Enzyme Modulators
Subcategories of "Enzyme Modulators"
Found 691 products for "Enzyme Modulators".
Sacubitril - Bio-X ™
CAS:This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C24H29NO5Purity:Min. 95%Color and Shape:PowderMolecular weight:411.49 g/molNeratinib - Bio-X ™
CAS:Neratinib is a protein kinase inhibitor that is used in the treatment of breast cancer. This drug binds to and inhibits EGFR, HER2 and HER4. As a result of this, it prevents autophosphorylation of tyrosine residues and reduces oncogenic signalling.Formula:C30H29ClN6O3Purity:Min. 95%Color and Shape:PowderMolecular weight:557.04 g/molLY 2874455
CAS:Inhibitor of FGFR kinase
Formula:C21H19Cl2N5O2Purity:(%) Min. 98%Molecular weight:443.09158SRT2104
CAS:Activator of SIRT1 deacetylaseFormula:C26H24N6O2S2Purity:Min. 95%Color and Shape:PowderMolecular weight:516.64 g/molPHA 793887
CAS:Inhibitor of cyclin dependend kinases
Formula:C19H31N5O2Purity:Min. 95%Color and Shape:SolidMolecular weight:361.24778Fluvastatin lactone
CAS:HMG-CoA reductase inhibitorFormula:C24H24FNO3Purity:Min. 95%Color and Shape:PowderMolecular weight:393.45 g/molSaxagliptin
CAS:DPP-4 enzyme inhibitor; anti-diabetic
Formula:C18H25N3O2Color and Shape:White PowderMolecular weight:315.41 g/molAZD 2098
CAS:A potent and selective agonist of CCR4 chemokine receptor with IC50 values ranging from 10 to 25 nM across different species. CCR4 is involved in activation and migration of Th2 lymphocytes to the lungs in response to allergens. Treating sensitised rats results in reduced inflammation of lung tissue.Formula:C11H9Cl2N3O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:334.18 g/molSorafenib tosylate - Bio-X ™
CAS:Sorafenib is a drug that belongs to the class of multikinase inhibitors. It inhibits a number of kinases, including the Mcl-1 protein, which is involved in apoptosis along with blocking picolinic acid (PA), an endogenous metabolite involved in apoptosis signal transduction. Sorafenib also binds to epidermal growth factor receptor (EGFR) on the surface of cancer cells, inhibiting the production of proteins that are required for angiogenesis, thus blocking the formation of new blood vessels. Sorafenib may also inhibit P-glycoprotein (Pgp) activity. Overall, these cytotoxic effects give Sorafenib anti-tumor properties, inhibiting angiogenesis and cellular transformation, which are the two main processes of tumor growth and metastasis. Sorafenib tosylate has been shown to be effective against a range of solid tumors such as breast, prostate and lung cancers and is also used for the treatment of metastatic colorectal cancer and renal cell carcinoma. A combination therapy group found that sorafenib was more effective when used with interferon alfa-2b for the treatment of advanced renal cell carcinoma. Sorafenib tosylate also has the potential for drug interactions with other drugs that are metabolized by cytochrome P450 enzymes.
Sorafenib tosylate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C21H16ClF3N4O3•C7H8O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:637.03 g/molTTK 21
CAS:CBP/p300 histone acetyltransferase activatorFormula:C17H15ClF3NO2Purity:Min. 95%Color and Shape:PowderMolecular weight:357.76 g/molErlotinib mesylate
CAS:EGFR tyrosine kinase inhibitorFormula:C23H27N3O7SPurity:Min. 95%Color and Shape:White PowderMolecular weight:489.54 g/molLGK 974
CAS:Inhibits Wnt signaling pathway by targeting porcupine, a membrane-bound O-acyltransferase involved in the palmitoylation and secretion of Wnt. Anti-cancer properties of LGK 974 have been demonstrated in various tumor models of breast cancer, head and neck squamous cell carcinoma and glioblastoma. Blocks LPS-mediated inflammatory response in epithelial and endothelial cells.
Formula:C23H20N6OPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:396.40 g/molGSK 583
CAS:A potent and selective inhibitor of cell death-inducing kinase RIP2 (IC50 = 5 nM). Reduces release of pro-inflammatory cytokines. Inhibits production of TNF-α and IL-6 in intestinal explants from patients with Crohn's disease and ulcerative colitis.
Formula:C20H19FN4O2SPurity:Min. 95%Color and Shape:PowderMolecular weight:398.46 g/molFluvastatin sodium salt - Bio-X ™
CAS:Fluvastatin is a statin that lowers blood cholesterol and triglycerides by inhibiting HMG-CoA reductase, an enzyme that plays a critical role in the synthesis of cholesterol. Fluvastatin has also been shown to reduce the incidence of myocardial infarction, and to reduce atherosclerotic lesions in animal models, reducing the incidence of cardiovascular disease. Fluvastatin also has been shown to inhibit the activation of toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS), which may be related to its anti-inflammatory effects. Furthermore, through lowering blood cholesterol, Fluvastatin also inhibits tubulointerstitial injury and prevents renal damage caused by high concentrations of the lipid.Formula:C24H25FNNaO4Purity:Min. 98%Molecular weight:433.45 g/molTAK 243
CAS:A potent inhibitor of ubiquitin activating enzyme E1. Lowers ubiquitin conjugates in cells, thereby disrupting cell signalling, cell cycle progression and repair of DNA damage. Anti-tumor effects have been demonstrated in vitro and in vivo. TAK 243 has been used to study the biology of ubiquitins and its potential as anti-cancer therapy.Formula:C19H20F3N5O5S2Purity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:519.52 g/molN-[3-(1,3-Benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-N',N'-dimethyl-propane-1,3-diamine
Selective inhibitor of the mutated RET variant RETV804M, which is the anticipated drug-resistant RET mutant that can occur in tumours treated with kinase inhibitors. The compound has a biochemical IC50 of 0.02 µM and selectivity for purified RETV804M over purified RET and KDR of 3.7 and 110, respectively. The efficacy of the compound was shown also in cell cultures with IC50 of 4.4 µM, and cell assay selectivity for RETV804M over RET and KDR of 0.89 and 2.3, respectively.Formula:C18H21N5O2Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:339.39 g/molAnagrelide HCl - Bio-X ™
CAS:Anagrelide is a thrombocytopenic drug that is used to treat thrombocythemia and related conditions. This drug works by decreasing the platelet count by suppressing transcription factors that are necessary for the maturation of platelets. This drug is also a phosphodiesterase III inhibitor.Formula:C10H7Cl2N3O•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:292.55 g/molSaracatinib
CAS:Inhibitor of Src and Abl tyrosine kinases; anti-proliferative; anti-migratoryFormula:C27H32ClN5O5Purity:Min. 95%Molecular weight:542.03 g/molUNC 0379
CAS:Inhibitor of the histone methyltransferase SETD8 that supresses methylation of the K20 residue in histone 4. UNC 0379 treatment of human glioma reduced recruitment of 53BP1 protein to double strand breaks and sensitised cells to radiotherapy without altering cell cycle kinetics.
Formula:C23H35N5O2Purity:Min. 95%Color and Shape:SolidMolecular weight:413.56 g/mol
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