Metabolismo

<p>Vitamin K2 (Menatetrenone) is a menaquinone compound and form of vitamin K2 with potential antineoplastic activity.</p>

<p>MitoPQ (MitoParaquat) inhibits insulin-stimulated glucose uptake and plasma membrane translocation in myotubes and can be used to study oxidative stress.</p>

<p>Epalrestat (ONO2235), an aldose reductase inhibitor, helps manage diabetic neuropathy symptoms and slows disease progression.</p>

<p>Linezolid (PNU-100766), the first of the oxazolidinone class, is a synthetic antibiotic used for the therapy of infections resulted from multi-resistant</p>

<p>ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rabbit PⅠNP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rabbit PⅠNP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rabbit PⅠNP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。</p>

<p>Aldose reductase-IN-1 (AT-001, Caficrestat) is a highly potent inhibitor of aldose reductase.Cost-effective and quality-assured.</p>

<p>3-Methylindolin-2-one (3-Methyloxindole) is a reactant for O-acetylation reactions, enantioselective α-amination reactions and for aldol reactions.</p>

<p>Sodium 2-mercaptoethanesulfonate (Uromitexan) is a sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from antineoplastic.</p>

<p>Denatonium benzoate, a salt with an inert anion, resembles lidocaine but has a benzyl group on its amino nitrogen.</p>

<p>LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)</p>

<p>AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO, IC50: 140 nM) which has similar potency in mouse and rat.</p>

<p>Nilvadipine (FK235), a calcium channel blocker (CCB), is utilized for treatment of hypertension.</p>

<p>LDN-212320 (OSU-0212320) is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by &gt; 6 fold at concentrations &lt; 5 μM after 24 h.</p>

<p>Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.</p>

<p>N-Carbethoxy-4-piperidone is an aminopyrimidine derivative, compositions containing them and there served as pharmaceuticals.</p>

<p>Cefadroxil (BL-S 578) is a Cephalosporin Antibacterial. The chemical classification of cefadroxil anhydrous is Cephalosporins.</p>

<p>PFB-FDGlu, a cell-permeable GCase substrate, is cleaved to emit fluorescein, used to assess GCase activity in live cells via flow cytometry.</p>

<p>Carbadox, an antibacterial for swine dysentery and growth promotion, is banned in the UK due to carcinogen and mutagen risks.</p>

<p>p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1].</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Human PⅠNP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PⅠNP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PⅠNP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with DOPAC protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to DOPAC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of DOPAC in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>4-Diethylaminobenzaldehyde: reversible ALDH1 inhibitor (Ki: 4 nM), potent anti-androgen (IC50: 1.71μM).</p>

<p>Meclofenoxate HCl (Lucidril) boosts memory and cognition; it's a DIMETHYLAMINOETHANOL and p-chlorophenoxyacetic acid ester.</p>

<p>Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease.</p>

<p>Cyclandelate (BS 572), a direct-acting smooth muscle relaxant, is used to dilate blood vessels.</p>

<p>Hi 76-0079: HSL inhibitor, IC50=184 nM; potential for obesity and diabetes research.</p>

<p>Praziquantel (Droncit) is an anthelmintic that paralyzes worms by increasing calcium in muscle cells, causing tegument damage and immune response.</p>

<p>Imirestat (HOE 843) is an aldose reductase inhibitor that can be used in diabetes research.</p>

<p>Otilonium bromide (SP63) , an antimuscarinic, is utilized as a spasmolytic agent.</p>

<p>Actarit (4-acetylaminophenylacetic acid) is an anti-inflammatory drug.</p>

<p>LY 195448 (4-(3-(2-Hydroxy-2-phenyl)ethylamino-3-methylbutyl)benzamide) shows antitumor activity in a mouse tumor model, blocking cells in the mid-stage.</p>

<p>Etofibrate is a combination of clofibrate and niacin, used to treat hyperlipemia.</p>

<p>Diethylcarbamazine citrate treats filariasis, targeting W. bancrofti and L. loa by inhibiting arachidonic acid in microfilaria.</p>

<p>trans-C75 ((±)-C75) is an enantiomer of C75. C75 is an inhibitor of fatty-acid synthase (FASN).</p>

<p>Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.</p>

<p>H-Lys(Tfa)-OH is an inhibitor of L-lysine cyclodeaminase.</p>

<p>CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor.</p>

<p>Ethylvanillin (Rhodiarome) is a flavorant used in the production of chocolate. It is about three times as potent as vanillin.</p>

<p>FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent inhibitor of FAAH(fatty acid amide hydrolase).</p>

<p>Hyaluronic acid sodium (MW 200 kDa) is a medium molecule sodium hyaluronate that penetrates into the dermis and stimulates skin metabolism.</p>

<p>DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.</p>

<p>IDH-305: Oral, mutation-specific IDH1 inhibitor, 200x selective for R132 mutants; IC50: 27/28/6.14 nM for R132H/C/WT.</p>

<p>10,11-Dihydrocarbamazepine (Dihydrocarbamazepine) is used as pharmaceutical intermediates.</p>

<p>Pitavastatin lactone, a major human metabolite, potently inhibits HMG-CoA reductase with minimal hepatic microsome metabolism.</p>

<p>3-Pyridinemethanol (Roniacol) is an alcohol analog of nicotinic acid which is a peripheral vasodilator that causes flushing and may decrease blood pressure.</p>

<p>Boc-LRR-AMC TFA is a fluorogenic protease substrate for detecting trypsin-like activity in the 26S proteasome or 20S proteasome core.</p>

<p>Sulfameter (Sulfametoxydiazine) is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.</p>

<p>Benzthiazide treats edema and hypertension by promoting diuresis and inhibiting kidney Na+/Cl- reuptake, but may reduce potassium and raise uric acid.</p>