Métabolisme

<p>Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.</p>

<p>Obicetrapib (AMG-899) is an inhibitor of cholesteryl ester transfer protein.</p>

STK-15 is a candidate for use as a fatty acid binding protein 5 (FABP5) inhibitor.

<p>Glycosyltransferase-IN-1 is a glycosyltransferase inhibitor with bacteriostatic activity, inhibiting MSSA, MRSA, Bacillus subtilis, and Enterobacteriaceae.</p>

<p>GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.</p>

SMND-309, a metabolite of salvianolic acid B, exhibits neuroprotective effects in cultured neurons and in rats subjected to permanent middle cerebral artery occlusion.

TC-F 2 is a FAAH inhibitor.

4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol), a potent COX-2 and hepatic NAT2 inhibitor used as an antipyretic and analgesic drug.

MK-0941 is an orally active and allosteric glucokinase activator, has potential in the treatment of type 2 diabetes.

PF-06747711 is an effective and selective retinoic acid receptor-related orphan C2 inverse agonist (IC50: 4.1 nM). PF-06747711 also has anti-skin inflammatory activity.

8-Dehydrocholesterol is a compound whose elevated concentration is a diagnostic biochemical hallmark of classical Smith-Lemli-Opitz syndrome.

PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2 and significantly increases the activity of the pyruvate dehydrogenase complex.

(S)-GNE-140 is the less active enantiomer of GNE-140.

Modecainide is metabolite of Encainide, is an antiarrhythmic agent.

β-Apo-13-carotenone is a naturally occurring β-apocarotenoid, and is a RXRα antagonist.

N3PT is a potent and selective inhibitor of transketolase(TK) with IC50 of 22 nM for Apo-TK)

BI-2545 is a potent and selective autotaxin (ATX) inhibitor with IC50 values of 2.2 nM and 3.4 nM for human and rat ATX, reduces plasma LPA levels.

6-Hydroxybentazon is a phase I metabolite of bentazon, a herbicide.

Calcitriol Impurities A refers to the contaminants found in Calcitriol, the hormonally active metabolite of vitamin D3, which serves to activate the vitamin D receptor.

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse MDA protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse MDA. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse MDA in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat VLDL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat VLDL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat VLDL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat VLDL in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

MRS2802 is a P2Y14 receptor agonist, its EC50 value for P2Y14 receptor is 63 nM.

PF-06445974 has good selectivity for PDE4D, excellent brain permeability, and has a high level of specific binding in the "cold tracer" study.

Lichenase, an enzyme, breaks down β-glucans in grains into GOS, aiding polysaccharide degradation in cell walls.

D21-2393 subjects received a single-oral-dose of edoxaban 30-90 mg in each study occasion under fasting condition. Serial blood samples were collected to measure the plasma concentrations of edoxaban and its major active metabolite D21-2393. Meanwhile, PT, INR, aPTT were measured pre- and post-dose.

<p>1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt (T64571) is a natural product utilized in life sciences research.</p>

Lysyl-tyrosyl-lysine is a bioactive chemical.

<p>L-N-Benzylserine is a useful organic compound for research related to life sciences. The catalog number is T65056 and the CAS number is 17136-45-7.</p>

Fmoc-1-methyl-L-histidine is a valuable organic compound for life sciences research (Catalog No.: T66680, CAS: 202920-22-7).

<p>TRC-766, a negative control of RTC-5 (TRC-382), is a compound that exhibits protein phosphatase 2A (PP2A) binding properties while lacking phosphatase activation capabilities.</p>

<p>3-Deoxy-galactosone, a 1,2-dicarbonyl compound, originates from the degradation of galactose. It forms in food during Maillard and caramelization reactions.</p>

<p>Creatinine-D3 is a deuterium-labeled Creatinine which is a break-down product of creatine phosphate in muscle.</p>

Methyl 2-(benzylamino)-3-hydroxypropanoate, catalog number T66013 and CAS number 144001-42-3, is a valuable organic compound for life sciences research.

<p>(Rac)-PD0299685 is a potent voltage-dependent calcium channel inhibitor for the study of retina-related diseases.</p>

<p>Fmoc-HoCys(ACM)-OH is an amino acid derivative and has a wide range of applications in life science related research.</p>

Dichloroiodomethane is a natural compound found in human beings[1].

<p>LCC-12 formate (LCC-12 FA) inhibits copper(II) in mitochondria and NAD(H) and inhibits macrophage activation, affects inflammation, cellular plasticity.</p>

4-Nitrophenyl N-acetyl-β-D-galactosaminide is a useful organic compound for research related to life sciences. The catalog number is T67691 and the CAS number is 14948-96-0.

1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid (LyP).

<p>Vitamin D3 octanoate, an ester derived from vitamin D3, is commonly known as cholecalciferol. Cholecalciferol is a naturally occurring form of vitamin D with notable properties such as inducing cell differentiation and impeding cancer cell proliferation.</p>

GDP-D-mannose disodium is a natural product for research related to life sciences and the catalog number is T65209.

<p>3-Hydroxy-4-aminopyridine is a natural product for research related to life sciences. The catalog number is T66009 and the CAS number is 52334-53-9.</p>

3,5-Dibromotyrosine is a useful organic compound for research related to life sciences. The catalog number is T65914 and the CAS number is 300-38-9.

<p>L-Glyceric acid sodium, a urinary metabolite, is predominantly found in individuals with the rare inherited metabolic disorder L-glyceric aciduria. This compound is a diagnostic tool for identifying primary hyperoxaluria type 2 (PH2) and distinguishing it from primary hyperoxaluria type 1 (PH1) based on its excretion pattern.</p>

<p>1-(2,3-Dichlorphenyl)-piperazine (DCPP) is a potent DHCR7 inhibitor. DHCR7 is the last enzyme in cholesterol biosynthesis.</p>

<p>2-(Methoxycarbonyl)benzoic acid is a natural product for research related to life sciences. The catalog number is T67426 and the CAS number is 4376-18-5.</p>

R-18986 is a biochemical substance.

CDE-096 is a plasminogenactivator inhibitor-1 (PAI-1) inactivator.

Valiolamine is a useful organic compound for research related to life sciences. The catalog number is T65494 and the CAS number is 83465-22-9.