Glucides et Glycoconjugués

<p>Applications Cytidine 5’-Phosphate Methyl Ester Sodium Salt is an byproduct formed in the synthesis of analogs of Cytidine 5’-Diphosphate with an important role in the metabolism of phospholipids.<br>References Trotter, P., et al.: J. Biol. Chem., 270, 6062 (1995), Janssen, M., et al.: Yeast, 16, 641 (2000), Henneberry, A., et al.: Mol. Biol. Cell, 12, 511 (2001), Boumann, H., et al.: Biochemistry, 42, 3054 (2003),<br></p>

<p>Stability Very Hygroscopic<br>Applications CDPcholine cholinephosphotransferase analog.<br>References Kennedy, E.P., et al.: J. Biol. Chem.,222,185 (1956),<br></p>

<p>Applications A monosaccharide (hexose) that can be used as a low-calorie sweetener, as an intermediate for synthesis of other optically active compounds, and as an additive in detergent, cosmetic, and pharmaceutical formulation.<br>References Oh, D. et al.: Appl. Microbiol. Biotech., 76, 76, 1 (2007); Lu, Y. et al.: Int. J. Cosm. Sci., 24, 225 (2002); Donner, T.W. et al.: Diab. Obes. Metab., 1, 285 (1999);<br></p>

<p>Applications Streptidine, is a metabolite derivative of Streptomycin (S687500), an antibiotic (antimycobacterial) drug, used for patients suffering from tuberculosis or other infectious diseases.<br>References Granados, O., et al.: Histology and Histopathology, 20(2), 357 (2005);<br></p>

<p>Applications D-(-)-Tartaric Acid the synthetic enantiomer of L-(+)-Tartaric Acid (T007630), used in the preparation of synthetic analgesics.<br>References Van Bever, W. et al.: J. Med. Chem., 17, 1047 (1974);<br></p>

<p>Applications Impurity of β-cyclodextrin (C987830), a cyclic oligosaccharide produced from starch via enzymatic conversion.<br>References Johnson, M.D., et al.: J. Pharma. Sci., 83, 1142 (1994); Jain, A.C., et al.: Int. J. Pharma., 212, 177 (2001);<br></p>

<p>Stability Very Hygroscopic<br>Applications 4-Nitrophenyl 3-O-(α-D-Mannopyranosyl)-α-D-mannopyranoside (cas# 93979-06-7) is a compound useful in organic synthesis.<br></p>

<p>Applications A sulfhydryl reactive biotinylaton reagent.<br>References Carlsson, J., et al.: Biochem. J., 173, 723 (1978), Ghebrehiwet, B., et al.: J. Immunol. Methods, 110, 251 (1988)<br></p>

<p>Stability Very Hygroscopic<br>Applications A metabolite profiling of hydroxycinnamate derivative in plasma and urine after the ingestion of coffee by humans: identification of biomarkers of coffee consumption.<br>References Buchanan, C., et al.: J. Sci. Food Agric., 71, 459 (1996), Andreasen, M., et al.: J. Agric. Food Chem., 49, 5679 (2001), Poquet, L., et al.: Drug Metab. Dispos., 36, 190 (2008),<br></p>

<p>Applications D-Glucosaminic Acid is a useful starting material for the synthesis of aldonic acids containing a free carboxyl group and having all hydroxyl functions esterified with a simple carboxylic acid are well established deriviatives.<br>References Major, R.T., et al.: J.A.C.S., 58, 2474 (1936), Hurd, C.D., et al.: J.A.C.S., 60, 235 (1938), Wolfrom, M., et al.: J.A.C.S., 61, 574 (1939)<br></p>

<p>Applications Lactulose is a synthetic, non-digestible sugar used in the treatment of chronic constipation; laxative.<br>References Voskuijl, W. et al.: Gut, 53, 1590 (2004);<br></p>

<p>Applications Erdosteine is a mucolytic. Erdosteine was developed for the treatment of chronic obstructive bronchitis.<br>References Kuvandik, G., et al.: Toxicol. Pathol., 36, 714 (2008), Koyu, A., et al.: Mol. Cell. Biochem., 331, 43 (2009), Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010),<br></p>

<p>Applications Erythritol a sugar alcohol used as a food additive.<br>References Leisso, R., et al.: J. Agr. Food. Chem., 61, 1373 (2013); Hillmann, H., et al.: J. Agr. Food. Chem., 60, 9974 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications (-)-Biotin Sulfoxide, is a metabolite of Biotin (B389040), which is a growth factor present in minute amounts in every living cell, and plays an indispensable role in numerous naturally occurring carboxylation reactions.<br>References du Vigneaud, et al.: J. Biol. Chem., 146, 475 (1942), Traub, et al.: Nature, 178, 649 (1956), Siegel, H., et al.: Experienta, 37, 789 (1981), Vesely, D.L., Science, 216, 1329 (1982), Hugues, M., et al.: Biochemistry, 31, 12 (1992),<br></p>

<p>Applications Used as a reference standard for the drug Sucralfate.<br></p>

<p>Applications Nitrosobiotin Impurity is a useful research chemical.<br></p>

<p>Applications 2-Methylcitric Acid is a metabolite of Citric Acid (C521000). It is formed from the condensation of propionoyl-CoA and oxaloacetic acid catalyzed by a citrate synthase enzyme.<br>References Allen, R. H., et al.: Metabolism, 42, 978 (1993)<br></p>

<p>Applications Citric Acid Monohydrate is a useful buffer component for antigen and epitope unmasking.<br></p>

<p>Applications Ligand used for the preparation of an affinity resin highly specific for glucosidase I purification. Glucosidase I is involved in the post-translational processing of N-linked glycoproteins.<br>References HettKamp, H., et al.: Eur. J. Biochem., 142, 85 (1984); Shailubhai, K., et al.: Biochem. J., 247, 555 (1987); Bause, E., et al.: FEBS, 278, 167 (1991)<br></p>

<p>Applications D-Lactose Monohydrate is an excipient used in dry powder inhaler of aspirin.<br>References Bais, N., et al.: Int. J. Pharm. Life Sci., 7, 5047-5050 (2016)<br></p>

<p>Applications A Vitamin D derivative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koeffler, M.R., et al.: Blood, 74, 82 (1989),<br></p>

<p>Impurity Biotin EP Impurity B<br>Applications Biotin Diacid (Biotin EP Impurity B) is an impurity of Biotin (B389040).<br>References Trotter, J., et al.: Biochemistry, 5, 713 (1966), Suurkuusk, J., et al.: Eur. J.Biochem., 28, 438 (1972),<br></p>

<p>Applications 6-O-β-D-Galactopyranosyl-D-galactose can be as a substrate of β-galactosidase in research studies.<br>References Kotake, T., et al.: Plant Physio., 138(3), 1563-1576 (2005)<br></p>

<p>Applications D-[13C5]Xylose is a labeled analog of D-Xylose, which is used in diagnostic malabsorption tests as well as in the production of Furfural.<br>References Ehrenpreis E.D. et al.: J. Acquir. Immune. Defic. Syndr., 5, 1047 (1992); Sérgio L. et al.: Cat. Comm., 9, 2144 (2008);<br></p>

<p>Stability Hygroscopic<br>Applications Sucrose Heptasulfate Potassium Salt is used as a reference standard for the drug Sucralfate.<br></p>

<p>Applications Meglumine Diatrizoate is a contrast agent used in abdominal computed tomography.<br>References Naidoo, N., et. al.: Curr. Pharm. Anal., 10, 92 (2014)<br></p>

<p>Applications trans-4-Aminocyclohexanol, used in the preparation of potential hypertensive agents and other biologically active compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chan, K.L. et al.: As. J. Pharmacol. Sci., 1, 91 (1979);<br></p>

<p>Applications Citric Acid 1,2-Diethyl Ester is an ethyl citrate found in lemon juice.<br>References Neurath, G. et al.: Zeitsch. Lebens.-Untersuch. Forsch., 136, 284 (1968);<br></p>

<p>Applications Xylitol, is a lower-calorie alternative to table sugar. Studies have shown xylitol chewing gum can help prevent acute otitis media. Xylitol is categorized by the U.S. Food and Drug Administration as a food additive.<br>References Code of Federal Regulations Title 21, US., FDA (2012); Azarparzhooh, A., et al.,: Cochrane data. Sys. Revi. (online) (11), (2011);<br></p>

<p>Stability Temperature Sensitive<br>Applications A metabolite of Shikimic Acid.<br>References Lauhon, C.T. and Bartlett, P.A.: Biochemistry, 33, 14100 (1994), Balasubramanian, S., et al.: Biochemistry, 34, 341 (1995),<br></p>

<p>Stability Air Sensitive, Hygroscopic<br>Applications The active metabolite of Erdosteine (E596050).<br>References Dechant, K., et al.: Drugs, 52, 875 (1996), Braga, P., et al.: Arzneim.-Forsch., 49, 344 (1999), Braga, P., et al.: Antimicrob. Agents Chemother., 43, 1013 (1999),<br></p>

<p>Applications An α-Glucosidase inhibitor used as an antidiabetic.<br>References Matsuo, T., et al.: Am. J. Clin. Nutr., 55, 314S (1992), Goke, B., et al.: Digestion, 56, 493 (1995), Shinozaki, K., et al.: Metabolism, 45, 731 (1996)<br></p>

<p>Applications An alkylated dipeptide reported to be 6000 to 10000 times sweeter than sucrose; structurally related to Aspartame. A non-nutritive sweetener.<br>References Ranney, R., et al.: J. Toxicol. Environ. Health, 2, 441 (1976), Padden, B.E., et al.: Anal. Chem., 71, 3325 (1999), Arai, H., et al.: Metabolism, 56, 115 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications A novel membrane-permeant allosteric effector of hemoglobin (Hb), enhances the regulated oxygen release capacity of red blood cells, thus counteracting the effects of hypoxia in diseases such as cancer and cardiovascular ailments.<br>References Duarte,C.D. et al.: Chembiochem., 11, 2543 (2010); Biolo, A. et al.: Proc. Nat. Acad. Sci. U.S.A., 106, 1926 (2009);<br></p>

<p>Applications Fructosazine is used in the treatment of osteoarthritis and rheumatoid arthritis.<br>References Yamaguchi, T., et al.: Biol. Pharm. Bull., 21, 205 (1998), Fenton, J., et al.: Osteoarthritis Cartilage, 8, 444 (2000), Shimamura, T., et al.: J. Agric. Food. Chem., 48, 1204 (2000)<br></p>

<p>Stability Very Hygrocsopic<br>Applications A labile hydrolysis product of the antitumor nuceloside 5-Azacytidine (A796000).<br>References Beisler, J. A. et al.: J. Med. Chem., 21, 204 (1978); Chan, K.K. et al.: J. Pharmac. Sci., 68, 807 (1979);<br></p>

<p>Impurity Acarbose EP Impurity A<br>Applications Acarbose D-Fructose (Acarbose EP Impurity A) is an impurity of Acarbose (A123500) (1,2,3,4). Acarbose impurity A.<br>References (1) Kim, I., et al.: J. Biol. Chem., 267, 22108 (1992) (2) Tonozuka, T., et al.: Carbohydr. Res., 261, 157 (1994) (3) Brzozowski, A., et al.: Biochemistry, 36, 10837 (1997) (4) Cha, H., et al.: Eur. J. Biochem., 253, 251 (1998)<br></p>

<p>Stability Light Sensitive<br>Applications Provisionally listed for use in food, drugs and cosmetics. Sunset Yellow is useful in fermented foods which must be heat treated. It may be found in orange sodas, orange jelly, marzipan, Swiss rolls, apricot jam, citrus marmalade, lemon curd, sweets, hot chocolate mix and packet soups, trifle mix, breadcrumbs, snack chips, shelf fresh noodles, cheese sauce mixes. Sunset Yellow is a sulfonated version of Sudan I, a possible carcinogen. Sunset Yellow itself may be responsible for causing an allergic reaction in people with an aspirin intolerance, resulting in various symptoms, including gastric upset, diarrhea, vomiting, nettle rash (urticaria), swelling of the skin (angioedema) and migraines. Dyes and metabolites, Environmental Testing<br>References Radomski, J.L., et al.: J. Pharmacol. Exp. Ther., 136, 259 (1962), Gaunt, I.F., et al.: Food Cosmet. Toxicol., 5, 747 (1967),<br></p>

<p>Applications Labelled 2-Oleoylglycerol (O528020). A metabolite of 2-acylglycerol used as biomarker.<br>References Owen, M., et al.: Biochem. J., 323, 17 (1997), Waterman, I., et al.: J. Lipid Res., 43, 1555 (2002), Chon, S., et al.: J. Biol. Chem., 282, 33346 (2007),<br></p>

<p>Applications Thiophanium is an impurity of Biotin (B389040) which is a growth factor present in minute amounts in every living cell.<br>References du Vigneaud, et al.: J. Biol. Chem., 146, 475 (1942), Traub, et al.: Nature, 178, 649 (1956), Siegel, H., et al.: Experienta, 37, 789 (1981), Vesely, D.L., Science, 216, 1329 (1982), Hugues, M., et al.: Biochemistry, 31, 12 (1992),<br></p>

<p>Stability Very Hygroscopic<br>Applications One of the main product of transformation of maltose into prebiotic isomaltooligosaccharides by novel α-glucosidase from Xantophyllomyces dendrorhous.<br>References Tzortzis, G., et al.: Appl. Microbiol. Biotechnol., 63, 286 (2003), Chaen, H., et al.: J. Biosci. Bioeng., 92, 177 (2001), Ferrer, M., et al.: Biochem. J., 391, 269 (2005),<br></p>

<p>Stability Very Hygroscopic<br>Applications Lactose-3’-sulfate (cas# 159358-51-7) is a compound useful in organic synthesis.<br></p>

<p>Impurity Bromhexine EP Impurity D<br>Applications 2-Amino-5-bromo-N-cyclohexyl-N-methylbenzylamine (Bromhexine EP Impurity D) is an impurity of Bromhexine hydrochloride (B678600). Bromhexine hydrochloride impurity D.<br>References Uboh, C.E., et al.: J. Pharmaceut. Biomed. Anal., 9, 33 (19991),<br></p>