Metabolismo

<p>DSPE-PEG1000-F3 is a PEG compound made from DSPE and a targeting peptide called nucleolin (F3). The F3 peptide can specifically bind to cell surface nucleolin, enabling efficient transport from the cell surface to the nucleus. DSPE-PEG1000-F3 is applicable in drug delivery.</p>

<p>Diglycyl-histidine is a tripeptide complexed with cupric ion designed to mimic specific Cu(II) transport site of ascorbate on albumin molecule.</p>

<p>Carbolactone is a biologically active metabolite from fungi [1] .</p>

<p>N4-Acetylcytidine triphosphate sodium is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription.</p>

<p>D-erythrose 4-sodium phosphate: sodium salt of monosaccharide, made from erythritol via 3 isomerases.</p>

<p>DSPE-PEG1000-CTT2 is a PEG compound comprised of DSPE and a gelatinase inhibitor [CTT2 (CTTHWGFTLC)]. The CTT2 (CTTHWGFTLC) peptide is capable of specifically targeting tumors. DSPE-PEG1000-CTT2 can be utilized for drug delivery.</p>

<p>Pegevongitide acts as an agonist of the angiopoietin-1 receptor.</p>

<p>Myristoyl coenzyme A lithium, a compound marked by lithium in its myristoylated form, plays a crucial role in the biochemical mechanism of myristoylation, essential for both viral functionalities and tumor growth in colon epithelial cells. This process is predominantly governed by N-myristoyltransferase (NMT), which exhibits increased activity in colon epithelial tumors compared to normal cells. The activity of NMT is significantly influenced by the reduction of coenzyme A (CoA), a vital regulator that enhances NMT's ability to induce myristoylation, unlike its oxidized form which impedes this process. Consequently, Myristoyl coenzyme A serves as an inhibitor to the demyristoylation activity, showcasing its potential as an anticancer and antiviral agent.</p>

<p>11-trans LTC4 is a C-11 isomer of LTC4, forms slowly on storage, is less common but similarly potent in contractions, pKis: 6.42 (LTC4), 6.58 (11-trans).</p>

<p>Trihydroxycholestanoic acid aids cholic acid creation; high levels indicate Zellweger syndrome due to faulty PEX genes.</p>

<p>S32826, a potent autotaxin inhibitor with an IC50 of 8.8 nM, blocks LPA release and targets α, β, γ isoforms.</p>

<p>Palitantin is a useful organic compound for research related to life sciences. The catalog number is T125757 and the CAS number is 15265-28-8.</p>

<p>CT140 is a human IgG4 monoclonal antibody (mAb) that specifically targets PAI-1. The suggested isotype control for this compound is Human IgG4 kappa, Isotype Control.</p>

<p>Carbonic anhydrase inhibitor32 (compound 5B) is an orally active, selective inhibitor of hCA (carbonic anhydrase) II/VII, with Ki values of 6.3 nM for hCA II, 10.1 nM for hCA VII, and 681 nM for hCA I. It shows potential for neuroprotection and anticonvulsant effects by reducing mTOR activation and increasing hippocampal KCC2 levels.</p>

<p>PTPσ Inhibitor ISP is a compound that binds to recombinant human PTPs, thereby inhibiting PTPσ signaling.</p>

<p>Fungal metabolite 19,20-Epoxycytochalasin D from Nemania sp. kills P. falciparum; non-toxic to Vero, toxic to BT-549, LLC-PK11, P388 cells.</p>

<p>DSPE-PEG1000-K237 is a PEG compound composed of DSPE and the KDR-targeting peptide (K237). K237 functionally disrupts the interaction between VEGF and KDR receptors, producing significant biological effects such as inhibiting angiogenesis and tumor growth. DSPE-PEG1000-K237 is applicable for drug delivery.</p>

<p>WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.</p>

<p>α-Amylase/α-Glucosidase-IN-16 (compound 15) is a potent dual inhibitor of α-amylase and α-glucosidase, with IC50 values of 0.8 μM and 1.2 μM, respectively. It is applicable for research in diabetes (DM).</p>

<p>alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) (Hp3/4FT) can be found in Helicobacter pylori .</p>

<p>"NU223612 is a potent IDO1-degrading PROTAC with Kd 640 nM, binds CRBN at 290 nM, and crosses the BBB."</p>

<p>Zabicipril HCl（S 9650） is a potent angiotensin-converting enzyme inhibitor.</p>

<p>Coumachlor, a first-generation anticoagulant rodenticide, blocks the formation of prothrombin and inhibits blood coagulation causing internal haemorrhage.</p>

<p>IRC-083864 is a novel bis quinone CDC25 phosphatase active inhibitor against human cancer cells.</p>

<p>(±)7(8)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid .</p>

<p>ADR-925 has the ability to protect neonatal rat cardiomyocytes from doxorubicin-induced injury.Cost-effective and quality-assured.</p>

<p>Curcumin monoglucuronide, curcumin's in vivo metabolite, useful for metabolic research and cancer study.</p>

<p>4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol. Carvedilol is a beta-blocker/alpha-1 blocker.</p>

<p>Lithium sn-glycerol 3-phosphate made by converting dihydroxyacetone phosphate via NADH from glycolysis.</p>

<p>α-Glucosidase-IN-27 (compound 8l), an α-glucosidase inhibitor with an IC50 value of 25.78 μM, demonstrates potential for research into type 2 diabetes (D2M) [1</p>

<p>CAXII-IN-2 (compound 3j) is a highly effective inhibitor of CAXII. It demonstrates inhibitory activity against CA IX and CAXII, with Ki values of 27.4 nM and 4.0 nM, respectively.</p>

Bupirimate, a systemic fungicide for powdery mildew in roses and apples, belongs to pyrimidines.

<p>A unique collection of 1268 cancer cellular metabolism related compounds for cancer research and high throughput screening (HTS) and high content screening (HCS</p>

<p>FABP4-IN-3 (Compound C3) is a highly selective inhibitor of FABP4, with an inhibition constant (Ki) of 25 ± 3 nM for FABP4 and a Ki of 15.03 μM for FABP3, showcasing a selectivity factor of 601 times over FABP3. It also demonstrates metabolic stability and potent anti-inflammatory activity in cells, making it a promising candidate for research in metabolic disorders, cardiac dysfunction, and inflammation-related diseases.</p>

<p>Digalacturonic acid, a pectin metabolite, aids in enzyme co-crystallization like proteinase K.</p>

<p>H-Met-Val-OH is a dipeptide inhibiting FMO1 and FMO3 and promoting neurite outgrowth, relevant for neuroregenerative and enzymatic modulation studies.</p>

<p>Yokonoside is a biochemical.</p>

<p>Glycerol phosphate dehydrogenase catalyzes the conversion of dihydroxyacetone phosphate to α-glycerol phosphate [1] .</p>

<p>DSPE-PEG5000-F3 consists of DSPE and the nucleolin-targeting peptide (F3) and is a PEGylated compound. The F3 peptide specifically binds to nucleolin on the cell surface, facilitating efficient transport from the cell surface to the nucleus. DSPE-PEG5000-F3 is applicable for drug delivery.</p>

<p>Sucunamostat (SCO-792) hydrochloride is an orally active, reversible inhibitor of enteropeptidase, displaying inhibition constants (IC50) of 4.6 nM for rat</p>

<p>7-Hydroxymethotrexate, major Methotrexate metabolite, inhibits dihydrofolate reductase and DNA synthesis by blocking folic acid conversion.</p>

<p>CAY10581, a derivative of pyranonaphthoquinone, serves as a highly specific and reversible uncompetitive inhibitor of IDO, demonstrating potency with an IC50</p>

<p>Alternaphenol B2, a selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1m), is sourced from the coral-derived fungus Parengyodontium album SCSIO</p>

<p>L,L-Dityrosine, a component found in the acid hydrolysates of various biological materials, such as insect cuticular resilin, plays a significant role in</p>

<p>Lysinoalanine is an unusual amino acid, not a dipeptide, which exists in proteins of cooked foods. It is formed in food that is heated or treated with alkali.</p>

<p>Ovotransferrin (328-332), with an IC50 of 20 μM, exhibits protective activity against hypertension by inhibiting the Angiotensin-Converting Enzyme (ACE) and</p>

<p>L-Isoleucyl-L-arginine, a dipeptide composed of L-isoleucine and L-arginine, acts as a potent angiotensin-converting enzyme (ACE) inhibitor and is utilized in</p>

<p>ω-Conotoxin Bu8 is a 25-amino-acid-residue ω-conotoxin that features three disulfide bridges.</p>

<p>Xanthine Oxidase-IN-11, an analog of XO8, is an inhibitor of xanthine oxidase (XO) [1].</p>

<p>7β,25-Dihydroxycholesterol, an endogenous metabolite, functions as chemoattractants for immune cells that express EBI2 [1].</p>

<p>CD13-IN-1 (Compound 5f) is a CD13 inhibitor with an IC50 value of 1.71 μM. It effectively suppresses the proliferation of various tumor cells, demonstrating antitumor activity.</p>

<p>10-FTHF is a donor of formyl groups in anabolism used as a substrate in formyltransferase reactions, which is important in purine biosynthesis.</p>

<p>L-Mevalonic acid, a cholesterol precursor, is studied in autoimmune, atherosclerosis, and Alzheimer's research.</p>

<p>DSPE-PEG1000-SP94 is a PEG compound composed of DSPE and the cell-penetrating peptide (SP94). SP94 exhibits specific binding affinity to hepatocellular carcinoma (HCC) cells.</p>

<p>LYP-IN-4 (compound D14), a reversible and selective lymphotyrosine phosphatase (LYP) inhibitor (Ki=1.34 μM, IC50=3.52μM), regulates TCR signaling, increases PD-</p>

<p>MTHFD2-IN-3 (compound 10), a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2), demonstrates significant efficacy in obstructing the activity</p>

<p>FA-Ala-Arg is a dipeptide featuring a furylacryloyl group that degrades to yield arginine.</p>

<p>1,2-Dilinoleoyl-sn-glycerol, a DAG with two linoleic acids, is in rat liver, spinach membranes, and indicates preeclampsia risk in pregnancy.</p>

<p>Amiquinsin hydrochloride monohydrate is a compound known for its antihypertensive activity. It undergoes metabolism in the body, with its primary metabolite being 4-amino-6,7-dimethoxy-3-quinolineol hydrochloride monohydrate.</p>

<p>Impurity F of Calcipotriol is a impurity of Calcipotriol. Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.</p>

<p>Pyruvate carboxylase, a biotin-containing enzyme, catalyzes the carboxylation of pyruvate to oxaloacetate, a reaction dependent on HCO3− and MgATP.</p>

<p>TEI-9647 is a vitamin D3 analog and VDR/DRE genomic antagonist.</p>

<p>Imperatoxin A, a peptide toxin sourced from the African scorpion Pandinus imperator, functions as an activator of Ca2+-release channels/ryanodine receptors (</p>

<p>ACAT-IN-2, from EP1236468A1 (ex. 187), inhibits ACAT and blocks NF-κB transcription.</p>

<p>α-Glucosidase-IN-78 (Compound 12m) is a reversible competitive inhibitor of α-glucosidase (α-glucosidase) with an IC50 of 6.0 μM. Due to its blood sugar-lowering properties, α-Glucosidase-IN-78 is applicable in diabetes research.</p>

<p>α-Glucosidase-IN-83 (compound I-1) is a potent inhibitor of α-glucosidase, demonstrating an IC50 of 1.49 μg/mL. This compound effectively reduces blood glucose levels in vivo.</p>

<p>Norimatinib mesylate, N-Desmethyl imatinib metabolite, inhibits v-Abl, c-Kit, PDGFR.</p>

<p>Chlorothiazide (Diuril) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.</p>

<p>DP-1 hydrochloride is a degradation product of SDC-TRAP-0063, a fragment of Ganetespib, a heat shock protein 90 (HSP90) inhibitor with antitumor activity.</p>

<p>(Iso)-Dehydroemetine (Dehydroisoemetine, (+/-)-) is a compound with antispasmolytic effect on smooth muscle.</p>

<p>α-Glucosidase-IN-36 (compound 5g) is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 6.69 ± 0.18 μM and inhibition constants Ki and Kis of 1.65</p>

<p>Pepsin A is a protease and endopeptidase in the stomach, capable of breaking down proteins in food into small peptide fragments.</p>

<p>Campestanol is a natural plant sterol from Brassica campestris.</p>

<p>Thymidine 5′-diphosphate (dTDP), a crucial product of pyrimidine synthesis in organisms, is synthesized through the thymidylate kinase (TMPK)-catalyzed</p>

<p>PDE4-IN-3, a new oral drug, potently blocks PDE4 enzyme with 4.2 nM IC50.</p>

<p>Spirolaxine from Sporotrichum laxum shows anti-Helicobacter pylori activity.</p>

<p>VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and</p>

<p>ω-Hexatoxin-Hv1a, a neurotoxin extracted from the venom of the spider Hadronyche versuta, inhibits voltage-gated calcium channels [1] [2].</p>

<p>Myoregulin (MLN peptide) TFA, belonging to the regulin family, is a regulator of muscle performance through modulation of intracellular calcium dynamics.</p>

<p>1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting</p>

<p>Xanthine oxidase-IN-13 (Compound 10) is a selective inhibitor of xanthine oxidase, with an IC50 of 149.56 μM for bovine xanthine oxidase. It is utilized in the study of inflammatory arthritis.</p>

<p>Lunine is a bioactive chemical.</p>

<p>Carbonic anhydrase inhibitor18 (Compound 9) is an inhibitor of human carbonic anhydrase (hCA) isozymes, with Ki values of 604.8 nM for hCA I, 333.6 nM for hCA II, 1.9 nM for hCA IX, and 6.7 nM for hCA XII. Carbonic anhydrase inhibitor18 is applicable in cancer research.</p>

<p>BMS-770767 is a novel 11-betahydroxysteroid dehydrogenase type I (11ß-HSD1) inhibitor.</p>

<p>Dactylocyclines A: novel antibiotic from Dactylosporangium, effective against tetracycline-resistant microbes.</p>

<p>DSPE-PEG1000-M2pep is a PEG compound comprised of DSPE and the M2 macrophage-targeting peptide (M2pep). M2pep acts as a mono- or multivalent ligand conjugated with pro-apoptotic peptides to focus the peptides' toxic effects on M2 macrophages. DSPE-PEG1000-M2pep can be utilized for drug delivery.</p>

<p>Impurity C of Calcitriol is an impurity of Calcitriol.Impurity C of Calcitriol is used in the synthesis of vitamin D3.</p>

<p>Photo-DL-lysine is a photo-reactive amino acid based on DL-lysine used to capture proteins that are post-translationally modified by lysine binding.</p>

<p>Cellobiosan is an anhydro sugar formed during biofuel production from the fast pyrolysis of wood.</p>

<p>RPR132595A (NPC) hydrochloride, an active metabolite of CPT-11, is produced via cytochrome P-450 3A4 (CYP3A4) metabolism and is ultimately eliminated via</p>

<p>AChE/BChE-IN-17 (compound 8m) is a potent inhibitor of AChE and BChE, displaying IC50 values of 125.06 nM and 119.68 nM, respectively. Additionally, AChE/BChE-IN-17 inhibits α-glucosidase, with an IC50 of 41050 nM.</p>

<p>5-Methoxyresorcinol (Flamenol) is a chemical intermediate.</p>

<p>Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes.</p>

<p>(S)-Higenamine, a benzylisoquinoline precursor, forms from dopamine and 4-HPAA via NCS.</p>

<p>Fellutanine A is a useful organic compound for research related to life sciences. The catalog number is T129801 and the CAS number is 175414-35-4.</p>

<p>PROTAC RAR Degrader-1, an RAR degrader, consists of a cIAP1 ligand binding group, a linker, and an RAR ligand binding group.</p>

<p>α-Glucosidase-IN-77 (Compound H7) is a non-competitive α-glucosidase inhibitor with an IC50 of 1.25 μM. It reduces blood glucose levels, improves glucose tolerance, regulates gut microbiota, and exhibits hepatoprotective effects in a mouse model of type 2 diabetes.</p>

<p>Asperglaucid A: a phthalide-like compound with strong antibacterial effects against Pseudomonas syringae pv actinidae and Bacillus cereus; MIC: 6.25 μM.</p>

<p>L-Amino acid oxidase catalyzes the oxidative deamination of L-amino acids, which have local oxidative effects as well as potent antimicrobial effects.</p>

<p>CYP1B1-IN-7 is a CYP1B1 inhibitor that can be used in synergy with anticancer compounds for the treatment of cancers.</p>

<p>(±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.</p>

<p>ent-Prostaglandin F2α is the enantiomer of PGF2α and is found in urine.</p>

<p>Pyrindolol, a S. alboverticillatus metabolite, inhibits bovine β-galactosidase at 2 μg/ml in acid; not effective on other species' enzymes.</p>

<p>ASM-IN-3 (Compound 21b) is a selective acid sphingomyelinase (ASM) inhibitor that can penetrate the blood-brain barrier, with an IC50 of 3.37 μM against purified human ASM. By inhibiting ASM activity in the hippocampus and promoting neurogenesis, ASM-IN-3 alleviates depressive-like behavior in reserpine-induced depressive rats.</p>

<p>β-1,4-GALT1-IN-1 (Compound 6) is a β-1,4-GALT1 inhibitor with an IC50 value of 6.2 μM. It is applicable in studying various pathological conditions, including cancer, autoimmune diseases, and viral infections.</p>

<p>AK-4 is an antidiabetic agent that functions as a mitochondrial uncoupler.</p>