shape:PowderMolecular weight:443.33 g/molDaun02
CAS:A prodrug of the DNA-intercalating agent daunorubicin with anti-tumoral activity, used for suicide gene therapy and activity-dependent ablation of cells. Daun02 is an inactive form of the toxin, which gets activated upon cleavage with prodrug-activating enzyme β-galactosidase, yielding daunorubicin. Genetic constructs have been designed carrying the lacZ gene, coding for β-galactosidase, under control of application-specific promoters. The cells expressing the β-gal undergo cell death since the enzyme hydrolizes the prodrug into the active toxin.Formula:C41H44N2O20Purity:Min. 95%Color and Shape:Red To Brown SolidMolecular weight:884.24874Sildenafil - Bio-X ™
CAS:Sildenafil is a potent inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5), consequently preventing the degradation of cGMP in the smooth muscle cells of the pulmonary vasculature and penis. For this reason Sildenafil can be used to increase blood flow, decrease inflammation and mucus production in the lungs and also can be used in the treatment of erectile dysfunction in men. This is largely due to the increased availability of cGMP which can cause the relaxation of the smooth muscles to be prolonged.
Formula:C22H30N6O4SPurity:(%) Min. 95%Color and Shape:PowderMolecular weight:474.58 g/molBortezomib
CAS:Selective and reversible inhibitor of the multicatalytic 26S proteasome. The inhibition of protein breakdown affects several metabolic pathways and leads to cell death. The compound is effective in treating multiple myeloma because it prevents the binding of myeloma cells to bone marrow stroma and inhibits osteoclast differentiation.Formula:C19H25BN4O4Purity:Min. 95%Color and Shape:White PowderMolecular weight:384.24 g/molPalbociclib - Bio-X ™
CAS:This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.
Formula:C24H29N7O2Purity:Min. 95%Color and Shape:PowderMolecular weight:447.53 g/mol(S)-(-)-Blebbistatin
CAS:Inhibitor of myosin?II?specific ATPase which blocks the myosin heads in an actin-detached state, disrupts contractility of myosin-actin filaments and stabilizes super-relaxed state of muscle fibres. It inhibits skeletal muscle myosin, non-muscle myosin II and heart muscle myosin.
Formula:C18H16N2O2Purity:Min. 98 Area-%Color and Shape:Yellow PowderMolecular weight:292.3 g/molLY2157299
CAS:Inhibitor of kinase domain of TGF-β receptor type 1Formula:C22H19N5OPurity:Min. 95%Color and Shape:PowderMolecular weight:369.42 g/molZaltoprofen
CAS:Cyclooxygenase inhibitor; anti-inflammatory; antipyretic; analgesicFormula:C17H14O3SPurity:Min. 95%Molecular weight:298.36 g/molKetoprofen - Bio-X ™
CAS:Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that has been used to treat pain and inflammation. Ketoprofen inhibits the production of inflammatory prostaglandins, which are released by platelets in response to injury or infection. The main mechanism of action is inhibition of cyclooxygenase enzymes COX 1 and COX 2 at the level of transcriptional activation. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation.Formula:C16H14O3Purity:Min. 95%Color and Shape:PowderMolecular weight:254.28 g/mol
