GPCR / proteína G
Los inhibidores de GPCR/proteínas G son compuestos que se dirigen a los receptores acoplados a proteínas G (GPCR) y a las proteínas G asociadas, que desempeñan roles cruciales en la transmisión de señales desde el exterior hacia el interior de las células. Estos inhibidores son esenciales para estudiar las vías de señalización mediadas por los GPCR, que están involucradas en numerosos procesos fisiológicos, incluyendo la percepción sensorial, la respuesta inmunitaria y la neurotransmisión. Los inhibidores de GPCR también son importantes en el desarrollo de fármacos, ya que muchos agentes terapéuticos tienen como objetivo estos receptores. En CymitQuimica, ofrecemos una amplia gama de inhibidores de GPCR/proteínas G de alta calidad para apoyar su investigación en farmacología, biología celular y campos relacionados.
Subcategorías de "GPCR / proteína G"
- Receptor 5-HT(1.025 productos)
- Receptor de adenosina(249 productos)
- Receptor adrenérgico(3.022 productos)
- Receptor de bombesina(35 productos)
- Receptor de bradicinina(61 productos)
- CXCR(158 productos)
- CaSR(34 productos)
- Receptor de cannabinoides(217 productos)
- Colecistoquinina(1 productos)
- Receptor de dopamina(445 productos)
- Receptor de endotelina(86 productos)
- Receptor GNRH(84 productos)
- GPCR19(33 productos)
- GRK(33 productos)
- GTPasa(23 productos)
- Receptor de glucagón(194 productos)
- Hedgehog / Smoothened(49 productos)
- Receptor de histamina(385 productos)
- Receptor LPA(21 productos)
- Receptor de melatonina(26 productos)
- Receptor de OX(41 productos)
- Receptor de opioides(327 productos)
- PAFR(14 productos)
- PKA(60 productos)
- Receptor S1P(18 productos)
- SGLT(31 productos)
- Receptor sigma(46 productos)
Mostrar 19 subcategorías más
Se han encontrado 5985 productos de "GPCR / proteína G"
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NMDAR antagonist 5
CAS:NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET). It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM). NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM). It has antidepressant properties and is useful for depression research.Fórmula:C17H21N3Forma y color:SolidPeso molecular:267.369MK-3207
CAS:MK-3207 is a potent, oral CGRP receptor antagonist with high selectivity for human and monkey receptors, inhibiting blood flow in vivo.Fórmula:C31H29F2N5O3Forma y color:SolidPeso molecular:557.59GRK6-IN-5
CAS:GRK6-IN-5 is an inhibitor of the GRK6 polypeptide, with an IC50 of 4.48 μM. GRK6-IN-5 is utilized in research focused on hematological malignancies, inflammatory diseases, and autoimmune disorders.Fórmula:C23H21N3O2Forma y color:SolidPeso molecular:371.432SGLT1/2-IN-8
CAS:SGLT1/2-IN-8 (compound 8) is a potent and orally active dual inhibitor of SGLT1/2, exhibiting IC50 values of 4 nM and 1 nM, respectively. It shows antihyperglycemic properties, making it suitable for related research.Fórmula:C22H26O6Forma y color:SolidPeso molecular:386.438CRHR1 antagonist 1
CAS:CRHR1 antagonist 1 (compound 10a) is a non-peptide antagonist of corticotropin-releasing hormone receptor 1 (CRHR1). It serves as a useful tool in the study of psychiatric disorders.Fórmula:C24H34N4OForma y color:SolidPeso molecular:394.553CB2 receptor antagonist 1
CAS:Compound 29 is a potent, CB2-selective antagonist/reverse agonist. Derivatives 23 & 24 offer antinociception; 24 activates cannabinoid/TRPV1 receptors.Fórmula:C28H47NO3Forma y color:SolidPeso molecular:445.68Arpromidine
CAS:Arpromidine (BU-E-50) acts as an agonist for the histamine H2 receptor and an antagonist for the histamine H1 receptor. It demonstrates positive inotropic effects with a lower risk of inducing arrhythmias. Arpromidine can be utilized in studies related to congestive heart failure.Fórmula:C21H25FN6Forma y color:SolidPeso molecular:380.462Org 274179-0
CAS:Org 274179-0 is an effective allosteric antagonist of the thyroid-stimulating hormone (TSH) receptor, with an IC50 in the nanomolar range. It fully inhibits TSH (and TSI)-mediated activation of the TSH receptor with minimal impact on the efficacy of TSH. This compound can be utilized in studies of Graves' disease (GD).Fórmula:C28H27F3N2O2Forma y color:SolidPeso molecular:480.521Opipramol dihydrochloride
CAS:Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) primarily functioning as a sigma (σ) receptor agonist. It interacts effectively with sigma recognition sites, having a Ki value of 50 nM. Opipramol is applicable in the study of generalized anxiety disorder (GAD).Fórmula:C23H31Cl2N3OForma y color:SolidPeso molecular:436.418BIIE-0246 HCl
CAS:BIIE-0246: A potent, non-peptide Y2 receptor antagonist; >650-fold more selective than Y1, Y4, Y5.Fórmula:C49H59Cl2N11O6Forma y color:SolidPeso molecular:968.97MRGPRX2 modulator-1
CAS:MRGPRX2 modulator-1 (example 17), a modulator of the mas-related G-protein receptor X2 (MRGPRX2), is employed in studies focused on inflammation, pain, and autoimmune disorders [1].Fórmula:C20H19F6N5OForma y color:SolidPeso molecular:459.39APJ receptor agonist 3
CAS:APJ receptor agonist 3 is a highly effective and orally administerable agonist of the APJ receptor, demonstrating a potent EC50 value of 0.027 nM.Fórmula:C26H29ClN4O5Forma y color:SolidPeso molecular:512.98BIBO3304 diTFA
CAS:BIBO3304 (diTFA), a selective neuropeptide Y (NPY) Y1 receptor antagonist, demonstrates oral efficacy. It exhibits high affinity for Y1 receptors in both humans and rats, with IC50 values of 0.38 nM and 0.72 nM, respectively. Additionally, BIBO3304 (diTFA) enhances bone-tendon healing via the Wnt/β-catenin signaling pathway [1] [2] [3].Fórmula:C33H37F6N7O7Forma y color:SolidPeso molecular:757.68Serotonin maleate
CAS:Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.Fórmula:C14H16N2O5Forma y color:SolidPeso molecular:292.287K-8794
CAS:K-8794 is an orally active and selective endothelin receptor ETB antagonist that can be utilized in cardiovascular disease research.Fórmula:C36H38N6O6SForma y color:SolidPeso molecular:682.789AM9405
AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.Fórmula:C24H33BrN2O2Pureza:98%Forma y color:SolidPeso molecular:461.44LY210073
CAS:LY210073 is an antagonist of the Leukotriene B4 (LTB4) receptor (IC50: 6.2 nM).Fórmula:C30H28O8Pureza:98%Forma y color:SolidPeso molecular:516.54CI-936
CAS:CI-936 (MRS-3310) is an orally active A2 agonist with a binding affinity of 25 nM. In preclinical studies, it has demonstrated potent and selective effects, indicating potential antipsychotic efficacy. Additionally, CI-936 inhibits exploratory behavior in mice.Fórmula:C24H25N5O4Forma y color:SolidPeso molecular:447.49MCTR1
CAS:MCTR1, a pro-resolving mediator derived from DHA, promotes tissue repair and reduces inflammation by enhancing phagocytosis and decreasing eicosanoids.Fórmula:C32H47N3O9SForma y color:SolidPeso molecular:649.8Rodatristat ethyl
CAS:Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels & lowering PAH at low doses.Fórmula:C29H31ClF3N5O3Pureza:98%Forma y color:SolidPeso molecular:590.04
