Métabolisme

PF-06424439 methanesulfonate: oral, potent, selective DGAT2 inhibitor (IC50=14 nM), noncompetitive, slowly reversible.

5-Phenylhydantoin is a Mephenytoin metabolite with anti-epileptic effects, targeting NVSCs.

1-Phenyl-1, 2-ethanediol is O-benzyl oxime ether derivatives and used as pesticides.

Hematin (Ferrihemic acid) is an iron-containing porphyrin.

Eliglustat hemitartrate (Genz-112638) , with an IC50 of 24 nM, is a specific, potent, oral active glucocerebral glycosidase inhibitor.

Procodazole (2-Benzimidazolepropionic acid) is a non-specific active immunoprotective agent against viral and bacterial infections.

Ipriflavone (Osteofix) (Osteofix) is a feed additive and a catabolic agent. It is used to inhibit bone resorption.

Chlormethiazole hydrochloride is an anticonvulsant and sedative. It also has neuroprotective.

This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Horse SDMA. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Horse SDMA. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Horse SDMA in the samples is then determined by comparing the OD of the samples to the standard curve.

Lunularic acid, a dihydrostilbene analog, efficiently inhibits hyaluronidase activity and can be used as an endogenous growth inhibitor in moss plants.

Mafenide hydrochloride (4-Aminomethylbenzenesulfonamide hydrochloride) is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-

KPLH1130, a PDK inhibitor, boosts glucose tolerance and reduces inflammation in high-fat diet mice.

ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].

D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride), a constituent of striated muscle and liver, is used in the treatment of hyperlipoproteinemias.

Acetylsulfamerazine, a metabolite of sulphamethazine, slightly inhibits cellulose digestion and rumen endocrine, with anti-microbial properties.

ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human APOB100, and the Human APOB100 standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human APOB100. After TMB substrate solution is added, only those wells that contain Human APOB100 and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human APOB100 in the samples is then determined by comparing the OD of the samples to the standard curve.

This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse ALD. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse ALD. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse ALD in the samples is then determined by comparing the OD of the samples to the standard curve.

L-Cysteine methyl ester hydrochloride (L-Cysteine methyl ester hydrochloride (Acdrile)) is an antitussive and an expectorant agent, used to relieve breathing