GPCR / proteína G
Los inhibidores de GPCR/proteínas G son compuestos que se dirigen a los receptores acoplados a proteínas G (GPCR) y a las proteínas G asociadas, que desempeñan roles cruciales en la transmisión de señales desde el exterior hacia el interior de las células. Estos inhibidores son esenciales para estudiar las vías de señalización mediadas por los GPCR, que están involucradas en numerosos procesos fisiológicos, incluyendo la percepción sensorial, la respuesta inmunitaria y la neurotransmisión. Los inhibidores de GPCR también son importantes en el desarrollo de fármacos, ya que muchos agentes terapéuticos tienen como objetivo estos receptores. En CymitQuimica, ofrecemos una amplia gama de inhibidores de GPCR/proteínas G de alta calidad para apoyar su investigación en farmacología, biología celular y campos relacionados.
Subcategorías de "GPCR / proteína G"
- Receptor 5-HT(1.025 productos)
- Receptor de adenosina(251 productos)
- Receptor adrenérgico(3.028 productos)
- Receptor de bombesina(35 productos)
- Receptor de bradicinina(61 productos)
- CXCR(158 productos)
- CaSR(34 productos)
- Receptor de cannabinoides(218 productos)
- Colecistoquinina(1 productos)
- Receptor de dopamina(445 productos)
- Receptor de endotelina(86 productos)
- Receptor GNRH(84 productos)
- GPCR19(36 productos)
- GRK(33 productos)
- GTPasa(23 productos)
- Receptor de glucagón(195 productos)
- Hedgehog / Smoothened(49 productos)
- Receptor de histamina(385 productos)
- Receptor LPA(21 productos)
- Receptor de melatonina(26 productos)
- Receptor de OX(41 productos)
- Receptor de opioides(327 productos)
- PAFR(14 productos)
- PKA(61 productos)
- Receptor S1P(18 productos)
- SGLT(31 productos)
- Receptor sigma(46 productos)
Mostrar 19 subcategorías más
Se han encontrado 6011 productos de "GPCR / proteína G"
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5-HT2A receptor agonist-7
CAS:5-HT2A receptor agonist-7 (517) functions as a modulator of the 5-HT2A receptor, with an EC50 value of less than 100 nM.Fórmula:C12H11F2N3Forma y color:SolidPeso molecular:235.233Beloxepin
CAS:Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.Fórmula:C19H21NO2Pureza:98%Forma y color:SolidPeso molecular:295.38MRGPRX2 modulator-3
CAS:MRGPRX2 modulator-3 (Compound 4-400) is a quinoline derivative and an MRGPRX2 regulator. It is utilized in the investigation of MRGPRX2-related conditions, including allergies, itching, pain, inflammation, and autoimmune diseases.Fórmula:C21H21ClF3N5OForma y color:SolidPeso molecular:451.87Nedocromil sodium
CAS:Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.Fórmula:C19H17NNaO7Pureza:98%Forma y color:SolidPeso molecular:394.335UTPγS trisodium salt
CAS:P2Y2 and P2Y4 receptor agonistFórmula:C9H12N2Na3O14P3SPureza:98%Forma y color:SolidPeso molecular:566.15GPR183 inverse agonist-1
CAS:GPR183 inverse agonist-1 (Compound 78) is an inverse agonist of GPR183. It inhibits GPR183-mediated Gi activation and β-arrestin2 recruitment while blocking PBMC migration. This compound is utilized in research concerning inflammation, autoimmune, and cancer-related diseases.Fórmula:C20H20BrN5O2Forma y color:SolidPeso molecular:442.31Terguride
CAS:Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.Fórmula:C20H28N4OForma y color:SolidPeso molecular:340.46SphK1-IN-1
SphK1-IN-1: SphK1 ATPase inhibitor, IC50=2.48 μM, potential for cancer research.Fórmula:C22H22N6O2Forma y color:SolidPeso molecular:402.45Setomagpran
CAS:Setomagpran is an antagonist of the mas-related G protein-coupled receptor (MRGPR) and possesses anti-inflammatory properties.Fórmula:C22H19Cl2F6N5OForma y color:SolidPeso molecular:554.316LX2761
CAS:LX2761 is a stable inhibitor for SGLT1/2 with IC50s of 2.2/2.7 nM; it targets SGLT1 in the GI tract.Fórmula:C32H47N3O6SPureza:98%Forma y color:SolidPeso molecular:601.80COX-2-IN-6
CAS:COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.Fórmula:C20H27NO6SPureza:99.29% - 99.32%Forma y color:SoildPeso molecular:409.5LK-732
CAS:LK-732 is a thrombin inhibitor with antithrombotic activity. It exhibits dose-dependent inhibition in models of hypercoagulability, with an IC50 value of 1.3 mg/kg. LK-732 is used in cardiovascular and cerebrovascular research.Fórmula:C25H29N5O3SForma y color:SolidPeso molecular:479.59BI-113823
CAS:BI-113823 is an orally active and selective bradykinin B1 receptor antagonist. It alleviates mechanical hyperalgesia induced by complete Freund's adjuvant in rats. BI-113823 is applicable for research on chronic inflammatory pain.Fórmula:C26H44N4O5SForma y color:SolidPeso molecular:524.716Sitamaquine hydrochloride
CAS:Sitamaquine hydrochloride (WR 6026) is an orally active 8-aminoquinoline analog with antileishmanial activity. This compound inhibits mitochondrial complex II (succinate dehydrogenase) and is characterized by its lipophilic weak base properties. It rapidly accumulates in the acidic compartments of Leishmania parasites, predominantly localizing within the acidocalcisomes.Fórmula:C21H35Cl2N3OForma y color:SolidPeso molecular:416.43(S)-YNT-3708
CAS:(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.Fórmula:C35H36N4O6SForma y color:SolidPeso molecular:640.749MrgprX2 antagonist-6
MrgprX2 antagonist-6 is a potent antiallergic agent with inhibitory effects on mast cell degranulation.Fórmula:C24H23F3N6O3Forma y color:SolidPeso molecular:500.47PF-06372222
CAS:PF-06372222: a small-molecule that modulates GCGR and antagonizes GLP-1R, affecting insulin and glucagon.Fórmula:C26H28F3N5O3Pureza:98%Forma y color:SolidPeso molecular:515.53LY 292728
CAS:LY 292728 is a highly potent antagonist of leukotriene B4 receptor.Fórmula:C34H29FO9Pureza:98%Forma y color:SolidPeso molecular:600.59LK 11
CAS:LK-11, an alkaloid derivative, inhibits the passive uptake of norepinephrine (NA) by synaptic vesicles in the thalamus, similarly to cocaine.Fórmula:C15H26N2O3Forma y color:SolidPeso molecular:282.38Pexacerfont
CAS:Pexacerfont (BMS-562086) is a selective antagonist of the corticotropin-releasing factor receptor (IC50: 6.1±0.6 nM for the human CRF1 receptor).Fórmula:C18H24N6OPureza:99.77%Forma y color:SolidPeso molecular:340.42
