GPCR / proteína G
Los inhibidores de GPCR/proteínas G son compuestos que se dirigen a los receptores acoplados a proteínas G (GPCR) y a las proteínas G asociadas, que desempeñan roles cruciales en la transmisión de señales desde el exterior hacia el interior de las células. Estos inhibidores son esenciales para estudiar las vías de señalización mediadas por los GPCR, que están involucradas en numerosos procesos fisiológicos, incluyendo la percepción sensorial, la respuesta inmunitaria y la neurotransmisión. Los inhibidores de GPCR también son importantes en el desarrollo de fármacos, ya que muchos agentes terapéuticos tienen como objetivo estos receptores. En CymitQuimica, ofrecemos una amplia gama de inhibidores de GPCR/proteínas G de alta calidad para apoyar su investigación en farmacología, biología celular y campos relacionados.
Subcategorías de "GPCR / proteína G"
- Receptor 5-HT(1.025 productos)
- Receptor de adenosina(249 productos)
- Receptor adrenérgico(3.023 productos)
- Receptor de bombesina(35 productos)
- Receptor de bradicinina(61 productos)
- CXCR(158 productos)
- CaSR(34 productos)
- Receptor de cannabinoides(217 productos)
- Colecistoquinina(1 productos)
- Receptor de dopamina(445 productos)
- Receptor de endotelina(86 productos)
- Receptor GNRH(84 productos)
- GPCR19(33 productos)
- GRK(33 productos)
- GTPasa(23 productos)
- Receptor de glucagón(194 productos)
- Hedgehog / Smoothened(49 productos)
- Receptor de histamina(385 productos)
- Receptor LPA(21 productos)
- Receptor de melatonina(26 productos)
- Receptor de OX(41 productos)
- Receptor de opioides(327 productos)
- PAFR(14 productos)
- PKA(60 productos)
- Receptor S1P(18 productos)
- SGLT(31 productos)
- Receptor sigma(46 productos)
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Se han encontrado 5990 productos de "GPCR / proteína G"
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MK-3207
CAS:MK-3207 is a potent, oral CGRP receptor antagonist with high selectivity for human and monkey receptors, inhibiting blood flow in vivo.Fórmula:C31H29F2N5O3Forma y color:SolidPeso molecular:557.59D4R antagonis-2
Potent D4R antagonist-2: selective, IC50=6.52 μM, good in vitro PK and brain penetration, potential for Parkinson's research.Fórmula:C21H23ClF2N2O2Forma y color:SolidPeso molecular:408.87ZK118182 isopropyl ester
CAS:ZK118182 isopropyl ester is a PG analog with potent DP-agonist activity (EC50 = 16.5 nM) and high affinity for the DP receptor (Ki = 74 nM).Fórmula:C23H37ClO5Pureza:98%Forma y color:SolidPeso molecular:428.99AL 8810
CAS:AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].Fórmula:C24H31FO4Forma y color:SolidPeso molecular:402.5SSTR5 antagonist 2 hydrochloride
SSTR5 antagonist 2 hydrochloride: potent, oral SSTR5 blocker with potential in type 2 diabetes research.Fórmula:C32H36ClFN2O5Forma y color:SolidPeso molecular:583.09Lp(a)-IN-8
CAS:LPA2 antagonist 3 (compound 15) serves as an Lp(a) antagonist. Lp(a) is a pathogenic risk factor for atherosclerotic cardiovascular disease (ASCVD).Fórmula:C21H40Cl2N4O5Forma y color:SolidPeso molecular:499.472NMDAR antagonist 5
CAS:NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET). It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM). NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM). It has antidepressant properties and is useful for depression research.Fórmula:C17H21N3Forma y color:SolidPeso molecular:267.369BD-1047
CAS:BD-1047 is a selective functional antagonist of sigma receptors. It can alleviate climbing behavior induced by Apomorphine and head twitching caused by Phencyclidine.Fórmula:C13H20Cl2N2Forma y color:SolidPeso molecular:275.217CRHR1 antagonist 1
CAS:CRHR1 antagonist 1 (compound 10a) is a non-peptide antagonist of corticotropin-releasing hormone receptor 1 (CRHR1). It serves as a useful tool in the study of psychiatric disorders.Fórmula:C24H34N4OForma y color:SolidPeso molecular:394.553SGLT1/2-IN-8
CAS:SGLT1/2-IN-8 (compound 8) is a potent and orally active dual inhibitor of SGLT1/2, exhibiting IC50 values of 4 nM and 1 nM, respectively. It shows antihyperglycemic properties, making it suitable for related research.Fórmula:C22H26O6Forma y color:SolidPeso molecular:386.438LTD4 antagonist 1
CAS:LTD4 antagonist 1 is a potent and orally active antagonist of leukotriene D4 (LTD4; Ki: 0.57 nM).Fórmula:C31H32F3N3O5SPureza:98%Forma y color:SolidPeso molecular:615.66BIIE-0246 HCl
CAS:BIIE-0246: A potent, non-peptide Y2 receptor antagonist; >650-fold more selective than Y1, Y4, Y5.Fórmula:C49H59Cl2N11O6Forma y color:SolidPeso molecular:968.97Edonentan hydrate
CAS:Edonentan (BMS 207940) hydrate effectively blocks the endothelin A (ETA) receptor as a potent and selective antagonist, featuring a K i of 10 pM. It exhibits complete (100%) oral bioavailability in rats [1].Fórmula:C28H34N4O6SForma y color:SolidPeso molecular:554.66APJ receptor agonist 3
CAS:APJ receptor agonist 3 is a highly effective and orally administerable agonist of the APJ receptor, demonstrating a potent EC50 value of 0.027 nM.Fórmula:C26H29ClN4O5Forma y color:SolidPeso molecular:512.98LPA2 antagonist 6
CAS:LPA2 antagonist 6 (example 2) acts as an antagonist of Lp(a). It inhibits the formation of Lp(a) with an IC50 value of 2.33 nM, making it useful for cardiovascular disease research.Fórmula:C26H34Cl2N2O6Forma y color:SolidPeso molecular:541.464MrgprX2 antagonist-7
MrgprX2 antagonist-7 is an anti-allergic agent with significant anti-allergic effects and inhibits mast cell degranulation.Fórmula:C24H22ClF3N6O3Forma y color:SolidPeso molecular:534.92WIN 62577
CAS:WIN 62577 is a species-selective tachykinin NK1 receptor antagonist and also serves as an allosteric enhancer with micromolar potency at M3 receptors. Additionally, WIN 62577 demonstrates potent antiviral activity against SARS-CoV-2.Fórmula:C29H31N3OForma y color:SolidPeso molecular:437.576Atumelnant
CAS:Atumelnant (CRN04894) is an MC2R antagonist used in the study of congenital adrenocortical hyperplasia (CAH) and Cushing's disease (CD).Fórmula:C33H42F3N5O3Pureza:98.41%Forma y color:SolidPeso molecular:613.71UK-432097
CAS:UK 432097 is an adenosine A2A agonist.Fórmula:C40H47N11O6Forma y color:SolidPeso molecular:777.87RXFP1 receptor agonist-10
CAS:RXFP1 receptor agonist-10 (Compound 188) is an RXFP1 receptor agonist with an EC50 of 0.5 nM. It is useful for research into heart failure.Fórmula:C39H44F6N4O5Forma y color:SolidPeso molecular:762.78
