Inmunología e inflamación

<p>S-(2-aminoethyl) isothiourea inhibits all NOS types: Ki for nNOS 1.8μM, eNOS 2.1μM, iNOS 0.59μM.</p>

<p>E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling.</p>

<p>Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) is a member of the class of compounds known as very-long-chain fatty acids.</p>

<p>N-Acetylcysteine amide is a thiol antioxidant and a neuroprotective agent with cell permeability and blood-brain barrier permeability. Cost-effective and quality-assured.</p>

<p>RIPA-56 is an inhibitor of RIP1</p>

<p>AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects.</p>

<p>PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM),</p>

<p>BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).</p>

<p>RP-54745, a potential antirheumatic compound. Inhibitor of macrophage stimulation and interleukin-1 production.</p>

<p>SB-366791 is a new and selective cinnamide TRPV1 antagonist.</p>

<p>p-Cresyl Sulfate is the major uremic toxin present in the blood of patients with chronic kidney disease.Cost-effective and quality-assured.</p>

<p>IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.</p>

<p>Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM.</p>

<p>Camstatin acetate, a 25-residue fragment, inhibits neuronal NOS by binding calmodulin.</p>

<p>DBT (NSC-701994) is a far-red/near-infrared fluorescent probe for specific in vitro and in vivo imaging of tumor-associated proteins.</p>

<p>CID1231538 is a potent GPR35 antagonist.</p>

<p>Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.</p>

<p>Propagermanium (Ge132), an organometallic compound of germanium, has been used as a therapeutic agent against chronic hepatitis B in Japan.</p>

<p>HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM.</p>

<p>JTE-607 is an inhibitor of cytokine production. It potentially for the treatment of systemic inflammatory response, and induces apoptosis accompanied.</p>

IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.

<p>GP130 receptor agonist-1 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami) is a potent, brain-penetrant and orally active GP130 receptor agonist.</p>

<p>Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.</p>

<p>RCGD423, a small molecule gp130 modulator, prevents articular cartilage degeneration and promotes repair.</p>

<p>Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.</p>

<p>NB-598 Maleate is a competitive squalene epoxidase (SE) inhibitor.</p>

<p>TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis</p>

<p>Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.</p>

<p>Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPK</p>

<p>Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.</p>

<p>GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).</p>

<p>Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng).</p>

<p>Stachydrine Hydrochloride is an effective component that mainly extracted from the leaf of Leonurussibiricus.</p>

<p>TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.</p>

<p>SP-13786 is an inhibitor of fibroblast activation protein (FAP) and prolyl oligopeptidase (PREP).Cost-effective and quality-assured.</p>

<p>Disufenton sodium (NXY-059), a new-type nitrone, exhibits potently neuroprotective effects.</p>

<p>7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.</p>

<p>Dehydrodiisoeugenol suppresses COX-2 expression and NF-κB activity, reducing inflammation in LPS-stimulated murine macrophages.</p>

<p>Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.</p>

<p>Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and</p>

<p>BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).</p>

<p>Sincalide (CCK-8) is an injectable drug used to diagnose gallbladder and pancreas disorders; it's a cholecystokinin fragment.</p>

<p>INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.</p>

<p>Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), &gt; 50-fold selectivity over TLR7.</p>

<p>IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.</p>

<p>GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.</p>

<p>ADH-503 (GB1275) is an orally available, allosteric CD11b small molecule agonist.Cost-effective and quality-assured.</p>

<p>NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor.</p>

<p>Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.</p>

<p>Visomitin (SKQ1) is a mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS).</p>

<p>TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.</p>

<p>PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50</p>

<p>Sulcotrione is a β-triketone herbicide. It also can inhibit hydroxyphenylpyruvate dioxygenase.</p>

<p>Ataquimast inhibits IL-5 secretion along with that of TNF-a, IL-4 and GM-CSF from human cells.</p>

<p>Hexetidine (NSC-17764) is a bactericidal and fungicidal antiseptic. It is used as a 0.1% mouthwash for local infections and oral hygiene.</p>

<p>Pectolinarin is a Cirsium isolate with anti-inflammatory activity.</p>

<p>PTP1B-IN-1 (PTP1B inhibitor) is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B) (IC50 : 1.6 mM)</p>

<p>Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr</p>

<p>Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.</p>

<p>Schisantherin A, a lignan from Schisandra fruit, is used as an antitussive, tonic, and sedative.</p>

<p>N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group.</p>

<p>JSH-23 is an NF-κB inhibitor that inhibits NF-κB transcriptional activity without affecting IκB degradation. JSH-23 is an antioxidant. Cost effective and quality assured.</p>

<p>(±)-Lisofylline is an enantiomer-specific, alkyl-substituted methylxanthine, which has specific and potent activity in down-regulating leukocyte activation.</p>

<p>GW 610, an antitumor benzothiazole, inhibits growth in various cancers, with GI50 &lt; 0.1 nM in MCF-7/MDA 468 cells.</p>

Efaproxiral Sodium (RSR13 sodium), a synthetic allosteric modifier of hemoglobin, is utilized for brain metastases originating from breast cancer.

<p>NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM.</p>

<p>Indole-3-pyruvic acid is a precursor for the plant growth hormone indole-3-acetic acid.</p>

<p>Myrislignan exhibits anti-inflammatory, anti-cancer properties, hinders NF-κB pathway, curbs A549 cell growth, and triggers apoptosis and cell cycle arrest.</p>

<p>QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.</p>

<p>Lobenzarit: immunomodulator for arthritis; repurposed for M. tuberculosis tryptophan biosynthesis.</p>

<p>Tri-Salicylic Acid, a product of the thermal decomposition of aspirin, is a compound for proteomics research.</p>

<p>CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.</p>

<p>PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.</p>

<p>EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.</p>

<p>Apilimod 2HCl (STA 5326 2HCl) is a PIKFYVE kinase inhibitor used in the study of amyotrophic lateral sclerosis.</p>

<p>N,N'-Diphenylguanidine (NSC-3272) is an agent of biochemical.</p>

<p>Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).</p>

<p>Propiconazole (PRO) is an orally active brassinosteroid biosynthesis inhibitor and a triazole fungicide with antifungal activity.</p>

<p>Imigliptin (KBP 3853) is a dipeptidyl peptidase-4 inhibitor used in the study of type 2 diabetes.</p>

<p>CORM-401 is an oxidant-sensitive CO-releasing molecule. It can be used in oxidative stress-mediated pathologies and the research of inflammatory.</p>

<p>(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).</p>

Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a NSAID with analgesic and anti-inflammatory effects.

<p>Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody against IL-33, which can be used to study chronic obstructive pulmonary disease.</p>

<p>GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity and inhibits kinase activity.</p>

<p>CBR-470-1 is a glycolytic phosphoglycerate kinase 1 inhibitor and Nrf2 activator that exhibits neuroprotective activity by activating the Keap1-Nrf2 cascade.</p>

<p>Simvastatin acid ammonium (Tenivastatin ammonium) is an HMG-CoA reductase (HMGCR) inhibitor.</p>

<p>PSMA I&amp;T is a PSMA-targeting radioactive compound that can be used as a diagnostic agent for prostate-specific membrane antigen-targeted therapy.</p>

<p>MK-0159 is an orally available, highly potent CD38 inhibitor with myocardial injury protection for the study of cardiac ischemia and reperfusion injury.</p>

<p>Satralizumab (SA-237) is a humanized antibody targeting interleukin-6 (IL-6), used in research on neuromyelitis optica spectrum disorder (NMOSD).</p>

<p>MIF098 is a MIF antagonist that inhibits the proliferation of pulmonary smooth muscle cells (PASMC) and can be used to study pulmonary hypertension.</p>

<p>Benzobicyclon is a 4-HPPD) inhibitor and herbicide that is spectrally active against annual grasses, sedges, and broadleaf weeds without toxicity to rice.</p>

<p>Sirukumab (CNTO-136) is a humanized monoclonal antibody binding to IL-6, inhibiting IL-6-mediated signaling and transcription activator activation.</p>

<p>NF-κB/MAPK-IN-1 is an NF-κB and MAPK pathway inhibitor. NF-κB/MAPK-IN-1 is used to prevent rheumatoid arthritis (RA).</p>

<p>Peramivir is a neuraminidase inhibitor used to treat influenza by preventing virus release from cells.</p>

<p>NLRP3-IN-11 is an NLRP3 protein inhibitor with potential anti-inflammatory activity.NLRP3-IN-11 can be used in the study of atherosclerosis and parkinsonism.</p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CD248. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CD248. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human CD248, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human CD248 in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>RA-839 is a Keap1 conjugate and Nrf2 signaling activator, and an inhibitor of Keap1/Nrf2 interaction with anticancer activity.</p>

<p>Tenivastatin (Simvastatin acid) is an anti-hyperlipidemic HMG-CoA reductase inhibitor used in the study of primary hyperlipidemia.</p>

<p>L-Cystine dihydrochloride, a sulfur-based glutathione precursor, maintains GSH balance, used in cell culture.</p>

<p>3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis and can be used to study inflammation.</p>