Endocrinología / Hormonas
Los inhibidores de endocrinología/hormonas son compuestos que bloquean la acción de las hormonas o interfieren con las vías de señalización hormonal. Estos inhibidores son esenciales para estudiar la regulación de los sistemas endocrinos y para desarrollar tratamientos para enfermedades relacionadas con las hormonas, como la diabetes, los trastornos tiroideos y los cánceres dependientes de hormonas. Al modular la actividad hormonal, estos inhibidores pueden ayudar a dilucidar las complejas interacciones dentro del sistema endocrino. En CymitQuimica, ofrecemos una amplia gama de inhibidores de endocrinología/hormonas de alta calidad para apoyar su investigación en endocrinología, farmacología y ciencias médicas.
Subcategorías de "Endocrinología / Hormonas"
- Receptor de andrógenos(229 productos)
- Anexina A(16 productos)
- Aromatasa(23 productos)
- Receptor de estrógeno / progestágeno(66 productos)
- GPR(1 productos)
- Receptor de glucocorticoides(165 productos)
- LHRH(2 productos)
- Receptor de opioides(327 productos)
- Receptor de prostaglandinas(122 productos)
- RAAS(89 productos)
- Reductasa(51 productos)
- Somatostatina(57 productos)
- Receptor de la hormona tiroidea (THR)(33 productos)
- Receptor de vasopresina(48 productos)
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Se han encontrado 3420 productos de "Endocrinología / Hormonas"
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CH5447240
CAS:CH5447240: potent hPTHR1 agonist, treats Hypoparathyroidism, EC50 12 nM, 55% oral bioavailability, raises rat serum calcium.Fórmula:C26H39N5O4SPureza:98%Forma y color:SolidPeso molecular:517.68ERβ agonist-1
CAS:ERβagonist-1 (Compound 8) functions as a dual-active selective ERβ agonist (EC50: 46.8 nM) and an AR antagonist (IC50: 1555 nM). By binding to ERβ, it activates its signaling pathways while simultaneously inhibiting AR activity. Retaining selective ERβ agonist activity in mouse models, ERβagonist-1 is applicable in prostate cancer research.Fórmula:C25H36O2Forma y color:SolidPeso molecular:368.55Emd 52297
CAS:Emd 52297 is an inhibitor of renin.Fórmula:C39H59N11O7Pureza:98%Forma y color:SolidPeso molecular:793.96ID11916
CAS:ID11916 is an orally active compound functioning as both an androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. It disrupts androgen binding to AR, impedes nuclear translocation, and blocks androgen-dependent transcriptional activity of AR, while simultaneously elevating intracellular cGMP levels by inhibiting PKG activation. Moreover, ID11916 exhibits potent anticancer effects in prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell line SK-BR-3.Fórmula:C29H27F3N8O3SForma y color:SolidPeso molecular:624.637AR antagonist 11
CAS:AR antagonist 11 (Compound c2) is a selective androgen receptor antagonist with an IC50 of 0.019 μM. It is also effective against the ARF877L/T878A mutant (IC50: 1.03 μM). Additionally, AR antagonist 11 inhibits LNCaP cell proliferation and decreases PSA protein expression (IC50: 0.54 μM). This compound is applicable in prostate cancer (PCa) research.Fórmula:C20H17ClN2OForma y color:SolidPeso molecular:336.815(E/Z)-OT-R antagonist 1
CAS:(E/Z)-OT-R antagonist 1 is a mixture of the E/Z configurations of OT-R antagonist 1. This compound is a novel, potent, selective, non-peptide OT-R antagonist that inhibits oxytocin-induced intracellular Ca2+ activity with an IC50 of 8 nM.Fórmula:C28H29N3O4Forma y color:SolidPeso molecular:471.55Ciprokiren
CAS:Ciprokiren, a renin inhibitor by Roche, halts human renin; IC50: 0.07/0.65 nmol/L. Lowers blood pressure in animals. Preclinical development ceased.Fórmula:C37H55N5O8SForma y color:SolidPeso molecular:729.93Phenethyl 4-ANPP
CAS:Phenethyl 4-ANPP is a MOR (μ-opioid receptor) agonist with a structure similar to known opioids.Fórmula:C27H32N2Forma y color:SolidPeso molecular:384.56LEO 134310
CAS:LEO 134310: Selective, non-steroidal GR agonist with 14 nM EC50, for topical skin disease treatment.Fórmula:C34H40N2O8Forma y color:SolidPeso molecular:604.69Androgen receptor antagonist 13
CAS:Androgen receptor antagonist 13 (compound 8a) is an orally active androgen receptor antagonist with an IC50 of 0.20 μM. It is used in prostate cancer research.Fórmula:C16H15N3O3SForma y color:SolidPeso molecular:329.37EN1441
CAS:EN1441 is a covalent degrader that targets the androgen receptor (AR) with an EC50 value of 4.2 μM, as well as its truncated variant AR-V7. It selectively and effectively degrades AR and AR-V7 in androgen-independent prostate cancer cells. EN1441 holds potential for research into androgen-independent prostate cancer.Fórmula:C13H13ClN2O2Forma y color:SolidPeso molecular:264.708Sob-AM2
CAS:Sob-AM2 is an effective substrate targeting the fatty acid amide hydrolase (FAAH) expressed in the brain, with a Km of 1.3 μM. It delivers higher concentrations of Sobetirome to the central nervous system at minimal peripheral systemic doses, thereby activating the central thyroid hormone receptor β (TRβ).Fórmula:C21H27NO3Forma y color:SolidPeso molecular:341.44AKR1C3-IN-5
AKR1C3-IN-5 inhibits AKR1C3, key in prostate/breast cancers, with MCF-7 cell IC50 of 9.6 μM.Fórmula:C34H44N2O7Forma y color:SolidPeso molecular:592.72Estrogen receptor antagonist 7
CAS:ER antagonist 7, compound 13, inhibits ERs, halts breast/ovarian cancer cell growth, has anticancer properties.Fórmula:C23H17N3O4Forma y color:SolidPeso molecular:399.4AR antagonist 10
CAS:AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.Fórmula:C18H17ClN4O3SForma y color:SolidPeso molecular:404.871PBPE hydrochloride
CAS:PBPE hydrochloride is a derivative of tamoxifen and functions as a selective ligand for antiestrogen binding sites (AEBS). The binding affinity (Ki) of PBPE hydrochloride and MBPE to AEBS is 8.79 nM and 17.57 nM, respectively.Fórmula:C19H24ClNOForma y color:SolidPeso molecular:317.853Estrogen receptor modulator 11
CAS:Estrogen receptor modulator11 (Compound 27) is a tetrahydroisoquinoline derivative. It exhibits affinity for the estrogen receptor (ER), with IC50 values of 285 nM for ERα and 421 nM for ERβ. Estrogen receptor modulator11 does not demonstrate antagonist activity in MCF-7 cell assays.Fórmula:C21H18FNOForma y color:SolidPeso molecular:319.372Bromadoline
CAS:Bromadoline is an opioid compound that exhibits anti-nociceptive properties in rodents.Fórmula:C15H21BrN2OForma y color:SolidPeso molecular:325.244Triisopropyl phosphate
CAS:Triisopropyl phosphate inhibits TFF1 and EGR3 gene expression and exhibits anti-estrogenic activity by suppressing Estradiol-induced proliferation of MCF-7 cells, with an EC50 of 341 μM. Additionally, Triisopropyl phosphate reduces estrogen response element (ERE)-stimulated luciferase activity in MVLN cells, with an EC50 of 900 μM.Fórmula:C9H21O4PForma y color:SolidPeso molecular:224.234LXT34
CAS:LXT34 (Example 2) is a GPR120 agonist with anti-inflammatory properties. This compound enhances GLP-1 formation in the gastrointestinal tract and improves insulin resistance in macrophages and pancreatic cells. LXT34 is applicable in studies related to inflammatory conditions, such as type 2 diabetes, obesity, and non-alcoholic fatty liver disease.Fórmula:C18H21NO3SForma y color:SolidPeso molecular:331.43
