Metabolismo
Los inhibidores del metabolismo son compuestos que interfieren con las vías metabólicas, alterando la producción y utilización de energía dentro de las células. Estos inhibidores se utilizan para estudiar la regulación del metabolismo, el papel de las vías metabólicas en enfermedades como el cáncer y la diabetes, y para desarrollar nuevas estrategias terapéuticas. Los inhibidores del metabolismo pueden dirigirse a diversas enzimas y procesos involucrados en la glucólisis, la oxidación de ácidos grasos y otras funciones metabólicas. En CymitQuimica, ofrecemos una amplia gama de inhibidores del metabolismo de alta calidad para apoyar su investigación en bioquímica, trastornos metabólicos y desarrollo de fármacos.
Subcategorías de "Metabolismo"
- AhR(42 productos)
- Aminopeptidasa(76 productos)
- CETP(20 productos)
- Anhídrido carbónico(196 productos)
- Caseína quinasa(139 productos)
- DHFR(30 productos)
- Descarboxilasa(4 productos)
- Deshidrogenasa(302 productos)
- FAAH(64 productos)
- FXR(62 productos)
- Factor Xa(87 productos)
- Ácido graso sintasa(37 productos)
- Ferroptosis(227 productos)
- GR(3 productos)
- GSNOR(3 productos)
- Glucoquinasa(56 productos)
- HIF / HIF Prolilhidroxilasa(146 productos)
- HMG-CoA reductasa(34 productos)
- Hidroxilasa(36 productos)
- IDO(84 productos)
- LDL(7 productos)
- Lipasa(107 productos)
- Lípido(62 productos)
- Lipoxigenasa(133 productos)
- MAO(85 productos)
- MPO(2 productos)
- NAMPT(40 productos)
- P450(6 productos)
- PAI-1(26 productos)
- PDE(170 productos)
- PED(1 productos)
- PKM(17 productos)
- PPAR(170 productos)
- Fosfolipasa(85 productos)
- ROR(47 productos)
- Receptor de retinoides(20 productos)
- SGK(10 productos)
- Tiorredoxina(12 productos)
- Transferasa(30 productos)
- Transportador(43 productos)
- UGT(4 productos)
- Inhibidores de la xantina oxidasa (XO)(9 productos)
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Se han encontrado 9197 productos de "Metabolismo"
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JTT-553
CAS:JTT-553 is a DGAT1 inhibitor with an IC50 of 2.38 nM. It effectively reduces plasma levels of glucose, insulin, non-esterified fatty acids (NEFA), total cholesterol (TC), and liver triglycerides (TG). JTT-553 enhances insulin-dependent glucose absorption and glucose intolerance in the adipose tissue of diet-induced obese (DIO) mice. In KK-Ay mice, it lowers TNF-α mRNA levels and elevates GLUT4 mRNA levels in adipose tissue. By contributing to weight loss, JTT-553 improves insulin resistance in adipose tissue and overall glucose metabolism. This compound is useful for research on obesity and type 2 diabetes mellitus (T2DM).Fórmula:C25H27F3N4O3Forma y color:SolidPeso molecular:488.50hCAII-IN-3
hCAII-IN-3 inhibits key hCA isoforms with Ki: hCA I (403.8 nM), hCA II (5.1 nM), hCA IX (10.2 nM), hCA XII (5.2 nM); shows anticancer potential.
Fórmula:C17H21N3O3SForma y color:SolidPeso molecular:347.43LEQ803
CAS:LEQ803 (N-DesmethylRibociclib) is a metabolite of the CDK4/6 inhibitor Ribociclib, produced through metabolism by CYP3A4. This compound holds potential applications in the field of oncology.Fórmula:C22H28N8OForma y color:SolidPeso molecular:420.511ent-8-iso-15(S)-Prostaglandin F2α
CAS:Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid.Fórmula:C20H34O5Forma y color:SolidPeso molecular:354.48PTP1B-IN-21
PTP1B-IN-21 inhibits PTP1B (IC50=1.56μM) selectively over TCPTP, a type 2 diabetes target.Fórmula:C22H22O11Forma y color:SolidPeso molecular:462.4APOL1-IN-3
CAS:APOL1-IN-3 is an APOL1 inhibitor used for kidney disease research.Fórmula:C16H19F3N4O2SForma y color:SolidPeso molecular:388.41HIF-1α-IN-4
HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.Fórmula:C16H12N2O3Forma y color:SolidPeso molecular:280.28α-Glucosidase-IN-13
α-Glucosidase-IN-13 is an inhibitor of α-glucosidase (IC50: 5.69 μM).Fórmula:C25H28N4O3S2Forma y color:SolidPeso molecular:496.64ATX inhibitor 22
ATX inhibitor 22 is a novel inhibitor of ATX (autotaxin) (IC50: 218.9 μM) that lacks inhibitory activity against LPAR1.Fórmula:C19H17Cl3F2N2O4SForma y color:SolidPeso molecular:513.77hCAII-IN-4
CAS:hCAII-IN-4 (Compound 12j) is a potent inhibitor of human carbonic anhydrase II (hCA II), exhibiting an inhibitory concentration (IC50) of 7.78 μM.Fórmula:C31H23NO9Forma y color:SolidPeso molecular:553.52IDH1 Inhibitor 1
CAS:Oral, brain-penetrant mutant IDH1 inhibitor targeting R132H/C with IC50: 0.021/0.045μM; 2.52μM for IDH1WT.Fórmula:C20H18F4N6O2Pureza:98%Forma y color:SolidPeso molecular:450.39hMAO-B/MB-COMT-IN-2
Dual inhibitor hMAO-B/MB-COMT-IN-2 targets hMAO-B (IC50: 4.27μM) & MB-COMT (IC50: 2.69μM), aids in neurodegenerative research.Fórmula:C17H18N2O3Forma y color:SolidPeso molecular:298.34HIF-1α-IN-5
HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A.Fórmula:C16H15N3O2Forma y color:SolidPeso molecular:281.31Falecalcitriol
CAS:Falecalcitriol is an analog of calcitriol. It has a higher potency both in vivo and in vitro systems, which is longer duration of action in vivo.Fórmula:C27H38F6O3Pureza:98%Forma y color:SolidPeso molecular:524.58SAL-0010042
CAS:SAL-0010042 is an inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP in gametocytes with an IC50 of 48.9 nM, thereby activating PKG and inhibiting the growth and development of Plasmodium (IC50s for 3D7 and Dd2 are 142 nM and 218 nM, respectively). It also inhibits hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, respectively.Fórmula:C15H15FN4OForma y color:SolidPeso molecular:286.304NTPDase-IN-2
CAS:NTPDase-IN-2 inhibits h-NTPDase-2/-8 (IC50: 0.04, 2.27 µM), non-competitive for h-NTPDase-1/-2 (Km: 74 µM); useful in cancer, immune, bacterial research.Fórmula:C24H20FN3OS2Forma y color:SolidPeso molecular:449.56(-)-Mesembrine
CAS:Mesembrine is a serotonin reuptake inhibitor and is also a weak inhibitor of the enzyme phosphodiesterase 4 (PDE4).Fórmula:C17H23NO3Forma y color:SolidPeso molecular:289.37(2S,4S)-Sacubitril
CAS:(2S,4S)-Sacubitril (Sacubitril Impurity C) is a stereoisomer derived from Sacubitril which is a potent NEP inhibitor.Fórmula:C24H29NO5Pureza:98%Forma y color:SolidPeso molecular:411.49TNP-470
CAS:TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.Fórmula:C19H28ClNO6Pureza:98%Forma y color:SolidPeso molecular:401.88Carbonic anhydrase inhibitor 2
CAS:Compound 7c inhibits carbonic anhydrase II, lowering intraocular pressure in glaucomatous rabbits.Fórmula:C12H16N4O6SForma y color:SolidPeso molecular:344.34
