Metabolismo

<p>L-Homocysteine thiolactone hydrochloride is neurotoxic and can induce epilepsy and Alzheimer's disease.</p>

<p>LEI-401 is a NAPE-PLD inhibitor.LEI-401 reduces the level of n-acyl ethanolamines in the brain of free-ranging mice and modulates their emotional behaviour.</p>

<p>Enalaprilat D5 is the deuterium labeled Enalaprilat, which is an angiotensin-converting enzyme (ACE) inhibitor.</p>

<p>GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM</p>

<p>Ketogestin is a progestational steroid and an inhibitor of enzyme 11β-hydroxysteroid dehydrogenase, and a weak negative modulator of GABAA receptors.</p>

<p>Bullatacin is a bis(tetrahydrofuranoid) fatty acid lactone that existed in some fruits from Annonaceae family.</p>

<p>Lysine monohydrate is a bioactive chemical.</p>

<p>Fmoc-Cys(Trt)-OH, with catalog number T67555 and CAS number 103213-32-7, is a valuable organic compound for life sciences research.</p>

Fmoc-Tyr(tBu)-Ser(psi(Me,Me)pro)-OH is a dipeptide.

<p>Z-Lys-OH is a competitive inhibitor of papain, a lysine derivative.</p>

<p>Apovincaminic acid hydrochloride, Vinpocetine's active metabolite, is oral, brain-penetrating, and neuroprotective.</p>

<p>ALDH1A3-IN-3 inhibits ALDH1A3 (IC50: 0.26 μM), acts on ALDH3A1, and is used in prostate cancer research.</p>

<p>N-Desmethyl Clomipramine hydrochloride is a primary plasma N-desmethyl Clomipramine metabolite .</p>

<p>H-DL-Lys-OH HCl is the hydrochloride salt of lysine, widely used in biochemical experiments and drug synthesis research.</p>

<p>Fmoc-Ala-OH is a protected alanine derivative used in solid-phase peptide synthesis, solar cell studies, and charge transfer and recombination.</p>

<p>O-desmethyl Mebeverine acid D5 is the deuterium labeled O-desmethyl Mebeverine acid.</p>

<p>Lauroyl alanine is a fatty acid amide. It may be used to support the physical gelation of binary mixtures of aliphatic and aromatic hydrocarbon solvents.</p>

<p>Hexanoyl glycine, an acylated amino acid, serves as a urinary biomarker for metabolic disorders, radiation exposure, and cancer detection.</p>

<p>FXR agonist 3 is an anti NASH compound with anti-fibrotic and active properties that inhibits the expression of COL1A1, TGF-β1, α-SMA and TIMP1.</p>

<p>Nucleoside Derivatives - Other modified nucleosides; Drugs and Inhibitors; Ribavirin related compound A; metabolite of Ribavirin</p>

Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart by increasing PKA-mediated phosphorylation.

Iloperidone metabolite Hydroxy Iloperidone is an atypical antipsychotic. It is a metabolite of Iloperidone.

<p>Trandolaprilate D5 is a deuterium-labeled Trandolaprilate. Trandolaprilate is an inhibitor of angiotensin-converting enzyme (ACE).</p>

<p>TMX-4100,PDE6D degrader (DC50 &lt;200 nM). Used in multiple myeloma research.</p>

<p>Dihydrotachysterol (HSDB 3314) is a vitamin D analog.Dihydrotachysterol has been used to study hypocalcemic hypoparathyroidism after surgical removal of the parathyroid glands and growth impairment in children with chronic renal insufficiency.</p>

<p>Lipase, triacylglycerol (Alkaline lipase) is a specific enzyme catabolism of triacylglycerol to glycerol and fatty acids,transfer to various tissues.</p>

<p>1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.</p>

DNMDP is a potent and selective PDE3A inhibitor with anticancer activity. It binds to PDE3A, promoting its interaction with Schlafen 12 (SLFN12).

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse IFN-γ. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse IFN-γ. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse IFN-γ, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse IFN-γ. You can calculate the concentration of Mouse IFN-γ in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human VEGF-A. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human VEGF-A. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human VEGF-A, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human VEGF-A. You can calculate the concentration of Human VEGF-A in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse GROα/CXCL1. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse GROα/CXCL1. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse GROα/CXCL1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse GROα/CXCL1. You can calculate the concentration of Mouse GROα/CXCL1 in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to TGF-β1. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for TGF-β1. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain TGF-β1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of TGF-β1. You can calculate the concentration of TGF-β1 in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse IL-6. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse IL-6. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse IL-6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse IL-6. You can calculate the concentration of Mouse IL-6 in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human IFN-α. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human IFN-α. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human IFN-α, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human IFN-α. You can calculate the concentration of Human IFN-α in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human IL-6. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human IL-6. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human IL-6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human IL-6. You can calculate the concentration of Human IL-6 in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse TNF-α. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse TNF-α. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse TNF-α, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse TNF-α. You can calculate the concentration of Mouse TNF-α in the samples by comparing the OD of the samples to the standard curve.

<p>SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor.</p>

<p>Norathiol (N-methyl-N-dithiocarboxyglucamine) is a metal chelator that promotes the excretion of 109Cd and may be used in the treatment of cadmium poisoning.</p>

<p>Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.</p>

<p>SR0987 is a RORγt agonist,</p>

<p>DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.</p>

<p>Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.</p>

<p>Dimethylfraxetin (6,7,8-Trimethoxycoumarin) is a Carbonic anhydrase inhibitor(Ki：0.0097 μM)</p>

<p>YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.</p>

<p>Probucol: Anti-hyperlipidemic, reduces cholesterol in coronary artery disease by boosting LDL breakdown.</p>

<p>Rosiptor (AQX-1125) (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects.</p>

<p>Zegocractin (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor.</p>

<p>Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.</p>

<p>1-Naphthaleneacetic acid potassium salt (1-NAA Potassium Salt) is a synthetic phytogrowth hormone that promotes plant growth and a PLA2 inhibitor.</p>

<p>AG-120 (racemic) is an oral IDH1 inhibitor with potential anti-cancer effects.</p>

<p>HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.</p>

<p>(±)-Haloxyfop (Haloxyfop Acid) is a herbicide.</p>

<p>L-Alanine (L-2-Aminopropionic acid) is an Amino Acid. Alanine is involved in the metabolism of tryptophan and vitamin pyridoxine.</p>

<p>(S)-3-Amino-2-methylpropanoic acid-HCl is a glutamate agonist affecting the nervous system.</p>

<p>3-(2-Hydroxyphenyl)propanoic acid, aka melilotic acid, found in cytoplasm, in foods like herbs, beetroot, cinnamon.</p>

<p>Methyl 13-cis-4-Oxoretinoate (13-cis-4-Oxo-retinoic acid Methyl Ester) is a retinoic acid metabolite in neuroblastoma.</p>

<p>AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).</p>

<p>Z944 is a T-type calcium channel blocker.</p>

<p>TOFA (MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA).</p>

<p>Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.</p>

<p>Mirogabalin (DS5565) is a calcium channel blocker with analgesic effects.</p>

<p>MLCK inhibitor peptide 18 acetate: Selective (IC50=50nM), 4000x more than CaM kinase II. Does not block PKA. Cell-permeable.</p>

<p>TPI-1 is a SHP-1 inhibitor.</p>

<p>NP118809 (39-1B4) is a potent N-type calcium channel blocker(IC50 : 0.11 μM).</p>

<p>PT-2385 is a selective HIF-2α inhibitor (Kd&lt;50 nM).</p>

<p>NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay),indirectly disrupting citrate binding</p>

<p>2-Deoxy-2-sulfoamino-D-glucose sodium (GlcN-2S) is possible to effect reaction at arthritis.</p>

<p>XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.</p>

<p>Proguanil hydrochloride, a biguanide, metabolizes into cycloguanil, an anti-malaria agent that inhibits plasmodium's DNA and protein synthesis.</p>

<p>Monobenzyl phthalate (Phthalic Acid Monobenzyl Ester) is Phthalate metabolite.</p>

<p>K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).</p>

<p>Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with</p>

<p>Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.</p>

<p>2,3-dihydrothieno-Thiadiazole Carboxylate is a CYP450 (CYP2E1 and CYP2B4) inhibitor.</p>

<p>Varespladib (LY315920) inhibits hnsPLA2 effectively (IC50=7 nM), studied for sickle cell, VOC, and acute coronary syndrome.</p>

<p>trans-AUCB (t-AUCB) is an effective and selective soluble epoxide hydrolase inhibitor (IC50s: 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively).</p>

<p>L-Gulose: unnatural L-hexose, sweet syrup, vitamin C biosynthesis intermediate.</p>

<p>Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat.</p>

<p>Clorgyline,M&amp;B 9302, an irreversible and selective MAO-A inhibitor with the advantages of oral activity and blood-brain barrier permeability, antidepressant.</p>

<p>Minaprine dihydrochloride: reversible MAO-A inhibitor, mild on acetylcholinesterase, used for depression.</p>

<p>D-fructose-1,6-diphosphate (D-fructose-1,6-diphosphate), also known as Fosfructose, is a cytoprotective natural sugar phosphate.</p>

<p>FOY 251 is a proteinase inhibitor, and is an anti-proteolytic active metabolite camostate.</p>

<p>GSK 650394 is an inhibitor of serum- and glucocorticoid-regulated kinases (SGK). GSK 650394 has antitumor activity. Cost-effective and quality-assured.</p>

<p>CVT-2738 (RS-94287) is a metabolite of Ranolazine. Ranolazine is a partial fatty acid oxidation (pFOX) inhibitor and anti-anginal drug.</p>

<p>UCPH-101 is an inhibitor of excitatory amino acid transporter subtype 1 (EAAT1) with an IC50 of 0.66 μM.</p>

<p>Anthraflavic acid (2,6-Dihydroxyanthraquinone), a flavonoid, is a potent IQ mutagenicity and cytochrome P-448 inhibitor.</p>

<p>Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33.</p>

<p>Evacetrapib (LY2484595) inhibits CETP strongly (IC50=5.5 nM), raises HDL cholesterol, no rise in aldosterone/blood pressure. Phase 3.</p>

<p>NFAT Inhibitor-2 is a compound used as a molecular building block.</p>

<p>CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat</p>

<p>PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.</p>

<p>Drotaverine Hydrochloride is a selective inhibitor of phosphodiesterase 4.</p>

<p>Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.</p>

<p>trans-4-Hydroxycyclohexanecarboxylic Acid is an organic intermediate.</p>

<p>TM5441 is an orally bioavailable fibrinogen activator inhibitor-1 inhibitor that inhibits several cancer cell lines with IC50 values ranging from 13.9 to 51.1 μM.Cost-effective and quality-assured.Cost-effective and quality-assured.</p>

<p>Imidapril: oral ACE &amp; MMP-9 inhibitor, lowers blood pressure, useful in hypertension, diabetic nephropathy, heart failure.</p>

Nicardipine (Cardene), a calcium channel blockers belonging to the dihydropyridine class, is a drug used to treat angina and high blood pressure.

<p>ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.</p>

<p>CDN1163 is a small molecule activator of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA).</p>

<p>Ruthenium Red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria.</p>

<p>Apixaban (BMS-562247-01) is an orally active inhibitor of coagulation factor Xa with anticoagulant activity.</p>